Samuel Steiner, PhD
Associate Research ScientistCards
Appointments
Microbial Pathogenesis
Primary
Contact Info
Yale School of Medicine
Boyer Center for Molecular Medicine, rm 347, 295 Congress Avenue
New Haven, CT 06536-0812
United States
About
Titles
Associate Research Scientist
Appointments
Microbial Pathogenesis
Associate Research ScientistPrimary
Other Departments & Organizations
Education & Training
- PhD
- University of Basel (2012)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Samuel Steiner's published research.
Publications Timeline
A big-picture view of Samuel Steiner's research output by year.
Craig Roy, PhD
Jun Liu, PhD
5Publications
506Citations
Publications
2022
Developmental Transitions Coordinate Assembly of the Coxiella burnetii Dot/Icm Type IV Secretion System
Park D, Steiner S, Shao M, Roy CR, Liu J. Developmental Transitions Coordinate Assembly of the Coxiella burnetii Dot/Icm Type IV Secretion System. Infection And Immunity 2022, 90: e00410-22. PMID: 36190257, PMCID: PMC9584302, DOI: 10.1128/iai.00410-22.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSmall cell variantLarge cell variantDot/Icm type IV secretion systemCell variantIntracellular replicationActive large cell variantHost cellsIntracellular bacterial pathogenType IV secretion systemDot/Icm T4SSObligate intracellular bacterial pathogenC. burnetiiCoxiella burnetiiBiphasic developmental cycleUnique biphasic developmental cycleInfectionNew host cellsSecretion systemBacterial pathogensInfectious formHost vacuoleBurnetiiMorphological changesCellsLater stages
2017
DNA Delivery and Genomic Integration into Mammalian Target Cells through Type IV A and B Secretion Systems of Human Pathogens
Guzmán-Herrador DL, Steiner S, Alperi A, González-Prieto C, Roy CR, Llosa M. DNA Delivery and Genomic Integration into Mammalian Target Cells through Type IV A and B Secretion Systems of Human Pathogens. Frontiers In Microbiology 2017, 8: 1503. PMID: 28878740, PMCID: PMC5572225, DOI: 10.3389/fmicb.2017.01503.Peer-Reviewed Original ResearchCitationsAltmetric
2015
Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication
Lori C, Ozaki S, Steiner S, Böhm R, Abel S, Dubey BN, Schirmer T, Hiller S, Jenal U. Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication. Nature 2015, 523: 236-239. PMID: 25945741, DOI: 10.1038/nature14473.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2012
Allosteric activation of exopolysaccharide synthesis through cyclic di‐GMP‐stimulated protein–protein interaction
Steiner S, Lori C, Boehm A, Jenal U. Allosteric activation of exopolysaccharide synthesis through cyclic di‐GMP‐stimulated protein–protein interaction. The EMBO Journal 2012, 32: 354-368. PMID: 23202856, PMCID: PMC3567491, DOI: 10.1038/emboj.2012.315.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsProtein-protein interactionsSecond messenger cInner membrane componentsEscherichia coli biofilmsGMP receptorGMP signalingGMP bindsSynthesis machineryExtracellular matrix componentsMajor extracellular matrix componentsAllosteric activationExopolysaccharide synthesisExopolysaccharide matrixMembrane componentsColi biofilmsGlycosyltransferase activityBacterial pathogensMachineryN-acetylglucosaminePathogenic bacteriaMatrix componentsEnzyme activityGMP concentrationGMPBacteria
2009
Second messenger signalling governs Escherichia coli biofilm induction upon ribosomal stress
Boehm A, Steiner S, Zaehringer F, Casanova A, Hamburger F, Ritz D, Keck W, Ackermann M, Schirmer T, Jenal U. Second messenger signalling governs Escherichia coli biofilm induction upon ribosomal stress. Molecular Microbiology 2009, 72: 1500-1516. PMID: 19460094, DOI: 10.1111/j.1365-2958.2009.06739.x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdhesins, BacterialAnti-Bacterial AgentsBeta-GlucansBiofilmsCyclic GMPEscherichia coliEscherichia coli ProteinsGene Expression Regulation, BacterialGuanosine TetraphosphatePhosphorus-Oxygen LyasesProtein BiosynthesisPyrophosphatasesRibosomesRNA Processing, Post-TranscriptionalSecond Messenger SystemsConceptsBiofilm inductionRibosome-targeting antibioticsNovel regulatory mechanismSecond messenger signalingSpecific derepressionBiosynthesis machineryRibosomal stressTranslational stressTranslation inhibitorsPpGpp levelsExposure of bacteriaMicrobial cellsRegulatory mechanismsAdhesin productionPolysaccharide adhesinBiofilm formationPpGppImportant synergistic roleMaximal inductionBiofilm controlMachineryBiofilm modelInductionGMPSubinhibitory concentrations
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Mailing Address
Yale School of Medicine
Boyer Center for Molecular Medicine, rm 347, 295 Congress Avenue
New Haven, CT 06536-0812
United States