Andrew Miranker, PhD
Cards
About
Titles
Professor of Molecular Biophysics and Biochemistry and of Chemical and Environmental Engineering
Appointments
Molecular Biophysics and Biochemistry
ProfessorPrimary
Other Departments & Organizations
- Biochemistry, Quantitative Biology, Biophysics and Structural Biology (BQBS)
- Diabetes Research Center
- High Performance Computation
- Molecular Biophysics and Biochemistry
- Molecular Medicine, Pharmacology, and Physiology
- Structural Biology
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Ventures
Education & Training
- PhD
- Harvard University (1992)
Research
Overview
Research in our laboratory is focused on conformational changes in proteins which give rise to a special class of protein complex known as amyloid fibrils. This folding problem is particularly fascinating as proteins which are seemingly unrelated in primary sequence and in their native 3 dimensional structure form aggregates which share common structural features. Depending on the protein involved, fibril formation gives rise or contributes to the pathogenesis of more than 20 clinical conditions. Projects currently underway in the laboratory include the islet amyloid polypeptide system which forms fibrils in the pancreas of type II diabetics, and beta-2 microglobulin which forms deposits on the connective tissues of long term dialysis patients. We are studying both the folding and the fibrillogenesis properties of these systems. Biophysical techniques enable these investigations to be conducted at a molecular level. These include high field NMR, optical spectroscopy and electrospray ionization mass spectrometry.
Links & Media
News
- July 21, 2020Source: Office of Cooperative Research
The Blavatnik Fund for Innovation at Yale Awards $2.6 Million For Faculty Research
- May 22, 2019
Researchers Receive a New Round of Awards from Blavatnik Fund for Innovation at Yale
- May 09, 2019Source: Patch
Eight Finalists Awarded At 2019 Yale Innovation Summit
- April 03, 2018
Taming an unruly target in diabetes