William Chang, MD, PhD
Assistant Professor of Medicine (Nephrology)DownloadHi-Res Photo
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Nephrology
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Assistant Professor of Medicine (Nephrology)
Appointments
Nephrology
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Nephrology Fellow
- Yale University (2012)
- Resident
- Yale New Haven Hospital (2008)
- Intern
- Yale New Haven Hospital (2007)
- PhD
- New York University, Oncology and Immunology (2006)
- MD
- New York University School of Medicine (2006)
- AB
- Harvard, Biology (1998)
Research
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Overview
Medical Research Interests
Biotechnology; Cell Biology; Kidney; Organoids
ORCID
0000-0002-7707-9242
Research at a Glance
Yale Co-Authors
Frequent collaborators of William Chang's published research.
Publications Timeline
A big-picture view of William Chang's research output by year.
Jordan Pober, MD, PhD
Alfred Bothwell, PhD
Diane Krause, MD, PhD
Francesc Lopez-Giraldez, PhD
Lawrence Young, MD
Lin Wang, MS
22Publications
1,690Citations
Publications
2020
Human Amniotic Membrane as a Novel Scaffold for Induced Pluripotent Stem Cell-Derived Kidney Organoids
Figetakis M, James K, Torres R, Chang W. Human Amniotic Membrane as a Novel Scaffold for Induced Pluripotent Stem Cell-Derived Kidney Organoids. Journal Of The American Society Of Nephrology 2020, 31: 145-145. DOI: 10.1681/asn.20203110s1145a.Peer-Reviewed Original ResearchDifferential functional roles of fibroblasts and pericytes in the formation of tissue-engineered microvascular networks in vitro
Kosyakova N, Kao DD, Figetakis M, López-Giráldez F, Spindler S, Graham M, James KJ, Won Shin J, Liu X, Tietjen GT, Pober JS, Chang WG. Differential functional roles of fibroblasts and pericytes in the formation of tissue-engineered microvascular networks in vitro. Npj Regenerative Medicine 2020, 5: 1. PMID: 31934351, PMCID: PMC6944695, DOI: 10.1038/s41536-019-0086-3.Peer-Reviewed Original ResearchCitationsAltmetric
2019
NSAID associated bilateral renal infarctions: a case report
Jeon Y, Lis JB, Chang WG. NSAID associated bilateral renal infarctions: a case report. International Journal Of Nephrology And Renovascular Disease 2019, 12: 177-181. PMID: 31447577, PMCID: PMC6682756, DOI: 10.2147/ijnrd.s212010.Peer-Reviewed Case Reports and Technical NotesCitationsConceptsNon-steroidal anti-inflammatory drugsRenal infarctionAnti-inflammatory drugsHigh-dose non-steroidal anti-inflammatory drugsRenal arterial blood flowBilateral renal infarctionYear old womanArterial blood flowPresence of NSAIDsNSAID useRenovascular vasoconstrictionRenal injuryVasoconstrictive effectRenal perfusionCase reportHigh prevalenceOlder womenBlood flowInfarctionCausative agentDrugsHypoperfusionVasoconstrictionPatientsInjuryTools for Kidney Tissue Engineering: Bioreactor Systems, Scaffolds, and Cell Sources
Chang WG. Tools for Kidney Tissue Engineering: Bioreactor Systems, Scaffolds, and Cell Sources. In R. L. Reis, & M. E. Gomes (Eds.), Encyclopedia of Tissue Engineering and Regenerative Medicine, Vol. 1 (pp. 199–208). Academic Press: Elsevier. (2019).Books
2017
A short discourse on vascular tissue engineering
Chang WG, Niklason LE. A short discourse on vascular tissue engineering. Npj Regenerative Medicine 2017, 2: 7. PMID: 29057097, PMCID: PMC5649630, DOI: 10.1038/s41536-017-0011-6.BooksCitationsAltmetric
2016
ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction
Bartulos O, Zhuang ZW, Huang Y, Mikush N, Suh C, Bregasi A, Wang L, Chang W, Krause DS, Young LH, Pober JS, Qyang Y. ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction. JCI Insight 2016, 1: e80920. PMID: 27525311, PMCID: PMC4982472, DOI: 10.1172/jci.insight.80920.Peer-Reviewed Original ResearchCitationsConceptsMyocardial infarctionControl animalsCardiovascular progenitor cellsProgenitor cellsVentricular contractile functionCardiac repair strategiesNew blood vesselsInfarct areaLineage-tracing studiesContractile functionCardiac repairBlood vessel formationMyocardial regenerationEndothelial cellsHeart tissueBlood vesselsMurine heartInfarctionVessel formationInjuryMiceDelivery approachCardiomyocytesHeartCellsBlocking MHC class II on human endothelium mitigates acute rejection
Abrahimi P, Qin L, Chang WG, Bothwell AL, Tellides G, Saltzman WM, Pober JS. Blocking MHC class II on human endothelium mitigates acute rejection. JCI Insight 2016, 1: e85293. PMID: 26900601, PMCID: PMC4756651, DOI: 10.1172/jci.insight.85293.Peer-Reviewed Original ResearchCitationsAltmetricConceptsClass II MHC moleculesCytotoxic T lymphocytesII MHC moleculesClass I MHC moleculesMHC moleculesI MHC moleculesEndothelial cellsAcute rejectionT cellsEffector memory T cellsT cell-mediated destructionAcute allograft rejectionCell-mediated destructionGraft endothelial cellsMemory T cellsAlloreactive cytotoxic T lymphocytesExperimental rodent modelsMajor histocompatibility complex moleculesSecondary lymphoid organsMHC class IIClass I major histocompatibility complex moleculesAllogeneic human lymphocytesHistocompatibility complex moleculesPrevents CD4Artery graft
2015
Tissue-Engineered Microvasculature to Reperfuse Isolated Renal Glomeruli
Chang WG, Fornoni A, Tietjen G, Mendez JJ, Niklason LE, Saltzman WM, Pober JS. Tissue-Engineered Microvasculature to Reperfuse Isolated Renal Glomeruli. Tissue Engineering Part A 2015, 21: 2673-2679. PMID: 26414101, PMCID: PMC4652181, DOI: 10.1089/ten.tea.2015.0060.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsEfficient Gene Disruption in Cultured Primary Human Endothelial Cells by CRISPR/Cas9
Abrahimi P, Chang WG, Kluger MS, Qyang Y, Tellides G, Saltzman WM, Pober JS. Efficient Gene Disruption in Cultured Primary Human Endothelial Cells by CRISPR/Cas9. Circulation Research 2015, 117: 121-128. PMID: 25940550, PMCID: PMC4490936, DOI: 10.1161/circresaha.117.306290.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsAnimalsCD4-Positive T-LymphocytesCell SeparationCells, CulturedCRISPR-Cas SystemsEndothelial Progenitor CellsFemaleFetal BloodGene DeletionGene Knockout TechniquesGenes, MHC Class IIGenetic VectorsHLA-DR AntigensHumansIntracellular Signaling Peptides and ProteinsLentivirusLymphocyte ActivationLymphocyte Culture Test, MixedMiceMice, SCIDNuclear ProteinsPrimary Cell CultureProteinsTetracyclineTrans-ActivatorsVesicular Transport Proteins
2013
Sustained delivery of proangiogenic microRNA‐132 by nanoparticle transfection improves endothelial cell transplantation
Devalliere J, Chang WG, Andrejecsk JW, Abrahimi P, Cheng CJ, Jane‐wit D, Saltzman WM, Pober JS. Sustained delivery of proangiogenic microRNA‐132 by nanoparticle transfection improves endothelial cell transplantation. The FASEB Journal 2013, 28: 908-922. PMID: 24221087, PMCID: PMC3898640, DOI: 10.1096/fj.13-238527.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHuman umbilical vein ECsEndothelial cellsMiR-132MicroRNA-132Cultured human umbilical vein endothelial cellsNumber of microvesselsGrowth factor-induced proliferationHuman umbilical vein endothelial cellsUmbilical vein endothelial cellsEndothelial cell transplantationCultured endothelial cellsEndogenous growth factorsEC transplantationVein endothelial cellsCell transplantationImmunodeficient miceTissue perfusionTransplantationMiR deliveryGrowth factorIntegrin αvβ3Endocytosed nanoparticlesSquare millimeterBiological effectsControl transfection
Academic Achievements & Community Involvement
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Activities
activity American Society of Nephrology
2008 - PresentProfessional OrganizationsMemberactivity American Society of Nephrology
05/30/2024 - 06/07/2024Peer Review Groups and Grant Study SectionsAbstract ReviewerDetailsASN 2024 abstract reviewer for Glomerular Diseases: Mechanismsactivity Engineering Bioartificial Kidneys: Combining Kidney Organoids and Peritoneal Dialysis
06/12/2023 - 06/12/2023Oral PresentationKidney X SummitDetailsWashington, DC, United Statesactivity Dutch Research Council
2022 - 2022Peer Review Groups and Grant Study SectionsAd-hoc revieweractivity Frontiers in Cell and Developmental Biology
2022 - 2022Journal ServiceReviewerDetailsAd hoc reviewer
Honors
honor Kidney X: Artificial Kidney Prize
06/12/2023National AwardASN and HHSDetailsUnited Stateshonor Invited panelist
12/02/2021Regional AwardCharles H. Hood FoundationDetailsUnited Stateshonor Blavatnik Fund Semifinalist
11/06/2019Yale University AwardYale Blavatnik Fund for Innovation at YaleDetailsUnited Stateshonor Yale Center for Clinical Investigation, Junior Faculty Scholar
11/01/2012Yale University AwardYale UniversityDetailsUnited Stateshonor Scholar in Training Award for Special Conferences on Ubiquitination in Normal and Cancer Cells
11/01/2002National AwardAmerican Association of Cancer ResearchDetailsUnited States
Teaching & Mentoring
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Teaching
Clinical Yale Affiliated Hospitals Program
LecturerLecture SettingDetails8/1/2023 - PresentForHouse Staff1 Average Instructional Hours Per YearFull-time faculty of the Department of Internal Medicine at Yale provide a series of lectures (including residency noon conferences, subspecialty presentations, ward rounds, and grand rounds) at the nine other affiliated hospitals. These lectures comprise a major proportion of the education of the residents at the affiliated institutions.
Mentoring
Fatemeh Asghari
Postdoc2023 - 2024Zeki Tan
Undergraduate Student2023 - PresentTushar Shenoy
Undergraduate Student2022 - 2022Julian Batista
Postgrad associate2022 - 2024
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