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A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology
Gupta P, Galimberti M, Liu Y, Beck S, Wingo A, Wingo T, Adhikari K, Kranzler H, Stein M, Gelernter J, Levey D. A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology. Nature Human Behaviour 2024, 8: 2235-2249. PMID: 39134740, PMCID: PMC11576509, DOI: 10.1038/s41562-024-01951-3.Peer-Reviewed Original ResearchMulti-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications
Levey D, Galimberti M, Deak J, Wendt F, Bhattacharya A, Koller D, Harrington K, Quaden R, Johnson E, Gupta P, Biradar M, Lam M, Cooke M, Rajagopal V, Empke S, Zhou H, Nunez Y, Kranzler H, Edenberg H, Agrawal A, Smoller J, Lencz T, Hougaard D, Børglum A, Demontis D, Gaziano J, Gandal M, Polimanti R, Stein M, Gelernter J. Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications. Nature Genetics 2023, 55: 2094-2103. PMID: 37985822, PMCID: PMC10703690, DOI: 10.1038/s41588-023-01563-z.Peer-Reviewed Original ResearchBi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions
Levey DF, Stein MB, Wendt FR, Pathak GA, Zhou H, Aslan M, Quaden R, Harrington KM, Nuñez YZ, Overstreet C, Radhakrishnan K, Sanacora G, McIntosh AM, Shi J, Shringarpure SS, Concato J, Polimanti R, Gelernter J. Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions. Nature Neuroscience 2021, 24: 954-963. PMID: 34045744, PMCID: PMC8404304, DOI: 10.1038/s41593-021-00860-2.Peer-Reviewed Original ResearchReproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program
Levey DF, Gelernter J, Polimanti R, Zhou H, Cheng Z, Aslan M, Quaden R, Concato J, Radhakrishnan K, Bryois J, Sullivan PF, Program M, Stein M. Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program. American Journal Of Psychiatry 2020, 177: 223-232. PMID: 31906708, PMCID: PMC7869502, DOI: 10.1176/appi.ajp.2019.19030256.Peer-Reviewed Original ResearchGenetic associations with suicide attempt severity and genetic overlap with major depression
Levey DF, Polimanti R, Cheng Z, Zhou H, Nuñez YZ, Jain S, He F, Sun X, Ursano RJ, Kessler RC, Smoller JW, Stein MB, Kranzler HR, Gelernter J. Genetic associations with suicide attempt severity and genetic overlap with major depression. Translational Psychiatry 2019, 9: 22. PMID: 30655502, PMCID: PMC6336846, DOI: 10.1038/s41398-018-0340-2.Peer-Reviewed Original ResearchTowards understanding and predicting suicidality in women: biomarkers and clinical risk assessment
Levey DF, Niculescu EM, Le-Niculescu H, Dainton HL, Phalen PL, Ladd TB, Weber H, Belanger E, Graham DL, Khan FN, Vanipenta NP, Stage EC, Ballew A, Yard M, Gelbart T, Shekhar A, Schork NJ, Kurian SM, Sandusky GE, Salomon DR, Niculescu AB. Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment. Molecular Psychiatry 2016, 21: 768-785. PMID: 27046645, DOI: 10.1038/mp.2016.31.Peer-Reviewed Original ResearchA contextual genomic perspective on physical activity and its relationship to health, well being and illness
Galimberti M, Levey D, Deak J, Adhikari K, Overstreet C, Gupta P, Nitin R, Zhou H, Lake N, Harrington K, Djousse L, Davis L, Gaziano J, Stein M, Gelernter J. A contextual genomic perspective on physical activity and its relationship to health, well being and illness. Nature Genetics 2025, 57: 1860-1871. PMID: 40691405, PMCID: PMC12339386, DOI: 10.1038/s41588-025-02260-9.Peer-Reviewed Original Research
2026
Opioid use disorder and dementia risk: evidence from observational and genetic analyses in diverse ancestry cohorts
Javidnia S, Roe J, Karhunen V, Gill D, Bell S, Deak J, Levey D, Kember R, Kranzler H, Cronjé H, Burgess S, Gelernter J, Ebmeier K, Topiwala A. Opioid use disorder and dementia risk: evidence from observational and genetic analyses in diverse ancestry cohorts. Alzheimer's & Dementia 2026, 22: e71418. PMID: 42170857, PMCID: PMC13240559, DOI: 10.1002/alz.71418.Peer-Reviewed Original ResearchAgedBrainCohort StudiesDementiaEuropean PeopleFemaleGenetic Predisposition to DiseaseGenetic Risk ScoreGenome-Wide Association StudyHumansMagnetic Resonance ImagingMaleMendelian Randomization AnalysisMiddle AgedOpioid-Related DisordersPolymorphism, Single NucleotideReceptors, Opioid, muRisk FactorsWhite PeopleGenetic Pathways Point to the Biology Underlying the Association Between Cannabis Use Disorder and Psychosis
Austin-Zimmerman I, Li Q, Johnson E, Trotta G, Spinazzola E, Coleman J, Li Z, Bond B, Quattrone D, Levey D, Gelernter J, Jauhar S, Murray R, Sham P, Vassos E, Di Forti M. Genetic Pathways Point to the Biology Underlying the Association Between Cannabis Use Disorder and Psychosis. Biological Psychiatry Global Open Science 2026, 6: 100711. PMID: 42181294, PMCID: PMC13196363, DOI: 10.1016/j.bpsgos.2026.100711.Peer-Reviewed Original ResearchGenomic Study of Resilience to Posttraumatic Stress Disorder in the Million Veteran Program
Overstreet C, Levey D, Adhikari K, Galimberti M, Pathak G, Pietrzak R, Zhou H, Løkhammer S, Polimanti R, Harrington K, Quaden R, Amstadter A, Gaziano J, Stein M, Gelernter J, Muralidhar S, Moser J, Deen J, Tsao P, Gaziano J, Hauser E, Kilbourne A, Matheny M, Oslin D, Voora D, Gaziano J, Tsao P, Brewer J, Brophy M, Cho K, Churby L, DuVall S, Pyarajan S, Ringer R, Selva L, Shayan S, Stephens B, Whitbourne S, Assimes T, Hung A, Kranzler H. Genomic Study of Resilience to Posttraumatic Stress Disorder in the Million Veteran Program. Biological Psychiatry 2026 PMID: 41763442, DOI: 10.1016/j.biopsych.2026.01.022.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
News
News
- July 28, 2026
Yale Scientists Gain New Insight Into Genetic Architecture of Fibromyalgia
- December 02, 2025Source: Nature Communications
Multi-Ancestry Investigation of the Genomics of Erectile Dysfunction
- September 24, 2025Source: BMJ Evidence-Based Medicine
Alcohol Use and Risk of Dementia in Diverse Populations: Evidence from Cohort, Case–Control and Mendelian Randomisation Approaches
- September 24, 2025
New Study Reveals Genetic, Psychiatric, and Environmental Factors Contributing to Alcohol Use Disorder