Mark Perazella, MD
Professor Emeritus of MedicineCards
About
Titles
Professor Emeritus of Medicine
Director, Acute Dialysis Unit; Medical Director, Yale Physician Associate Program; Medical Director, Yale PA Online Program
Appointments
Nephrology
EmeritusPrimary
Other Departments & Organizations
Education & Training
- MD
- New York Medical College (1988)
- Resident
- St. Mary's Hospital
- Fellow
- Yale University School of Medicine
Research
Overview
Medical Research Interests
Dialysis; Drug-Related Side Effects and Adverse Reactions; Hemodialysis Units, Hospital; HIV; Hypotension; Kidney Diseases; Kidney Failure, Chronic; Nephrogenic Fibrosing Dermopathy; Nephrology
Publications
2025
Is Intravenous Contrast-Associated Acute Kidney Injury a Significant Problem and Are Risk Scores Useful?
Perazella M. Is Intravenous Contrast-Associated Acute Kidney Injury a Significant Problem and Are Risk Scores Useful? Kidney360 2025, 6: 9-11. PMID: 40146910, PMCID: PMC11793183, DOI: 10.34067/kid.0000000636.Peer-Reviewed Original Research
2024
Drug-Related Glomerular Phenotypes: A Global Pharmacovigilance Perspective
Baptista A, Macedo A, Marreiros A, Coelho A, Perazella M. Drug-Related Glomerular Phenotypes: A Global Pharmacovigilance Perspective. Journal Of Clinical Medicine 2024, 13: 4869. PMID: 39201010, PMCID: PMC11355908, DOI: 10.3390/jcm13164869.Peer-Reviewed Original ResearchGlomerular disordersAdverse drug reactionsPotential nephrotoxinsNephrotoxic potentialDrug reactionsDisproportion indexNotifications of adverse drug reactionsAssociated with medicationsAssociated with drug useNephrotoxic drugsOver-the-counter drugsNon-nephrotoxicMethods:</b>Physiopathological mechanismsOver-the-counterNephrotoxic rolePrescribed medicationsSpontaneous notificationsVigiBaseDrug useEvaluate medicationsMedicationMedication useNephrotoxinsDrugProton Pump Inhibitors and Kidney Disease: What Gives?
Perazella M. Proton Pump Inhibitors and Kidney Disease: What Gives? Kidney360 2024, 5: 1374-1376. PMID: 39325592, PMCID: PMC11441802, DOI: 10.34067/kid.0000000000000521.Peer-Reviewed Original ResearchRemembering Fred S. Wright, M.D. (1937–2023)
Aronson P, Ellison D, Okusa M, Perazella M. Remembering Fred S. Wright, M.D. (1937–2023). Kidney360 2024, 5: 768-770. PMCID: PMC11146636, DOI: 10.34067/kid.0000000000000438.Peer-Reviewed Original ResearchIdentification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis
Moledina D, Obeid W, Smith R, Rosales I, Sise M, Moeckel G, Kashgarian M, Kuperman M, Campbell K, Lefferts S, Meliambro K, Bitzer M, Perazella M, Luciano R, Pober J, Cantley L, Colvin R, Wilson F, Parikh C. Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis. Journal Of Clinical Investigation 2024, 134: e180583. PMID: 38488004, PMCID: PMC10940080, DOI: 10.1172/jci180583.Peer-Reviewed Original ResearchToxic Nephropathies of the Tubulointerstitium: Core Curriculum 2024
Krishnan N, Moledina D, Perazella M. Toxic Nephropathies of the Tubulointerstitium: Core Curriculum 2024. American Journal Of Kidney Diseases 2024, 83: 659-676. PMID: 38243994, DOI: 10.1053/j.ajkd.2023.09.017.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsRenal injurySeverity of renal injuryToxic nephropathyTubulointerstitial renal injuryIrreversible renal injuryToxin-induced renal injuryImmune response genesNephrotoxic riskClinical presentationTubulointerstitial injuryRenal functionClinical manifestationsPatient characteristicsTubular secretionGlomerular filtrationComorbid conditionsMetabolic handlingDrug metabolismExcretory pathwayInjuryTransport defectAdverse effectsTubulointerstitiumNephropathyExogenous toxins
2023
Hiding in Plain Sight: Catastrophic Diethylene Glycol Poisoning in Children
Perazella M. Hiding in Plain Sight: Catastrophic Diethylene Glycol Poisoning in Children. Kidney360 2023, 4: 1534-1535. PMID: 37831818, PMCID: PMC10695641, DOI: 10.34067/kid.0000000000000269.Peer-Reviewed Original ResearchA Patient with an Unusual Cause of AKI and Scrotal Swelling
Gomez D, Perazella M. A Patient with an Unusual Cause of AKI and Scrotal Swelling. Kidney360 2023, 4: 1188-1189. PMID: 37651667, PMCID: PMC10484347, DOI: 10.34067/kid.0000000000000125.Peer-Reviewed Original ResearchIdentification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis
Moledina D, Obeid W, Smith R, Rosales I, Sise M, Moeckel G, Kashgarian M, Kuperman M, Campbell K, Lefferts S, Meliambro K, Bitzer M, Perazella M, Luciano R, Pober J, Cantley L, Colvin R, Wilson F, Parikh C. Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis. Journal Of Clinical Investigation 2023, 133: e168950. PMID: 37395276, PMCID: PMC10313360, DOI: 10.1172/jci168950.Peer-Reviewed Original ResearchConceptsUrinary CXCL9External validation cohortValidation cohortControl groupAIN diagnosisDiscovery cohortKidney tissueDiagnostic biomarkersAcute interstitial nephritisCXCL9 mRNA expressionAcute kidney injuryBiopsy-confirmed diagnosisAvailable clinical testsNational InstituteKidney injuryTubulointerstitial nephritisInterstitial nephritisKidney biopsyHistological confirmationHistological diagnosisTreatment optionsLymphocyte chemotaxisCXCL9MRNA expression differencesPatientsContrast-Induced Acute Kidney Injury and Cardiovascular Imaging: Danger or Distraction?
Davenport M, Perazella M, Nallamothu B. Contrast-Induced Acute Kidney Injury and Cardiovascular Imaging: Danger or Distraction? Circulation 2023, 147: 847-849. PMID: 36913495, DOI: 10.1161/circulationaha.122.062783.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
News
News
- December 01, 2023
Dr. Mark Perazella, Internationally Renowned Nephrologist, Retires at Year End
- October 24, 2023
Yale Contributions Shape ASN Kidney Week 2023
- May 25, 2023
YSM PA Online Graduates Celebrated for "Fierce Advocacy"
- May 11, 2023
Discoveries & Impact (May 2023)
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