Vinod H. Srihari, MD
Professor of PsychiatryDownloadHi-Res Photo
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Additional Titles
Director, STEP Program
Fellow, Davenport College
Contact Info
Psychiatry
34 Park Street
New Haven, CT 06519
United States
About
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Titles
Professor of Psychiatry
Director, STEP Program; Fellow, Davenport College
Biography
Dr. Srihari's scholarly focus is on improving the outcomes of early course schizophrenia spectrum disorders. His research interests span the translational continuum from studies of etiology and pathophysiology to interventions on clinical samples, to service level innovations. As Director of the STEP Program, he leads activities that connect this research to the missions of delivering a model service (the STEP Clinic), disseminating clinical best practices (via Learning Health Networks), education and workforce development and influencing policies that support the public health mission of early Intervention for schizophrenia spectrum disorders.
In his curricular work, he has led the development and implementation of an Evidence-Based Medicine (EBM) based approach to enabling psychiatrists in training to ask, access, appraise and apply the best available scientific evidence to their practice and to audit the health of the populations they are responsible for.
Dr. Srihari also consults with academic and non-academic healthcare systems that seek to initiate or refine early intervention services for recent onset or 'first-episode' psychosis.
Last Updated on May 07, 2025.
Appointments
Psychiatry
ProfessorPrimary
Other Departments & Organizations
- Center for Brain & Mind Health
- Connecticut Mental Health Center
- Division of Neurocognition, Neurocomputation & Neurogenetics
- Division of Public Psychiatry Research
- Global Health Studies
- Psychiatry
- Psychosis Program at Yale
- South Asian Studies
- Specialized Treatment for Early Psychosis (STEP) Program
- Yale Global Mental Health Program
- Yale Ventures
Education & Training
- Fellow
- Yale University School of Medicine (2005)
- Resident
- Yale University School of Medicine (2003)
- MD
- University of Rochester (1998)
- BA
- University of Rochester, Biology; Religion & Classics (1994)
Board Certifications
Psychiatry
- Certification Organization
- AB of Psychiatry & Neurology
- Latest Certification Date
- 2025
- Original Certification Date
- 2005
Research
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Overview
Medical Research Interests
Biomarkers; Curriculum; Evidence-Based Medicine; Exosomes; Health Care Quality, Access, and Evaluation; Learning Health System; Mental Health Services; Mitochondrial Diseases; Oxidative Stress; Population Health; Psychotic Disorders; Public Health Informatics; Schizophrenia Spectrum and Other Psychotic Disorders
Public Health Interests
Health Policy; Capacity Building
ORCID
0000-0003-1556-2332- View Lab Website
STEP
Research at a Glance
Yale Co-Authors
Frequent collaborators of Vinod H. Srihari's published research.
Publications Timeline
A big-picture view of Vinod H. Srihari's research output by year.
Research Interests
Research topics Vinod H. Srihari is interested in exploring.
Fangyong Li, MS, MPH
Maria Ferrara, MD
Cenk Tek, MD
Sinan Guloksuz, MD, PhD
Hadar Hazan, PhD
Laura Yoviene Sykes, PhD
144Publications
4,993Citations
Psychotic Disorders
Mental Health Services
Evidence-Based Medicine
Learning Health System
Exosomes
Biomarkers
Publications
2025
The potential of AI for scale development: A self-report psychosis symptoms measure using ChatGPT
Tayfur S, Hazan H, Li F, Song Z, Corbera S, Tek C, Srihari V. The potential of AI for scale development: A self-report psychosis symptoms measure using ChatGPT. Schizophrenia Research 2025, 284: 111-113. PMID: 40763549, DOI: 10.1016/j.schres.2025.07.030.Peer-Reviewed Original ResearchCitationsUtilization of a psychosis consultation service: Early lessons from a statewide initiative
Tayfur S, Yoviene Sykes L, Tek C, Srihari V. Utilization of a psychosis consultation service: Early lessons from a statewide initiative. Schizophrenia Research 2025, 282: 198-202. PMID: 40614351, PMCID: PMC12276959, DOI: 10.1016/j.schres.2025.06.019.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsRecent-onset psychosisEarly psychosis interventionContinuing carePsychosis programPsychosis interventionPsychosisCare of young peoplePsychosis careTransitions of careConsultation serviceLearning health systemFamily support strategiesClinical issuesSpecialty careLearning CollaborativeHealthcare leadersHealth systemOut-of-stateStatewide initiativeFamily engagementTeam meetingsSupport strategiesSpecial treatmentCareEarly lessonsEnhancing Coordinated Specialty Care Through Early Detection: Impact of Reduced Duration of Untreated Psychosis
Hazan H, Ferrara M, Zhou B, Li F, Imetovski S, Sykes L, Pollard J, Cahill J, Gibbs-Dean T, Corbera S, Karmani S, Riley S, Tayfur S, Tek C, Keshavan M, Srihari V. Enhancing Coordinated Specialty Care Through Early Detection: Impact of Reduced Duration of Untreated Psychosis. Schizophrenia Bulletin 2025, 51: 1730-1737. PMID: 40339151, PMCID: PMC12597490, DOI: 10.1093/schbul/sbaf044.Peer-Reviewed Original ResearchCitationsConceptsDuration of untreated psychosisFirst-episode psychosisCoordinated Specialty CareUntreated psychosisMediation analysisShorter duration of untreated psychosisFirst-episode psychosis patientsEarly interventionEarly psychosisBenefits of early interventionPsychosisGAFFunctional outcomesGlobal assessmentEarly detection campaignsSpecialty careIntake processRecovery outcomesSpecial treatmentQuality of lifeStreamlining referralsFunctional recoveryScoresPatientsInterventionSex-Specific Treatment Strategies in First Episode Psychosis
Ferrara M, Srihari V. Sex-Specific Treatment Strategies in First Episode Psychosis. Biological Psychiatry 2025, 97: s53. DOI: 10.1016/j.biopsych.2025.02.144.Peer-Reviewed Original ResearchInsight and Its Trajectory: Predicting the Risk of Psychiatric Hospitalizations Among First-Episode Psychosis During the First Year of Coordinated Specialty Care
Hazan H, Ferrara M, Gibbs-Dean T, Tayfur S, Corbera S, Karmani S, Song Z, Li F, Vlachos I, Selakovic M, Tek C, Srihari V. Insight and Its Trajectory: Predicting the Risk of Psychiatric Hospitalizations Among First-Episode Psychosis During the First Year of Coordinated Specialty Care. Schizophrenia Bulletin 2025, sbaf019. PMID: 40227145, DOI: 10.1093/schbul/sbaf019.Peer-Reviewed Original ResearchConceptsCoordinated Specialty CareFirst-episode psychosisBaseline insightRisk of psychiatric hospitalizationFirst-episodeEarly psychosisInsight groupLength of stayPsychiatric hospitalSpecialty carePsychosisLongitudinal trajectoriesGreater reductionsHospital outcomesHigh-low-highPredicting clinical improvementHospital dataModifiable factorsMonths pre-ParticipantsHospitalization riskClinical improvementRecovery trajectoriesReduce hospitalizationsBaselineHONE: A learning health system platform for advancing early intervention in first episode psychosis
Mathis W, Gibbs-Dean T, Cahill J, Srihari V. HONE: A learning health system platform for advancing early intervention in first episode psychosis. Schizophrenia Research 2025, 280: 1-9. PMID: 40209525, PMCID: PMC12052476, DOI: 10.1016/j.schres.2025.04.009.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsLearning health systemEarly intervention servicesFirst-episode psychosisLearning health system frameworkQuality improvementDiverse healthcare settingsContinuous quality improvementMental health outcomesUser-centered designPatient-reported outcomesEvidence-based outcomesDiverse data sourcesCare deliveryEpisode psychosisImprove careKnowledge translationHealth outcomesHealth systemHealthcare settingsLifetime illnessHealthcare reformData visualizationUser engagementTransformation frameworkDuration of untreated psychosisThe problem of missing data for learning health systems focused on first-episode psychosis
Robinson D, Schooler N, John M, Cahill J, Gonzalez C, Marcy P, Adams C, Distasio M, Gerber C, Hackett B, Nunez M, Srihari V, Kane J. The problem of missing data for learning health systems focused on first-episode psychosis. Schizophrenia Research 2025, 279: 79-86. PMID: 40174487, PMCID: PMC12051462, DOI: 10.1016/j.schres.2025.03.021.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsFirst-episode psychosisCoordinated Specialty CarePrematurely terminated treatmentLearning health systemGlobal functioningCharacteristics of individualsLong-actingPatient-reported outcomesSocial scaleExploratory analysisPsychosisProcess of recoveryHealth systemCSC treatmentParticipantsUnstable housingRates of missing dataClinic patientsSpecialty careImprove careUS clinicsScaleLong durationCommercial insuranceResearch prioritiesComparative effectiveness of long-acting injectable versus oral antipsychotic medication after a first episode of psychosis
Szmulewicz A, Martínez-Alés G, Logan R, Joober R, Ferrara M, Kelly C, Fredrikson D, Thorpe L, Conderino S, Díaz-Caneja C, Srihari V, Yatham L, Sarpal D, Shinn A, Arango C, Shah J, Öngür D, Hernán M. Comparative effectiveness of long-acting injectable versus oral antipsychotic medication after a first episode of psychosis. Nature Mental Health 2025, 3: 421-428. DOI: 10.1038/s44220-025-00407-5.Peer-Reviewed Original ResearchAltmetricConceptsEpisode of psychosisPsychotic relapseLong-actingTarget trialsRisk of psychotic relapseLong-acting antipsychoticsOral antipsychotic medicationEffects of long-actingLAI therapyAntipsychotic therapyAntipsychotic medicationSchizophrenia trialsTherapy initiationRisk of relapseOral therapyPsychosisRisk differenceFEPObservational cohort of peopleHospitalization riskCohort of peopleNetwork meta-analysesNo risk reductionNon-adherenceRelapseForging a learning health system for early psychosis: Insights from the academic community EPINET
Vohs J, Cahill J, Taylor S, Heckers S, Weiss A, Chaudhry S, Silverstein S, Tso I, Breitborde N, Vinson A, Lapidos A, Visco A, Satchivi A, Gaunnac M, Breier A, Srihari V. Forging a learning health system for early psychosis: Insights from the academic community EPINET. Schizophrenia Research 2025, 278: 109-118. PMID: 40147210, PMCID: PMC12011207, DOI: 10.1016/j.schres.2025.03.020.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsLearning healthcare systemEarly Psychosis Intervention NetworkQuality improvementClinical workflowLearning health systemProvision of intervention servicesQuality improvement effortsCulture of continuous learningIntervention NetworkHealth systemDisease trajectoryInterventional careHealthcare systemPractice-based researchImprovement effortsEvidence-basedClinical sitesIntervention servicesSocietal costsSteering CommitteeFirst-episode psychosisImplementation lessonsEarly psychosisEngaging stakeholdersSix-month intervalsThe STEP Learning Collaborative: A statewide Learning Healthcare System (LHS) for first episode psychosis
Yoviene Sykes L, Levine N, Tayfur S, Gibbs-Dean T, Hazan H, Imetovski S, James J, Karmani S, Mathis W, Markovich P, Purushothaman D, Riley S, Tek C, Veillette C, Cahill J, Giard J, Marracino A, Barrette K, Bozak S, Gregory F, McDermott G, Srihari V. The STEP Learning Collaborative: A statewide Learning Healthcare System (LHS) for first episode psychosis. Schizophrenia Research 2025, 278: 96-108. PMID: 40132282, PMCID: PMC11981821, DOI: 10.1016/j.schres.2025.03.029.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsLearning healthcare systemLearning CollaborativeHealthcare systemSchizophrenia spectrum disordersPopulation health outcomesLearning health systemSystems of careCare modelHigh-quality treatmentStage of illnessHealth outcomesHealth systemWorkforce developmentDuration of untreated psychosisStatewide systemEarly stages of illnessEarly psychosisWorkforce readinessStrengthening integrationPolicy advocacyLeverage informaticsCareEpisode psychosisStakeholder engagementUntreated psychosis
Clinical Trials
Current Trials
MitoQ for improving cognition in early course psychosis illnesses
HIC ID2000038056RolePrincipal InvestigatorPrimary Completion Date12/31/2027Recruiting ParticipantsStudy of Brain Function Across the Lifespan
HIC ID2000020891RoleSub InvestigatorPrimary Completion Date07/31/2022Recruiting ParticipantsGenderBothAge18 years - 65 years
Academic Achievements & Community Involvement
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Activities
activity Schizophrenia Research
07/01/2018 - PresentJournal ServiceEditorial Board Memberactivity Schizophrenia International Research Society (SIRS)
07/01/2015 - PresentProfessional OrganizationsMemberactivity International Early Psychosis Association (IEPA)
07/01/2005 - PresentProfessional OrganizationsMemberactivity Center for Evidence Based Medicine (CEBM), Oxford, U.K.
07/01/2005 - PresentProfessional OrganizationsMemberactivity Early Psychosis Collaboration
02/01/2021 - PresentResearchDetailsFerrara, Emilia-Romagna, ItalyCollaboratorsAbstract/SynopsisBuilding a European hub for collaborative clinical and research projects.
Honors
honor Stephen Fleck Award
06/08/2018Yale School of Medicine AwardYale University Department of PsychiatryDetailsUnited Stateshonor PRA Teaching Award
06/10/2011Yale School of Medicine AwardYale Psychiatry Residents AssociationDetailsUnited Stateshonor Model Curriculum in Evidence-Based Mental Health
03/04/2011National AwardAmerican Association of Directors of Psychiatric Residency TrainingDetailsUnited Stateshonor Chairman's Award
06/15/2007Yale School of Medicine AwardYale University Department of PsychiatryDetailsUnited Stateshonor Resident Teaching Award
06/15/2004Yale School of Medicine AwardYale University Department of PsychiatryDetailsUnited States
News & Links
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Media
News
- December 16, 2025
Srihari Guest Edits Special Issue of 'Schizophrenia Research'
- December 12, 2025
STEP Learning Collaborative: 2025 Statewide Impact & Year-End Review
- July 31, 2025
Connecticut Leaders Highlight Statewide Effort to Transform Early Psychosis Care
- May 20, 2025Source: Yale Medicine
How to Help Someone Who is Having a Psychotic Episode
Get In Touch
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Contacts
Mailing Address
Psychiatry
34 Park Street
New Haven, CT 06519
United States
Locations
The STEP Program
Lab
Connecticut Mental Health Center
34 Park Street
New Haven, CT 06519
Events
Feb 202611Wednesday
Restricted Vinod H. Srihari, MD - Nina Levine, LMSW, MPH - Laura Yoviene Sykes, PhDAll sessions will be held on Zoom. Interested community members can email Nina.Levine@yale.edu
Mar 202612Thursday
Restricted Vinod H. Srihari, MD - Nina Levine, LMSW, MPH - Laura Yoviene Sykes, PhDAll sessions will be held on Zoom. Interested community members can email Nina.Levine@yale.edu
Apr 20269Thursday
Restricted Vinod H. Srihari, MD - Nina Levine, LMSW, MPH - Laura Yoviene Sykes, PhDAll sessions will be held on Zoom. Interested community members can email Nina.Levine@yale.edu