Patrick Gallagher, MD, BS
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Appointments
Neonatal-Perinatal Medicine
Primary
Titles
Director, Yale Center for Blood Disorders
Contact Info
Appointments
Neonatal-Perinatal Medicine
Primary
Titles
Director, Yale Center for Blood Disorders
Contact Info
Appointments
Neonatal-Perinatal Medicine
Primary
Titles
Director, Yale Center for Blood Disorders
Contact Info
About
Titles
Professor Emeritus of Pediatrics
Director, Yale Center for Blood DisordersAppointments
Neonatal-Perinatal Medicine
EmeritusPrimary
Other Departments & Organizations
- Gallagher Lab
- Molecular Cell Biology, Genetics and Development
- Neonatal Transport Program
- Neonatal-Perinatal Medicine
- Newborn Special Care Unit
- Pathology and Molecular Medicine
- Pathology Research
- Pediatrics
- Rheumatic Diseases Research Core
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Stem Cell Center
- Yale Ventures
- YCCEH
Education & Training
- Fellow - Molecular Hematology
- Yale University School of Medicine (1994)
- Fellow - Neonatal-Perinatal Medicine
- Yale University School of Medicine (1992)
- Chief Resident
- Children's Hospital Medical Center, University of Cincinnati (1989)
- Intern & Resident
- Children's Hospital Medical Center, University of Cincinnati (1988)
- MD
- Northeastern Ohio University (1985)
- BS
- Ohio State University (1976)
Research
Overview
Dr. Gallagher has trained numerous undergraduate, graduate and medical students, MD and PhD postdoctoral fellows, and sabbatical faculty. Laboratory graduates hold positions throughout the world and trainees have
received awards and honors from local, regional, and national organizations. After serving as the PI on the Yale Neonatal/Perinatal Medicine T32 training grant for many years, he now participates in training grants in Genetics, Medicine, and Laboratory Medicine. He serves on the Department of Pediatrics Scholarship Oversight Committee (SOC). He has served on numerous individual SOCs as member or chair, as well as various medical and graduate school mentoring committees, PhD thesis committees, etc.
Medical Subject Headings (MeSH)
Anemia, Sickle Cell; Diseases; Elliptocytosis, Hereditary; Erythropoiesis; Genetics; Genomics; Health Care; Hemoglobinopathies; Hydrops Fetalis; Information Science; Neonatology; Pathology; Pediatrics; Polycythemia; Pyruvate Kinase; Spherocytosis, Hereditary
ORCID
0000-0002-5424-0224
Research at a Glance
Yale Co-Authors
Frequent collaborators of Patrick Gallagher's published research.
Publications Timeline
A big-picture view of Patrick Gallagher's research output by year.
Research Interests
Research topics Patrick Gallagher is interested in exploring.
Vincent Schulz, PhD
Louise-Marie Dembry, MD, FACP, MS, MBA, FIDSA, BS
Diane Krause, MD, PhD
Matthew Bizzarro, MD
Joseph Craft, MD
Jesse Rinehart, PhD
261Publications
9,389Citations
Erythropoiesis
Spherocytosis, Hereditary
Elliptocytosis, Hereditary
Hydrops Fetalis
Anemia, Sickle Cell
Hemoglobinopathies
Publications
2024
Survey research in perinatal medicine
Conroy S, Gallagher P. Survey research in perinatal medicine. Journal Of Perinatology 2024, 44: 771-772. PMID: 38538912, DOI: 10.1038/s41372-024-01940-4.Peer-Reviewed Original ResearchThe diagnostic utility of obtaining two blood cultures for the diagnosis of early onset sepsis in neonates
Fleiss N, Shabanova V, Murray T, Gallagher P, Bizzarro M. The diagnostic utility of obtaining two blood cultures for the diagnosis of early onset sepsis in neonates. Journal Of Perinatology 2024, 44: 745-747. PMID: 38409330, DOI: 10.1038/s41372-024-01914-6.Peer-Reviewed Original ResearchDiagnosis and management of pyruvate kinase deficiency: international expert guidelines
Al-Samkari H, Shehata N, Lang-Robertson K, Bianchi P, Glenthøj A, Sheth S, Neufeld E, Rees D, Chonat S, Kuo K, Rothman J, Barcellini W, van Beers E, Pospíšilová D, Shah A, van Wijk R, Glader B, Mañú Pereira M, Andres O, Kalfa T, Eber S, Gallagher P, Kwiatkowski J, Galacteros F, Lander C, Watson A, Elbard R, Peereboom D, Grace R. Diagnosis and management of pyruvate kinase deficiency: international expert guidelines. The Lancet Haematology 2024, 11: e228-e239. PMID: 38330977, DOI: 10.1016/s2352-3026(23)00377-0.Peer-Reviewed Original ResearchAltmetricConceptsExpert panelCountry of practiceCare of patientsEvidence-based guidelinesQuality of lifeClinical care of patientsPyruvate kinase deficiencySystematic literature searchDeficient careGuideline methodologistsPK deficiencyClinical careClinical guidelinesInternational expert guidelinesEstimated prevalenceHaemolytic anaemiaConsensus procedureManagement of chronic complicationsDraft recommendationsGRADE methodologyAGREE II frameworkExpert guidelinesLiterature searchClinical practiceInternational guidelinesJoint bleeds in mild hemophilia: Prevalence and clinical characteristics
Chiari J, Prozora S, Feinn R, Louizos E, Gallagher P, Bona R. Joint bleeds in mild hemophilia: Prevalence and clinical characteristics. Haemophilia 2024, 30: 331-335. PMID: 38240020, DOI: 10.1111/hae.14939.Peer-Reviewed Original ResearchAltmetricConceptsMild haemophiliaJoint bleedsJoint range of motionHepatitis CRange of motionMild diseaseHistory of joint bleedsInstitutional review board approvalJoint rangeRetrospective chart reviewHemophilia treatment centersReview board approvalJoint healthHistory of traumaDisease burdenMedical recordsChart reviewClinical characteristicsMitigate disease burdenRisk factorsBoard approvalBleedingTraumatic bleedingAverage ageHemophilic arthropathy
2023
Multimodality Platelet Evaluation By Mass Cytometry and Genetic Analysis in Patients with Bleeding Disorders
Gu S, Gallagher P, Butt A, Gu V, Lezon-Geyda K, Schulz V, Prozora S, Lee A, Neparidze N, Bar N, Martin K, Cornell J, Chirico G, Chakraborty R, Rinder H, Hwa J, Bona R. Multimodality Platelet Evaluation By Mass Cytometry and Genetic Analysis in Patients with Bleeding Disorders. Blood 2023, 142: 1197. DOI: 10.1182/blood-2023-177946.Peer-Reviewed Original ResearchConceptsBleeding tendencyBleeding disorderPlatelet markersPlatelet aggregometryMass cytometryPlatelet functionPlatelet disordersSingle-center prospective studyLow-risk groupAbnormal bleeding tendencyQualitative platelet disordersLarge patient cohortQuantitative platelet disordersCommon underlying causeGenetic variantsMultimodality evaluationTotal patientsRisk stratificationLaboratory suspicionPlatelet dysfunctionProspective studyPatient cohortUnivariate analysisPlatelet volumeRisk groupsIdentification of a Novel Gene Regulatory Element in Human Erythroid Progenitor Cells
Schulz V, Lezon-Geyda K, Shan P, Papoin J, Narla M, Steiner L, Blanc L, Palis J, Gallagher P. Identification of a Novel Gene Regulatory Element in Human Erythroid Progenitor Cells. Blood 2023, 142: 9. DOI: 10.1182/blood-2023-186046.Peer-Reviewed Original ResearchConceptsErythroid progenitor cellsActive enhancersEarly erythropoiesisChIP-seqRegulatory elementsGene expressionATAC-seqRUNX motifsGATA motifSingle nucleotide polymorphismsProgenitor cellsGATA1 bindingDisease genesEnhancer regionErythroid lineageTissue-specific transcription factorsNovel gene regulatory elementsNovel enhancer regionErythrocyte traitsGenome-wide association studiesDirect tissue-specific expressionNovel regulatory elementGene regulatory elementsHuman erythroid progenitor cellsTerminal erythroid differentiationPhenotypic and Proteomic Characterization of the Human Erythroid Progenitor Continuum Reveal Dynamic Changes in Cell Cycle and in Metabolic Pathways
Papoin J, Yan H, Leduc M, le-Gall M, Narla A, Steiner L, Gallagher P, Hillyer C, Gauthier E, Narla M, Blanc L. Phenotypic and Proteomic Characterization of the Human Erythroid Progenitor Continuum Reveal Dynamic Changes in Cell Cycle and in Metabolic Pathways. Blood 2023, 142: 2455. DOI: 10.1182/blood-2023-189566.Peer-Reviewed Original ResearchConceptsCell cycleFaster cycling cellsProgenitor differentiationProgenitor populationsOxidative phosphorylationMass spectrometry-based proteomicsErythroid progenitorsS phaseProtein copy numbersSpectrometry-based proteomicsErythroid progenitor differentiationCycle-related genesG2/MTerminal erythropoiesisProgenitor biologyProteomic characterizationHematopoietic stem cellsE2F membersHuman erythropoiesisHuman bone marrowFunctional analysisErythroid lineageMurine erythropoiesisMetabolic pathwaysS transitionErythroid Progenitor Cells in the Murine Bone Marrow: Parallels with Human Counterparts and Response to Acute Anemia
McGrath K, Kingsley P, Rust E, Schulz V, Koniski A, Schofield T, Vit L, Narla M, Blanc L, Steiner L, Gallagher P, Palis J. Erythroid Progenitor Cells in the Murine Bone Marrow: Parallels with Human Counterparts and Response to Acute Anemia. Blood 2023, 142: 2451. DOI: 10.1182/blood-2023-187741.Peer-Reviewed Original ResearchConceptsGene Ontology termsErythroid progenitor cellsErythroid progenitorsOntology termsTranscription factorsProgenitor cellsMurine erythroid progenitor cellsEPO-responsive genesMurine counterpartGlobal transcriptomic studiesLineage-specific progenitor cellsHuman erythroid progenitor cellsAnalysis of genesCholesterol homeostasisHuman counterpartLate-stage erythroid progenitorsMature red blood cellsUpregulated transcription factorsMurine erythroid progenitorsRNA-seq studiesCholesterol biosynthesis genesColony-forming progenitorsBiosynthesis genesErythroid progenitor populationsMurine bone marrowRps19 and Rpl5 Play Distinct Roles in hematopoietic Stem Cell maintenance and Erythroid Differentiation
Tang Y, Ling T, Khan M, Rao R, Schulz V, Papoin J, Narla A, Lipton J, Palis J, Steiner L, Gallagher P, Narla M, Crispino J, Blanc L. Rps19 and Rpl5 Play Distinct Roles in hematopoietic Stem Cell maintenance and Erythroid Differentiation. Blood 2023, 142: 144. DOI: 10.1182/blood-2023-189146.Peer-Reviewed Original ResearchConceptsFailure of erythropoiesisErythroid differentiationVav-iCreHematopoietic stem cell maintenanceFetal hematopoiesisHematopoietic stemProtein translation ratesStem cell maintenanceRibosomal protein haploinsufficiencyGlobal protein synthesisTerminal erythroid differentiationCell compartmentExpression of RUNX1Stem cell compartmentErythroid fateProgenitor cell compartmentFetal liverRibosome biogenesisPolysome profilingNormal expression levelsRibosomal proteinsProgenitor biologyCell maintenanceScRNAseq studiesTranscription factorsA Novel β-Globin Locus Deletional Syndrome: εγ-Thalassemia
Gallagher P. A Novel β-Globin Locus Deletional Syndrome: εγ-Thalassemia. Clinical Chemistry 2023, 69: 671-672. PMID: 37279577, DOI: 10.1093/clinchem/hvad067.Peer-Reviewed Original ResearchAltmetric
Links & Media
Media
News
- July 05, 2023
Hwa to Co-Lead Yale Cooperative Center of Excellence in Hematology
- July 02, 2019
Yale Researchers Crack the Code of a Rare, Inherited Anemia
- February 24, 2019
Patrick Gallagher, MD Named Editor-in-Chief to The Journal of Perinatology
- October 19, 2017Source: BLOOD
“Novel mechanisms of PIEZO1 dysfunction in hereditary xerocytosis
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