2024
Return-to-Play After Plasmodium falciparum Malaria in a Professional American Football Player
Mun J, Ryan E, Whalen J, Martin S. Return-to-Play After Plasmodium falciparum Malaria in a Professional American Football Player. JBJS Case Connector 2024, 14: e24.00457. PMCID: PMC11581430, DOI: 10.2106/jbjs.cc.24.00457.Peer-Reviewed Original ResearchPlasmodium falciparum malariaPersistent splenomegalyHigh-grade feverProfessional American football playersAmerican football playersFalciparum malariaFootball playersPatient's symptomsCollision sport athletesMalariaEmergency departmentReturn-to-playBlood smearsHospital admissionRisk of deconditioningSplenomegalyNoncontact activityPatientsSport athletesSymptomsWeeksPlasmodiumOn-fieldFeverSmears
2020
Fedratinib hydrochloride to treat intermediate-2 or high-risk primary or secondary myelofibrosis.
Schiffer M, Kowalski A, Zhao J, Bewersdorf JP, Lewis RS, Zeidan AM. Fedratinib hydrochloride to treat intermediate-2 or high-risk primary or secondary myelofibrosis. Drugs Of Today 2020, 56: 755-768. PMID: 33332482, DOI: 10.1358/dot.2020.56.12.3230206.Peer-Reviewed Original ResearchConceptsSecondary myelofibrosisClinical holdSelective Janus kinase 2 inhibitorNovel oral agentsCommon adverse effectsClinical trial dataFurther drug developmentGastrointestinal symptomsLiver transaminasesOral agentsSymptom burdenJanus kinase 2 inhibitorDrug AdministrationMyeloproliferative neoplasmsTrial dataU.S. FoodAdverse effectsKinase 2 inhibitorPhase IIDrug developmentMyelofibrosisSignificant reductionFurther investigationFedratinibSplenomegaly
2018
A rare case of visceral leishmaniasis in an immunocompetent traveler returning to the United States from Europe
Haque L, Villanueva M, Russo A, Yuan Y, Lee EJ, Topal J, Podoltsev N. A rare case of visceral leishmaniasis in an immunocompetent traveler returning to the United States from Europe. PLOS Neglected Tropical Diseases 2018, 12: e0006727. PMID: 30286207, PMCID: PMC6171829, DOI: 10.1371/journal.pntd.0006727.Peer-Reviewed Case Reports and Technical NotesConceptsVisceral leishmaniasisHealthy travelersRare caseEndemic areasEndemic visceral leishmaniasisSuccessful initial treatmentLiposomal amphotericin BBone marrow biopsyImmunocompetent adultsImmunocompetent travelersNight sweatsImmunocompetent individualsInitial treatmentMarrow biopsyRelapseAmphotericin BPreventive measuresLeishmaniasisTreatmentUnited StatesExtensive experiencePancytopeniaSplenomegalyBiopsyPatients
2011
Genotype–phenotype study of familial haemophagocytic lymphohistiocytosis type 3
Sieni E, Cetica V, Santoro A, Beutel K, Mastrodicasa E, Meeths M, Ciambotti B, Brugnolo F, Stadt U, Pende D, Moretta L, Griffiths G, Henter J, Janka G, Aricò M. Genotype–phenotype study of familial haemophagocytic lymphohistiocytosis type 3. Journal Of Medical Genetics 2011, 48: 343. PMID: 21248318, PMCID: PMC4115201, DOI: 10.1136/jmg.2010.085456.Peer-Reviewed Original ResearchConceptsCentral nervous systemCombination of feverUNC13D mutationsCentral nervous system involvementStudy of patientsDisruptive mutationsEthnic-specific mutationsCD107a expressionGenotype-phenotype studiesNK activityEvaluating patientsClinical patternRelease assayPatientsThrombocytopeniaMissense mutationsSplenomegalyNervous systemFeverHyperferritinaemiaType 3UNC13DSplicing errorsMutationsEthnic origin
2010
Focal splenic lesions in type I Gaucher disease are associated with poor platelet and splenic response to macrophage‐targeted enzyme replacement therapy
Stein P, Malhotra A, Haims A, Pastores GM, Mistry PK. Focal splenic lesions in type I Gaucher disease are associated with poor platelet and splenic response to macrophage‐targeted enzyme replacement therapy. Journal Of Inherited Metabolic Disease 2010, 33: 769-774. PMID: 20683668, PMCID: PMC3008694, DOI: 10.1007/s10545-010-9175-6.Peer-Reviewed Original ResearchConceptsFocal splenic lesionsEnzyme replacement therapyGD1 patientsReplacement therapySplenic lesionsMacrophage-targeted enzyme replacement therapyPlatelet responseYears of ERTPrevalence of osteonecrosisGaucher disease type IDeterminants of responseType IPoor plateletsAvascular osteonecrosisSuboptimal responseSevere manifestationsSplenic responseIntact spleenClinical significanceSplenic parenchymaPatientsWorse thrombocytopeniaRoutine evaluationSplenomegalyTherapy
2008
Hereditary spherocytosis
Perrotta S, Gallagher PG, Mohandas N. Hereditary spherocytosis. The Lancet 2008, 372: 1411-1426. PMID: 18940465, DOI: 10.1016/s0140-6736(08)61588-3.Peer-Reviewed Original ResearchConceptsHereditary spherocytosisHaemolytic anaemiaSevere haemolytic anaemiaCommon inherited disorderErythrocyte transfusionMost patientsAplastic crisisCommon complicationPrimary lesionNorthern European ancestryClinical severityHaemolytic episodeAnemiaInherited disorderIsolated mutationsCareful assessmentSpherocytosisEuropean ancestryDisordersMain causeCholelithiasisSplenectomyJaundiceSplenomegalyTransfusion
2004
Hereditary elliptocytosis: spectrin and protein 4.1R
Gallagher PG. Hereditary elliptocytosis: spectrin and protein 4.1R. Seminars In Hematology 2004, 41: 142-164. PMID: 15071791, DOI: 10.1053/j.seminhematol.2004.01.003.Peer-Reviewed Original Research
2000
T‐gamma gene rearrangement and CMV mononucleosis
Mathew P, Hudnall S, Elghetany M, Payne D. T‐gamma gene rearrangement and CMV mononucleosis. American Journal Of Hematology 2000, 66: 64-66. PMID: 11426498, DOI: 10.1002/1096-8652(200101)66:1<64::aid-ajh1013>3.0.co;2-v.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, ViralBlood CellsBone Marrow CellsClone CellsCytomegalovirusCytomegalovirus InfectionsDiagnosis, DifferentialFemaleGene Rearrangement, gamma-Chain T-Cell Antigen ReceptorHumansImmunoglobulin MImmunophenotypingInfectious MononucleosisLymphoproliferative DisordersMiddle AgedT-Lymphocyte SubsetsViremiaConceptsT gamma gene rearrangementCMV infectionLymphoproliferative diseaseAcute CMV infectionGene rearrangementsAtypical lymphocytosisCMV mononucleosisCMV viremiaNight sweatsIgM serologyClinical featuresLymphoid aggregatesBlood countPeripheral bloodHemolytic anemiaImmune responseBone marrowWeight lossCytomegalovirusInfectionDiseaseMononucleosisViremiaSplenomegalyLymphocytosis
1994
Splenomegaly and variceal bleeding--hemodynamic basis and treatment implications.
Gusberg RJ, Peterec SM, Sumpio BE, Meier GH. Splenomegaly and variceal bleeding--hemodynamic basis and treatment implications. Hepatogastroenterology 1994, 41: 573-7. PMID: 7721248.Peer-Reviewed Original ResearchMeSH KeywordsBlood PressureEsophageal and Gastric VaricesFemaleGastrointestinal HemorrhageHepatic VeinsHumansHypertension, PortalLiver Cirrhosis, AlcoholicMaleMonitoring, IntraoperativePortal PressureProspective StudiesRadiographyRegional Blood FlowRetrospective StudiesSplenic VeinSplenomegalySplenorenal Shunt, SurgicalConceptsCirrhotic patientsPortal pressurePortal hypertensionSplenic embolizationVariceal bleedingHemodynamic basisSpleen sizeDistal splenorenal shuntPortal hypertensive patientsSplenic venous flowVariceal bleedersDefinitive therapyHypertensive patientsSplenorenal shuntSplenic enlargementSplenic veinVenous flowHemodynamic significancePatientsSplenomegalySplenic inflowTreatment implicationsHypertensionBleedingSplenectomyCarcinosarcoma of the Spleen
Westra W, Anderson B, Klimstra D. Carcinosarcoma of the Spleen. The American Journal Of Surgical Pathology 1994, 18: 309-315. PMID: 8116800, DOI: 10.1097/00000478-199403000-00012.Peer-Reviewed Original Research
1987
Thymic hypoplasia, splenomegaly and immune depression in guinea pigs with neonatal cytomegalovirus infection
Zheng Z, Lavallee J, Bia F, Griffith B. Thymic hypoplasia, splenomegaly and immune depression in guinea pigs with neonatal cytomegalovirus infection. Developmental & Comparative Immunology 1987, 11: 407-418. PMID: 3040485, DOI: 10.1016/0145-305x(87)90084-x.Peer-Reviewed Original ResearchConceptsGuinea pigsCMV infectionCytomegalovirus infectionThymic hypoplasiaProliferative responseImmune proliferative responsesNeonatal cytomegalovirus infectionAcute CMV infectionT lymphocyte populationsNeonatal guinea pigsT cell mitogensConcanavalin AB cell mitogensImmunodepressive effectImmune depressionLymphocyte populationsSpleen cellsInfectious virusGrowth retardationDissimilar alterationsHigh titersSpleenInfectionThymusSplenomegaly
1979
Treatment of refractory splenomegaly in myeloproliferative disease by splenic artery infusion.
Canellos G, Sutliffe S, DeVita V, Lister T. Treatment of refractory splenomegaly in myeloproliferative disease by splenic artery infusion. Blood 1979, 53: 1014-7. PMID: 435637, DOI: 10.1182/blood.v53.5.1014.bloodjournal5351014.Peer-Reviewed Original ResearchConceptsSplenic artery infusionArterial infusionBlastic phase of chronic granulocytic leukemiaRefractory to previous therapyPhase of chronic granulocytic leukemiaChronic granulocytic leukemiaResponse to treatmentBlastic phasePrevious therapyMassive splenomegalyMyeloproliferative diseaseSystemic toxicityGranulocytic leukemiaSpleen sizeSymptomatic reliefCytosine arabinosidePatientsSplenomegalyInfusionTreatmentHypersplenismPainLeukemiaTherapyArabinosideTreatment of Refractory Splenomegaly in Myeloproliferative Disease by Splenic Artery Infusion
Canellos G, Sutliffe S, DeVita V, Lister T. Treatment of Refractory Splenomegaly in Myeloproliferative Disease by Splenic Artery Infusion. Blood 1979, 53: 1014-1017. DOI: 10.1182/blood.v53.5.1014.1014.Peer-Reviewed Original ResearchSplenic artery infusionArterial infusionBlastic phase of chronic granulocytic leukemiaRefractory to previous therapyPhase of chronic granulocytic leukemiaChronic granulocytic leukemiaResponse to treatmentBlastic phasePrevious therapyMassive splenomegalyMyeloproliferative diseaseSystemic toxicityGranulocytic leukemiaSpleen sizeSymptomatic reliefCytosine arabinosidePatientsSplenomegalyInfusionTreatmentHypersplenismPainLeukemiaTherapyArabinoside
1973
Liver‐spleen scan in hodgkin's disease
Milder M, Larson S, Bagley C, Devita V, Johnson R, Johnston G. Liver‐spleen scan in hodgkin's disease. Cancer 1973, 31: 826-834. PMID: 4706049, DOI: 10.1002/1097-0142(197304)31:4<826::aid-cncr2820310410>3.0.co;2-m.Peer-Reviewed Original ResearchConceptsLiver-spleen scanLiver involvementHodgkin's diseaseFilling defectPhysical examinationTumor involvementLiver biopsyPathologic findingsHepatic lobeLiver scanSplenic tumorAdvanced stageReliable signDiseaseSpleenTumorsScansLymphangiogramPatientsLiverInvolvementExaminationSplenomegalyBiopsyFindings
1972
KINETICS OF GRAFT-VERSUS-HOST SPLENOMEGALY IN NEONATAL F1 RECIPIENTS OF PARENTAL STRAIN MOUSE LYMPH NODE CELLS AND/OR THYMOCYTES
Tigelaar R, Asofsky R. KINETICS OF GRAFT-VERSUS-HOST SPLENOMEGALY IN NEONATAL F1 RECIPIENTS OF PARENTAL STRAIN MOUSE LYMPH NODE CELLS AND/OR THYMOCYTES. Transplantation 1972, 14: 805-807. PMID: 4404987, DOI: 10.1097/00007890-197212000-00025.Peer-Reviewed Original Research
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