Andrea Roberts, MD
Assistant Professor in Medicine (General Medicine)Cards
About
Research
Publications
2025
Corrigendum to “Posttraumatic stress disorder and epigenetic signatures of inflammation in middle-aged women” [Psychoneuroendocrinology 182 (2025) 107654]
Liu J, Ratanatharathorn A, Yaskolka Meir A, Murchland A, Zhu Y, Roberts A, Lawn R, Sumner J, Haneuse S, Liang L, Kubzansky L, Koenen K, Chibnik L. Corrigendum to “Posttraumatic stress disorder and epigenetic signatures of inflammation in middle-aged women” [Psychoneuroendocrinology 182 (2025) 107654]. Psychoneuroendocrinology 2025, 184: 107687. PMID: 41240613, DOI: 10.1016/j.psyneuen.2025.107687.Peer-Reviewed Original ResearchPosttraumatic stress disorder and epigenetic signatures of inflammation in middle-aged women
Liu J, Ratanatharathorn A, Yaskolka Meir A, Murchland A, Zhu Y, Roberts A, Lawn R, Sumner J, Haneuse S, Liang L, Kubzansky L, Koenen K, Chibnik L. Posttraumatic stress disorder and epigenetic signatures of inflammation in middle-aged women. Psychoneuroendocrinology 2025, 182: 107654. PMID: 41135353, PMCID: PMC12720495, DOI: 10.1016/j.psyneuen.2025.107654.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderPost-traumatic stress disorder symptom severitySymptom severityAssociated with higher levelsNurses' Health Study IIStress disorderMeasures of post-traumatic stress disorderPost-traumatic stress disorder diagnosisConsistency of associationsWhite blood cell proportionsCross-sectional studyLifetime PTSD diagnosisPosttraumatic stress disorderWeak positive associationTime of blood drawMiddle-aged womenMeasurement of plasma C-reactive proteinSociodemographic factorsPlasma C-reactive proteinLinear mixed-effects modelsC-reactive proteinPTSD diagnosisTrauma exposureMixed-effects modelsStudy IIEstimating the associations between women’s maltreatment in childhood and inflammatory biomarker levels prior to and during pregnancy
Wu B, Vyas C, Medina A, Slopen N, Mahalingaiah S, Chavarro J, Mukherjee R, Weisskopf M, Roberts A. Estimating the associations between women’s maltreatment in childhood and inflammatory biomarker levels prior to and during pregnancy. PLOS ONE 2025, 20: e0331905. PMID: 40920854, PMCID: PMC12416833, DOI: 10.1371/journal.pone.0331905.Peer-Reviewed Original ResearchConceptsTumor necrosis factor alpha receptor 2Associated with higher riskC-reactive proteinAdverse neurodevelopmentInflammatory biomarkersNurses' Health Study 3Risk of adverse neurodevelopmentInterleukin-6Gestational risk factorsMaternal childhood abuseMaternal childhood maltreatmentGeneralized Estimating EquationsSample of well-educatedChronic systemic inflammationInflammatory biomarker levelsChildhood maltreatmentNon-HispanicExposure to maltreatmentPregnant participantsVulnerable populationsOffspring neurodevelopmentSystemic inflammationIFN-gProspective cohortInterferon-gammaPsychological Distress and Cognitive Function in Women: Exploring Potential Mediation by Use of Opiates, Sleep Aids, or Minor Tranquilizers
Sampson L, Lawn R, Murchland A, Liu J, Marquez C, Scoglio A, Jha S, Sumner J, Roberts A, Kang J, Chibnik L, Koenen K, Kubzansky L. Psychological Distress and Cognitive Function in Women: Exploring Potential Mediation by Use of Opiates, Sleep Aids, or Minor Tranquilizers. Journal Of Women's Health 2025, 34: 924-936. PMID: 40336460, PMCID: PMC12241842, DOI: 10.1089/jwh.2024.0991.Peer-Reviewed Original ResearchPosttraumatic stress disorderCognitive functionMedication useMinor tranquilizersMeasures of posttraumatic stress disorderNurses' Health Study IIAssociated with lower cognitive functionCogstate Brief BatterySleep aidsEvidence of mediationLower cognitive functionLearning/working memoryBrief batteryStress disorderPsychomotor speed/attentionAssociated with useDistress scoresHigh distressMediation analysisPsychological distressLinear regression modelsPotential mediatorsSelf-ReportAssessed associationsDepressionChildhood or adolescent abuse and primary open-angle glaucoma in a longitudinal cohort of women
Yu M, Hwang H, Roberts A, Koenen K, Wiggs J, Pasquale L, Kang J. Childhood or adolescent abuse and primary open-angle glaucoma in a longitudinal cohort of women. Eye 2025, 39: 1975-1982. PMID: 40211014, PMCID: PMC12209413, DOI: 10.1038/s41433-025-03785-3.Peer-Reviewed Original ResearchConceptsPrimary open-angle glaucomaPOAG subtypesAssociated with primary open-angle glaucomaOpen-angle glaucomaPrimary open-angle glaucoma casesHazard ratioPrimary open-angle glaucoma riskHigh riskMultivariable-adjusted Cox proportional hazards modelsSignificant dose-response relationshipNurses' Health Study IILongitudinal cohort of womenCox proportional hazards modelsCohort of womenConfidence intervalsMedical record reviewDose-response relationshipEstimate hazard ratiosProportional hazards modelAdverse associationEye examAdverse experience dataGlaucomaRecord reviewAbuse historyCOVID-19 Pandemic–Related Exposures and Cognitive Function in Middle-Aged Women
Wang S, Menor A, Chibnik L, Kang J, Vyas C, Blacker D, Kubzansky L, Koenen K, Roberts A. COVID-19 Pandemic–Related Exposures and Cognitive Function in Middle-Aged Women. JAMA Network Open 2025, 8: e255532. PMID: 40244583, PMCID: PMC12006873, DOI: 10.1001/jamanetworkopen.2025.5532.Peer-Reviewed Original ResearchConceptsMiddle-aged womenCognitive AssessmentStudy of registered nursesNurses' Health Study IICognitive functionCohort study analyzed dataCOVID-19 pandemicAssociated with cognitive functionCognitive declineCogstate Brief BatteryPost-COVID-19 conditionAssociated with cognitive declineAssociated with risk factorsStudy analyzed dataPandemic-related eventsComposite cognitive scoreCognitive test batteryReduced cognitive functionMain OutcomesEducation levelTest practice effectsCohort studyCOVID-19Brief batteryStudy IIResponse to Lehrer
Roberts A, Kubzansky L, Tworoger S. Response to Lehrer. Journal Of The National Cancer Institute 2025, 117: 1088-1089. PMID: 40036193, PMCID: PMC12058251, DOI: 10.1093/jnci/djaf044.Peer-Reviewed Original ResearchEarly-life cognitively stimulating activities and late-life cognitive function in the St. Louis Baby Tooth Later Life Health Study
Roberts A, Qiu X, McAlaine K, Germine L, Rotem R, Weisskopf M. Early-life cognitively stimulating activities and late-life cognitive function in the St. Louis Baby Tooth Later Life Health Study. Scientific Reports 2025, 15: 2105. PMID: 39814743, PMCID: PMC11736041, DOI: 10.1038/s41598-024-79083-x.Peer-Reviewed Original ResearchConceptsCognitively stimulating activitiesVisual short-term memoryCognitive functionWorking memoryShort-term memoryProcessing speedTests of crystallized intelligenceAssociated with specific cognitive domainsSpecific cognitive domainsVisual working memoryAssociated with higher cognitive functionOverall cognitive functionHigher cognitive functionsAssociated with overall cognitionLate-life cognitive functionAssociated with higher cognitive scoresCognitive controlEpisodic memoryVerbal reasoningCognitive domainsHigher cognitive scoresSustained attentionAssociated with activationOverall cognitionCognitive testsTiming of depression in relation to risk of ovarian cancer
Roberts A, Townsend M, Chibnik L, Kubzansky L, Tworoger S. Timing of depression in relation to risk of ovarian cancer. Journal Of The National Cancer Institute 2025, 117: 989-996. PMID: 39745894, PMCID: PMC12058258, DOI: 10.1093/jnci/djae348.Peer-Reviewed Original ResearchRisk of ovarian cancerAssociation of depressionAscertainment periodIncident cancerAssociated with greater cancer riskAssociated with increased risk of ovarian cancerAssociated with elevated riskTime of depressionAssociated with increased riskP-value thresholdCox proportional hazards modelsCancer ascertainmentProportional hazards modelCancer riskTests of statistical significanceStatistical significanceExamined depressionOvarian cancerElevated riskProspective cohortBehavioral factorsAscertainmentHazards modelConsecutive two-year periodDepression
2024
Association of Childhood Abuse With Incident Inflammatory Bowel Disease
Anyane-Yeboa A, Casey K, Roberts A, Lopes E, Burke K, Ananthakrishnan A, Richter J, Cozier Y, Koenen K, Chan A, Khalili H. Association of Childhood Abuse With Incident Inflammatory Bowel Disease. Clinical And Translational Gastroenterology 2024, 15: e00718. PMID: 39450870, PMCID: PMC11671083, DOI: 10.14309/ctg.0000000000000718.Peer-Reviewed Original ResearchIncident casesCohort of female health professionalsHazard ratios of CDNurses' Health Study IIIncident inflammatory bowel diseaseIncident cases of UCFemale health professionalsRisk of inflammatory bowel diseaseIncident cases of CDIncreased risk of CDInflammatory bowel diseaseRisk of Crohn's diseaseReview of medical recordsCox proportional hazards modelsDiagnosis of inflammatory bowel diseaseRisk of UCHealth professionalsStressful life eventsProportional hazards modelRisk of CDEmotional abuse subscaleSelf-ReportHazard ratioLife stressorsStudy II