Hung-Mo Lin
Professor of Anesthesiology and BiostatisticsCards
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Professor of Anesthesiology and Biostatistics
Biography
Meet Yale Center for Analytical Sciences' Hung-Mo Lin.
Last Updated on June 08, 2023.
Appointments
Anesthesiology
ProfessorPrimaryBiostatistics
ProfessorSecondary
Other Departments & Organizations
Education & Training
- ScD
- Harvard University School of Public Health, Biostatistics
- MS
- Harvard University School of Public Health, Biostatistics
Research
Publications
2025
Association of Prophylactic Antibiotic Guideline Non-Adherence with Surgical Site Infections in Patients Receiving Perioperative Vancomycin: Results from a Multi-Institutional Combined NSQIP and MPOG Registry.
Bardia A, Lin H, Michel G, Fisher C, Zhao X, Shuster K, Colquhoun D, Mathis M, Anders M, Kheterpal S, Schonberger R. Association of Prophylactic Antibiotic Guideline Non-Adherence with Surgical Site Infections in Patients Receiving Perioperative Vancomycin: Results from a Multi-Institutional Combined NSQIP and MPOG Registry. Annals Of Surgery 2025 PMID: 40833154, DOI: 10.1097/sla.0000000000006903.Peer-Reviewed Original ResearchAssociated with surgical site infectionNational Surgical Quality Improvement ProgramSurgical site infectionInfectious Diseases Society of AmericaSociety for Healthcare Epidemiology of AmericaSociety for Healthcare EpidemiologySurgical Infection SocietyAntibiotic choiceSite infectionMulticenter Perioperative Outcomes GroupNon-adherenceIncidence of surgical site infectionTiming of vancomycin administrationOdds of surgical site infectionSurgical Quality Improvement ProgramIntraoperative antibiotic prophylaxisDose of vancomycinHealthcare Epidemiology of AmericaMulticenter observational studyNon-cardiac proceduresGuideline non-adherenceYears of agePerioperative vancomycinVancomycin prophylaxisAntibiotic prophylaxisAge-dependent brain responses to mechanical stress determine resilience in a chronic lymphatic drainage impairment model
Gursky Z, Khan Z, Koundal S, Bhardwaj A, Melgarejo J, Xu K, Chen X, Lin H, Gu X, Lee H, Kipnis J, Dori Y, Tannenbaum A, Santambrogio L, Benveniste H. Age-dependent brain responses to mechanical stress determine resilience in a chronic lymphatic drainage impairment model. Journal Of Clinical Investigation 2025, 135: e182555. PMID: 40663395, PMCID: PMC12404751, DOI: 10.1172/jci182555.Peer-Reviewed Original ResearchConceptsDeep cervical lymph nodesLymph nodesContrast-enhanced magnetic resonance imagingDynamic contrast-enhanced magnetic resonance imagingCervical lymph nodesEvidence of hydrocephalusBlood-brain barrier leakageImpaired lymphatic drainageLow-grade inflammationLymphatic drainage pathwaysCerebral homeostasisMagnetic resonance imagingDCE-MRILymphatic drainageIntracranial pressureLymphatic vesselsMeningeal lymphatic vesselsLong-term mechanical stressResonance imagingBarrier leakageRatsSolute clearanceGlymphatic influxDrainage pathwaysAge groupsAnterior Quadratus Lumborum Block for Microvascular Free-Flap Breast Reconstruction: A Propensity-Score-Weighted Study
Pierson D, Kim L, Lin H, Long A, Zurich H, Evans B, Wu C, He Z, Dai F, Ayyala H, Golshan M, Li J. Anterior Quadratus Lumborum Block for Microvascular Free-Flap Breast Reconstruction: A Propensity-Score-Weighted Study. A&A Practice 2025, 19: e02017. PMID: 40698851, DOI: 10.1213/xaa.0000000000002017.Peer-Reviewed Original ResearchConceptsAnterior quadratus lumborum blockContinuous quality improvementDeep inferior epigastric artery perforatorFree flap breast reconstructionPostoperative opioid consumptionLength of stayMilligram morphine equivalentsOpioid consumptionQuadratus lumborum blockPost-anesthesia care unitDexamethasone sodium phosphateLiposomal bupivacainePain scoresMethylprednisolone acetateBreast reconstructionUltrasound-guided anterior quadratus lumborum blockMicrosurgical free flap breast reconstructionMicrovascular free flap breast reconstructionAverage daily opioid consumptionAverage daily pain scoreSecondary outcomesInferior epigastric artery perforatorDeep inferior epigastric artery perforator flap reconstructionDaily opioid consumptionDaily pain scoresUltrasound Gel versus Saline for Acoustic Coupling in Ultrasound-Guided Regional Anesthesia: A Randomized, Cross-Over, Simulation Study.
Burnett G, Bhavsar A, Hojsak S, Jeng C, Anderson M, Ouyang Y, Lin H, Park C. Ultrasound Gel versus Saline for Acoustic Coupling in Ultrasound-Guided Regional Anesthesia: A Randomized, Cross-Over, Simulation Study. Anesthesia & Analgesia 2025 PMID: 40408299, DOI: 10.1213/ane.0000000000007585.Peer-Reviewed Original ResearchComparison of Posterior Quadratus Lumborum Block vs Surgical Wound Infiltration in Patients Undergoing Bariatric Sleeve Gastrectomy Surgery
Shariat A, Kadakia R, Lin H, Egorova N, Jin S, Latmore M, Epstein J, Pai B.H P, Park K, Kini S, Bhatt H. Comparison of Posterior Quadratus Lumborum Block vs Surgical Wound Infiltration in Patients Undergoing Bariatric Sleeve Gastrectomy Surgery. Obesity Surgery 2025, 35: 2673-2679. PMID: 40404913, DOI: 10.1007/s11695-025-07934-1.Peer-Reviewed Original ResearchPosterior quadratus lumborum blockLaparoscopic sleeve gastrectomySurgical wound infiltrationPostoperative opioid consumptionVAS pain scoresPostoperative day 1Quadratus lumborum blockWound infiltrationPain scoresRandomized pilot studyOpioid consumptionLocal anestheticsDay 1Decreased postoperative opioid consumptionVisual analog pain scorePostoperative VAS pain scoresInfiltration of local anestheticWound infiltration groupAnalog pain scoresASA 3 patientsPostoperative analgesic medicationPostoperative day 2Incidence of nauseaSleeve gastrectomy surgeryMorphine equivalentsOpioid Dose Variation in Cardiac Surgery: A Multicenter Study of Practice
Fisher C, Janda A, Zhao X, Deng Y, Bardia A, Yanez N, Burns M, Aziz M, Treggiari M, Mathis M, Lin H, Schonberger R. Opioid Dose Variation in Cardiac Surgery: A Multicenter Study of Practice. Anesthesia & Analgesia 2025, 140: 1016-1027. PMID: 39167548, PMCID: PMC11842693, DOI: 10.1213/ane.0000000000007128.Peer-Reviewed Original ResearchCardiac surgeryOpioid doseDose variationIntraoperative opioid administrationIntraoperative opioid doseHigh-dose opioidsAdult cardiac surgerySurgical differencesOpioid-freeOpioid administrationOpioid useMultimodal analgesiaAnalgesic techniquesCardiopulmonary bypassMulticenter studyFentanyl equivalentsSufentanil infusionSurgical patientsOpioidSurgeryAnesthetic techniqueCardiac casesAttending anesthesiologistPatientsDosePreoperative submaximal cardiopulmonary exercise testing and its association with early postoperative complications
Carr Z, Charchaflieh J, Brenes-Bastos A, He H, Lin H, Jankelovits A, Gu E, Zafar J, Ghali F, Tan W, Heerdt P. Preoperative submaximal cardiopulmonary exercise testing and its association with early postoperative complications. BJA Open 2025, 14: 100407. PMID: 40421445, PMCID: PMC12105740, DOI: 10.1016/j.bjao.2025.100407.Peer-Reviewed Original ResearchLength of staySubmaximal cardiopulmonary exercise testingInstitutional review board approvalPostoperative complication riskReview board approvalDuke Activity Status IndexCardiopulmonary exercise testingIncreased length of stayAdjusted multivariable regression modelsPostoperative complications predictionPulmonary capacitanceOpen-labelPeak oxygen uptakePerioperative surveillancePrimary endpointNoncardiac surgeryPostoperative complicationsSecondary endpointsSingle-centreComplication riskMET assessmentPeak VOBoard approvalMultivariate regression modelMetabolic equivalentsPost-transfusion activation of coagulation pathways during severe COVID-19 correlates with COVID-19 convalescent plasma antibody profiles
Weiss S, Lin H, Acosta E, Komarova N, Chen P, Wodarz D, Baine I, Duerr R, Wajnberg A, Gervais A, Bastard P, Casanova J, Arinsburg S, Swartz T, Aberg J, Bouvier N, Liu S, Alvarez R, Chen B. Post-transfusion activation of coagulation pathways during severe COVID-19 correlates with COVID-19 convalescent plasma antibody profiles. Journal Of Clinical Investigation 2025, 135: e181136. PMID: 40091845, PMCID: PMC11910229, DOI: 10.1172/jci181136.Peer-Reviewed Original ResearchConceptsCOVID-19 convalescent plasmaCOVID-19 convalescent plasma unitsActivation of coagulation pathwaysSevere COVID-19Post-transfusionAntibody profilesEffectiveness of COVID-19 convalescent plasmaSevere SARS-CoV-2 infectionCoagulation pathwayD-dimer levelsHospitalized COVID-19 patientsHigher-riskCCP recipientsSARS-CoV-2 infectionTreat severe COVID-19SARS-CoV-2 spikeCOVID-19 patientsAntibody therapyD-dimerD-dimer trendsConvalescent plasmaSevere diseaseBetacoronavirus OC43Higher mortalityIn vitro assaysBrain Signatures of Very Early Cognitive Decline in Asymptomatic Middle‐Aged Offspring of People With Alzheimer's Disease
Ramsingh N, Lin H, Ouyang Y, Ravona‐Springer R, Livny A, Soleimani L, Bendlin B, Matatov A, Niv T, Shamir T, Ganmore I, Heymann A, Sano M, Azuri J, Beeri M. Brain Signatures of Very Early Cognitive Decline in Asymptomatic Middle‐Aged Offspring of People With Alzheimer's Disease. International Journal Of Geriatric Psychiatry 2025, 40: e70060. PMID: 40050014, DOI: 10.1002/gps.70060.Peer-Reviewed Original ResearchConceptsSuperior longitudinal fasciculusCortical volumeCortical brain volumesWhite matterAlzheimer's Prevention studyEarly cognitive declineBrain signaturesBrain regionsCognitive changesWM microstructureMiddle-aged adultsBrain volumeLongitudinal fasciculusCognitive declinePreclinical cognitive changesOffspring of peopleBrain tractsPatient's offspringTarget individualsEarly interventionCorpus callosumParental historyBrainAlzheimer's diseaseLinear regression modelsPostoperative acute kidney injury is associated with persistent renal dysfunction: a multicentre propensity-matched cohort study
Stannard B, Epstein R, Gabel E, Nadkarni G, Ouyang Y, Lin H, Salari V, Hofer I. Postoperative acute kidney injury is associated with persistent renal dysfunction: a multicentre propensity-matched cohort study. BJA Open 2025, 14: 100384. PMID: 40129614, PMCID: PMC11930183, DOI: 10.1016/j.bjao.2025.100384.Peer-Reviewed Original ResearchPostoperative acute kidney injuryGlomerular filtration rateAcute kidney injuryRenal functionKidney injuryRates of postoperative acute kidney injuryOccurrence of postoperative acute kidney injuryAcute Kidney Injury Network classificationLong-term renal functionRetrospective propensity-matched studyCox modelPropensity-matched cohort studyPersistent renal dysfunctionIncreased hazardKaplan-Meier analysisFollow-up outpatient visitsFollow-up glomerular filtration ratePropensity-Matched StudyTertiary care hospitalHaemodialysis requirementRenal dysfunctionAdult patientsFiltration rateCohort studyHazard ratio
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