Nima Fattahi, MD
Associate Research Scientist (Digestive Diseases)Cards
About
Research
Publications
2025
Refining Mouse Models of Gaucher Disease: Advancing Mechanistic Insights, Biomarker Discovery, and Therapeutic Strategies
Fattahi N, Ruan J, Belinsky G, Xing S, Mistry P, Nair S. Refining Mouse Models of Gaucher Disease: Advancing Mechanistic Insights, Biomarker Discovery, and Therapeutic Strategies. International Journal Of Molecular Sciences 2025, 26: 11915. PMID: 41465340, PMCID: PMC12733336, DOI: 10.3390/ijms262411915.Peer-Reviewed Original ResearchMouse modelGaucher diseaseMouse model of Gaucher diseaseMouse model developmentContribution of macrophagesBiallelic pathogenic variantsLineage-specific modelsClinically meaningful endpointsGD mouse modelPatient-derived mutationsModel of Gaucher diseaseSubtypes of GDImmune dysregulationTherapeutic responseMulti-omics integrationB cellsPathogenic variantsTherapeutic strategiesPerinatal lethalityLysosomal disorderClinical translationImmune architectureBiomarker developmentGene editing platformMultisystem conditionNational and sub-national sero-epidemiology of immunoglobulin G against SARS-CoV-2 in Iran in 2021
Azangou-Khyavy M, Ghasemi E, Ebrahimi N, Rashidi M, Abbasi-Kangevari M, Ahmadi N, Khanali J, Kazemi A, Dilmaghani-Marand A, Farzi Y, Yoosefi M, Abdolhamidi E, Moghimi M, Nasserinejad M, Fattahi N, Azadnajafabad S, Alipour-Daroei A, Rezaee K, Djalalinia S, Rezaei N, Jamshidi H, Farzadfar F. National and sub-national sero-epidemiology of immunoglobulin G against SARS-CoV-2 in Iran in 2021. PLOS ONE 2025, 20: e0313795. PMID: 40743259, PMCID: PMC12312912, DOI: 10.1371/journal.pone.0313795.Peer-Reviewed Original ResearchConceptsPopulation-based cross-sectional studyCross-sectional studySARS-CoV-2Population-based seroprevalence studyAge-standardized seroprevalenceIntervening factorsInfection rateSeroprevalence of IgGN antigenPCR test resultsRisk of infectionCOVID-19 infectionProtective factorsSymptomatic casesELISA kitsInfectionImmunoglobulin GSeroprevalence studySerological samplesLiver Diseases in Inborn Errors of Metabolism Bridging Pediatric and Adult Hepatology
Ain N, Fattahi N, Jain D, Mistry P. Liver Diseases in Inborn Errors of Metabolism Bridging Pediatric and Adult Hepatology. Clinics In Liver Disease 2025, 29: 347-369. PMID: 40670027, DOI: 10.1016/j.cld.2025.04.001.Peer-Reviewed Original ResearchModeling bone marrow microenvironment and hematopoietic dysregulation in Gaucher disease through VavCre mediated Gba deletion
Belinsky G, Ruan J, Fattahi N, Mehta S, Boddupalli C, Mistry P, Nair S. Modeling bone marrow microenvironment and hematopoietic dysregulation in Gaucher disease through VavCre mediated Gba deletion. Human Molecular Genetics 2025, 34: 952-966. PMID: 40197748, PMCID: PMC12085781, DOI: 10.1093/hmg/ddaf045.Peer-Reviewed Original ResearchGD miceImmune dysregulationGaucher diseaseExpansion of monocytesImmune cell deconvolutionKnockout modelsBone marrow microenvironmentGlucocerebrosidase activityC57BL/6 J backgroundDeficient glucocerebrosidase activityGaucher cell infiltrationInfluence disease severityGD biomarkersGD pathologyGD pathophysiologyLysosomal storage disorderImmune landscapeDendritic cellsHematopoietic stemMarrow microenvironmentAccumulation of glucosylceramideVav-CreBone marrowCell infiltrationHematopoietic cells
2024
Alcohol consumption among Iranian population based on the findings of STEPS survey 2021
Hajebi A, Nasserinejad M, Rezaei N, Azadnajafabad S, Rashidi M, Ahmadi N, Ghasemi E, Farzi Y, Yoosefi M, Djalalinia S, Fattahi N, Rezaei S, Foroutan Mehr E, Kazemi A, Haghshenas R, Rezaee K, Momen Nia Rankohi A, Afsari M, Mahdavihezaveh A, Jamshidi H, Farzadfar F. Alcohol consumption among Iranian population based on the findings of STEPS survey 2021. Scientific Reports 2024, 14: 16819. PMID: 39039151, PMCID: PMC11263364, DOI: 10.1038/s41598-024-66257-w.Peer-Reviewed Original ResearchConceptsAlcohol consumptionAssociation of alcohol consumptionPrevalence of alcohol consumptionAlcohol useModified Persian versionPrevalence of alcohol usePer capita alcohol consumptionAdult populationBehavioral risk factorsPopulation-based surveyRisk factorsMetabolic risk factorsQuantity-frequency methodLifetime alcohol consumptionSTEPS questionnaireSTEPS surveyPersian versionLifestyle variablesLifetime smokersFactor associationsOdds ratioCluster samplingMonthly prevalenceIranian populationPhysical injury
2023
Exploring metabolically healthy obesity: prevalence, characteristics, and cardiovascular risk in the Iranian population based on the STEPS 2021
Langroudi A, Farzi Y, Masinaei M, Varniab Z, Shahin S, Rashidi M, Moghaddam S, Rahimi S, Khalili M, Keykhaei M, Ahmadi N, Kazemi A, Ghasemi E, Azadnajafabad S, Yoosefi M, Fattahi N, Nasserinejad M, Rezaei N, Haghshenas R, Dilmaghani-Marand A, Abdolhamidi E, Djalalinia S, Rezaei N, Larijani B, Farzadfar F. Exploring metabolically healthy obesity: prevalence, characteristics, and cardiovascular risk in the Iranian population based on the STEPS 2021. Journal Of Diabetes & Metabolic Disorders 2023, 23: 881-893. PMID: 38932890, PMCID: PMC11196437, DOI: 10.1007/s40200-023-01364-5.Peer-Reviewed Original ResearchPrevalence of metabolically healthy obesityMetabolically Healthy ObesityMetabolically unhealthy obesityHealthy obesityIranian populationCardiovascular diseaseOdds ratioMetabolically Healthy Obese IndividualsMetabolically healthy obese phenotypeMetabolically healthy obese groupPrevalence of obesityIncreasing prevalence of obesityCrude odds ratioCardiovascular disease riskRisk of cardiovascular diseaseCardiovascular riskHigh-risk individualsMetabolic syndrome criteriaAHA-NHLBIPublic health concernSubgroups of obesityUnhealthy obesityResultsThe prevalenceFramingham scoreMUO individualsPrevalence of plasma lipid abnormalities and associated risk factors among Iranian adults based on the findings from STEPs survey 2021
Khanali J, Ghasemi E, Rashidi M, Ahmadi N, Ghamari S, Azangou-Khyavy M, Malekpour M, Abbasi-Kangevari M, Hashemi S, Naderian M, Rezaei N, Dilmaghani-Marand A, Farzi Y, Kazemi A, Yoosefi M, Hajebi A, Rezaei S, Azadnajafabad S, Fattahi N, Nasserinejad M, Abdolhamidi E, Haghshenas R, Rezaei N, Djalalinia S, Larijani B, Farzadfar F. Prevalence of plasma lipid abnormalities and associated risk factors among Iranian adults based on the findings from STEPs survey 2021. Scientific Reports 2023, 13: 15499. PMID: 37726324, PMCID: PMC10509214, DOI: 10.1038/s41598-023-42341-5.Peer-Reviewed Original ResearchConceptsLow HDL-CPrevalence of dyslipidemiaHigh LDL-CPrevalence of lipid abnormalitiesLipid abnormalitiesLDL-CHDL-CRisk factorsRisk factors associated with dyslipidemiaFactors associated with dyslipidemiaIranian adultsLower prevalence of dyslipidemiaLow HDL-C.Plasma lipid abnormalitiesPrevalence of high cholesterolAbnormal lipid levelsLipid-lowering medicationsPopulation-based household surveyPrimary healthcare systemSelf-reported useMixed dyslipidemiaDyslipidemia prevalencePromote metabolic healthHDL-C.Family historyEvaluation of the diabetes care cascade and compliance with WHO global coverage targets in Iran based on STEPS survey 2021
Azadnajafabad S, Ahmadi N, Rezaei N, Rashidi M, Saeedi Moghaddam S, Mohammadi E, Abbasi-Kangevari M, Naderian M, Ghasemi E, Farzi Y, Kazemi A, Dilmaghani-Marand A, Yoosefi M, Rezaei S, Nasserinejad M, Fattahi N, Rezaei N, Haghshenas R, Foroutan Mehr E, Koolaji S, Razi F, Djalalinia S, Larijani B, Farzadfar F. Evaluation of the diabetes care cascade and compliance with WHO global coverage targets in Iran based on STEPS survey 2021. Scientific Reports 2023, 13: 13528. PMID: 37598214, PMCID: PMC10439917, DOI: 10.1038/s41598-023-39433-7.Peer-Reviewed Original ResearchConceptsCare cascadeSTEPS surveyCoverage targetsDM diagnosisDiabetes care cascadeTreatment coverageSub-optimal careGlycemic controlPrevalence of DMDiabetes mellitusDiabetes awarenessNational prevalenceWorld Health OrganizationControl statusCareGood glycemic controlIranian populationPrediabetesHealth OrganizationGlobal targetsDiabetesPrevalenceSurveyPopulationComplianceGlobal, Regional, and National Quality of Care Index (QCI) of Gastric Cancer: A Systematic Analysis for the Global Burden of Disease Study 1990-2017
Fattahi N, Ghanbari A, Djalalinia S, Rezaei N, Mohammadi E, Azadnajafabad S, Abbasi-Kangevari M, Aryannejad A, Aminorroaya A, Rezaei N, Azmin M, Ramezani R, Jafari F, Aghili M, Farzadfar F. Global, Regional, and National Quality of Care Index (QCI) of Gastric Cancer: A Systematic Analysis for the Global Burden of Disease Study 1990-2017. Journal Of Gastrointestinal Cancer 2023, 55: 247-262. PMID: 37365424, DOI: 10.1007/s12029-023-00950-3.Peer-Reviewed Original ResearchQuality of care indexQuality of careIncidence ratiosHigher quality of care indexQuality-of-care indicesGlobal Burden of Disease StudyBurden of Disease StudyLow SDI countriesSocio-demographic groupsPrevalence ratiosCare indexSDI countriesConclusionThe qualityGlobal burdenCancer deathDisease StudyCareHigher scoresNational qualityTherapeutic programScale 0ScoresEarly detectionNational levelCancer treatmentTobacco consumption patterns among Iranian adults: a national and sub-national update from the STEPS survey 2021
Abbasi-Kangevari M, Ghanbari A, Fattahi N, Malekpour M, Masinaei M, Ahmadi N, Ghamari S, Naderian M, Rashidi M, Rezaei N, Ghasemi E, Farzi Y, Yoosefi M, Rezaei N, Foroutan Mehr E, Moghimi M, Nasserinejad M, Maleki A, Abbasi-Kangevari Z, Farzadfar F. Tobacco consumption patterns among Iranian adults: a national and sub-national update from the STEPS survey 2021. Scientific Reports 2023, 13: 10272. PMID: 37355699, PMCID: PMC10290637, DOI: 10.1038/s41598-023-37299-3.Peer-Reviewed Original ResearchConceptsSTEPwise approach to chronic disease risk factor surveillancePrevalence of second-hand smokingAll-age prevalenceSecond-hand smokeIranian adultsChronic Disease Risk Factor SurveillanceEffectiveness of tobacco control programsTobacco consumptionEvidence-based tobacco control policiesPrevalence of current tobacco smokingPrevalence of current cigarette smokingRisk factor surveillanceTobacco control programsTobacco control policiesTobacco consumption patternsMultistage cluster sampling methodCurrent tobacco smokingCurrent cigarette smokingPublic health priorityPopulation-based dataCluster sampling methodCross-sectional studyHealth priorityHookah smokingHookah use
Academic Achievements & Community Involvement
News & Links
News
- November 03, 2025
Creating Spaces of Care: A Q&A With Nima Fattahi, MD
- December 10, 2024
Welcome New Staff, Faculty, Fellows & Postdocs (December 2024)
- October 12, 2022
Welcome New Staff, Faculty, Fellows, Postgrads, Postdocs (October 2022)