Israel Safiriyu, MBChB
Clinical FellowAbout
Research
Publications
2025
Outcomes of transcatheter aortic valve implantation in Africa: A systematic review and meta-analysis
Ahmed A, Safiriyu I, Kaddoura R, Mohyeldin M, Nwokeocha N, Sandeep N, Khalil H, Alhusain R, Zarich S. Outcomes of transcatheter aortic valve implantation in Africa: A systematic review and meta-analysis. International Journal Of Cardiology 2025, 429: 133139. PMID: 40074042, DOI: 10.1016/j.ijcard.2025.133139.Peer-Reviewed Original ResearchTranscatheter aortic valve implantationOutcomes of transcatheter aortic valve implantationAll-Cause MortalityAortic valve implantationAdverse eventsValve implantationIn-hospital all-cause mortalitySevere aortic stenosisMeta-analysisProcedural success rateTranscatheter aortic valve implantation outcomesStandard of careSurgical riskAortic stenosisPooled proportionProcedural successFollow-upObservational studyInterquartile rangeNational registryMortality rateGrey literatureHealthcare systemSuccess rateConfidence intervalsEarly sedation with dexmedetomidine in patients with acute myocardial infarction requiring mechanical ventilation
Banna S, Schenck C, Singh A, Safiriyu I, Jimenez J, Franko A, Thomas A, Heck C, Ludmir J, Gage A, Ali T, Katz J, Dudzinski D, Ross J, Miller P. Early sedation with dexmedetomidine in patients with acute myocardial infarction requiring mechanical ventilation. European Heart Journal Acute Cardiovascular Care 2025, 14: 270-278. PMID: 39919040, DOI: 10.1093/ehjacc/zuaf022.Peer-Reviewed Original ResearchInverse probability of treatment weightingAcute myocardial infarctionPrimary diagnosis of acute myocardial infarctionCompared to usual careInvasive mechanical ventilationUsual care groupEstimate adjusted risk differencesAdjusted risk differencesAssociated with lower mortalityDiagnosis of acute myocardial infarctionVentilator-free daysRandomized Controlled TrialsUsual careCare groupClinical data baseMyocardial infarctionProbability of treatment weightingIn-Hospital MortalityIll populationRisk differenceMechanical ventilationDays of invasive mechanical ventilationAnalgesic usePrimary diagnosisEarly sedationLeft Ventricular Assist Device Therapy in Cold and Dry Patients
Varrias D, Balgobind A, Safiriyu I, Al Deen Alhuarrat M, Fang J, Patel S, Villela M. Left Ventricular Assist Device Therapy in Cold and Dry Patients. Circulation Heart Failure 2025, 18: e011224. PMID: 39772776, DOI: 10.1161/circheartfailure.123.011224.Peer-Reviewed Original ResearchConceptsPulmonary capillary wedge pressureCapillary wedge pressureDry patientsEnd-stage heart failureKansas City Cardiomyopathy QuestionnaireWedge pressureAdverse eventsHeart failureLow pulmonary capillary wedge pressureMean pulmonary capillary wedge pressureIncidence of adverse eventsQuality of lifeBaseline renal functionRight heart catheterizationMedian Follow-UpFunctional capacityLeft ventricular sizeScores 1 yearTest distanceBaseline functional capacityVentricular assist device therapyWalk test distanceStatistically significant differenceRates of hospitalizationHeart catheterization
2024
Prevalence, predictors, and in-hospital outcomes of ST-elevation myocardial infarction among young adults without traditional cardiovascular risk factors in the United States.
Shamaki GR, Safiriyu I, Antia A, Abd El-Radi WK, Tinago CB, Ilonze O. Prevalence, predictors, and in-hospital outcomes of ST-elevation myocardial infarction among young adults without traditional cardiovascular risk factors in the United States. Am Heart J Plus 2024, 43: 100408. PMID: 38882592, DOI: 10.1016/j.ahjo.2024.100408.Peer-Reviewed Original Research
2023
Incidence and Prognostic Implications of Cardiac-Implantable Device-Associated Tricuspid Regurgitation: A Meta-Analysis and Meta-Regression Analysis
Safiriyu I, Mehta A, Adefuye M, Nagraj S, Kharawala A, Hajra A, Shamaki G, Kokkinidis D, Bob-Manuel T. Incidence and Prognostic Implications of Cardiac-Implantable Device-Associated Tricuspid Regurgitation: A Meta-Analysis and Meta-Regression Analysis. The American Journal Of Cardiology 2023, 209: 203-211. PMID: 37863117, DOI: 10.1016/j.amjcard.2023.09.064.Peer-Reviewed Original ResearchConceptsCardiac implantable electronic devicesTricuspid regurgitationMeta-regression analysisHF hospitalizationCause mortalityPrognostic implicationsEligible studiesComposite of mortalityHeart failure hospitalizationVentricular ejection fractionElectronic databases MEDLINEMeta-Analyses (PRISMA) guidelinesPreferred Reporting ItemsRandom-effects modelFinal quantitative analysisWeb of ScienceCardiac implantable devicesImplantable electronic devicesFailure hospitalizationMean followEjection fractionDevice implantationTrue incidenceMean ageOdds ratioComparison of in-hospital outcomes and complications of left atrial appendage closure with the Watchman device between males and females.
Alhuarrat MAD, Pargaonkar S, Rahgozar K, Safiriyu I, Zhang X, Faillace RT, Di Biase L. Comparison of in-hospital outcomes and complications of left atrial appendage closure with the Watchman device between males and females. Europace 2023, 25 PMID: 37503957, DOI: 10.1093/europace/euad228.Peer-Reviewed Original ResearchRecent Advances and Future Prospects of Treatment of Pulmonary Hypertension.
Hajra A, Safiriyu I, Balasubramanian P, Gupta R, Chowdhury S, Prasad AJ, Kumar A, Kumar D, Khan B, Bilberry RSF, Sarkar A, Malik P, Aronow WS. Recent Advances and Future Prospects of Treatment of Pulmonary Hypertension. Curr Probl Cardiol 2023, 48: 101236. PMID: 35500734, DOI: 10.1016/j.cpcardiol.2022.101236.Peer-Reviewed Original ResearchThirty-Day Readmission Rate and Healthcare Economic Effects of Patients With Transcatheter Aortic Valve Replacement and Coexisting Chronic Congestive Heart Failure.
Fatuyi M, Udongwo N, Favour M, Alshami A, Sanyi A, Amah C, Safiriyu I, Al-Amoodi M, Sealove B, Shishehbor MH, Shemisa K. Thirty-Day Readmission Rate and Healthcare Economic Effects of Patients With Transcatheter Aortic Valve Replacement and Coexisting Chronic Congestive Heart Failure. Curr Probl Cardiol 2023, 48: 101695. PMID: 36921650, DOI: 10.1016/j.cpcardiol.2023.101695.Peer-Reviewed Original ResearchImpact of COVID-19 Infection on the Clinical Outcomes of Pulmonary Embolism Hospitalizations : A Nationwide Analysis.
Safiriyu I, Fatuyi M, Mehta A, Naser A, Alexander E, Vovan H, Shamaki GR, Bob-Manuel T. Impact of COVID-19 Infection on the Clinical Outcomes of Pulmonary Embolism Hospitalizations : A Nationwide Analysis. Curr Probl Cardiol 2023, 48: 101669. PMID: 36841316, DOI: 10.1016/j.cpcardiol.2023.101669.Peer-Reviewed Original ResearchTranscatheter edge-to-edge repair of the mitral valve in end stage renal disease patients: mortality fact check.
Safiriyu I, Nagraj S. Transcatheter edge-to-edge repair of the mitral valve in end stage renal disease patients: mortality fact check. Ann Transl Med 2023, 11: 305. PMID: 37404987, DOI: 10.21037/atm-23-1363.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
News
News
- November 18, 2025
Upcoming Conference: Obesity and Genetic Heart Disease in the Era of Preventive Cardiology
- March 05, 2025
Celebrating Clinical Educators: Residents and Fellows Receive Dr. Peggy Bia Teaching Awards
- July 11, 2023
Eleven future cardiologists join the Yale Cardiovascular Medicine Fellowship Program