Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsGregor Gryglewski, MD, PhD
Assistant Professor Adjunct in the Child Study CenterAbout
Research
Publications
2026
Acute effects of selective serotonin reuptake inhibitors on cerebral glucose metabolism and blood flow
Silberbauer L, Reed M, Gryglewski G, Murgaš M, Nics L, Godbersen G, Stimpfl T, Hahn A, Hacker M, Lanzenberger R. Acute effects of selective serotonin reuptake inhibitors on cerebral glucose metabolism and blood flow. Translational Psychiatry 2026, 16: 54. PMID: 41633980, PMCID: PMC12873367, DOI: 10.1038/s41398-026-03849-2.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsSerotonin reuptake inhibitorsReuptake inhibitorsSerotonin transporterPseudo-continuous arterial spin labelingAcute pharmacological effectsDorsal raphe nucleusAcute effectsBOLD signal changesBOLD fMRI studiesCerebral glucose metabolismFunctional positron emission tomographyFMRI studyPsychopharmacological researchRaphe nucleusSerotonergic projectionsNeuropsychiatric disordersBrain activityOccipital cortexNeuroimaging protocolsPositron emission tomographyDouble-blind study designNeuronal activityPlacebo-ControlledBrain energy demand
2025
Oral ketamine for the treatment of major depressive and bipolar disorder, a randomized controlled trial and meta-analysis
Silberbauer L, Eggerstorfer B, Michenthaler P, Reichel S, Stimpfl T, Vanicek T, Naderi-Heiden A, Kasper S, Lanzenberger R, Gryglewski G. Oral ketamine for the treatment of major depressive and bipolar disorder, a randomized controlled trial and meta-analysis. Journal Of Affective Disorders 2025, 394: 120466. PMID: 41101490, DOI: 10.1016/j.jad.2025.120466.Peer-Reviewed Original ResearchConceptsKetamine treatmentPrimary endpointRandomized Controlled TrialsSevere depressive episodeSpecialized centersExposure to ketamineMeta-analysis of randomized controlled trialsAntidepressant efficacyAntidepressant treatmentAntidepressant therapyDepressive episodeDouble-blind trialOutcomes of patientsBipolar disorderForty-five patientsMeta-analysisEvidence up-to-dateOral ketamineWell-toleratedScore reductionAdverse eventsKetamineActive comparatorMidazolam solutionOral applicationPhenotyping extracellular vesicles and their serotonin transporter cargo in major depressive disorder
Zadka Ł, Eggerstorfer B, Buzalewicz I, Vraka C, Rusak A, Godbersen G, Opalińska A, Unterholzner J, Ulatowska-Jarża A, Philippe C, Haczkiewicz-Leśniak K, Silberbauer L, Murgaš M, Nics L, Hahn A, Hacker M, Gomułkiewicz A, Rujescu D, Podhorska-Okołów M, Lanzenberger R, Gryglewski G. Phenotyping extracellular vesicles and their serotonin transporter cargo in major depressive disorder. Journal Of Affective Disorders 2025, 389: 119740. PMID: 40550277, DOI: 10.1016/j.jad.2025.119740.Peer-Reviewed Original ResearchSerotonin transporterDepressive disorderPresence of serotonin transporterAntidepressant treatment responseSerotonin transporter levelsMDD patientsNanoparticle tracking analysisMood disordersPsychiatric disordersMDDBinding potentialExtracellular vesiclesTreatment response predictionPositron emission tomographyTreatment responseDisordersHealthy controlsExosome markers CD63Blood-brain barrierEmission tomographyStudy intercellular communicationPrognostic valueConcentration of extracellular vesiclesPatient stratificationExosomal markersA large-scale multimodal investigation of the interplay between the serotonergic system and emotion processing
Klöbl M, Murgaš M, Reed M, Silberbauer L, Hartmann A, Godbersen G, Gryglewski G, Nics L, Hahn A, Rujescu D, Hacker M, Lanzenberger R. A large-scale multimodal investigation of the interplay between the serotonergic system and emotion processing. Translational Psychiatry 2025, 15: 196. PMID: 40500269, PMCID: PMC12159172, DOI: 10.1038/s41398-025-03407-2.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortex activationAnterior cingulate cortexMajor depressive disorderFunctional magnetic resonance imagingSerotonin transporter availabilitySerotonin transporterEmotional processingSerotonergic systemDiagnosis of major depressive disorderAnxiolytic effect of citalopramFacial emotion processing taskMonths of antidepressant treatmentViewing fearful facesAcute anxiolytic effectsEmotion processing taskEffect of citalopramReduced fMRI activationSuperior frontal sulcusSERT availabilityFearful facesHappy facesAntidepressant treatmentFear processingNeutral facesDepressive disorderConnecting the dots: approaching a standardized nomenclature for molecular connectivity in positron emission tomography
Reed M, Cocchi L, Sander C, Chen J, Matheson G, Fisher P, Volpi T, Khattar N, DeLorenzo C, Gryglewski G, Silberbauer L, Murgaš M, Godbersen G, Nics L, Walter M, Hacker M, Bertoldo A, Lubberink M, Silfstein M, Ogden R, Mann J, Suhara T, Varrone A, Boellaard R, Gunn R, Hammers A, Biswal B, Rosen B, Knudsen G, Carson R, Price J, Lanzenberger R, Hahn A. Connecting the dots: approaching a standardized nomenclature for molecular connectivity in positron emission tomography. European Journal Of Nuclear Medicine And Molecular Imaging 2025, 53: 48-58. PMID: 40455254, PMCID: PMC12660352, DOI: 10.1007/s00259-025-07357-1.Peer-Reviewed Original ResearchFunctional connectivityFMRI resting-state functional connectivityResting-state functional connectivityNeurobiological underpinningsMeasured PET signalBrain regionsConnectivity analysisPositron emission tomographyConnectivity metricsConnectivity studiesBetween-subjectsPET signalEmission tomographyBrainImaging modalitiesDiverse methodologiesMolecular connectivityMolecular covariatesFMRIPositronSimplified methods for SERT occupancy estimation measured with [11C]DASB PET bolus plus infusion
Ponce de León M, Murgaš M, Silberbauer L, Hacker M, Gryglewski G, Hahn A, Lanzenberger R. Simplified methods for SERT occupancy estimation measured with [11C]DASB PET bolus plus infusion. NeuroImage 2025, 311: 121208. PMID: 40221064, DOI: 10.1016/j.neuroimage.2025.121208.Peer-Reviewed Original ResearchSerotonin transporterBolus plus constant infusionSerotonin transporter occupancyDepressive disorderBinding potentialBolus plus infusionReference regionCitalopramHealthy controlsArterial blood samplesPET/MRI scansPET scansOccupational valuesIntravenous applicationConstant infusionBlood samplesIn vivoAntidepressantsInfusionSaline solutionSerotoninHighest agreementDisordersRadioligandPlaceboTHE ANTERIOR CINGULATE CORTEX LINKS SEROTONIN TRANSPORTER GENETICS AND EMOTION PROCESSING
Kloebl *, Murgaš M, Reed M, Silberbauer L, Hartmann A, Godbersen G, Hahn A, Gryglewski G, Rujescu D, Lanzenberger R. THE ANTERIOR CINGULATE CORTEX LINKS SEROTONIN TRANSPORTER GENETICS AND EMOTION PROCESSING. The International Journal Of Neuropsychopharmacology 2025, 28: i18-i19. PMCID: PMC11814669, DOI: 10.1093/ijnp/pyae059.032.Peer-Reviewed Original ResearchAnterior cingulate cortex activationAnterior cingulate cortexEmotional processingSerotonin reuptake inhibitorsSerotonin transporterSerotonin transporter expressionBrain functionHappy facesNeutral facesCingulate cortexReuptake inhibitorsBrain activitySerotonin transporter binding potentialMeasures of emotional processingSingle nucleotide polymorphism rs25531Anterior cingulate cortex connectivityImpact of 5-HTTLPRAssess attributional styleSituational Attributions QuestionnaireAcute tryptophan depletionFacial emotion processingIncreased amygdala activationSerotonin transporter bindingSerotonin transporter polymorphismEffect of citalopramEXTRACELLULAR VESICLES IN MAJOR DEPRESSIVE DISORDER AND THEIR RELATIONSHIP TO TREATMENT OUTCOME
Eggerstorfer *, Zadka Ł, Rusak A, Godbersen G, Opalińska A, Unterholzner J, Haczkiewicz-Leśniak K, Silberbauer L, Hahn A, Murgaš M, Gomułkiewicz A, Rujescu D, Podhorska-Okołów M, Lanzenberger R, Gryglewski G. EXTRACELLULAR VESICLES IN MAJOR DEPRESSIVE DISORDER AND THEIR RELATIONSHIP TO TREATMENT OUTCOME. The International Journal Of Neuropsychopharmacology 2025, 28: i32-i33. PMCID: PMC11815236, DOI: 10.1093/ijnp/pyae059.056.Peer-Reviewed Original ResearchMDD patientsPathophysiology of psychiatric disordersPlasma of MDD patientsOutcome of MDDAntidepressant treatment responseSerotonin transporter occupancyDepression Rating ScaleTreated with escitalopramHealthy controlsExpression of SLC6A4Expression of exosome markersAntidepressant treatmentDepressive disorderSerotonin transporterExosomal markersPsychiatric disordersTransporter occupancyNanoparticle tracking analysisMDDMental disordersMRNA expressionDiverse neurotransmittersRating ScaleCD9 expressionExtracellular vesicles
2024
Extracellular vesicles in major depression and their serotonin transporter cargo
Eggerstorfer B, Zadka Ł, Buzalewicz I, Vraka C, Rusak A, Godbersen G, Opalińska A, Unterholzner J, Ulatowska-Jarża A, Philippe C, Haczkiewicz-Leśniak K, Silberbauer L, Murgaš M, Nics L, Hahn A, Hacker M, Gomułkiewicz A, Rujescu D, Podhorska-Okołów M, Lanzenberger R, Gryglewski G. Extracellular vesicles in major depression and their serotonin transporter cargo. Neuroscience Applied 2024, 3: 104920. DOI: 10.1016/j.nsa.2024.104920.Peer-Reviewed Original ResearchSerotonin transporter connectivity mapping reveals distinct anterior cingulate cortex association profiles in healthy vs. depressed subjects under pharmacological challenge
Klug S, Silberbauer L, Murgaš M, Klöbl M, Nics L, Godbersen G, Gryglewski G, Hacker M, Lanzenberger R, Hahn A. Serotonin transporter connectivity mapping reveals distinct anterior cingulate cortex association profiles in healthy vs. depressed subjects under pharmacological challenge. Neuroscience Applied 2024, 3: 104945. DOI: 10.1016/j.nsa.2024.104945.Peer-Reviewed Original Research