David Monedero-Alonso
Associate Research Scientist in GeneticsAbout
Research
Publications
2025
The inner core enables transient touch detection in the Pacinian corpuscle
Ziolkowski L, Nikolaev Y, Chikamoto A, Oda M, Feketa V, Monedero-Alonso D, Ardasheva S, Bae S, Xu C, Pang S, Gracheva E, Bagriantsev S. The inner core enables transient touch detection in the Pacinian corpuscle. Science Advances 2025, 11: eadt4837. PMID: 40009676, PMCID: PMC11864184, DOI: 10.1126/sciadv.adt4837.Peer-Reviewed Original Research
2024
The Upstream Sequence Transcription Complex dictates nucleosome positioning and promoter accessibility at piRNA genes in the C. elegans germ line
Paniagua N, Roberts C, Gonzalez L, Monedero-Alonso D, Reinke V. The Upstream Sequence Transcription Complex dictates nucleosome positioning and promoter accessibility at piRNA genes in the C. elegans germ line. PLOS Genetics 2024, 20: e1011345. PMID: 38985845, PMCID: PMC11262695, DOI: 10.1371/journal.pgen.1011345.Peer-Reviewed Original ResearchPiRNA genesPiRNA clustersGenomic domainsC. elegans germ lineUpstream sequence transcription complexSmall RNA pathwaysGermline-specific expressionGlobal genome organizationPiRNA precursorsPiRNA pathwayChromosome IVGenome organizationRNA pathwaysChromatin stateTranscribed genesNucleosome positioningNucleosome densityGenome integrityTranscriptional regulationTranscription complexC. elegansPiRNAsGerm lineISW-1Nucleosomal environment
2021
Altered Ca2+ Homeostasis in Red Blood Cells of Polycythemia Vera Patients Following Disturbed Organelle Sorting during Terminal Erythropoiesis
Buks R, Dagher T, Rotordam M, Alonso D, Cochet S, Gautier E, Chafey P, Cassinat B, Kiladjian J, Becker N, Plo I, Egée S, Nemer W. Altered Ca2+ Homeostasis in Red Blood Cells of Polycythemia Vera Patients Following Disturbed Organelle Sorting during Terminal Erythropoiesis. Cells 2021, 11: 49. PMID: 35011611, PMCID: PMC8750512, DOI: 10.3390/cells11010049.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCell SizeErythroblastsErythrocytesErythroid CellsErythropoiesisHomeostasisHumansIntermediate-Conductance Calcium-Activated Potassium ChannelsIntracellular SpaceJanus Kinase 2MiceMice, Inbred C57BLMutationOrganellesPolycythemia VeraProteomeReticulocytesRibosomesThrombocytosisConceptsJAK2V617FCalcium homeostasisPolycythemia veraRed blood cellsEndoplasmic-reticulum-residing proteinsErythroid differentiationPolycythemia vera patientsTyrosine kinase Janus kinase 2Elevated levelsRegulation of signaling pathwaysWhole cell proteomeRBC membraneVera patientsIon channel activityPV patientsTerminal erythroid differentiationV617F mutationMyeloproliferative neoplasmsErythroid proliferationThrombotic eventsEnucleation stepOrganelle retentionChannel activityMembrane proteomeCell proteomeThe Chloride Conductance Inhibitor NS3623 Enhances the Activity of a Non-selective Cation Channel in Hyperpolarizing Conditions
Alonso D, Pérès L, Hatem A, Bouyer G, Egée S. The Chloride Conductance Inhibitor NS3623 Enhances the Activity of a Non-selective Cation Channel in Hyperpolarizing Conditions. Frontiers In Physiology 2021, 12: 743094. PMID: 34707512, PMCID: PMC8543036, DOI: 10.3389/fphys.2021.743094.Peer-Reviewed Original ResearchNon-selective cation channelNon-selective cationRed blood cellsCation channelsChannel activitySodium entryActivation of NSC channelsNon-selective cation conductanceCation conductanceMembrane potentialVoltage dependent mannerNon-selective cation channel activitySickle cell anemiaNSC channelsCalcium pumpDepolarizing mediumRed blood cell membraneCell anemiaChannel blockGenetic defectsConduction inhibitionBlood cellsPathophysiological situationsCation permeabilityElectrophysiological eventsMultiple thrombosis in a patient with Gardos channelopathy and a new KCNN4 mutation
Mansour‐Hendili L, Egée S, Monedero‐Alonso D, Bouyer G, Godeau B, Badaoui B, Lunati A, Noizat C, Aissat A, Kiger L, Mekki C, Picard V, Moutereau S, Fanen P, Bartolucci P, Garçon L, Galactéros F, Funalot B. Multiple thrombosis in a patient with Gardos channelopathy and a new KCNN4 mutation. American Journal Of Hematology 2021, 96: e318-e321. PMID: 34004026, DOI: 10.1002/ajh.26245.Peer-Reviewed Original ResearchCharacterisation of Asp669Tyr Piezo1 cation channel activity in red blood cells: an unexpected phenotype
Pérès L, Alonso D, Nudel M, Figeac M, Bruge J, Sebda S, Picard V, Nemer W, Preudhomme C, Rose C, Egée S, Bouyer G. Characterisation of Asp669Tyr Piezo1 cation channel activity in red blood cells: an unexpected phenotype. British Journal Of Haematology 2021, 194: e51-e55. PMID: 33973227, DOI: 10.1111/bjh.17467.Peer-Reviewed Original ResearchAmino Acid SubstitutionAnemia, Hemolytic, CongenitalCarbonyl Cyanide m-Chlorophenyl HydrazoneChild, PreschoolErythrocyte DeformabilityErythrocytesExome SequencingGain of Function MutationHumansIon ChannelsIon TransportMaleMembrane PotentialsMutation, MissenseOsmolar ConcentrationOsmotic FragilityPatch-Clamp TechniquesPhenotypePoint MutationPotassiumSodiumIncreased incidence of germline PIEZO1 mutations in individuals with idiopathic erythrocytosis
Filser M, Giansily-Blaizot M, Grenier M, Monedero Alonso D, Bouyer G, Pérès L, Egée S, Aral B, Airaud F, Da Costa L, Picard V, Cougoul P, Palach M, Béziau S, Garrec C, Aguilar-Martinez P, Gardie B, Girodon F. Increased incidence of germline PIEZO1 mutations in individuals with idiopathic erythrocytosis. Blood 2021, 137: 1828-1832. PMID: 33181827, DOI: 10.1182/blood.2020008424.Peer-Reviewed Original Research
2020
Gardos channelopathy: functional analysis of a novel KCNN4 variant
Fermo E, Monedero-Alonso D, Petkova-Kirova P, Makhro A, Pérès L, Bouyer G, Marcello A, Longo F, Graziadei G, Barcellini W, Bogdanova A, Egee S, Kaestner L, Bianchi P. Gardos channelopathy: functional analysis of a novel KCNN4 variant. Blood Advances 2020, 4: 6336-6341. PMID: 33351129, PMCID: PMC7756992, DOI: 10.1182/bloodadvances.2020003285.Peer-Reviewed Original Research
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