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INFORMATION FOR

    I. George Miller Jr, MD

    John F. Enders Professor of Pediatrics (Infectious Disease) and Professor of Epidemiology (Microbial Diseases) and of Molecular Biophysics and Biochemistry
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    John F. Enders Professor of Pediatrics (Infectious Disease) and Professor of Epidemiology (Microbial Diseases) and of Molecular Biophysics and Biochemistry

    Biography

    Dr. Miller’s laboratory studies the mechanisms underlying the switch between latency and lytic replication of two oncogenic herpesviruses, Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus. Current experiments explore how viral and cellular transcription factors that selectively bind to methylated DNA control expression of viral and cellular genes, how cellular gene expression is selectively inhibited while viral gene expression is enhanced, and how viral DNA replication is regulated by cellular proteins. Recent studies focus on a new class of anti-viral agents that inhibit reactivation of Epstein-Barr virus from latency into lytic infection.

    Appointments

    Other Departments & Organizations

    Education & Training

    Research Fellow
    Children's Hospital, Boston (1969)
    Research Fellow
    Harvard Medical School (1969)
    Fellow
    CDC (1966)
    Intern & Assistant Resident
    University Hospital, Cleveland (1964)
    MD
    Harvard Medical School (1962)
    AB
    Harvard College (1958)

    Board Certifications

    • Internal Medicine

      Certification Organization
      AB of Internal Medicine
      Original Certification Date
      1972

    Research

    Overview

    We study two related human tumor viruses: Epstein-Barr virus (EBV), which is associated with lymphomas and carcinomas; and Kaposi’s sarcoma-associated herpesvirus (KSHV), which is associated with Kaposi’s sarcoma and lymphomas that occur in patients with AIDS. Both viruses establish “latent states” in host cells, during which only a limited number of viral genes are expressed. We have discovered multifunctional virally encoded transcription factors and replication proteins, ZEBRA and Rta in EBV and KSHV ORF50, which mediate a switch between latency and the lytic cycle. Our lab studies the control of ZEBRA, Rta and ORF50 expression and their mechanisms of action and interaction. We are interested in the basis of viral specificity of these activators. We also investigate how the immune system detects and regulates the latent and lytic cycle program of EBV in B cells.

    Medical Research Interests

    Biophysics; Epstein-Barr Virus Infections; Infectious Disease Medicine; Pediatrics; Sarcoma, Kaposi; Virology

    Research at a Glance

    Yale Co-Authors

    Frequent collaborators of I. George Miller's published research.

    Publications

    2019

    2008

    2001

    2000

    1999

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