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INFORMATION FOR

    Preston C. Sprenkle, MD

    Associate Professor of Urology
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    Additional Titles

    Director, Urology Research Fellowship, Urology

    Co-Chair, Cancer Liaison Committee, Oncology, VA Connecticut Healthcare System

    Co-Chair, NCCN Guidelines Committee on Prostate Cancer Early Detection, National Comprehensive Cancer Network (NCCN)

    Division Chief, Division of Urology at VA Connecticut Healthcare System, Urology, VA Connecticut Healthcare System

    About

    Titles

    Associate Professor of Urology

    Director, Urology Research Fellowship, Urology

    Positions outside Yale

    Co-Chair, Cancer Liaison Committee, Oncology, VA Connecticut Healthcare System; Co-Chair, NCCN Guidelines Committee on Prostate Cancer Early Detection, National Comprehensive Cancer Network (NCCN); Division Chief, Division of Urology at VA Connecticut Healthcare System, Urology, VA Connecticut Healthcare System

    Biography

    Dr. Preston C. Sprenkle specializes in the treatment of urologic cancers, primarily prostate cancer, but also including kidney cancer, bladder cancer, and testicular cancer.

    Dr. Sprenkle has dedicated his career to using the latest technologies to improve prostate cancer diagnosis and treatment that minimizes the impact on a man's quality of life.

    He was one of the first physicians nationwide to implement the use of the Artemis Device. This machine, introduced in 2009, allows a surgeon to use 3D ultrasound technology and merge it with even more precise magnetic resonance imaging (MRI) to accurately identify cancerous tumors.

    “Skilled and experienced radiologists are rare for this relatively new technique,” Dr. Sprenkle explains. “At Yale, we are fortunate to have some of the world leaders in prostate MRI.”

    Dr. Sprenkle is also a pioneer in “focal therapy,” which allows a surgeon to treat tiny prostate lesions, rather than the whole organ. This avoids many of the side effects—such as erectile dysfunction and incontinence—that may follow the removal of the whole prostate.

    “Exciting technological advances are revolutionizing urology. Prostate cancer is very common and current treatments can majorly impact a man's sexual and urinary function,” Dr. Sprenkle says. “Developing ways to minimize the impact of prostate cancer diagnosis and treatment on a man's health and quality of life is tremendously rewarding.”

    Dr. Sprenkle believes in working with patients to come up with individualized treatment plans. “I want my patients to feel that I hear their concerns and treat them like a person. I am pleased at the end of a long consultation when they feel like they understand their disease and their options.”

    Appointments

    • Urology

      Associate Professor on Term
      Primary

    Other Departments & Organizations

    Education & Training

    Non Degree Program
    Yale School of Management, Emerging Leaders Program (2018)
    Fellowship
    Memorial Sloan Kettering Cancer Center (2011)
    Residency
    New York Presbyterian Hospital (2009)
    Internship
    New York Presbyterian Hospital (2005)
    MD
    Columbia University (2004)
    BA
    Stanford University, Human Biology (1998)

    Research

    Overview

    Improving accuracy of prostate cancer diagnosis, staging, and treatment through enhanced imaging techniques with Prostate MRI and targeted prostate biopsies using our clinical outcomes database.

    Clinical trial interventions on patients with high risk prostate cancer as well as utilizing new techniques and technologies for ablation (destruction) of prostate cancer using such technologies as cryoablation, irreversible electroporation, TULSA, laser ablation, and others.

    Medical Research Interests

    Ablation Techniques; Genomics; High-Intensity Focused Ultrasound Ablation; Machine Learning; Magnetic Resonance Imaging; Prostatectomy; Urology

    Research at a Glance

    Yale Co-Authors

    Frequent collaborators of Preston C. Sprenkle's published research.

    Publications

    2024

    Clinical Trials

    Academic Achievements & Community Involvement

    • activity

      NCCN Prostate Cancer Early Detection Guideline Panel

    • activity

      Scientific Advisory Board

    • activity

      Frontiers

    • activity

      Urologic Oncology

    • activity

      Oncotarget

    Clinical Care

    Overview

    Preston C. Sprenkle, MD, specializes in the treatment of urologic cancers, including prostate cancer, kidney cancer, bladder cancer, testicular cancer and sarcoma—a rare kind of cancer that grows in cells that connect or support other parts of the body, like bone or muscle.

    Dr. Sprenkle has dedicated his career to using the latest imaging technologies to improve diagnosis. He was one of the first physicians nationwide to implement the use of the Artemis Device. This machine, introduced in 2009, allows a surgeon to use 3D ultrasound technology and merge it with even more precise magnetic resonance imaging (MRI) to accurately identify cancerous tumors.

    “Skilled and experienced radiologists are rare for this relatively new technique,” Dr. Sprenkle explains. “At Yale, we are fortunate to have some of the world leaders in prostate MRI.”

    Dr. Sprenkle is also a pioneer in “focal therapy,” which allows a surgeon to treat tiny prostate lesions, rather than the whole organ. This avoids many of the side effects—such as erectile dysfunction and incontinence—that may follow the removal of the whole prostate.

    “Exciting technological advances are revolutionizing urology. Prostate cancer is very common and current treatments can majorly impact a man's sexual and urinary function,” Dr. Sprenkle says. “Developing ways to minimize the impact of prostate cancer diagnosis and treatment on a man's health and quality of life is tremendously rewarding.”

    Dr. Sprenkle believes in working with patients to come up with individualized treatment plans. “I want my patients to feel that I hear their concerns and treat them like a person. I am pleased at the end of a long consultation when they feel like they understand their disease and their options.”

    Clinical Specialties

    Urology; Urologic Oncology

    Fact Sheets

    Yale Medicine News

    Get In Touch

    Contacts

    Appointment Number
    Clinic Fax Number
    Mailing Address

    Urology

    PO Box 208058

    New Haven, CT 06520-8058

    United States

    Locations

    • Patient Care Locations

      Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.