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Association Between Hospital Safety-Net Status and Delivery of Rehabilitation to Older Adults With Acute Respiratory Failure
Jimenez J, Zhang L, Lin Z, Ferrante L, Falvey J, Walkey A, Krumholz H, Jain S. Association Between Hospital Safety-Net Status and Delivery of Rehabilitation to Older Adults With Acute Respiratory Failure. Chest 2025, 169: 94-105. PMID: 40818773, PMCID: PMC12895337, DOI: 10.1016/j.chest.2025.07.4079.Peer-Reviewed Original ResearchSafety-net hospitalMedian odds ratioSafety-net hospital statusDelivery of rehabilitationOlder adultsRehabilitation deliveryNon-SNHsIntensive care unitSocioeconomic disadvantageRetrospective cohort studyCohort study of older adultsHospital safety-net statusDisproportionate share hospital indexRetrospective cohort study of older adultsHierarchical multivariable logistic regression modelsStudy of older adultsSafety-net statusMedicare Provider AnalysisMultivariate logistic regression modelCritical illnessLogistic regression modelsRehabilitation servicesSocioeconomic disparitiesHospital characteristicsUS hospitalsElectric impedance tomography-guided PEEP titration reduces mechanical power in ARDS: a randomized crossover pilot trial
Jimenez J, Munroe E, Weirauch A, Fiorino K, Culter C, Nelson K, Labaki W, Choi P, Co I, Standiford T, Prescott H, Hyzy R. Electric impedance tomography-guided PEEP titration reduces mechanical power in ARDS: a randomized crossover pilot trial. Critical Care 2023, 27: 21. PMID: 36650593, PMCID: PMC9843117, DOI: 10.1186/s13054-023-04315-x.Peer-Reviewed Original ResearchConceptsPositive end-expiratory pressureAcute respiratory distress syndromeRespiratory distress syndromeDistress syndromeRandomized crossover pilot trialCrossover pilot trialModerate-severe acute respiratory distress syndromePEEP titrationStatic respiratory system complianceMethodsA single-centerPositive end-expiratory pressure titrationRespiratory system compliancePilot trialPositive end-expiratory pressure selectionEnd-expiratory pressureConclusionsIn patientsEIT-guided PEEP titrationPaO2/FiO2 ratioBackgroundIn patientsSingle-centerMechanical ventilationStatistically significant changesPrimary outcomeSecondary outcomesDriving pressureLowering PCO2 With Noninvasive Ventilation Is Associated With Improved Survival in Chronic Hypercapnic Respiratory Failure
Jimenez J, Ackrivo J, Hsu J, Wilson M, Labaki W, Hansen-Flaschen J, Hyzy R, Choi P. Lowering PCO2 With Noninvasive Ventilation Is Associated With Improved Survival in Chronic Hypercapnic Respiratory Failure. Respiratory Care 2023, 68: 1613-1622. PMID: 37137711, PMCID: PMC10676248, DOI: 10.4187/respcare.10813.Peer-Reviewed Original ResearchConceptsChronic hypercapnic respiratory failureHypercapnic respiratory failureRespiratory failureAssociated with improved survivalAssociated with high mortalityNon-invasive ventilationNoninvasive ventilationImproved survivalChronic hypercapniaHigher mortalityNon-invasiveMortalityVentilationLowering pCO2
2026
Impact of Right Heart Failure in Patients with Cardiogenic Shock
Arroyo R, Khosla P, Caraballo C, Jimenez J, Schwann A, Gage A, Brusca S, Barnett C, Jacobs M, Ali T, Miller P. Impact of Right Heart Failure in Patients with Cardiogenic Shock. European Heart Journal Acute Cardiovascular Care 2026, zuag041. PMID: 41863824, DOI: 10.1093/ehjacc/zuag041.Peer-Reviewed Original ResearchConcomitant cardiogenic shockRight heart failurePrimary admission diagnosisInverse probability of treatment weightingSCAI shock stageIn-Hospital MortalityAcute myocardial infarctionAdmission diagnosisOut-of-hospital cardiac arrestHeart failureInverse probabilityPatients admitted with CSMarkers of acuityCardiogenic shockDiagnosis of right heart failureClinical data basePresence of right heart failureProbability of treatment weightingSociety of Cardiovascular AngiographyDiagnosis of CSAbsolute mortalityCardiac arrestCardiovascular AngiographyHospital mortalityTreatment weightingLung and Venous Excess Ultrasound Correlation With Intracardiac Pressures Before and After Decongestion in Critically Ill Patients With Acute Decompensated Heart Failure
Jimenez J, Narula S, Callegari S, Argaiz E, Chen E, Arroyo R, Miao J, Feldman Z, Ali T, Donroe J, Miller P. Lung and Venous Excess Ultrasound Correlation With Intracardiac Pressures Before and After Decongestion in Critically Ill Patients With Acute Decompensated Heart Failure. Critical Care Explorations 2026, 8: e1385. PMID: 41805782, PMCID: PMC12978832, DOI: 10.1097/cce.0000000000001385.Peer-Reviewed Original ResearchConceptsPulmonary artery occlusion pressureAcute decompensated heart failureDecompensated heart failureRight atrial pressureCritically ill patientsRenal venous stasis indexHeart failurePulsatility fractionIll patientsIntracardiac pressuresLung ultrasoundHemodynamic monitoringPulmonary artery catheter placementIntracardiac filling pressuresCardiac filling pressuresLung ultrasound scoreMultiple organ dysfunctionArtery catheter placementPilot study of adultsArtery occlusion pressureCardiac intensive carePaired measurementsUltrasound correlationStudy of adultsCatheter placement
2025
Home Mechanical Ventilators Indications for Use in Chronic Respiratory Failure
Jimenez J, Choi P. Home Mechanical Ventilators Indications for Use in Chronic Respiratory Failure. Sleep Medicine Clinics 2025, 20: 519-525. PMID: 41136083, DOI: 10.1016/j.jsmc.2025.07.004.Peer-Reviewed Original ResearchIdentifying Daytime Hypercapnia Using Transcutaneous Carbon Dioxide Monitoring in Patients With Amyotrophic Lateral Sclerosis
Morrison A, Jimenez J, Hsu J, Elman L, Choi P, Ackrivo J. Identifying Daytime Hypercapnia Using Transcutaneous Carbon Dioxide Monitoring in Patients With Amyotrophic Lateral Sclerosis. Muscle & Nerve 2025, 71: 611-619. PMID: 39936179, PMCID: PMC11887530, DOI: 10.1002/mus.28366.Peer-Reviewed Original ResearchConceptsPulmonary function testsMaximum inspiratory pressureForced Vital CapacityDaytime hypercapniaAmyotrophic lateral sclerosisClinical significanceValues of maximum inspiratory pressurePrevalence of hypercapniaTranscutaneous carbon dioxide monitoringTranscutaneous carbon dioxideRate of deathRespiratory failureCause of deathLateral sclerosisRetrospective studyProspective studyAmyotrophic lateral sclerosis clinicInspiratory pressurePatient's symptomsFunction testsClinical rolePatientsVital capacityHypercapniaCarbon dioxide monitoringEarly sedation with dexmedetomidine in patients with acute myocardial infarction requiring mechanical ventilation
Banna S, Schenck C, Singh A, Safiriyu I, Jimenez J, Franko A, Thomas A, Heck C, Ludmir J, Gage A, Ali T, Katz J, Dudzinski D, Ross J, Miller P. Early sedation with dexmedetomidine in patients with acute myocardial infarction requiring mechanical ventilation. European Heart Journal Acute Cardiovascular Care 2025, 14: 270-278. PMID: 39919040, DOI: 10.1093/ehjacc/zuaf022.Peer-Reviewed Original ResearchInverse probability of treatment weightingAcute myocardial infarctionPrimary diagnosis of acute myocardial infarctionCompared to usual careInvasive mechanical ventilationUsual care groupEstimate adjusted risk differencesAdjusted risk differencesAssociated with lower mortalityDiagnosis of acute myocardial infarctionVentilator-free daysRandomized Controlled TrialsUsual careCare groupClinical data baseMyocardial infarctionProbability of treatment weightingIn-Hospital MortalityIll populationRisk differenceMechanical ventilationDays of invasive mechanical ventilationAnalgesic usePrimary diagnosisEarly sedationIsolated subsegmental pulmonary embolism identification based on international classification of diseases (ICD)-10 codes and imaging reports
Rashedi S, Bejjani A, Hunsaker A, Aghayev A, Khairani C, McGonagle B, Lo Y, Mahajan S, Caraballo C, Jimenez J, Krishnathasan D, Zarghami M, Monreal M, Barco S, Secemsky E, Klok F, Muriel A, Hussain M, Appah-Sampong A, Rahaghi F, Sadeghipour P, Lin Z, Mojibian H, Aneja S, Konstantinides S, Goldhaber S, Wang L, Zhou L, Jimenez D, Krumholz H, Piazza G, Bikdeli B, Investigators T. Isolated subsegmental pulmonary embolism identification based on international classification of diseases (ICD)-10 codes and imaging reports. Thrombosis Research 2025, 247: 109271. PMID: 39862754, DOI: 10.1016/j.thromres.2025.109271.Peer-Reviewed Original ResearchInternational Classification of Diseases (ICD)-10 codesICD-10International ClassificationPositive predictive valueDischarge diagnosisAccuracy of ICD-10Radiology reportsPrincipal discharge diagnosisSecondary discharge diagnosisIsolated subsegmental pulmonary embolismMedical records of adult patientsHealth systemRecords of adult patientsPredictive valueBlinded re-evaluationExpert radiologistsSubsegmental pulmonary embolismQuality improvementMedical recordsChart reviewPresence of PEProximal PEPulmonary embolismAdult patientsImaging Reporting
2024
Validating International Classification of Diseases Code 10th Revision algorithms for accurate identification of pulmonary embolism
Bikdeli B, Khairani C, Bejjani A, Lo Y, Mahajan S, Caraballo C, Jimenez J, Krishnathasan D, Zarghami M, Rashedi S, Jimenez D, Barco S, Secemsky E, Klok F, Hunsaker A, Aghayev A, Muriel A, Hussain M, Appah-Sampong A, Lu Y, Lin Z, Mojibian H, Aneja S, Khera R, Konstantinides S, Goldhaber S, Wang L, Zhou L, Monreal M, Piazza G, Krumholz H, Investigators P. Validating International Classification of Diseases Code 10th Revision algorithms for accurate identification of pulmonary embolism. Journal Of Thrombosis And Haemostasis 2024, 23: 556-564. PMID: 39505153, PMCID: PMC12945443, DOI: 10.1016/j.jtha.2024.10.013.Peer-Reviewed Original ResearchDischarge codesInternational ClassificationICD-10Yale New Haven Health SystemPositive predictive valueMass General Brigham hospitalsAccuracy of ICD-10ICD-10 codesPulmonary embolismHealth systemImage codingElectronic databasesF1 scorePre-specified protocolExcellent positive predictive valueIndependent physiciansHighest F1 scoreIdentification of pulmonary embolismAcute pulmonary embolismSecondary codePE codesScoresIdentified PERevised algorithm
Academic Achievements & Community Involvement
News
News
- June 11, 2025
Yale Internal Medicine Faculty and Trainees Receive Outstanding Teaching Awards
- July 10, 2024
Yale Internal Medicine Traditional Residency Honors Faculty and Trainees for Outstanding Teaching
- April 01, 2024
Yale Faculty Present Groundbreaking Clinical Research at the 2024 American College of Cardiology Scientific Sessions