Qin Li, MD
Associate Research Scientist in PathologyCards
About
Research
Publications
2025
Clonorchis sinensis infection are associated with calcium phosphate gallbladder stones: A single-center retrospective observational study in China
Ma R, Luo X, Liu Y, Li Q. Clonorchis sinensis infection are associated with calcium phosphate gallbladder stones: A single-center retrospective observational study in China. Medicine 2025, 104: e45739. PMID: 41239721, PMCID: PMC12622692, DOI: 10.1097/md.0000000000045739.Peer-Reviewed Original ResearchConceptsCalcium phosphate stonesRetrospective observational studyGallbladder stonesHigh-incidence regionsLow-incidence regionsPhosphate stonesSingle-center retrospective observational studyCalcium phosphate stone formationObservational studyC sinensis infectionRegional prevalenceClinical characteristicsStone compositionStone casesStone formationInfectionClonorchis sinensis infectionClinical attributesC sinensisClonorchis sinensisGallbladderPatients
2023
A novel defined pyroptosis-related gene signature predicts prognosis and correlates with the tumour immune microenvironment in lung adenocarcinoma
Chen Z, Ge L, Xu S, Li Q, Zhou L. A novel defined pyroptosis-related gene signature predicts prognosis and correlates with the tumour immune microenvironment in lung adenocarcinoma. Scientific Reports 2023, 13: 9921. PMID: 37337018, PMCID: PMC10279685, DOI: 10.1038/s41598-023-36720-1.Peer-Reviewed Original ResearchConceptsPyroptosis-related genesTumor-infiltrating immune cellsTumor mutational burdenLung adenocarcinomaImmune cellsMutational burdenPrognostic signaturePyroptosis-related gene signatureTumor microenvironmentGene Expression Omnibus (GEO) cohortSelection operator CoxImmune cell infiltrationRole of pyroptosisIndependent prognostic biomarkerTumor immune microenvironmentCox regression modelImmune checkpoint regulatorsCancer-related deathCancer Genome Atlas (TCGA) databaseSpearman correlation analysisFuture studiesImmune microenvironmentCell infiltrationLUAD patientsCommon causeIntegrated analysis of competitive endogenous RNA networks in elder patients with non-small cell lung cancer
Chen Z, Yu F, Zhu B, Li Q, Yu Y, Zong F, Liu W, Zhang M, Wu S. Integrated analysis of competitive endogenous RNA networks in elder patients with non-small cell lung cancer. Medicine 2023, 102: e33192. PMID: 36897674, PMCID: PMC9997791, DOI: 10.1097/md.0000000000033192.Peer-Reviewed Original ResearchConceptsMRNA ceRNA networkEndogenous RNA (ceRNA) networkCeRNA networkMessenger RNAsRNA networkLncRNA-miRNACompetitive endogenous RNA (ceRNA) networkLong non-coding RNAsPotential ceRNA networksNon-coding RNAsFunctions of DEmRNAsCancer-related processesCancer Genome AtlasGenome analysisGene OntologyKyoto EncyclopediaDevelopment of NSCLCGene Expression Omnibus (GEO) cohortNovel insightsGenome AtlasSurvival packageExpression levelsIntegrated analysisDEmRNAsMiRNAs
2022
A systematic study on 33 gallbladder stones resembling adult Clonorchis sinensis worms
Ma R, Wang X, Li Q, Cai H, Luo X. A systematic study on 33 gallbladder stones resembling adult Clonorchis sinensis worms. Journal Of Helminthology 2022, 96: e90. PMID: 36573372, DOI: 10.1017/s0022149x22000773.Peer-Reviewed Original Research
2021
An update: the emerging evidence of complement involvement in COVID-19
Li Q, Chen Z. An update: the emerging evidence of complement involvement in COVID-19. Medical Microbiology And Immunology 2021, 210: 101-109. PMID: 33811541, PMCID: PMC8019074, DOI: 10.1007/s00430-021-00704-7.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeCOVID-19 patientsCOVID-19Pre-clinical samplesRespiratory distress syndromePotential treatment optionCoronavirus disease 2019Host immune responseMultiorgan failureComplement involvementSystemic inflammationDistress syndromeSevere patientsOrgan damageKidney failureTreatment optionsInflammatory responseTissue injuryDisease 2019Immune responseAnimal modelsMultiple organsAbnormal activationInnate immunityComplement inhibitorsLong noncoding RNA TINCR is a novel regulator of human bronchial epithelial cell differentiation state
Omote N, Sakamoto K, Li Q, Schupp JC, Adams T, Ahangari F, Chioccioli M, DeIuliis G, Hashimoto N, Hasegawa Y, Kaminski N. Long noncoding RNA TINCR is a novel regulator of human bronchial epithelial cell differentiation state. Physiological Reports 2021, 9: e14727. PMID: 33527707, PMCID: PMC7851438, DOI: 10.14814/phy2.14727.Peer-Reviewed Original ResearchConceptsTerminal differentiation-induced lncRNANormal human bronchial epithelial cellsTINCR overexpressionCell differentiationNotch genesTissue developmentBronchial epithelial cellsExtracellular matrix organizationCell phenotypeRNA sequencing analysisNumerous biological functionsRole of lncRNAsCell differentiation stateEpithelial cellsHuman bronchial epithelial cellsCiliated cell differentiationStaufen1 proteinNovel regulatorBasal cell phenotypeDownstream regulatorsRNA immunoprecipitationBiological functionsCritical regulatorDifferential expressionDifferentiation state
2020
Tumor-targeted pH-low insertion peptide delivery of theranostic gadolinium nanoparticles for image-guided nanoparticle-enhanced radiation therapy
Liu W, Deacon J, Yan H, Sun B, Liu Y, Hegan D, Li Q, Coman D, Parent M, Hyder F, Roberts K, Nath R, Tillement O, Engelman D, Glazer P. Tumor-targeted pH-low insertion peptide delivery of theranostic gadolinium nanoparticles for image-guided nanoparticle-enhanced radiation therapy. Translational Oncology 2020, 13: 100839. PMID: 32763504, PMCID: PMC7408331, DOI: 10.1016/j.tranon.2020.100839.Peer-Reviewed Original ResearchHuman lung cancer cellsA549 human lung cancer cellsMolecular MRI techniqueTumor-bearing miceLung cancer cellsClonogenic survival assaysVivo radiosensitizationRadiation therapySolid tumorsTumor cell metabolismTumorsEnhanced radiosensitivityTumor cellsMR imagingSurvival assaysMRI techniquesCancer cellsTreatment planningRadiotherapyTumor coreGeneral hallmarkRadiotherapy treatment planningRadiosensitivityPeptide deliveryDeliveryCorrection to: A pooled analysis of the LAMP assay for the detection of Neisseria meningitidis
Fan SJ, Tan HK, Xu YC, Chen YZ, Xie TA, Pan ZY, Ouyang S, Li Q, Li XY, Li ZX, Guo XG. Correction to: A pooled analysis of the LAMP assay for the detection of Neisseria meningitidis. BMC Infectious Diseases 2020, 20: 560. PMID: 32736603, PMCID: PMC7395387, DOI: 10.1186/s12879-020-05300-3.Peer-Reviewed Original ResearchA pooled analysis of the LAMP assay for the detection of Neisseria meningitidis
Fan SJ, Tan HK, Xu YC, Chen YZ, Xie TA, Pan ZY, Ouyang S, Li Q, Li XY, Li ZX, Guo XG. A pooled analysis of the LAMP assay for the detection of Neisseria meningitidis. BMC Infectious Diseases 2020, 20: 525. PMID: 32689953, PMCID: PMC7372874, DOI: 10.1186/s12879-020-05250-w.Peer-Reviewed Original ResearchConceptsLoop-mediated isothermal amplificationBacterial meningitisFunnel plotPublication biasHigh mortality rateLAMP assayWeb of ScienceSROC curvePooled analysisMortality rateClinical practiceDiagnostic accuracyMajor causeMeningococcusNeisseria meningitidisSummary receiverCharacteristic curveMeningitisReliable diagnosisDeeks' funnel plotIsothermal amplificationDepressed areasOriginal studyMeningitidisBacterial culturePooled analysis of the Xpert MTB/RIF assay for diagnosing tuberculous meningitis
Chen YZ, Sun LC, Wen YH, Li ZW, Fan SJ, Tan HK, Qiu M, Pan ZY, Li Q, Zhao YZ, Li ZX, Guo XG. Pooled analysis of the Xpert MTB/RIF assay for diagnosing tuberculous meningitis. Bioscience Reports 2020, 40: bsr20191312. PMID: 31778149, PMCID: PMC6946622, DOI: 10.1042/bsr20191312.Peer-Reviewed Original ResearchConceptsXpert MTB/RIFMTB/RIFTuberculous meningitisPositive likelihood ratioNegative likelihood ratioDiagnostic odds ratioOdds ratioEarly diagnosisCerebrospinal fluidCSF samplesPooled sensitivityLikelihood ratioReceiver operator characteristic curveOverall pooled sensitivityOperator characteristic curveExtrapulmonary tuberculosisDiagnostic delayPooled analysisSummary receiver operator characteristic curveDiagnostic efficacyClinical diagnosisMeningitisPooled specificityRelevant studiesDiagnosis