Edward L. Snyder, MD, FACP
Professor of Laboratory MedicineCards
About
Research
Overview
We are conducting 2 Phase III RCTs for pathogen reduced RBCs. One involves patients undergoing complex cardiovascular surgery (ReCePI) and the other anemic oncology patients receiving simple transfusions (RedeS).
Medical Research Interests
Blood Banks; Blood Transfusion; Chemicals and Drugs; Medical Laboratory Science; Membranes; Metabolism; Organisms
Publications
2024
Addressing platelet insecurity – A national call to action
Gehrie E, Young P, Basavaraju S, Bracey A, P. A, Culler L, Dunbar N, Homer M, Isufi I, Macedo R, Petraszko T, Ramsey G, Tormey C, Kaufman R, Snyder E. Addressing platelet insecurity – A national call to action. Transfusion 2024, 64: 2001-2013. PMID: 39133194, PMCID: PMC11921857, DOI: 10.1111/trf.17987.Peer-Reviewed Original Research
2009
Analysis of transfusion reactions associated with prestorage‐pooled platelet components
Tormey CA, Sweeney JD, Champion MH, Pisciotto PT, Snyder EL, Wu Y. Analysis of transfusion reactions associated with prestorage‐pooled platelet components. Transfusion 2009, 49: 1242-1247. PMID: 19389029, DOI: 10.1111/j.1537-2995.2009.02128.x.Peer-Reviewed Original ResearchConceptsRandom donor plateletsSingle-donor plateletsTransfusion reactionsPlatelet infusionTransfusion-related acute lung injuryCommon adverse eventsPLT productsAcute lung injuryTertiary care hospitalCases of sepsisAllergic transfusion reactionsTransfusion reaction ratesSignificant differencesAdverse eventsLung injuryCare hospitalVolume overloadFebrile reactionsChi-square analysisTotal infusionPlatelet componentsInfusionStudy designP-valuePlateletsDevelopment of a Humanized Mouse Model to Study the Role of Macrophages in Allograft Injury
Kirkiles-Smith NC, Harding MJ, Shepherd BR, Fader SA, Yi T, Wang Y, McNiff JM, Snyder EL, Lorber MI, Tellides G, Pober JS. Development of a Humanized Mouse Model to Study the Role of Macrophages in Allograft Injury. Transplantation 2009, 87: 189-197. PMID: 19155972, PMCID: PMC2776641, DOI: 10.1097/tp.0b013e318192e05d.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAdult Stem CellsAnimalsAntigens, CDAntigens, CD34Antigens, Differentiation, MyelomonocyticArteriesDisease Models, AnimalGraft RejectionHematopoietic Stem Cell TransplantationHematopoietic Stem CellsHumansInterleukin Receptor Common gamma SubunitLipopolysaccharide ReceptorsMacrophagesMiceMice, Inbred NODMice, KnockoutMice, SCIDReceptors, Cell SurfaceSkinSkin TransplantationT-LymphocytesTransplantation, HomologousWhole-Body IrradiationConceptsT cellsImmunodeficient micePeripheral blood monuclear cellsHematopoietic stem cellsAllogeneic T cellsHuman cell engraftmentHumanized mouse modelHuman monocytes/macrophagesRole of macrophagesArterial interposition graftsMonocytes/macrophagesImmunodeficient mouse hostsStem cellsHuman skinAllograft injuryArtery graftAdoptive transferInterposition graftPeripheral bloodTransplant rejectionIntimal expansionHuman allograftsMouse modelCell engraftmentTissue graft
2008
Component therapy to cellular therapy and beyond— a Darwinian approach to transfusion medicine
Snyder EL. Component therapy to cellular therapy and beyond— a Darwinian approach to transfusion medicine. Transfusion 2008, 48: 2000-2007. PMID: 18694467, DOI: 10.1111/j.1537-2995.2008.01859.x.Peer-Reviewed Original ResearchMobilization, collection, and transplantation of peripheral blood hematopoietic progenitor cells in a patient with multiple myeloma and hemoglobin SC disease
Tormey CA, Snyder EL, Cooper DL. Mobilization, collection, and transplantation of peripheral blood hematopoietic progenitor cells in a patient with multiple myeloma and hemoglobin SC disease. Transfusion 2008, 48: 1930-1933. PMID: 18513256, DOI: 10.1111/j.1537-2995.2008.01777.x.Peer-Reviewed Original ResearchConceptsHigh-dose G-CSFHemoglobin SC diseaseHematopoietic progenitor cellsHPC mobilizationVasoocclusive crisisSC diseaseG-CSFVasoocclusive complicationsAutologous stem cell transplantationAutologous hematopoietic progenitor cellsPeripheral blood hematopoietic progenitor cellsBlood hematopoietic progenitor cellsProgenitor cellsStem cell transplantationG-CSF administrationG-CSF mobilizationPosttransplant periodMyeloablative chemotherapyCell transplantationMultiple myelomaErythrocytapheresisPatientsCell engraftmentComplicationsBlood harvesting
2007
Successful in vivo recovery and extended storage of additive solution (AS)‐5 red blood cells after deglycerolization and resuspension in AS‐3 for 15 days with an automated closed system
Bandarenko N, Cancelas J, Snyder EL, Hay SN, Rugg N, Corda T, Joines AD, Gormas JF, Pratt GP, Kowalsky R, Rose M, Rose L, Foley J, Popovsky MA. Successful in vivo recovery and extended storage of additive solution (AS)‐5 red blood cells after deglycerolization and resuspension in AS‐3 for 15 days with an automated closed system. Transfusion 2007, 47: 680-686. PMID: 17381627, DOI: 10.1111/j.1537-2995.2007.01171.x.Peer-Reviewed Original ResearchLogistics of Platelet Concentrates
Eisenbarth S, Champion M, Snyder EL. Logistics of Platelet Concentrates. Vox Sang. 2007:Peer-Reviewed Original Research
2005
Platelet dose consistency and its effect on the number of platelet transfusions for support of thrombocytopenia: an analysis of the SPRINT trial of platelets photochemically treated with amotosalen HCl and ultraviolet A light
Murphy S, Snyder E, Cable R, Slichter SJ, Strauss RG, McCullough J, Lin J, Corash L, Conlan MG, Group T. Platelet dose consistency and its effect on the number of platelet transfusions for support of thrombocytopenia: an analysis of the SPRINT trial of platelets photochemically treated with amotosalen HCl and ultraviolet A light. Transfusion 2005, 46: 24-33. PMID: 16398727, DOI: 10.1111/j.1537-2995.2005.00671.x.Peer-Reviewed Original ResearchConceptsNumber of plateletsTransfusion intervalCount incrementPLT dosePCT plateletsControl groupRed blood cell transfusionSPRINT trialBlood cell transfusionComparison of patientsTransfusion requirementsCell transfusionPCT groupControl patientsPCT patientsRBC transfusionPlatelet transfusionsAmotosalen HClTransfusion responseConventional plateletsPLT transfusionsComparable dosesControl transfusionsTransfusionPatients
Clinical Trials
Current Trials
Study to Evaluate the Efficacy & Safety of the INTERCEPT Blood System for RBCs in Complex Cardiac Surgery Patients (ReCePI)
HIC ID2000024812RolePrincipal InvestigatorPrimary Completion Date12/31/2022Recruiting ParticipantsGenderBothAge11+ years
Academic Achievements & Community Involvement
Clinical Care
Overview
Edward Snyder, MD, directs the Yale New Haven Hospital Blood Bank/Transfusion Service at Yale Medicine. The blood bank provides compatibility testing and blood products to Yale New Haven Hospital (YNHH) and its outpatient facilities.
“The Transfusion Service supports all of the YNHH service lines, including orthopedics, oncology, pediatrics, transplants, surgery, and Ob/Gyn,” says Dr. Snyder. “Any patient in any department might need blood at some point.” Dr. Snyder oversees the blood needs of these programs, which together transfuse about 48,000 blood products each year, he says.
Dr. Snyder first discovered his interest in blood banking as an undergraduate student working summers as a blood bank technologist at the Bronx Municipal Hospital Center in New York City. “I was intrigued by the way red blood cells clumped in the glass test tubes, which is a signal of blood incompatibility,” he says.
In addition to his director role, Dr. Snyder also conducts clinical research on the pathogen reduction of blood products. This research is designed to determine how to efficiently and safely prevent the transmission of bacteria and viruses during transfusions.
At Yale School of Medicine, Dr. Snyder is a professor of laboratory medicine.
Clinical Specialties
Internal Medicine; Hematology & Oncology; Laboratory Medicine
Fact Sheets
Apheresis
Learn More on Yale Medicine
Board Certifications
Blood Banking/Transfusion Medicine
- Certification Organization
- AB of Pathology
- Original Certification Date
- 1999
Hematology (Internal Medicine)
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 1978
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 1976
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Laboratory Medicine
PO Box 208035
New Haven, CT 06520-8035
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