Anish Sharda, MD, MPH
Assistant ProfessorCards
About
Research
Publications
2026
Correction: A proteomic map of thromboinflammatory signatures in antiphospholipid syndrome: results from antiphospholipid syndrome alliance for clinical trials and international networking (APS ACTION) registry
Pine A, Butt A, Andreoli L, Knight J, Gerosa M, Cecchi I, Branch D, Lopez-Pedrera R, Belmont H, Kello N, Petri M, Cervera R, Pengo V, Meroni P, Cohen H, Willis R, Bertolaccini M, Goshua G, Gu S, Hwa J, Lee A, Erkan D, Sharda A. Correction: A proteomic map of thromboinflammatory signatures in antiphospholipid syndrome: results from antiphospholipid syndrome alliance for clinical trials and international networking (APS ACTION) registry. Frontiers In Immunology 2026, 17: 1807468. DOI: 10.3389/fimmu.2026.1807468.Peer-Reviewed Original Research
2025
Platelet-related biomarkers and catheter-associated thrombosis in critically ill children: An exploratory study
Regmi H, Li I, Prozora S, Sharda A, Shabanova V, Faustino E, Investigators C. Platelet-related biomarkers and catheter-associated thrombosis in critically ill children: An exploratory study. Thrombosis Research 2025, 256: 109534. PMID: 41223722, PMCID: PMC12712714, DOI: 10.1016/j.thromres.2025.109534.Peer-Reviewed Original ResearchConceptsCatheter-associated deep venous thrombosisClinically Relevant BleedingCritically Ill ChildrenCentral venous catheterProphylactic enoxaparinPlatelet factor 4P-selectinIL-6Ill childrenTNF-aPlatelet activationBiomarkers of platelet activationCatheter-associated thrombosisDeep venous thrombosisFactor 4Platelet-poor plasmaSeverity of illnessRelevant bleedingPharmacological prophylaxisPlatelet countVenous cathetersMulticenter studyVenous thrombosisIL-2IL-1BElevated d-dimer predicts worse outcomes in hospitalized adults with sickle cell crisis: A real-world multicenter study
Samat D, Singh S, Sharda A. Elevated d-dimer predicts worse outcomes in hospitalized adults with sickle cell crisis: A real-world multicenter study. Blood 2025, 146: 4748-4748. DOI: 10.1182/blood-2025-4748.Peer-Reviewed Original ResearchAcute chest syndromeElevated D-dimerNon-elevated groupRisk of acute chest syndromeSickle cell diseaseSickle cell crisisD-dimer levelsD-dimerAssociated with higher riskMulticenter cohort studyVenous thromboembolismHazard ratioBlood transfusionCell crisisMulticenter cohort study of adultsHospitalized adultsRecurrent vaso-occlusive crisesElevated D-dimer levelsElevated D-dimer groupNormal D-dimerKaplan-Meier survival analysisD-dimer groupVenous thromboembolic eventsLong-term morbidityCohort study of adultsA proteomic map of thromboinflammatory signatures in antiphospholipid syndrome: results from antiphospholipid syndrome alliance for clinical trials and international networking (APS ACTION) registry
Pine A, Butt A, Andreoli L, Knight J, Gerosa M, Cecchi I, Branch D, Lopez-Pedrera R, Belmont H, Kello N, Petri M, Cervera R, Pengo V, Meroni P, Cohen H, Willis R, Bertolccini M, Goshua G, Gu S, Hwa J, Lee A, Erkan D, Sharda A. A proteomic map of thromboinflammatory signatures in antiphospholipid syndrome: results from antiphospholipid syndrome alliance for clinical trials and international networking (APS ACTION) registry. Frontiers In Immunology 2025, 16: 1676578. PMID: 41181143, PMCID: PMC12571811, DOI: 10.3389/fimmu.2025.1676578.Peer-Reviewed Original ResearchConceptsAntiphospholipid syndromeInflammatory signatureClinical trialsAdaptive immune response pathwaysPersistently aPL-positive patientsPathogenesis of antiphospholipid syndromeClinical antiphospholipid syndromePathophysiology of antiphospholipid syndromeAPL-positive patientsCirculating antiphospholipid antibodiesPresence of aPLAntiphospholipid syndrome classificationAdaptive immune activationActivation of coagulationStatistical significanceAntiPhospholipid Syndrome AllianceMultiple pathophysiological mechanismsObstetric morbidityAntiphospholipid antibodiesImmune response pathwaysImmune cellsImmune activationAutoimmune diseasesProteomic screenClinical severityEROdicating arterial thrombosis with a novel endoplasmic reticulum oxidoreductase 1α inhibitor
Yarovinsky T, Sharda A, Hwa J. EROdicating arterial thrombosis with a novel endoplasmic reticulum oxidoreductase 1α inhibitor. Molecular Therapy 2025, 33: 4682-4683. PMID: 40975058, PMCID: PMC12848167, DOI: 10.1016/j.ymthe.2025.09.012.Peer-Reviewed Original ResearchAnalytical Review: Neutrophil Extracellular Traps and Antiphospholipid syndrome
Butt A, Sharda A, Lee A, Knight J. Analytical Review: Neutrophil Extracellular Traps and Antiphospholipid syndrome. Transfusion Medicine Reviews 2025, 40: 150909. PMID: 40783311, DOI: 10.1016/j.tmrv.2025.150909.Peer-Reviewed Original ResearchNeutrophil extracellular trapsAntiphospholipid syndromeAdenosine A2A receptorNegative regulatorP-selectin glycoprotein ligand-1Anti-NET antibodiesInduction of NETosisTranscription factor KLF2Regulation of NETosisAutoimmune prothrombotic disorderDecondensed chromatinDevelopment of thrombosisElevated NET levelsNeutrophil-mediated mechanismsGranule proteinsComplement system activationActivated Protein CObstetric complicationsAntiphospholipid antibodiesProthrombotic disordersNeutrophil-derived granule proteinsThrombotic eventsThrombotic riskClinical manifestationsAutoimmune disordersRalB uncoupling from exocyst is required for endothelial Weibel-Palade body exocytosis.
Yang M, Boye-Doe A, Ali M, Abosabie S, Barr A, Mendez L, Sharda A. RalB uncoupling from exocyst is required for endothelial Weibel-Palade body exocytosis. Molecular Biology Of The Cell 2025, 36: ar62. PMID: 40172988, PMCID: PMC12086567, DOI: 10.1091/mbc.e24-11-0493.Peer-Reviewed Original ResearchConceptsWeibel-Palade body exocytosisHypervariable regionWeibel-Palade bodiesC-terminal hypervariable regionHemostatic protein von Willebrand factorGDP-bound stateGTP-bound stateExocytosis of Weibel-Palade bodiesDegree of homologyRal isoformsEffector proteinsCell stimulationProtein kinase C (PKC)-dependent phosphorylationNonphosphorylatable mutantRal GTPasesExocystSite mutantsSerine residuesRas-likeCellular processesExocytosisRalBRegulate effectorsEndothelial secretory granulesSecretory granulesCongenital T-cell activation impairs transitional-to-follicular B-cell maturation in humans
Allard-Chamard H, Hillier K, Ramseier M, Bertocchi A, Kaneko N, Premo K, Yuen G, Karpel M, Mahajan V, Tsekeri C, Hong J, Vencic J, Crotty R, Sharda A, Barmettler S, Westermann-Clark E, Walter J, Ghebremichael M, Shalek A, Farmer J, Pillai S. Congenital T-cell activation impairs transitional-to-follicular B-cell maturation in humans. Blood Advances 2025, 9: 520-532. PMID: 39626280, PMCID: PMC11814514, DOI: 10.1182/bloodadvances.2024013267.Peer-Reviewed Original ResearchConceptsCytotoxic T-lymphocyte-associated protein 4B cell maturationRegulatory T cellsT cell activationT cellsMammalian target of rapamycin complex 1B cellsEffector CD4+ T cellsExcessive T cell activationFunctional regulatory T cellsCD4+ T cellsHumoral immune dysfunctionB cell defectsMammalian targetPatients lymph nodesTransitional B cellsB cell stageB cell developmentCell-to-cell contactCD27- B cellsMammalian target of rapamycin complex 1 signalingCD40L levelsImmune dysfunctionReplacement therapyLymph nodes
2024
Phenotypic and Transcriptomic Profiling of MPN Endothelium
Abosabie S, Mendez L, Sharda A. Phenotypic and Transcriptomic Profiling of MPN Endothelium. Blood 2024, 144: 1228. DOI: 10.1182/blood-2024-211468.Peer-Reviewed Original ResearchBlood outgrowth endothelial cellsMyeloproliferative neoplasmsVon Willebrand factorP-selectin surface expressionOutgrowth endothelial cellsPrimary myelofibrosisEssential thrombocythemiaThromboembolic eventsPeripheral bloodEndothelial cellsElevated risk of thromboembolic eventsRisk of transformation to acute myeloid leukemiaTransformation to acute myeloid leukemiaP-selectinSurface expressionRisk of thromboembolic eventsComplement pathway abnormalitiesHistory of thromboembolismClassical myeloproliferative neoplasmsVon Willebrand factor expressionAcute myeloid leukemiaElevated riskEndothelial cell activationMature blood cellsVE-cadherinPpara Deletion Promotes Monocytic Leukemia Granulocytic Differentiation
Diolombi M, Sharda A, Chen M, Sejour L, Bester A, Nachmani D, Clohessy J, Pandolfi P, Mendez L. Ppara Deletion Promotes Monocytic Leukemia Granulocytic Differentiation. Blood 2024, 144: 4118. DOI: 10.1182/blood-2024-211508.Peer-Reviewed Original ResearchAcute myeloid leukemiaBone marrow mononuclear cellsAdaptive immune responsesRegulation of adaptive immune responsesAssociated with positive regulationPeroxisome proliferator activated receptorGranulocytic differentiationImmune responseSecondary recipientsPositive regulatorAggressive malignancyResponse to various environmental cuesAcute myeloid leukemia maintenanceEnvironmental cuesCellular gene expression programsSubgroup of acute myeloid leukemiaStatistically significant survival advantageUpregulated pathwaysAnti-tumor immunityBiological process termsBeat AML databaseMLL-AF9 leukemiaPeripheral blood MNCsSignificant survival advantageBalance self-renewal
Academic Achievements & Community Involvement
Clinical Care
Overview
Anish Sharda, MBBS (a medical degree awarded outside of the U.S.), is a physician-scientist and an assistant professor of medicine at Yale School of Medicine. Dr Sharda is a classical hematologist who specializes in the treatment of bleeding, clotting, and platelet disorders.
Dr. Sharda runs a National Institutes of Health-funded laboratory that conducts research in bleeding and clotting disorders, specifically von Willebrand disease. His research aims to improve understanding of this bleeding disorder as well as discover novel treatments.
Dr. Sharda completed his medical training at B.P. Koirala Institute of Health Sciences in Nepal, followed by a residency in internal medicine at the University of Minnesota Medical Center. He then pursued a clinical and research fellowship in hematology and oncology at Beth Israel Deaconess Medical Center and Harvard Medical School, where he was a faculty member until 2022.
Clinical Specialties
Hematology
Fact Sheets
Bleeding Disorders
Learn More on Yale MedicineBlood Clots in Veins, Heart and Lungs
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Yale Medicine News
News & Links
Media
Smilow Shares with Primary Care: Benign Hematology and Elevated Blood Counts
January 7, 2025
Presentations by: Frank Ciminiello, MD, Kelsey Martin, MD, and Anish Sharda, MD, MPH
News
- January 08, 2025
Smilow Shares with Primary Care: Benign Hematology and Elevated Blood Counts
- February 15, 2024
Educational Exchange Brings Ugandan Hematologist Dr. Christine Sekaggya-Wiltshire to Yale School of Medicine
- December 08, 2023
New Research Reveals How Modifying a Key Molecular Regulator Could Improve the Treatment of von Willebrand Disease
- November 28, 2023
Yale Cancer Center Experts Present New Research at Hematology Annual Meeting
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Hematology
300 George St
New Haven, Connecticut 06511
United States
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