Song Pang

Director, FIB-SEM Collaboration Core

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song.pang@yale.edu

203.785.4484

FIB-SEM Collaboration Core (F-SCC)

350 George Street

New Haven, CT 06511

United States

FIB-SEM Collaboration Core

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Publications Overview

45 Publications
3,281 Citations
11 Yale Co-Authors

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About

At the forefront of volume Electron Microscopy (vEM), we welcome your collaboration to take discoveries in biology, physiology, and pathology to a whole new level.

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Director, FIB-SEM Collaboration Core

Biography

Pang's primary research focus is to nucleate transformative technology development and to foster discoveries in life science. At YSM, she aims to expand the application of the proprietary enhanced Focused Ion Beam Scanning Electron Microscopy (eFIB-SEM) technology beyond experimental model systems into translational and clinical research.

Prior to joining YSM, Pang was the lead scientist in the FIB-SEM Technologies group at the Janelia Research Campus of Howard Hughes Medical Institute. She proposed and developed the enhanced FIB-SEM pipeline beyond Drosophila connectome research. Together with colleagues, she created the very first open-access 3D atlas at the finest isotropic resolution using the eFIB-SEM platform.

Inspired to probe brain functions using semiconductor technologies, Pang applied her semiconductor device integration expertise to brain research. She oversaw all facets of device fabrication for customized extracellular neuroprobes and facilitated a partnership between Janelia and IMEC, a leading semiconductor research institute. Her vision and initiative transformed the Neuroprobe project into a massive multi-institute collaboration.

During her tenure in the semiconductor industry, Pang contributed to several major technology breakthroughs, from concept initiation to global implementation. At Intel Research, she led process development for a silicon-based optical modulator, achieving a fiftyfold improvement over previous world records. She also spearheaded the integration of Alternate Phase Shift Mask technology into Intel's high-volume manufacturing. At leading semiconductor equipment companies, Pang launched innovative inspection solutions at KLA that revolutionized defect inspection in the photomask industry and introduced the first computational lithography calibration product at ASML, capturing over 90% market share within two years.

At YSM, Pang envisions the FIB-SEM Collaboration Core as a discovery powerhouse — a vibrant ecosystem integrating advanced imaging technologies, diverse applications, and robust data pipelines. She welcomes collaborations and looks forward to advancing life science research alongside her team and collaborators.

Last Updated on August 11, 2026.

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Enhanced FIB-SEM Pipeline and Discoveries

By coupling nanoscale isotropic resolution with meso- and macro-scale volumes, the enhanced FIB-SEM pipeline (Pang & Xu, 2023) represents the beginning of a new field of high-resolution large volume electron microscopy to reveal the structure-function relationships in biology. This is demonstrated by over 40 publications since the technology's debut ( Xu et al., 2017), including Nature (Xu et al., 2021; Heinrich et al., 2021; Parlakgül et al., 2022; Obara et al., 2024), Science (Nixon-Abell et al., 2016; Gao et al., 2019; Hoffman et al., 2020; Ritter et al., 2022), and Cell (Ioannou et al., 2019; Weigel et al., 2021; Sheu et al., 2022; Benedetti et al., 2024), and Neuron (Handler et al., 2023), etc., many of which are major landmarks in the field.