2021
Somatostatin-expressing parafacial neurons are CO2/H+ sensitive and regulate baseline breathing
Cleary C, Milla B, Kuo F, James S, Flynn W, Robson P, Mulkey D. Somatostatin-expressing parafacial neurons are CO2/H+ sensitive and regulate baseline breathing. ELife 2021, 10: e60317. PMID: 34013884, PMCID: PMC8169115, DOI: 10.7554/elife.60317.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarbon DioxideChemoreceptor CellsDisease Models, AnimalEpilepsies, MyoclonicFemaleGlutamic AcidHydrogenIntralaminar Thalamic NucleiLungMaleMice, 129 StrainMice, Inbred C57BLMice, TransgenicNAV1.1 Voltage-Gated Sodium ChannelNeural InhibitionRespirationSomatostatinSynaptic TransmissionConceptsParafacial neuronsRTN chemoreceptorsBaseline breathingParafacial regionInhibitory neuronsInhibitory synaptic interactionsInhibitory neural activityRTN chemoreceptionRTN neuronsChemogenetic suppressionDravet syndromeGlutamatergic neuronsInhibitory inputsMouse modelRespiratory chemoreceptorsSynaptic propertiesSynaptic interactionsTissue CONeuronsBreathingContext of diseaseNeural activityDependent mannerChemoreceptorsNucleus function
2018
Adenosine Signaling through A1 Receptors Inhibits Chemosensitive Neurons in the Retrotrapezoid Nucleus
James SD, Hawkins VE, Falquetto B, Ruskin DN, Masino SA, Moreira TS, Olsen ML, Mulkey DK. Adenosine Signaling through A1 Receptors Inhibits Chemosensitive Neurons in the Retrotrapezoid Nucleus. ENeuro 2018, 5: eneuro.0404-18.2018. PMID: 30627640, PMCID: PMC6325544, DOI: 10.1523/eneuro.0404-18.2018.Peer-Reviewed Original ResearchMeSH Keywords6-Cyano-7-nitroquinoxaline-2,3-dioneAdenosineAnimalsAnimals, NewbornBariumCarbon DioxideChemoreceptor CellsExcitatory Amino Acid AntagonistsFemaleMaleMice, Inbred C57BLMice, TransgenicNeuronal PlasticityNeurotransmitter AgentsPotassium Channel BlockersPurinergic AgentsRatsRats, Sprague-DawleyReceptors, Purinergic P1Respiratory CenterSignal TransductionSodium Channel BlockersTetrodotoxinConceptsChemosensitive RTN neuronsRTN neuronsA1 receptorsRTN chemoreceptorsChemoreceptor activitySelective A1 receptor antagonistFrequency of EPSCsWild-type mouse pupsA1 receptor antagonistExcitatory synaptic inputsReceptor-dependent mechanismEffects of adenosineSubset of neuronsCell-attached recordingsLike conductanceRTN chemoreceptionChemosensitive neuronsRetrotrapezoid nucleusReceptor antagonistSynaptic mechanismsMouse pupsSynaptic inputsRespiratory chemoreceptorsPurinergic signalingPurinergic regulation
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