2013
Apelin-APJ Signaling Is a Critical Regulator of Endothelial MEF2 Activation in Cardiovascular Development
Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T, Chun HJ. Apelin-APJ Signaling Is a Critical Regulator of Endothelial MEF2 Activation in Cardiovascular Development. Circulation Research 2013, 113: 22-31. PMID: 23603510, PMCID: PMC3739451, DOI: 10.1161/circresaha.113.301324.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell NucleusAdipokinesAnimalsApelinApelin ReceptorsCardiovascular AbnormalitiesCardiovascular SystemEndocardiumEndothelium, VascularFemaleFetal HeartGene Expression Regulation, DevelopmentalGenes, LethalGTP-Binding Protein alpha Subunits, G12-G13Histone DeacetylasesIntercellular Signaling Peptides and ProteinsKruppel-Like Transcription FactorsMaleMEF2 Transcription FactorsMiceMice, Inbred C57BLMice, KnockoutMyogenic Regulatory FactorsPhosphorylationProtein Processing, Post-TranslationalReceptors, G-Protein-CoupledSignal TransductionTranscription, GeneticConceptsCardiovascular developmentVentricular wall developmentMyocyte enhancer factor 2Embryonic lethal phenotypeCardiovascular developmental defectsFactor 2Apelin-APJHistone deacetylase 4MEF2 functionModel organismsLethal phenotypeEmbryonic lethalityTranscriptional targetsMEF2 activationKrüppel-like factor 2Wall developmentHDAC5 phosphorylationCushion formationNuclear localizationVascular smooth muscle cellsEndothelial cellsDevelopmental defectsMolecular mechanismsCritical regulatorLigand apelin
2009
MicroRNA-1 Negatively Regulates Expression of the Hypertrophy-Associated Calmodulin and Mef2a Genes
Ikeda S, He A, Kong SW, Lu J, Bejar R, Bodyak N, Lee KH, Ma Q, Kang PM, Golub TR, Pu WT. MicroRNA-1 Negatively Regulates Expression of the Hypertrophy-Associated Calmodulin and Mef2a Genes. Molecular And Cellular Biology 2009, 29: 2193-2204. PMID: 19188439, PMCID: PMC2663304, DOI: 10.1128/mcb.01222-08.Peer-Reviewed Original Research
2008
TGF-β activates ERK5 in human renal epithelial cells
Browne JA, Pearson AL, Zahr RA, Niculescu-Duvaz I, Baines DL, Dockrell ME. TGF-β activates ERK5 in human renal epithelial cells. Biochemical And Biophysical Research Communications 2008, 373: 440-444. PMID: 18588859, DOI: 10.1016/j.bbrc.2008.06.058.Peer-Reviewed Original ResearchMeSH KeywordsCell Line, TumorEpithelial CellsHumansImidazolesKidneyMADS Domain ProteinsMEF2 Transcription FactorsMitogen-Activated Protein Kinase 7Myogenic Regulatory Factorsp38 Mitogen-Activated Protein KinasesProtein Kinase InhibitorsProtein Serine-Threonine KinasesPyridinesReceptor, Transforming Growth Factor-beta Type IReceptors, Transforming Growth Factor betaTransforming Growth Factor betaConceptsExtracellular signal-regulated kinase 5Epidermal growth factorMAP kinaseERK5 activationMyocyte enhancer factor 2Epithelial cell phenotypeP38 MAP kinase inhibitorRenal epithelial cellsMAP kinase inhibitorHuman renal epithelial cellsEmbryonic lethalityGrowth factorExtracellular signalsSB 202190Cell differentiationKinase 5Human PTECsPhospho-ERK5Cell phenotypeFactor 2KinaseEpithelial cellsKinase inhibitorsReceptor activityActivation
2000
Antiapoptotic role of the p38 mitogen-activated protein kinase–myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation
Okamoto S, Krainc D, Sherman K, Lipton S. Antiapoptotic role of the p38 mitogen-activated protein kinase–myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 7561-7566. PMID: 10852968, PMCID: PMC16585, DOI: 10.1073/pnas.130502697.Peer-Reviewed Original ResearchConceptsMyocyte enhancer factor 2Mitogen-activated protein kinase p38alphaNeuronal differentiationDominant-negative p38alphaProtein kinase p38alphaDominant-negative formTranscription factor pathwaysMADS familyMEF2 familyMEF2 pathwayCell divisionTranscription factorsMyogenic phenotypeExpression patternsMyogenic factorsAntiapoptotic roleCell deathMammalian cerebral cortexP38alphaApoptotic deathNegative formPrecursor cellsFactor 2Factor pathwayApoptosis
1998
Synergistic Activation of theN-Methyl-d-aspartate Receptor Subunit 1 Promoter by Myocyte Enhancer Factor 2C and Sp1*
Krainc D, Bai G, Okamoto S, Carles M, Kusiak J, Brent R, Lipton S. Synergistic Activation of theN-Methyl-d-aspartate Receptor Subunit 1 Promoter by Myocyte Enhancer Factor 2C and Sp1*. Journal Of Biological Chemistry 1998, 273: 26218-26224. PMID: 9748305, DOI: 10.1074/jbc.273.40.26218.Peer-Reviewed Original ResearchMeSH KeywordsBinding SitesCell LineDNA-Binding ProteinsEpidermal Growth FactorFibroblast Growth Factor 2Gene Expression Regulation, DevelopmentalMEF2 Transcription FactorsMyogenic Regulatory FactorsNerve Tissue ProteinsNuclear ProteinsPromoter Regions, GeneticProtein BindingReceptors, N-Methyl-D-AspartateRNA, MessengerSp1 Transcription FactorTranscriptional ActivationConceptsMyocyte enhancer factor 2CSp1 sitesSp1 proteinMEF2 siteFactor 2CNMDA receptor subunit 1Results of yeastNR1 promoterMuscle transcription factorsCo-immunoprecipitation experimentsDifferentiated P19 cellsGrowth factorGrowth factor regulationTwo-hybridActivation domainSp1 cDNAEssential subunitTranscription factorsEpidermal growth factorP19 cellsFactor regulationPromoter activityFibroblast growth factorBasic fibroblast growth factorNeuronal development
1995
Assignment of Human Myocyte-Specific Enhancer Binding Factor 2C (hMEF2C) to Human Chromosome 5q14 and Evidence That MEF2C Is Evolutionarily Conserved
Krainc D, Haas M, Ward D, Lipton S, Bruns G, Leifer D. Assignment of Human Myocyte-Specific Enhancer Binding Factor 2C (hMEF2C) to Human Chromosome 5q14 and Evidence That MEF2C Is Evolutionarily Conserved. Genomics 1995, 29: 809-811. PMID: 8575784, DOI: 10.1006/geno.1995.9927.Peer-Reviewed Original ResearchAnimalsBase SequenceBiological EvolutionBrainChromosome MappingChromosomes, Human, Pair 5Conserved SequenceDNA PrimersDNA-Binding ProteinsGene LibraryHumansHybrid CellsKaryotypingMADS Domain ProteinsMammalsMEF2 Transcription FactorsMolecular Sequence DataMyogenic Regulatory FactorsPolymerase Chain ReactionRestriction MappingRodentiaTranscription Factors
1993
hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors.
McDermott J, Cardoso M, Yu Y, Andres V, Leifer D, Krainc D, Lipton S, Nadal-Ginard B. hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors. Molecular And Cellular Biology 1993, 13: 2564-2577. PMID: 8455629, PMCID: PMC359588, DOI: 10.1128/mcb.13.4.2564.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingAmino Acid SequenceAnimalsBase SequenceBrainCells, CulturedCloning, MolecularConsensus SequenceDNA-Binding ProteinsGene ExpressionGenesHumansImmunologic TechniquesIn Vitro TechniquesMEF2 Transcription FactorsMiceMolecular Sequence DataMusclesMyogenic Regulatory FactorsNeuronsOligodeoxyribonucleotidesPolymerase Chain ReactionRNA, MessengerSequence AlignmentTissue DistributionTranscription FactorsTranscription, GeneticConceptsSkeletal muscleSubset of neuronsCortical neuronsBrain-specific transcription factorTranscription factorsMRNA levelsPotential targetTrans-activating activityMuscleMEF2 transcription factorsNeuronsBrainBrain transcriptsMEF2 factorsMuscle-specific enhancerExpressionMyogenic differentiationTissue-specific isoformsUbiquitous expressionFactorsTissue-specific patternsGenesNeurogenesisMEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex.
Leifer D, Krainc D, Yu Y, McDermott J, Breitbart R, Heng J, Neve R, Kosofsky B, Nadal-Ginard B, Lipton S. MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 1546-1550. PMID: 7679508, PMCID: PMC45911, DOI: 10.1073/pnas.90.4.1546.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsbeta-GalactosidaseBlotting, NorthernBrainCerebral CortexChloramphenicol O-AcetyltransferaseCloning, MolecularDNADNA-Binding ProteinsFetusGene LibraryGenetic VectorsHumansMADS Domain ProteinsMEF2 Transcription FactorsMolecular Sequence DataMultigene FamilyMyogenic Regulatory FactorsOrgan SpecificityRatsRecombinant Fusion ProteinsRNASequence Homology, Amino AcidTranscription FactorsTransfection
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