Ashwani Kumar, PhD
Associate Research ScientistCards
About
Research
Publications
2025
Author Correction: LILRB3 genetic variation is associated with kidney transplant failure in African American recipients
Sun Z, Yi Z, Wei C, Wang W, Ren T, Cravedi P, Tedla F, Ward S, Azeloglu E, Schrider D, Li Y, Khan A, Zanoni F, Fu J, Ali S, Liu S, Liang D, Liu T, Li H, Xi C, Vy T, Mosoyan G, Sun Q, Kumar A, Zhang Z, Farouk S, Campell K, Ochando J, Lee K, Coca S, Xiang J, Connolly P, Gallon L, O’Connell P, Colvin R, Menon M, Nadkarni G, He J, Kraft M, Jiang X, Zhang X, Kiryluk K, Cherukuri A, Lakkis F, Zhang W, Chen S, Heeger P, Zhang W. Author Correction: LILRB3 genetic variation is associated with kidney transplant failure in African American recipients. Nature Medicine 2025, 31: 1712-1712. PMID: 40234733, DOI: 10.1038/s41591-025-03706-7.Peer-Reviewed Original ResearchLILRB3 genetic variation is associated with kidney transplant failure in African American recipients
Sun Z, Yi Z, Wei C, Wang W, Ren T, Cravedi P, Tedla F, Ward S, Azeloglu E, Schrider D, Li Y, Khan A, Zanoni F, Fu J, Ali S, Liu S, Liang D, Liu T, Li H, Xi C, Vy T, Mosoyan G, Sun Q, Kumar A, Zhang Z, Farouk S, Campell K, Ochando J, Lee K, Coca S, Xiang J, Connolly P, Gallon L, O’Connell P, Colvin R, Menon M, Nadkarni G, He J, Kraft M, Jiang X, Zhang X, Kiryluk K, Cherukuri A, Lakkis F, Zhang W, Chen S, Heeger P, Zhang W. LILRB3 genetic variation is associated with kidney transplant failure in African American recipients. Nature Medicine 2025, 31: 1677-1687. PMID: 40065170, DOI: 10.1038/s41591-025-03568-z.Peer-Reviewed Original ResearchSingle-nucelotide polymorphismsAssociated with death-censored graft lossDeath-censored graft lossGenetic variationGraft lossImmunoreceptor tyrosine-based inhibitory motifTyrosine-based inhibitory motifAA individualsApolipoprotein L1Rate of graft lossEnd-stage renal diseaseMissense mutationsInhibitory motifRNA sequencingKidney transplant outcomesKidney transplant failureMultiomics analysisImmune-related diseasesAmino acidsAfrican American recipientsTransplant cohortTransplant failureTransplant outcomesAnalysis of bloodProspective study
2024
Shroom3-Rock Interaction and Profibrotic Function: Resolving the Mechanism of a CKD Genome-Wide Association Study Risk Allele
Reghuvaran A, Kumar A, Barsotti G, Pell J, Tanvir E, He J, Menon M. Shroom3-Rock Interaction and Profibrotic Function: Resolving the Mechanism of a CKD Genome-Wide Association Study Risk Allele. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024qmq3drgr. DOI: 10.1681/asn.2024qmq3drgr.Peer-Reviewed Original ResearchClinical Characteristics and Outcomes of Neural Epidermal Growth Factor-like 1 Protein-Associated Membranous Nephropathy
Narayanasami S, Vijayakumar N, Trivedi M, Sekar A, Sulaiman S, Nayak S, Inamdar N, Sharma S, Parthasarathy R, Kadam V, Keskar V, Bagai S, Kumar A, Reen B, Kurien A, Sharma A, Khullar D, Hafeeq B, Krishnakumar A, Rahman Kv S, Na I, Nair S, Divyaveer S, Rathi M, Kohli H, Nada R, Ramachandran R. Clinical Characteristics and Outcomes of Neural Epidermal Growth Factor-like 1 Protein-Associated Membranous Nephropathy. Kidney International Reports 2024, 9: 1513-1516. PMID: 38707806, PMCID: PMC11068952, DOI: 10.1016/j.ekir.2024.02.1405.Peer-Reviewed Original ResearchRationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis
Barsotti G, Luciano R, Kumar A, Meliambro K, Kakade V, Tokita J, Naik A, Fu J, Peck E, Pell J, Reghuvaran A, Tanvir E, Patel P, Zhang W, Li F, Moeckel G, Perincheri S, Cantley L, Moledina D, Wilson F, He J, Menon M. Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis. Kidney International Reports 2024, 9: 1354-1368. PMID: 38707807, PMCID: PMC11068976, DOI: 10.1016/j.ekir.2024.02.006.Peer-Reviewed Original ResearchMinimal change diseaseRandomized Controlled TrialsSafety of metforminDouble-blindPodocyte injuryAdjunctive therapyPlacebo-controlled randomized controlled trialsPhase III studyPhase II trialPrimary glomerular diseaseFocal segmental glomerulosclerosisEffect of metforminPhase IIPlacebo-ControlledPreclinical dataNovel urineChange diseaseTissue markersRandomized trialsSegmental glomerulosclerosisGlomerular diseaseMechanistic biomarkersObservational studyFSGSInexpensive agent
2023
An Enigmatic Case of Jaundice and Photosensitivity in an Adolescent
Bhagat N, Singh P, De A, Mitra S, Kumar A, Dhanasekaran V, Parkhi M, Ray D, Duseja A. An Enigmatic Case of Jaundice and Photosensitivity in an Adolescent. ACG Case Reports Journal 2023, 10: e00996. PMID: 36891180, PMCID: PMC9988325, DOI: 10.14309/crj.0000000000000996.Peer-Reviewed Original ResearchLoss-of-function mutationsErythropoietic protoporphyriaGenetic analysisInborn error of heme biosynthesisEnd-stage liver diseaseAdolescent boysHepatobiliary manifestationsAbdominal painProgressive jaundiceClinical featuresLiver diseaseLiver enzymesJaundiceInborn errorsMetal-free protoporphyrinProtoporphyrin depositionHeme biosynthesisLiverFerrochelataseMutationsBrown pigmentBoysCholelithiasisPainProtoporphyrinComplementary medicine and phospholipase A2 receptor (PLA2R)–related membranous nephropathy—fortuitous or causal?
Kaur P, Prabhahar A, Kumar A, Pal D, Kumar V, Sekar A, Jha V, Nada R, Sethi J, Divyaveer S, Rathi M, Kohli H, Ramachandran R. Complementary medicine and phospholipase A2 receptor (PLA2R)–related membranous nephropathy—fortuitous or causal? Kidney International 2023, 103: 425-427. PMID: 36681458, DOI: 10.1016/j.kint.2022.11.008.Peer-Reviewed Original ResearchUncommon histopathological features of cytomegalovirus encephalitis and measles inclusion body encephalitis on autopsy in two patients with primary immunodeficiency.
Jindal A, Suri D, Gupta K, Kumar A, Pandiarajan V, Pilania R, Guleria S, Rawat A, Vyas S, Bhatia A, Singh S, Radotra B. Uncommon histopathological features of cytomegalovirus encephalitis and measles inclusion body encephalitis on autopsy in two patients with primary immunodeficiency. Clinical Neuropathology 2023, 42: 15-25. PMID: 36278299, DOI: 10.5414/np301476.Peer-Reviewed Original ResearchConceptsMeasles inclusion body encephalitisSevere combined immunodeficiencyInclusion body encephalitisPrimary immunodeficiencyCombined immunodeficiencyViral encephalitisCase 2Primary immunodeficiency diseasesFeatures of viral encephalitisWhole-exome sequencingRare giant cellsFatal viral encephalitisCytomegalovirus encephalitisImmunodeficiency diseaseMicroglial nodulesCystic encephalomalaciaHistopathological featuresBacterial pneumoniaHistological featuresAlveolar damageExtracranial organsPathogenic variantsImmunodeficiencyGenetic testingExome sequencingAlcoholic foamy degeneration: an unusual presentation of the alcoholic liver disease diagnosed on autopsy
Joshi R, Parkhi M, Gupta A, Susngi T, Kumar A, Dhibar D, Mitra S. Alcoholic foamy degeneration: an unusual presentation of the alcoholic liver disease diagnosed on autopsy. Autopsy And Case Reports 2023, 13: e2023446. PMID: 38034523, PMCID: PMC10688259, DOI: 10.4322/acr.2023.446.Peer-Reviewed Original ResearchAlcoholic foamy degenerationAlcoholic liver diseasePresentation of alcoholic liver diseaseLiver diseaseUnusual presentationAlcohol abstinenceAlcoholic hepatitisDiabetic menHistological findingsFoamy degenerationMidzonal regionInjury mechanismAutopsyDiseasePresentationBiopsyPrognosisFibrosisHepatitisPatientsInflammation
2022
POS-066 INFECTION-RELATED GLOMERULONEPHRITIS IN DEVELOPING COUNTRY-AN INSTITUTIONAL EXPERIENCE
Sekar A, Nada R, Dhanasekaran V, Joshi R, Rathi M, Kumar V, Ramachandran R, Kumar A, Kohli H. POS-066 INFECTION-RELATED GLOMERULONEPHRITIS IN DEVELOPING COUNTRY-AN INSTITUTIONAL EXPERIENCE. Kidney International Reports 2022, 7: s494. DOI: 10.1016/j.ekir.2022.07.083.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
News
Get In Touch
Contacts
Mailing Address
Yale School of Medicine
Internal Medicine-Nephrology, The Anlyan Center, 1 Gilbert Street
New Haven, Connecticut 06519
United States