2023
A Multi-Center, Randomized, Blinded Clinical Study Evaluating the Efficacy and Safety of a Novel Topical Product for Facial Dyschromia.
Wang J, Fabi S, Robinson D, Bajaj S, Geronemus R, Bell M, Widgerow A. A Multi-Center, Randomized, Blinded Clinical Study Evaluating the Efficacy and Safety of a Novel Topical Product for Facial Dyschromia. Journal Of Drugs In Dermatology 2023, 22: 333-338. PMID: 37026875, DOI: 10.36849/jdd.7340.Peer-Reviewed Original ResearchConceptsModified Melasma Area Severity IndexHydroquinone 4%Post-inflammatory hyperpigmentationFacial dyschromiaBlinded clinical studyFollow-upClinical studiesTopical productsAdverse eventsModified melasma area severity index scoreMulti-centerMelasma Area Severity IndexArea Severity IndexNo adverse eventsClearance of pigmentIn vitro studiesExcessive sun exposureBlinded investigatorRight cheekWeek 4Griffiths ScalesReduced clearanceSun exposureMedical disordersTolerability assessments
2019
Acetyl zingerone: An efficacious multifunctional ingredient for continued protection against ongoing DNA damage in melanocytes after sun exposure ends
Chaudhuri RK, Meyer T, Premi S, Brash D. Acetyl zingerone: An efficacious multifunctional ingredient for continued protection against ongoing DNA damage in melanocytes after sun exposure ends. International Journal Of Cosmetic Science 2019, 42: 36-45. PMID: 31538664, PMCID: PMC7004018, DOI: 10.1111/ics.12582.Peer-Reviewed Original ResearchConceptsSun exposureSolar-simulated ultraviolet radiationReactive oxygen speciesIntracellular levelsCyclobutane pyrimidine dimersΑ-tocopherolCPD formationTraditional sunscreensScavenge peroxynitriteUVR exposureOngoing DNA damageAntioxidant α-tocopherolUltraviolet radiationUVA radiationMelanocytesROS formationExposureQuench singlet oxygenUse of AZEfficacyOxygen speciesKeratinocytesDNA damageFree radicalsHours
2016
Germline MC1R status influences somatic mutation burden in melanoma
Robles-Espinoza CD, Roberts ND, Chen S, Leacy FP, Alexandrov LB, Pornputtapong N, Halaban R, Krauthammer M, Cui R, Timothy Bishop D, Adams DJ. Germline MC1R status influences somatic mutation burden in melanoma. Nature Communications 2016, 7: 12064. PMID: 27403562, PMCID: PMC4945874, DOI: 10.1038/ncomms12064.Peer-Reviewed Original ResearchMeSH KeywordsAgedAllelesCohort StudiesFemaleGenetic Predisposition to DiseaseGenetic VariationGerm-Line MutationHair ColorHead and Neck NeoplasmsHumansMaleMelanomaMelanosisMiddle AgedMutationMutation AccumulationNeoplasm InvasivenessPolymorphism, Single NucleotideReceptor, Melanocortin, Type 1Skin NeoplasmsSkin PigmentationConceptsR allelePhenotypic risk factorsCutaneous melanoma riskYears of ageSomatic mutation burdenRisk factorsMutation burdenSun exposureGeneral populationMelanoma riskMutational burdenSun sensitivityMC1R statusMajor genetic determinantMelanoma developmentReceptor geneT mutationMelanomaRed hairGenetic determinantsMutation classesDisruptive variantsBurdenAllelesMelanocortin 1 receptor (MC1R) gene
2013
Association between ultraviolet radiation, skin sun sensitivity and risk of pancreatic cancer
Tran B, Whiteman DC, Webb PM, Fritschi L, Fawcett J, Risch HA, Lucas R, Pandeya N, Schulte A, Neale RE, Group F. Association between ultraviolet radiation, skin sun sensitivity and risk of pancreatic cancer. Cancer Epidemiology 2013, 37: 886-892. PMID: 24075798, DOI: 10.1016/j.canep.2013.08.013.Peer-Reviewed Original ResearchConceptsHigh ambient ultraviolet radiationPancreatic cancerAmbient ultraviolet radiationLower riskAustralian case-control studyPancreatic cancer incidenceSkin sun sensitivityCase-control studyMarkers of exposureFair skin colorCancer incidenceInverse associationSkin lesionsSun exposureLesion treatmentSun sensitivityCancerLight skin colorSkin typeSkin colorDark skin colorUltraviolet radiationIndividual-level studiesSkin lesion treatmentRiskSingle v. multiple measures of skin carotenoids by resonance Raman spectroscopy as a biomarker of usual carotenoid status
Scarmo S, Cartmel B, Lin H, Leffell DJ, Ermakov IV, Gellermann W, Bernstein PS, Mayne ST. Single v. multiple measures of skin carotenoids by resonance Raman spectroscopy as a biomarker of usual carotenoid status. British Journal Of Nutrition 2013, 110: 911-917. PMID: 23351238, PMCID: PMC3696054, DOI: 10.1017/s000711451200582x.Peer-Reviewed Original ResearchConceptsSkin carotenoid statusRecent sun exposureCarotenoid statusSkin carotenoidsSun exposureRR measuresFruit/vegetable intakeLower carotenoid statusSeason of measurementMean ageNon-invasive methodVegetable intakeInverse associationDietary dataTime pointsSignificant predictorsMultiple measuresPositive associationIntakeBiomarkersPresent studyStatusPredictorsAssociationExposure
2012
High salt induces pathogenic Th17 cells and exacerbates autoimmune diseases (60.13)
Kleinewietfeld M, Manzel A, Wu C, Titze J, Kuchroo V, Linker R, Muller D, Hafler D. High salt induces pathogenic Th17 cells and exacerbates autoimmune diseases (60.13). The Journal Of Immunology 2012, 188: 60.13-60.13. DOI: 10.4049/jimmunol.188.supp.60.13.Peer-Reviewed Original ResearchPathogenic Th17 cellsExperimental autoimmune encephalomyelitisEnvironmental risk factorsTh17 cellsAutoimmune diseasesRisk factorsMultiple sclerosisHigh-salt dietHelper T cellsGenetic risk factorsExacerbated inductionAutoimmune encephalomyelitisSalt dietSalt intakeCardiovascular diseaseT cellsSun exposureSevere formDiseaseGenetic factorsDietCertain pathogensInduction of murineInductionPivotal role
2010
Cancer Screening Adherence
Gierisch J, Bastian L. Cancer Screening Adherence. 2010, 123-150. DOI: 10.1007/978-1-4419-5866-2_6.Peer-Reviewed Original ResearchBurden of cancerCancer Screening AdherenceNon-skin cancerScreening adherencePrimary preventionPhysical inactivityRisk factorsUnhealthy dietTobacco useSun exposureAlcohol consumptionScreening testCancerEarly detectionEffective optionGenetic mutationsBehavioral modificationSmall proportionBurdenObesityDiseasePrevention
2007
Ultraviolet Radiation Exposure and Risk of Non-Hodgkin's Lymphoma
Zhang Y, Holford TR, Leaderer B, Boyle P, Zhu Y, Wang R, Zou K, Zhang B, Wise JP, Qin Q, Kilfoy B, Han J, Zheng T. Ultraviolet Radiation Exposure and Risk of Non-Hodgkin's Lymphoma. American Journal Of Epidemiology 2007, 165: 1255-1264. PMID: 17327216, DOI: 10.1093/aje/kwm020.Peer-Reviewed Original ResearchConceptsHodgkin's lymphomaLymphoma subtypesNon-Hodgkin lymphomaCase-control studyHodgkin lymphoma subtypesUltraviolet radiation exposureHighest tertileConnecticut womenSun exposureLymphomaRadiation exposureDuration of timeWomenSuntanRiskFurther investigationDurationExposureTertileYearsSubtypesMonths
2006
Communication about behavioral health risks
Makoul G, Dhurandhar A, Goel M, Scholtens D, Rubin A. Communication about behavioral health risks. Journal Of General Internal Medicine 2006, 21: 698-703. PMID: 16808769, PMCID: PMC1924697, DOI: 10.1111/j.1525-1497.2006.00467.x.Peer-Reviewed Original ResearchConceptsBehavioral health risksInternal medicine practiceHealth behavior changeInitial visitGeneral internal medicine practiceMedicine practiceRisk behaviorsHealth risk screeningHealth risksNew patient visitsPrimary care practicesAcademic medical centerBehavior changePatient agePreventable morbidityRisk factorsPatient visitsObservational studyRisk screeningMedical CenterGeneral internistsSun exposureNational guidelinesCare practicesMajor cause
2005
Long-term effects of hormone therapy on skin rigidity and wrinkles
Wolff EF, Narayan D, Taylor HS. Long-term effects of hormone therapy on skin rigidity and wrinkles. Fertility And Sterility 2005, 84: 285-288. PMID: 16084862, DOI: 10.1016/j.fertnstert.2004.12.062.Peer-Reviewed Original ResearchConceptsHormone therapyHT usersLong-term hormone therapyAcademic medical centerSkin rigidityCross-sectional analysisWrinkle scoreHormone usersCosmetic benefitsInclusion criteriaLong-term effectsMedical CenterSun exposureTobacco useMAIN OUTCOMENonhormone usersSunscreen useSkin typeTherapyPlastic surgeonsWomenLemperle scaleFacial locationCheekVisual assessment
2002
Vitamin and carotenoid intake and risk of squamous cell carcinoma of the skin
Fung TT, Spiegelman D, Egan KM, Giovannucci E, Hunter DJ, Willett WC. Vitamin and carotenoid intake and risk of squamous cell carcinoma of the skin. International Journal Of Cancer 2002, 103: 110-115. PMID: 12455062, DOI: 10.1002/ijc.10798.Peer-Reviewed Original ResearchConceptsCases of SCCHEALTHY studyProspective cohort study designMale health professionalsHealth Professionals FollowCohort study designIntake of vitaminsSquamous cell carcinomaSignificant inverse associationDevelopment of SCCImportant protective roleIncidence of SCCBiennial questionnairesProfessionals FollowMultivariate adjustmentCell carcinomaSCC incidenceDietary factorsInverse associationMedical recordsRisk factorsRelative riskLarge cohortCarotenoid intakeSun exposureIntake of alcohol and alcoholic beverages and the risk of basal cell carcinoma of the skin.
Fung TT, Hunter DJ, Spiegelman D, Colditz GA, Rimm EB, Willett WC. Intake of alcohol and alcoholic beverages and the risk of basal cell carcinoma of the skin. Cancer Epidemiology Biomarkers & Prevention 2002, 11: 1119-22. PMID: 12376519.Peer-Reviewed Original ResearchConceptsAlcohol intakeSun sensitivity factorsMultivariate relative riskTotal alcohol intakeFood frequency questionnaireRisk of BCCBasal cell carcinomaIntake of alcoholPooled logistic regressionAlcoholic beveragesLast physical examinationCases of BCCFrequency questionnaireMultivitamin useSignificant positive associationCell carcinomaPhysical examinationInverse associationRelative riskLarge cohortSun exposureOutdoor walkingLogistic regressionIntakeMore alcoholVitamins and carotenoids intake and the risk of basal cell carcinoma of the skin in women (United States)
Fung TT, Hunter DJ, Spiegelman D, Colditz GA, Speizer FE, Willett WC. Vitamins and carotenoids intake and the risk of basal cell carcinoma of the skin in women (United States). Cancer Causes & Control 2002, 13: 221-230. PMID: 12020103, DOI: 10.1023/a:1015036317596.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge DistributionAscorbic AcidCarcinoma, Basal CellCarotenoidsCohort StudiesConfidence IntervalsDietDietary SupplementsFemaleHumansIncidenceLogistic ModelsMiddle AgedProbabilityProspective StudiesRisk AssessmentSensitivity and SpecificitySkin NeoplasmsUnited StatesVitamin AVitamin EVitaminsConceptsBasal cell carcinomaVitamin ACell carcinomaDietary intakeRelative riskSun sensitivity factorsMultivariate relative riskFood frequency questionnaireRisk of BCCSignificant inverse associationIncidence of BCCImportant protective roleFirst diagnosisDietary factorsInverse associationSun exposureLatency periodProtective roleSpecific carotenoidsLogistic regressionVitamin CBottom quintileIntakeCarcinomaRisk
1999
Oral contraceptive use and risk of melanoma in premenopausal women
Feskanich D, Hunter DJ, Willett WC, Spiegelman D, Stampfer MJ, Speizer FE, Colditz GA. Oral contraceptive use and risk of melanoma in premenopausal women. British Journal Of Cancer 1999, 81: 918-923. PMID: 10555769, PMCID: PMC2374297, DOI: 10.1038/sj.bjc.6690787.Peer-Reviewed Original ResearchConceptsCurrent OC usersOral contraceptive useRisk of melanomaOC usersRisk factorsContraceptive useSun exposureHealth Study II cohortLow-dose oestrogen pillsPast OC usersBody mass indexPossible risk factorsLonger durationPremenopausal white womenLogistic regression modelsNHS IIOC usePremenopausal womenSignificant twofold increaseMass indexSuperficial spreadingNodular melanomaSkin reactionsIncidence rateSunburn historyRisk Factors for Basal Cell Carcinoma of the Skin in Men: Results from the Health Professionals Follow-up Study
van Dam R, Huang Z, Rimm E, Weinstock M, Spiegelman D, Colditz G, Wiflett W, Giovannucci E. Risk Factors for Basal Cell Carcinoma of the Skin in Men: Results from the Health Professionals Follow-up Study. American Journal Of Epidemiology 1999, 150: 459-468. PMID: 10472945, DOI: 10.1093/oxfordjournals.aje.a010034.Peer-Reviewed Original ResearchConceptsBasal cell carcinomaBCC riskCell carcinomaSun exposureElevated riskUS male health professionalsMale health professionalsHealth Professionals FollowConstitutional factorsRisk of BCCYears of ageRegion of residenceBlistering sunburnsProfessionals FollowProspective cohortRisk factorsNorth European ancestryHealth professionalsLifetime numberCarcinomaRiskMenRed hairEuropean ancestrySkin
1998
Sunlamp use and the risk of cutaneous malignant melanoma: a population-based case-control study in Connecticut, USA
Chen Y, Dubrow R, Zheng T, Barnhill R, Fine J, Berwick M. Sunlamp use and the risk of cutaneous malignant melanoma: a population-based case-control study in Connecticut, USA. International Journal Of Epidemiology 1998, 27: 758-765. PMID: 9839730, DOI: 10.1093/ije/27.5.758.Peer-Reviewed Original ResearchConceptsCutaneous malignant melanomaSunlamp useMalignant melanomaHigh riskPopulation-based case-control studyFirst primary cutaneous melanomaRecreational sun exposurePrimary cutaneous melanomaCase-control studyRisk of melanomaUse of sunlampsRandom digit dialingCutaneous melanomaSubgroup analysisSun exposureCutaneous phenotypeGeneral populationStudy subjectsMelanomaLimited evidenceCaucasian populationFirst useRiskSunlampsAmount of exposure
1996
Malignant melanoma risk factors by anatomic site: A case‐control study and polychotomous logistic regression analysis
Chen Y, Dubrow R, Holford T, Zheng T, Barnhill R, Fine J, Berwick M. Malignant melanoma risk factors by anatomic site: A case‐control study and polychotomous logistic regression analysis. International Journal Of Cancer 1996, 67: 636-643. PMID: 8782651, DOI: 10.1002/(sici)1097-0215(19960904)67:5<636::aid-ijc8>3.0.co;2-v.Peer-Reviewed Original ResearchConceptsMelanoma risk factorsCase-control studyRisk factorsAnatomic sitesSun exposurePopulation-based case-control studySun exposure-related factorsIntermittent sun exposureHistory of sunburnOnly risk factorPolychotomous logistic regression analysisInvasive melanoma casesNumber of neviLogistic regression analysisExposure-related factorsDevelopment of melanomaSex differencesPolychotomous logistic regressionHistologic subtypeMalignant melanomaClothing habitsPigmentary characteristicsMelanoma casesStudy subjectsLogistic regression
1995
Aging skin
Bolognia J. Aging skin. The American Journal Of Medicine 1995, 98: s99-s103. PMID: 7825648, DOI: 10.1016/s0002-9343(99)80066-7.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAlpha-reductase activityTissue androgensChronologic agingCumulative sun exposureAndrogen receptor bindingElastic fiber degenerationSebaceous gland activityInfluence of androgensAge-dependent decreaseInfluence of testosteroneAge-dependent mannerAge-related changesEffects of hormonesCutaneous changesPubic skinSkin changesFiber degenerationSun exposureActinic damageHormonal influencesThigh skinSolar lentiginesAndrogensReceptor bindingSoft tissue
1992
Sun Protection and Vitamin D Status in Infants-Reply
BOLOGNIA J, FINE J, JASMIN M, BERWICK M, SIMPSON P. Sun Protection and Vitamin D Status in Infants-Reply. JAMA Pediatrics 1992, 146: 1260-1260. DOI: 10.1001/archpedi.1992.02160230018006.Peer-Reviewed Original ResearchSun exposure and sunscreen use following a community skin cancer screening
Berwick M, Fine J, Bolognia J. Sun exposure and sunscreen use following a community skin cancer screening. Preventive Medicine 1992, 21: 302-310. PMID: 1614992, DOI: 10.1016/0091-7435(92)90029-h.Peer-Reviewed Original Research
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