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INFORMATION FOR

    Jiyeon Kim, PhD

    Assistant Professor of Urology and Cellular & Molecular Physiology
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    Contact Info

    jiyeon.kim1@yale.edu

    Yale School of Medicine

    310 Cedar St., BML

    New Haven, Connecticut 06519

    United States

    About

    Titles

    Assistant Professor of Urology and Cellular & Molecular Physiology

    Biography

    Dr. Kim is a basic research scientist in the Department of Urology with a joint appointment in the Department of Cellular and Molecular Physiology. She received her PhD from the Department of Molecular Cancer Biology at Duke University under the supervision of Dr. Sally Kornbluth, and her postdoctoral training from Dr. Ralph DeBerardinis at UT-Southwestern Medical Center. Before coming to Yale, she was The Kim lab is focused on understanding how metabolic alterations elicit dependencies and liabilities in certain signaling pathways and how we can target the pathway as cancer’s Achilles' heel. 

    The lab has been actively applying metabolic flux analysis to panels of cancer cell lines with various mutations to understand the full breadth of metabolic diversity in cancer. These studies are complemented by in vivo analyses of cancer metabolism in mice, and by translational efforts designed to understand and exploit the metabolic idiosyncrasies of tumor cells.


    Appointments

    Other Departments & Organizations

    Education & Training

    Postdoctoral fellow
    UT-Southwestern Medical Center (2018)
    PhD
    Duke University, Molecular Cancer Biology (2012)

    Research

    Research at a Glance

    Publications Timeline

    A big-picture view of Jiyeon Kim's research output by year.
    10Publications

    Publications

    2022

    2020

    • The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer.
      Kim J, Lee HM, Cai F, Ko B, Yang C, Lieu EL, Muhammad N, Rhyne S, Li K, Haloul M, Gu W, Faubert B, Kaushik AK, Cai L, Kasiri S, Marriam U, Nham K, Girard L, Wang H, Sun X, Kim J, Minna JD, Unsal-Kacmaz K, DeBerardinis RJ. The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer. Nat Metab 2020, 2: 1401-1412. PMID: 33257855, DOI: 10.1038/s42255-020-00316-0.
      Peer-Reviewed Original Research
    • Amino acids in cancer.
      Lieu EL, Nguyen T, Rhyne S, Kim J. Amino acids in cancer. Exp Mol Med 2020, 52: 15-30. PMID: 31980738, DOI: 10.1038/s12276-020-0375-3.
      Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements

    2019

    2017

    • CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells.
      Kim J, Hu Z, Cai L, Li K, Choi E, Faubert B, Bezwada D, Rodriguez-Canales J, Villalobos P, Lin YF, Ni M, Huffman KE, Girard L, Byers LA, Unsal-Kacmaz K, Peña CG, Heymach JV, Wauters E, Vansteenkiste J, Castrillon DH, Chen BPC, Wistuba I, Lambrechts D, Xu J, Minna JD, DeBerardinis RJ. CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells. Nature 2017, 546: 168-172. PMID: 28538732, DOI: 10.1038/nature22359.
      Peer-Reviewed Original Research

    2016

    2013

    2012

    2009

    Academic Achievements & Community Involvement

    • honor

      Innovation Award

      National AwardAmerican Lung Association
    • honor

      Research Scholar Grant

      National AwardAmerican Cancer Society
    • honor

      V Scholar Award

      National AwardV Foundation
    • honor

      K22 Transition Career Development Award

      National AwardNational Cancer Institute
    • honor

      Cancer Discovery Award

      National AwardAmerican Lung Association

    Get In Touch

    Contacts

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    Mailing Address

    Yale School of Medicine

    310 Cedar St., BML

    New Haven, Connecticut 06519

    United States

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