About
Titles
Assistant Professor
Biography
Serena Tucci is Assistant Professor of Anthropology and Principal Investigator of the Human Evolutionary Genomics Laboratory at Yale University. She is also affiliated with the Department of Ecology and Evolutionary Biology. Dr. Tucci’s research addresses fundamental questions in human evolution and population history using DNA from present-day and ancient humans. Prior to joining Yale, she conducted postdoctoral research at the Department of Genome Sciences at the University of Washington Seattle and at the Lewis-Sigler Institute for Integrative Genomics at Princeton University. She was supported by the Lewis and Clark Fund for Exploration and Field Research from the American Philosophical Society. Tucci received her Ph.D. in Evolutionary and Environmental Biology from the University of Ferrara in Italy, where she was awarded the Young Investigator Fellowship in 2013 and 2015.
Appointments
Anthropology
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- PhD
- University of Ferrara, Evolutionary and Environmental Biology
Research
Overview
Medical Subject Headings (MeSH)
- View Lab Website
Human Evolutionary Genomics
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Brenda Cabrera-Mendoza, MD/PhD
Patrick F Reilly, PhD
Renato Polimanti, PhD, MSc
Neanderthals
Genomics
Evolution, Molecular
Adaptation, Biological
Genomic Structural Variation
DNA, Ancient
Publications
Featured Publications
The contribution of Neanderthal introgression to modern human traits
Reilly P, Tjahjadi A, Miller S, Akey J, Tucci S. The contribution of Neanderthal introgression to modern human traits. Current Biology 2022, 32: r970-r983. PMID: 36167050, PMCID: PMC9741939, DOI: 10.1016/j.cub.2022.08.027.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and ConceptsConceptsNeanderthal introgressionNeanderthal allelesPresent-day peopleModern human traitsNeanderthal DNAWestern EurasiaAncient specimensHuman adaptationNovel climate conditionsClosest extinct relativesNeanderthalsHuman genetic backgroundBody of workEvolutionary forcesDistinct fatesPhenotypic variationHuman genomeGenomic sequencesExtinct relativesIntrogressionGenomic landscapeHuman traitsHuman biologyGenetic backgroundGenomeEvolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia
Tucci S, Vohr SH, McCoy RC, Vernot B, Robinson MR, Barbieri C, Nelson BJ, Fu W, Purnomo GA, Sudoyo H, Eichler EE, Barbujani G, Visscher PM, Akey JM, Green RE. Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia. Science 2018, 361: 511-516. PMID: 30072539, PMCID: PMC6709593, DOI: 10.1126/science.aar8486.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPygmy populationsFlores IslandFADS Gene ClusterRecent positive selectionArchaic homininsModern humansSingle nucleotide polymorphism dataHominin speciesWhole genome sequencesInsular dwarfismComplex historyModern individualsMultiple independent instancesGene flowPolygenic selectionEvolutionary relationshipsEvolutionary historyGene clusterPositive selectionPolymorphism dataFloresShort stature phenotypeHistoryIslandsIndependent instancesAnalysis of Human Sequence Data Reveals Two Pulses of Archaic Denisovan Admixture
Browning SR, Browning BL, Zhou Y, Tucci S, Akey JM. Analysis of Human Sequence Data Reveals Two Pulses of Archaic Denisovan Admixture. Cell 2018, 173: 53-61.e9. PMID: 29551270, PMCID: PMC5866234, DOI: 10.1016/j.cell.2018.02.031.Peer-Reviewed Original ResearchCitationsAltmetricDenisovan and Neanderthal archaic introgression differentially impacted the genetics of complex traits in modern populations
Koller D, Wendt F, Pathak G, De Lillo A, De Angelis F, Cabrera-Mendoza B, Tucci S, Polimanti R. Denisovan and Neanderthal archaic introgression differentially impacted the genetics of complex traits in modern populations. BMC Biology 2022, 20: 249. PMID: 36344982, PMCID: PMC9641937, DOI: 10.1186/s12915-022-01449-2.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsArchaic introgressionComplex traitsDenisovan introgressionNeanderthal allelesNeanderthal introgressionSignatures of admixtureAncestry groupsModern populationsPhenome-wide association studyModern human populationsMajor histocompatibility complex regionIntrogressionEvolutionary pressureGenetic poolDisease heritabilityGenomic signaturesEAS populationsExtinct NeanderthalsAssociation studiesMetabolic traitsDenisovansUK BiobankRed hair colorEuropean descentHuman traitsExcavating Neandertal and Denisovan DNA from the genomes of Melanesian individuals
Vernot B, Tucci S, Kelso J, Schraiber JG, Wolf AB, Gittelman RM, Dannemann M, Grote S, McCoy RC, Norton H, Scheinfeldt LB, Merriwether DA, Koki G, Friedlaender JS, Wakefield J, Pääbo S, Akey JM. Excavating Neandertal and Denisovan DNA from the genomes of Melanesian individuals. Science 2016, 352: 235-239. PMID: 26989198, PMCID: PMC6743480, DOI: 10.1126/science.aad9416.Peer-Reviewed Original ResearchCitationsAltmetric
2021
Genome structural variation in human evolution
Hollox E, Zuccherato L, Tucci S. Genome structural variation in human evolution. Trends In Genetics 2021, 38: 45-58. PMID: 34284881, DOI: 10.1016/j.tig.2021.06.015.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsRole of SVsStructural variationsHuman evolutionHuman structural variationGenomic structureGenomic regionsReference genomeSequencing technologiesGenome sequencingRecent large-scale studiesCopy numberNumber variationsGenomeSequencingFocused analysisEvolutionVariationLarge-scale studiesAdaptationInfectious diseases
2020
Human Migrations: Tales of the Pacific
Friedlaender JS, Tucci S. Human Migrations: Tales of the Pacific. Current Biology 2020, 30: r1478-r1481. PMID: 33352129, DOI: 10.1016/j.cub.2020.11.008.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsLet's stream! A beginners' guide to livestreaming scientific conferences
Amorim C, Tucci S. Let's stream! A beginners' guide to livestreaming scientific conferences. Evolutionary Anthropology Issues News And Reviews 2020, 29: 90-93. PMID: 32275790, DOI: 10.1002/evan.21830.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords
2019
The long walk to African genomics
Tucci S, Akey JM. The long walk to African genomics. Genome Biology 2019, 20: 130. PMID: 31248437, PMCID: PMC6598360, DOI: 10.1186/s13059-019-1740-1.Peer-Reviewed Original ResearchCitationsAltmetric
2017
Nature Digest
Tucci S, Akey J. Nature Digest. Nature Digest 2017, 14: 26-28. DOI: 10.1038/ndigest.2017.170126.Peer-Reviewed Original Research