About
Research
Publications
2025
Systemic administration of an RNA binding and cell-penetrating antibody targets therapeutic RNA to multiple mouse models of cancer
Quijano E, Martinez-Saucedo D, Ianniello Z, Pinto-Medici N, Rackear M, Chen H, Lola-Pereira L, Liu Y, Hegan D, Shan X, Tseng R, Yugawa D, Chowdhury S, Khang M, Singh J, Abdullah R, Azhir P, Kashima S, Woods W, Gosstola N, Turner B, Squinto S, Ludwig D, Bindra R, Robert M, Braun D, Perez Pinera P, Saltzman W, Escobar-Hoyos L, Glazer P. Systemic administration of an RNA binding and cell-penetrating antibody targets therapeutic RNA to multiple mouse models of cancer. Science Translational Medicine 2025, 17: eadk1868. PMID: 40668891, PMCID: PMC12375925, DOI: 10.1126/scitranslmed.adk1868.Peer-Reviewed Original ResearchConceptsMouse modelAntitumor efficacyTumor cellsMouse model of pancreatic cancerActivation of cytotoxic T cellsOrthotopic pancreatic cancer modelImmune responseModel of pancreatic cancerAntitumor immune responseCytotoxic T cellsPancreatic cancer modelTreatment of patientsMultiple mouse modelsRIG-IPattern recognition receptorsInnate immune responseImmunocompetent miceTumor massT cellsMalignant cellsPancreatic cancerCancer modelsTumor targetingNonmalignant cellsTumor growth
2019
Helminth-derived molecules inhibit colitis-associated colon cancer development through NF-κB and STAT3 regulation.
Callejas BE, Mendoza-Rodríguez MG, Villamar-Cruz O, Reyes-Martínez S, Sánchez-Barrera CA, Rodríguez-Sosa M, Delgado-Buenrostro NL, Martínez-Saucedo D, Chirino YI, León-Cabrera SA, Pérez-Plasencia C, Vaca-Paniagua F, Arias-Romero LE, Terrazas LI. Helminth-derived molecules inhibit colitis-associated colon cancer development through NF-κB and STAT3 regulation. Int J Cancer 2019, 145: 3126-3139. PMID: 31407335, DOI: 10.1002/ijc.32626.Peer-Reviewed Original ResearchTaenia crassiceps-Excreted/Secreted Products Induce a Defined MicroRNA Profile that Modulates Inflammatory Properties of Macrophages.
Martínez-Saucedo D, Ruíz-Rosado JD, Terrazas C, Callejas BE, Satoskar AR, Partida-Sánchez S, Terrazas LI. Taenia crassiceps-Excreted/Secreted Products Induce a Defined MicroRNA Profile that Modulates Inflammatory Properties of Macrophages. J Immunol Res 2019, 2019: 2946713. PMID: 31218234, DOI: 10.1155/2019/2946713.Peer-Reviewed Original Research
2018
Parasites as negative regulators of cancer.
Callejas BE, Martínez-Saucedo D, Terrazas LI. Parasites as negative regulators of cancer. Biosci Rep 2018, 38 PMID: 30266743, DOI: 10.1042/BSR20180935.Peer-Reviewed Original ResearchAngiotensin II receptor I blockade prevents stenosis of tissue engineered vascular grafts
de Dios Ruiz‐Rosado J, Lee Y, Mahler N, Yi T, Robledo‐Avila F, Martinez‐Saucedo D, Lee AY, Shoji T, Heuer E, Yates AR, Pober JS, Shinoka T, Partida‐Sanchez S, Breuer CK. Angiotensin II receptor I blockade prevents stenosis of tissue engineered vascular grafts. The FASEB Journal 2018, 32: 6822-6832. PMID: 29906242, PMCID: PMC6219835, DOI: 10.1096/fj.201800458.Peer-Reviewed Original ResearchAngiotensin II receptor ITEVG stenosisPrevents stenosisMononuclear cellsAngiotensin II type 1 receptor antagonistReceptor IBone marrow-derived mononuclear cellsShort-term losartan treatmentType 1 receptor antagonistMarrow-derived mononuclear cellsVascular graftsShort-term administrationCongenital heart surgeryTissue-engineered vascular graftsLong-term patencyWidespread clinical useLosartan treatmentPharmacologic treatmentAcute phaseMonocyte infiltrationHeart surgeryReceptor antagonistCCR2 knockoutRecipient miceClinical trials
2017
Helminth-induced Ly6C(hi) monocyte-derived alternatively activated macrophages suppress experimental autoimmune encephalomyelitis.
Terrazas C, de Dios Ruiz-Rosado J, Amici SA, Jablonski KA, Martinez-Saucedo D, Webb LM, Cortado H, Robledo-Avila F, Oghumu S, Satoskar AR, Rodriguez-Sosa M, Terrazas LI, Guerau-de-Arellano M, Partida-Sánchez S. Helminth-induced Ly6C(hi) monocyte-derived alternatively activated macrophages suppress experimental autoimmune encephalomyelitis. Sci Rep 2017, 7: 40814. PMID: 28094319, DOI: 10.1038/srep40814.Peer-Reviewed Original Research In Press
2015
Uncovering Leishmania-macrophage interplay using imaging flow cytometry.
Terrazas C, Oghumu S, Varikuti S, Martinez-Saucedo D, Beverley SM, Satoskar AR. Uncovering Leishmania-macrophage interplay using imaging flow cytometry. J Immunol Methods 2015, 423: 93-8. PMID: 25967951, DOI: 10.1016/j.jim.2015.04.022.Peer-Reviewed Original ResearchThe macrophage galactose-type lectin-1 (MGL1) recognizes Taenia crassiceps antigens, triggers intracellular signaling, and is critical for resistance to this infection.
Montero-Barrera D, Valderrama-Carvajal H, Terrazas CA, Rojas-Hernández S, Ledesma-Soto Y, Vera-Arias L, Carrasco-Yépez M, Gómez-García L, Martínez-Saucedo D, Becerra-Díaz M, Terrazas LI. The macrophage galactose-type lectin-1 (MGL1) recognizes Taenia crassiceps antigens, triggers intracellular signaling, and is critical for resistance to this infection. Biomed Res Int 2015, 2015: 615865. PMID: 25664320, DOI: 10.1155/2015/615865.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
Teaching & Mentoring
Mentoring
Deanne Yugawa
Graduate student2022 - 2025
News
News
- July 16, 2025
Yale Researchers Develop Novel Antibody-RNA Therapy for Resistant Cancers
- May 28, 2025
Yale RNA Center Travel Grants Support Attendance at RNA 2025 in San Diego
- May 13, 2025
Yale representation at the Microsymposium on RNA Biology
- February 02, 2024
Innovative Researcher Dr. Giulia Biancon Honored with 2024 Eclipse Award