Sameet Mehta, PhD
he/him/his
Associate Research ScientistAbout
Research
Publications
2026
Parkin deficiency impairs female fertility, oocyte development, fertilization and mitochondrial function in mice
Volovsky M, Rodríguez-Eguren A, Ergun Y, Yildirim R, Sahin G, Garcia Milian R, Mehta S, Turanli L, Cervelló I, Scott R, Seli E. Parkin deficiency impairs female fertility, oocyte development, fertilization and mitochondrial function in mice. Npj Aging 2026, 12: 33. PMID: 41571641, PMCID: PMC12916830, DOI: 10.1038/s41514-026-00332-6.Peer-Reviewed Original ResearchWild typeOocyte yieldMitochondrial E3 ubiquitin ligaseKO miceParkin deficiencyE3 ubiquitin ligaseMII oocyte countFemale fertilityUbiquitin ligaseCellular homeostasisExpressed genesFertilizing capacityRNA sequencingMitochondrial functionYoung miceOld miceParkinParkin deletionReproductive competenceOocyte countParkin knockoutMiceFemale reproductionPathway changesOverall fertility
2025
Codanin-1, defective in congenital dyserythropoietic anemia I (CDA-I), regulates erythroid differentiation
Bosques L, Modepalli S, Nagarajan A, Tang C, Martínez-Morilla S, Rahman N, Mehta S, Krause D, Tamary H, Gallagher P, Hattangadi S, Kupfer G. Codanin-1, defective in congenital dyserythropoietic anemia I (CDA-I), regulates erythroid differentiation. Annals Of Hematology 2025, 104: 4987-5001. PMID: 41028447, PMCID: PMC12619753, DOI: 10.1007/s00277-025-06540-6.Peer-Reviewed Original ResearchCodanin-1CDA-ICDA-I.Gene regulatory regionsCongenital dyserythropoietic anemia IHigh-throughput sequencingAbnormal morphologyErythroid differentiationGlobal gene expressionErythroid progenitor developmentBone marrow erythroblastsHuman K562 cellsAutosomal recessive disorderErythroid cell differentiationRegulatory regionsChromatin immunoprecipitationAHSP geneCDAN1 geneErythroid genesMarrow erythroblastsIneffective erythropoiesisPeripheral bloodGene expressionHuman CD34GenesCerebrospinal Fluid Immune Cell Alterations in Women With Neuropsychiatric Long COVID
Orlinick B, Mehta S, McAlpine L, Khoshbakht S, Fertuzinhos S, Nelson A, Chiarella J, Das B, Patel V, Filippidis P, Corley M, Spudich S, Farhadian S. Cerebrospinal Fluid Immune Cell Alterations in Women With Neuropsychiatric Long COVID. Journal Of Infectious Diseases 2025, 233: e109-e117. PMID: 40920586, PMCID: PMC12811860, DOI: 10.1093/infdis/jiaf468.Peer-Reviewed Original ResearchPeripheral blood mononuclear cellsCerebrospinal fluidPeripheral blood mononuclear cell samplesImmune cell alterationsBlood mononuclear cellsLong COVIDAcute COVID-19Lumbar punctureGenes related to oxidative stressMononuclear cellsAndrogen responsivenessCellular stress pathwaysMolecular profilingNeurological syndromeBlood drawImmune responseCell alterationsCOVID statusReactive oxygen speciesP53 responseStress pathwaysWomenMTORC1 signalingOxidative stressLipid metabolismTumor microenvironment of non-small cell lung cancer impairs immune cell function among people with HIV
Desai S, Salahuddin S, Yusuf R, Ranjan K, Gu J, Osmani L, Lin Y, Mehta S, Talmon R, Kang I, Kluger Y, Zhao H, Schalper K, Emu B. Tumor microenvironment of non-small cell lung cancer impairs immune cell function among people with HIV. Journal Of Clinical Investigation 2025, 135: e177310. PMID: 40459946, PMCID: PMC12259253, DOI: 10.1172/jci177310.Peer-Reviewed Original ResearchNon-small cell lung cancerTumor microenvironmentImmune cellsLung cancerCohort of non-small cell lung cancerExpression of PD-1Impairs anti-tumor responsesTumor-infiltrating CD8+Tumor-specific immune responsesCD4+ T cellsHIV-associated tumorsInfiltrating CD8+Expression of immunoregulatory moleculesAnti-tumor responsesTumor-associated macrophagesCell lung cancerImmune cell functionNSCLC cell linesPD-1Tumor killingBlocker therapyCD8+LAG-3Immune landscapeImmunoregulatory phenotypeModeling bone marrow microenvironment and hematopoietic dysregulation in Gaucher disease through VavCre mediated Gba deletion
Belinsky G, Ruan J, Fattahi N, Mehta S, Boddupalli C, Mistry P, Nair S. Modeling bone marrow microenvironment and hematopoietic dysregulation in Gaucher disease through VavCre mediated Gba deletion. Human Molecular Genetics 2025, 34: 952-966. PMID: 40197748, PMCID: PMC12085781, DOI: 10.1093/hmg/ddaf045.Peer-Reviewed Original ResearchGD miceImmune dysregulationGaucher diseaseExpansion of monocytesImmune cell deconvolutionKnockout modelsBone marrow microenvironmentGlucocerebrosidase activityC57BL/6 J backgroundDeficient glucocerebrosidase activityGaucher cell infiltrationInfluence disease severityGD biomarkersGD pathologyGD pathophysiologyLysosomal storage disorderImmune landscapeDendritic cellsHematopoietic stemMarrow microenvironmentAccumulation of glucosylceramideVav-CreBone marrowCell infiltrationHematopoietic cells
2024
Epigenetic Changes in Cerebrospinal Fluid and Blood of People With Neurosyphilis
Mostaghimi D, Mehta S, Yoon J, Kosana P, Marra C, Corley M, Farhadian S. Epigenetic Changes in Cerebrospinal Fluid and Blood of People With Neurosyphilis. Journal Of Infectious Diseases 2024, 231: 883-893. PMID: 39356164, PMCID: PMC11998562, DOI: 10.1093/infdis/jiae476.Peer-Reviewed Original ResearchPeripheral blood mononuclear cellsCerebrospinal fluidRNA expression changesEpigenetic changesExpression changesBlood mononuclear cellsDifferentially methylated sitesDNA methylation profilesInsulin-responsive pathwaysAntibiotic treatmentImmune cellsB cellsMononuclear cellsMethylation changesDNA methylationMethylation profilesMatched ControlsBacterial infectionsNon-NENeurosyphilisBlood of peopleInfectionRNANsEarly adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent mice
Islam R, White J, Arefin T, Mehta S, Liu X, Polis B, Giuliano L, Ahmed S, Bowers C, Zhang J, Kaffman A. Early adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent mice. Biology Of Sex Differences 2024, 15: 39. PMID: 38715106, PMCID: PMC11075329, DOI: 10.1186/s13293-024-00616-0.Peer-Reviewed Original ResearchConceptsLateral entorhinal cortexContextual fear conditioningDorsal hippocampusHippocampal developmentSex differencesFear conditioningEarly adversityLimited beddingSevere deficitsModel of early adversitySex-specific deficitsReelin-positive neuronsPerforant pathwayReelin-positive cellsDiffusion magnetic resonance imagingEx vivo diffusion magnetic resonance imagingContextual freezingContextual memoryAdolescent miceHippocampal functionLife adversityEntorhinal cortexHippocampusDeficitsAdolescent males
2023
Early cellular and molecular signatures correlate with severity of West Nile virus infection
Lee H, Zhao Y, Fleming I, Mehta S, Wang X, Vander Wyk B, Ronca S, Kang H, Chou C, Fatou B, Smolen K, Levy O, Clish C, Xavier R, Steen H, Hafler D, Love J, Shalek A, Guan L, Murray K, Kleinstein S, Montgomery R. Early cellular and molecular signatures correlate with severity of West Nile virus infection. IScience 2023, 26: 108387. PMID: 38047068, PMCID: PMC10692672, DOI: 10.1016/j.isci.2023.108387.Peer-Reviewed Original ResearchWest Nile virusEffective anti-viral responseInnate immune cell typesWest Nile virus infectionPro-inflammatory markersAcute time pointsImmune cell typesAnti-viral responseMolecular signaturesHost cellular activitiesAcute infectionAsymptomatic donorsPeripheral bloodSevere infectionsVirus infectionImmune responseSevere casesCell activityIll individualsSerum proteomicsInfectionInfection severityHigh expressionTime pointsNile virusMicroRNA-1 protects the endothelium in acute lung injury
Korde A, Haslip M, Pednekar P, Khan A, Chioccioli M, Mehta S, Lopez-Giraldez F, Bermejo S, Rojas M, Dela Cruz C, Matthay M, Pober J, Pierce R, Takyar S. MicroRNA-1 protects the endothelium in acute lung injury. JCI Insight 2023, 8: e164816. PMID: 37737266, PMCID: PMC10561733, DOI: 10.1172/jci.insight.164816.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeAcute lung injuryVascular endothelial growth factorAngiopoietin-2Lung injuryAcute injuryMiR-1MicroRNA-1Endothelial cell-specific overexpressionSevere endothelial dysfunctionRespiratory distress syndromeSurvival of miceIntrinsic protective effectContext of injuryCell-specific overexpressionEndothelial growth factorFamily member 3Pneumonia cohortMiR-1 targetsEndothelial dysfunctionDistress syndromeBarrier dysfunctionCapillary leakProtective effectSevere formA systems biology approach identifies the role of dysregulated PRDM6 in the development of hypertension
Gunawardhana K, Hong L, Rugira T, Uebbing S, Kucharczak J, Mehta S, Karunamuni D, Cabera-Mendoza B, Gandotra N, Scharfe C, Polimanti R, Noonan J, Mani A. A systems biology approach identifies the role of dysregulated PRDM6 in the development of hypertension. Journal Of Clinical Investigation 2023, 133: e160036. PMID: 36602864, PMCID: PMC9927944, DOI: 10.1172/jci160036.Peer-Reviewed Original ResearchConceptsDevelopment of hypertensionParallel reporter assaysRenin inhibitor aliskirenNeural crest-derived cellsRenin-producing cellsSystems biology approachRNA-seq analysisCell-specific disruptionCrest-derived cellsSmooth muscle cellsMuscle cell proteinsSystemic hypertensionBlood pressureWT miceAntihypertensive drugsBiology approachSuper enhancersFine mappingWT littermatesThird intronMultiple GWASCollagen depositionMouse aortaReporter assaysFate mapping
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