Seunghoon Lee, PhD
Research Scientist of Ophthalmology and Visual ScienceCards
About
Research
Publications
2025
SARS-CoV-2 induces Alzheimer’s disease–related amyloid-β pathology in ex vivo human retinal explants and retinal organoids
Miller S, Dhodapkar R, Sutova H, Xue Y, Lee S, Logan R, Ran C, Bhatta S, Gomm A, Ju I, Heyang M, Darji R, DiStasio M, Tanzi R, Zhang C, Zhou Z, Hafler B. SARS-CoV-2 induces Alzheimer’s disease–related amyloid-β pathology in ex vivo human retinal explants and retinal organoids. Science Advances 2025, 11: eads5006. PMID: 40614201, PMCID: PMC12227045, DOI: 10.1126/sciadv.ads5006.Peer-Reviewed Original ResearchConceptsAmyloid-bSpike 1 proteinPathogen infectionImmune response to pathogen infectionResponse to pathogen infectionInnate immune response to pathogen infectionEtiology of Alzheimer's diseaseExtracellular protein aggregatesSARS-CoV-2 spike 1 proteinAlzheimer's diseasePharmacological inhibitionPresence of microbesAmyloid plaquesAntimicrobial hypothesisProtein aggregationSARS-CoV-2Inhibition of neuropilin-1Electrophysiologically active neuronsHuman retinal explantsMicrobesRetinal organoidsAlzheimerRetinal explantsNeuropilin-1Human retinal organoids