2022
Proximity proteomics of synaptopodin provides insight into the molecular composition of the spine apparatus of dendritic spines
Falahati H, Wu Y, Feuerer V, Simon HG, De Camilli P. Proximity proteomics of synaptopodin provides insight into the molecular composition of the spine apparatus of dendritic spines. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2203750119. PMID: 36215465, PMCID: PMC9586327, DOI: 10.1073/pnas.2203750119.Peer-Reviewed Original ResearchConceptsSpine apparatusDendritic spinesSubset of neuronsAxon initial segmentDendritic shaftsER cisternsNonneuronal cellsSynaptopodinSpineSmooth endoplasmic reticulumEndoplasmic reticulumCisternal organelleInitial segmentSpecific localizationCisternsBinding proteinPDLIM7Expression patternsSubsetProteinSmall subsetDiseaseNeuronsBrainFunctional partnership
2020
Stac protein regulates release of neuropeptides
Hsu IU, Linsley JW, Zhang X, Varineau JE, Berkhoudt DA, Reid LE, Lum MC, Orzel AM, Leflein A, Xu H, Collins CA, Hume RI, Levitan ES, Kuwada JY. Stac protein regulates release of neuropeptides. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 29914-29924. PMID: 33168737, PMCID: PMC7703553, DOI: 10.1073/pnas.2009224117.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedBehavior Observation TechniquesBehavior, AnimalCalcium ChannelsDrosophila melanogasterDrosophila ProteinsFemaleIntracellular Signaling Peptides and ProteinsIntravital MicroscopyLarvaMaleModels, AnimalMotor NeuronsMuscle, SkeletalNeuromuscular JunctionNeuropeptidesOptical ImagingPatch-Clamp TechniquesPresynaptic TerminalsConceptsSTAC proteinsRelease of neuropeptidesVertebrate skeletal muscleSubset of neuronsMolecular regulationGenetic manipulationKey regulatorMotor neuronsCytosolic CaNumerous neural functionsSmall familyCentral nervous systemExcitation-contraction couplingGenesSkeletal muscleL-type CaProteinNeuropeptide releaseNervous systemNeural functionDrosophilaNeuropeptidesVertebratesNeuronsRegulatorDstac Regulates Excitation-Contraction Coupling in Drosophila Body Wall Muscles
Hsu IU, Linsley JW, Reid LE, Hume RI, Leflein A, Kuwada JY. Dstac Regulates Excitation-Contraction Coupling in Drosophila Body Wall Muscles. Frontiers In Physiology 2020, 11: 573723. PMID: 33123029, PMCID: PMC7573238, DOI: 10.3389/fphys.2020.573723.Peer-Reviewed Original ResearchExcitation-contraction couplingL-type voltage-gated calcium channelsVoltage-gated calcium channelsSubset of neuronsBody wall musclesL-type CaCalcium channelsNormal expression levelsEC couplingMuscle contractionSkeletal muscleSpecific antibodiesMuscleLarval body wall musclesDmca1DExpression levelsWall musclesNormal locomotionDrosophila body wall musclesNeuronsVertebrate skeletal muscleAntibodiesDeficient larvaeDissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs
Burke EE, Chenoweth JG, Shin JH, Collado-Torres L, Kim SK, Micali N, Wang Y, Colantuoni C, Straub RE, Hoeppner DJ, Chen HY, Sellers A, Shibbani K, Hamersky GR, Diaz Bustamante M, Phan BN, Ulrich WS, Valencia C, Jaishankar A, Price AJ, Rajpurohit A, Semick SA, Bürli RW, Barrow JC, Hiler DJ, Page SC, Martinowich K, Hyde TM, Kleinman JE, Berman KF, Apud JA, Cross AJ, Brandon NJ, Weinberger DR, Maher BJ, McKay RDG, Jaffe AE. Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs. Nature Communications 2020, 11: 462. PMID: 31974374, PMCID: PMC6978526, DOI: 10.1038/s41467-019-14266-z.Peer-Reviewed Original ResearchConceptsHuman induced pluripotent stem cellsNeural precursor cellsExpression dataSingle-cell expression dataNeuronal differentiationSequencing read alignmentsInduced pluripotent stem cellsEarly neuronal differentiationPluripotent stem cellsTranscriptomic resourcesIPSC donorNeuronal culturesSubclonal linesNeural differentiationTranscriptomic signaturesHuman neural precursor cellsNeuronal cellsStem cellsPrecursor cellsCell sortingGlobal patternsPowerful modelSubset of neuronsRead alignmentDifferentiation
2018
Adenosine Signaling through A1 Receptors Inhibits Chemosensitive Neurons in the Retrotrapezoid Nucleus
James SD, Hawkins VE, Falquetto B, Ruskin DN, Masino SA, Moreira TS, Olsen ML, Mulkey DK. Adenosine Signaling through A1 Receptors Inhibits Chemosensitive Neurons in the Retrotrapezoid Nucleus. ENeuro 2018, 5: eneuro.0404-18.2018. PMID: 30627640, PMCID: PMC6325544, DOI: 10.1523/eneuro.0404-18.2018.Peer-Reviewed Original ResearchMeSH Keywords6-Cyano-7-nitroquinoxaline-2,3-dioneAdenosineAnimalsAnimals, NewbornBariumCarbon DioxideChemoreceptor CellsExcitatory Amino Acid AntagonistsFemaleMaleMice, Inbred C57BLMice, TransgenicNeuronal PlasticityNeurotransmitter AgentsPotassium Channel BlockersPurinergic AgentsRatsRats, Sprague-DawleyReceptors, Purinergic P1Respiratory CenterSignal TransductionSodium Channel BlockersTetrodotoxinConceptsChemosensitive RTN neuronsRTN neuronsA1 receptorsRTN chemoreceptorsChemoreceptor activitySelective A1 receptor antagonistFrequency of EPSCsWild-type mouse pupsA1 receptor antagonistExcitatory synaptic inputsReceptor-dependent mechanismEffects of adenosineSubset of neuronsCell-attached recordingsLike conductanceRTN chemoreceptionChemosensitive neuronsRetrotrapezoid nucleusReceptor antagonistSynaptic mechanismsMouse pupsSynaptic inputsRespiratory chemoreceptorsPurinergic signalingPurinergic regulation
2017
Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control
Ramírez S, Gómez-Valadés AG, Schneeberger M, Varela L, Haddad-Tóvolli R, Altirriba J, Noguera E, Drougard A, Flores-Martínez Á, Imbernón M, Chivite I, Pozo M, Vidal-Itriago A, Garcia A, Cervantes S, Gasa R, Nogueiras R, Gama-Pérez P, Garcia-Roves PM, Cano DA, Knauf C, Servitja JM, Horvath TL, Gomis R, Zorzano A, Claret M. Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control. Cell Metabolism 2017, 25: 1390-1399.e6. PMID: 28591639, DOI: 10.1016/j.cmet.2017.05.010.Peer-Reviewed Original ResearchConceptsMitofusin 1Mitochondrial dynamicsGene expression programsNutrient sensing mechanismsExpression programsMitochondrial architectureMitochondrial oxygen fluxNutrient sensingMitochondrial flexibilityNutrient availabilityPancreatic β-cellsUnrecognized linkDefective insulin secretionOxygen species generationMetabolism controlΒ-cellsSubset of neuronsSystemic glucose metabolismPOMC neuronsCritical sensorsSpecies generationPrecise mechanismGlucose homeostasisBIN1 localization is distinct from Tau tangles in Alzheimer's disease.
De Rossi P, Buggia-Prevot V, Andrew RJ, Krause SV, Woo E, Nelson PT, Pytel P, Thinakaran G. BIN1 localization is distinct from Tau tangles in Alzheimer's disease. Matters 2017, 2017 PMID: 29479533, PMCID: PMC5823513, DOI: 10.19185/matters.201611000018.Peer-Reviewed Original ResearchTangle pathologyHuman ADBIN1 expressionNeurofibrillary tangle pathologyBrains of patientsSubset of neuronsRisk factor genesAD brainNeurofibrillary tanglesTau tanglesPeripheral tissuesSenile plaquesTau propagationPathological lesionsWhite matterAlzheimer's diseaseMature oligodendrocytesGray matterCellular markersBrainCellular expressionComplex cellular mechanismsInverse correlationCellular mechanismsDisease
2015
Reelin Prevents Apical Neurite Retraction during Terminal Translocation and Dendrite Initiation
O'Dell RS, Cameron DA, Zipfel WR, Olson EC. Reelin Prevents Apical Neurite Retraction during Terminal Translocation and Dendrite Initiation. Journal Of Neuroscience 2015, 35: 10659-10674. PMID: 26224852, PMCID: PMC4518046, DOI: 10.1523/jneurosci.1629-15.2015.Peer-Reviewed Original ResearchConceptsApical dendritesCortical laminationGlycoprotein ReelinMigration arrestPrimary neuritesMarginal zoneNormal target areaWild-type neuronsSubset of neuronsReeler cortexReeler neuronsDendritic arborsDendritic outgrowthReelin functionMouse cortexReelin proteinNeuronal migrationNeuronsLeading processCortexReelinMin periodNeurite retractionNeuritesTerminal phase
2013
Mosaic Copy Number Variation in Human Neurons
McConnell MJ, Lindberg MR, Brennand KJ, Piper JC, Voet T, Cowing-Zitron C, Shumilina S, Lasken RS, Vermeesch JR, Hall IM, Gage FH. Mosaic Copy Number Variation in Human Neurons. Science 2013, 342: 632-637. PMID: 24179226, PMCID: PMC3975283, DOI: 10.1126/science.1243472.Peer-Reviewed Original ResearchConceptsCopy number variationsHiPSC-derived neuronsSingle-cell genomic approachesNumber variationsDNA copy number variationsSingle-cell sequencingHuman neuronsLarge copy number variationsStem cell linesNeural progenitor cellsNovo copy-number variationsPluripotent stem cell lineAneuploid neuronsGenomic approachesDe novo copy-number variationsSubchromosomal copy number variationsAberrant genomesFrontal cortex neuronsLarge deletionsProgenitor cellsCell linesSubset of neuronsEuploid neuronsDeletionMultiple alterations
2012
An evolutionarily conserved mode of modulation of Shaw‐like K+ channels
Cotella D, Hernandez‐Enriquez B, Duan Z, Wu X, Gazula V, Brown MR, Kaczmarek LK, Sesti F. An evolutionarily conserved mode of modulation of Shaw‐like K+ channels. The FASEB Journal 2012, 27: 1381-1393. PMID: 23233530, PMCID: PMC3606535, DOI: 10.1096/fj.12-222778.Peer-Reviewed Original ResearchConceptsEffect of phosphorylationC. elegansACP-2Acid phosphataseMammalian homologMammalian homologueCaenorhabditis elegansMouse nervous systemRegulatory partnersBiochemical experimentsMolecular mechanismsElegansBehavioral defectsMode of modulationPhosphorylationPharmacological disruptionShaw familyMammalian brainSubset of neuronsVentricular zonePhosphataseModel systemNervous systemMice resultsElectrophysiological analysisGradients and Modulation of K+ Channels Optimize Temporal Accuracy in Networks of Auditory Neurons
Kaczmarek LK. Gradients and Modulation of K+ Channels Optimize Temporal Accuracy in Networks of Auditory Neurons. PLOS Computational Biology 2012, 8: e1002424. PMID: 22438799, PMCID: PMC3305353, DOI: 10.1371/journal.pcbi.1002424.Peer-Reviewed Original ResearchConceptsSpontaneous activityPotassium currentRandom spontaneous activityAuditory brainstem neuronsAuditory brainstem nucleiSubset of neuronsMaximal firing rateHigh rateNormal auditory processingPattern of stimulationBrainstem neuronsBrainstem nucleiSynaptic outputAuditory neuronsChannel expressionSuch neuronsStimulus rateAction potentialsTonotopic axisSound stimulationFiring ratePotassium conductanceNeuronsKv3 channelsIndividual neurons
1999
The Odor Specificities of a Subset of Olfactory Receptor Neurons Are Governed by Acj6, a POU-Domain Transcription Factor
Clyne P, Certel S, de Bruyne M, Zaslavsky L, Johnson W, Carlson J. The Odor Specificities of a Subset of Olfactory Receptor Neurons Are Governed by Acj6, a POU-Domain Transcription Factor. Neuron 1999, 22: 339-347. PMID: 10069339, DOI: 10.1016/s0896-6273(00)81094-6.Peer-Reviewed Original ResearchConceptsPOU domain transcription factorOlfactory neuronsTranscription factorsIndividual olfactory neuronsOdorant response profilesSubset of neuronsOlfactory receptor neuronsOdor specificityPhysiological analysisAcj6Neuronal identityOlfactory behaviorMolecular analysisReceptor neuronsNeuronsReceptor geneOlfactory codingGenesResponse profilesMutantsSpecificitySubset
1996
Chattering Cells: Superficial Pyramidal Neurons Contributing to the Generation of Synchronous Oscillations in the Visual Cortex
Gray C, McCormick D. Chattering Cells: Superficial Pyramidal Neurons Contributing to the Generation of Synchronous Oscillations in the Visual Cortex. Science 1996, 274: 109-113. PMID: 8810245, DOI: 10.1126/science.274.5284.109.Peer-Reviewed Original ResearchConceptsPyramidal neuronsVisual stimulationSuperficial pyramidal neuronsSubset of neuronsIntracellular recordingsSpontaneous activityGamma frequency bandRhythmic firingGamma-band activityVisual cortexCortical oscillationsNeuronsRepetitive burstsCortexIntracortical contributionsSuperficial layersStimulationMembrane potentialFunctional significanceCellsLarge populationSynchronous oscillationsResponse
1995
Modulation of calcium currents by a D1 dopaminergic protein kinase/phosphatase cascade in rat neostriatal neurons
Surmeier D, Bargas J, Hemmings H, Nairn A, Greengard P. Modulation of calcium currents by a D1 dopaminergic protein kinase/phosphatase cascade in rat neostriatal neurons. Neuron 1995, 14: 385-397. PMID: 7531987, DOI: 10.1016/0896-6273(95)90294-5.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-3-isobutylxanthine2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl esterAnimalsBrainCalcium Channel BlockersCalcium ChannelsCells, CulturedColforsinCyclic AMPCyclic AMP-Dependent Protein KinasesElectrophysiologyKineticsMembrane PotentialsNeostriatumNeuronsNifedipinePhosphoprotein PhosphatasesProtein Phosphatase 1RatsRats, WistarReceptors, Dopamine D1TetraethylammoniumTetraethylammonium CompoundsTime FactorsConceptsProtein phosphatase 1Protein kinaseInhibition of PP1Cyclic AMP-dependent protein kinaseAMP-dependent protein kinaseInhibition of PKARat neostriatal neuronsPhosphatase cascadePP1 activityReceptor-mediated activationPhosphatase 1Neostriatal neuronsCalcium currentPKA enhancementDifferential regulationHigh voltage-activated calcium currentsVoltage-activated calcium currentsWhole-cell voltage-clamp techniqueD1 pathwayMedium spiny neuronsCyclic AMP analogueD1 dopamine receptorsL-type currentDiversity of effectsSubset of neurons
1993
hMEF2C Gene Encodes Skeletal Muscle- and Brain-Specific Transcription Factors
McDermott J, Cardoso M, Yu Y, Andres V, Leifer D, Krainc D, Lipton S, Nadal-Ginard B. hMEF2C Gene Encodes Skeletal Muscle- and Brain-Specific Transcription Factors. Molecular And Cellular Biology 1993, 13: 2564-2577. DOI: 10.1128/mcb.13.4.2564-2577.1993.Peer-Reviewed Original ResearchSkeletal muscleSubset of neuronsCortical neuronsBrain-specific transcription factorTranscription factorsMRNA levelsPotential targetTrans-activating activityMuscleMEF2 transcription factorsNeuronsBrainBrain transcriptsMEF2 factorsMuscle-specific enhancerExpressionMyogenic differentiationTissue-specific isoformsUbiquitous expressionFactorsTissue-specific patternsGenesNeurogenesishMEF2C gene encodes skeletal muscle- and brain-specific transcription factors.
McDermott J, Cardoso M, Yu Y, Andres V, Leifer D, Krainc D, Lipton S, Nadal-Ginard B. hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors. Molecular And Cellular Biology 1993, 13: 2564-2577. PMID: 8455629, PMCID: PMC359588, DOI: 10.1128/mcb.13.4.2564.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingAmino Acid SequenceAnimalsBase SequenceBrainCells, CulturedCloning, MolecularConsensus SequenceDNA-Binding ProteinsGene ExpressionGenesHumansImmunologic TechniquesIn Vitro TechniquesMEF2 Transcription FactorsMiceMolecular Sequence DataMusclesMyogenic Regulatory FactorsNeuronsOligodeoxyribonucleotidesPolymerase Chain ReactionRNA, MessengerSequence AlignmentTissue DistributionTranscription FactorsTranscription, GeneticConceptsSkeletal muscleSubset of neuronsCortical neuronsBrain-specific transcription factorTranscription factorsMRNA levelsPotential targetTrans-activating activityMuscleMEF2 transcription factorsNeuronsBrainBrain transcriptsMEF2 factorsMuscle-specific enhancerExpressionMyogenic differentiationTissue-specific isoformsUbiquitous expressionFactorsTissue-specific patternsGenesNeurogenesis
1992
Differential actions of acetylcholinesterase on the soma and dendrites of dopaminergic substantia nigra neurons in vitro
Hajós M, Greenfield S. Differential actions of acetylcholinesterase on the soma and dendrites of dopaminergic substantia nigra neurons in vitro. Brain Research 1992, 585: 416-420. PMID: 1511329, DOI: 10.1016/0006-8993(92)91248-d.Peer-Reviewed Original ResearchConceptsPars reticulataApical dendritesDopaminergic neuronsDopaminergic substantia nigra neuronsSubstantia nigra neuronsSubset of neuronsNon-cholinergic actionsAction of AChEPars compactaSubstantia nigraCalcium conductanceNeuronsPotassium channelsSodium channelsDifferential actionIonic basisDendritesAChEHyperpolarizationReticulataCompactaNigraActionSoma
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