Andre Levchenko
John C. Malone Professor of Biomedical EngineeringDownloadHi-Res Photo
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Neurosurgery
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John C. Malone Professor of Biomedical Engineering
Appointments
Neurosurgery
ProfessorSecondary
Other Departments & Organizations
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- Cancer Signaling Networks
- Immunology
- Neurosurgery
- Program in Neurodevelopment and Regeneration
- Yale Biomedical Imaging Institute
- Yale Cancer Center
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale CTAP
- Yale Fibrosis Program
- Yale-BI Biomedical Data Science Fellowship
- YCCEH
Research
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Overview
Medical Research Interests
Cell Communication; Microfluidics; Signal Transduction; Systems Biology
ORCID
0000-0001-6262-1222
Research at a Glance
Yale Co-Authors
Frequent collaborators of Andre Levchenko's published research.
Publications Timeline
A big-picture view of Andre Levchenko's research output by year.
Research Interests
Research topics Andre Levchenko is interested in exploring.
Michael Murrell
Sung Hoon Lee
Jesse Rinehart, PhD
Sidi Chen, PhD
Alexandre Jourdon, PhD
Alexej Abyzov, PhD
62Publications
4,554Citations
Signal Transduction
Cell Communication
Systems Biology
Publications
2026
Disruption of WNT/Notch signaling in pancreatic cancer reveals tumors depend on the intricate equilibrium of malignant cell states
Torborg S, Kim J, Singhal A, Grbovic-Huezo O, Holm M, Wu K, Han X, Ho Y, Haglund C, Mitchell M, Lowe S, Dow L, Pitter K, Sanchez-Rivera F, Levchenko A, Tammela T. Disruption of WNT/Notch signaling in pancreatic cancer reveals tumors depend on the intricate equilibrium of malignant cell states. Developmental Cell 2026 PMID: 41875882, DOI: 10.1016/j.devcel.2026.02.017.Peer-Reviewed Original ResearchAltmetricConceptsPancreatic ductal adenocarcinomaControl of cell identityGenetic inactivationCell statesGenetically engineered mouse modelsCancer cell statesNotch pathway componentsMalignant cell statesCell identityPancreatic ductal adenocarcinoma cellsFunctional nichesPathway componentsWnt secretionWnt signalingMalignant cellsPancreatic cancerDuctal adenocarcinomaTumor growthCancer cellsMouse modelTumor organizationOrthotopic allograftsHuman PDAC tissuesTissue organizationLineage tracingCRISPR screen of human pancreatic cancer xenografts identifies a KLF5 proliferation vulnerability through epigenetic modifiers NCAPD2 and MTHFD1
Maeda M, Sherman K, Zhou W, Cheng J, Nihongaki Y, Idrizi A, Tryggvadottir R, Camacho O, Shang X, Min J, Koldobskiy M, Maitra A, Levchenko A, Slusher B, Ji H, Feinberg A. CRISPR screen of human pancreatic cancer xenografts identifies a KLF5 proliferation vulnerability through epigenetic modifiers NCAPD2 and MTHFD1. Molecular Cancer 2026, 25: 75. PMID: 41668133, PMCID: PMC12998327, DOI: 10.1186/s12943-026-02575-z.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMetastatic cell proliferationPrimary tumorHuman patient-derived xenograftsModifier genesHuman pancreatic cancer xenograftsAssociated with patient survivalPrimary pancreatic tumorsPatient-derived xenograftsHuman pancreatic cancerPancreatic cancer xenograftsPro-metastatic genesCell proliferationKLF5 expressionEpigenetic modifier genesPeritoneal metastasisDistant metastasisMetastatic tumorsEpithelial-mesenchymal transitionCRISPR screensXenograft linesCancer xenograftsLung metastasesMetastatic proliferationPancreatic tumorsPatient survivalThe hierarchical timescale hypothesis: Functional and structural convergence of biological networks and artificial neural nets
Lee S, Nemenman I, Levchenko A. The hierarchical timescale hypothesis: Functional and structural convergence of biological networks and artificial neural nets. Cell Systems 2026, 17: 101507. PMID: 41713403, DOI: 10.1016/j.cels.2025.101507.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsArchitecture of artificial neural networksArtificial neural netsSignal transduction networksNeural netsArtificial neural networkNeural networkOptimization processTransduction networksDiverse outputsSignaling networksNetworkBiological networksProcessing of complex signalsLiving cellsStructural convergenceComplex signalsMultiple propertiesSynaptic networksMulti-step processMultiple layersBrain cellsInputSensory inputArchitectureCells
2025
Dynamic decoding of VEGF signaling and coordinated control of multiple phenotypes by the Src-TEM4-YAP pathway
Lee S, Kang T, Shang X, Levchenko A. Dynamic decoding of VEGF signaling and coordinated control of multiple phenotypes by the Src-TEM4-YAP pathway. Cell Systems 2025, 16: 101321. PMID: 40541183, PMCID: PMC12276906, DOI: 10.1016/j.cels.2025.101321.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSequential activation of SrcPaper's transparent peer review processTransparent peer review processActivation of SrcPathway levelMultiple phenotypesPhenotypic outcomesRearrangement of cellsPathway componentsPathway organizationNotch signalingPhysiological processesCell contactSequential activationPathwayVascular endothelial growth factor signalingSignal inputVascular endothelial growth factorDiverse time scalesDynamic decoderCoordinated controlVEGF signalingGrowth factorSignalElevated levelsYAP controls cell migration and invasion through a Rho GTPase switch
Shah S, Ren C, Tippens N, Park J, Mohyeldin A, Wang S, Vela G, Martinez-Gutierrez J, Margolis S, Schmidt S, Quiñones-Hinojosa A, Levchenko A. YAP controls cell migration and invasion through a Rho GTPase switch. Science Signaling 2025, 18: eadu3794. PMID: 40424361, PMCID: PMC12268267, DOI: 10.1126/scisignal.adu3794.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsBrain NeoplasmsCell Line, TumorCell MovementFemaleGlioblastomaGuanine Nucleotide Exchange FactorsHumansMiceNeoplasm InvasivenessPhosphoproteinsProtein Serine-Threonine Kinasesrac1 GTP-Binding ProteinrhoA GTP-Binding ProteinSignal TransductionSTAT3 Transcription FactorTranscription FactorsYAP-Signaling ProteinsConceptsCell migrationGuanine nucleotide exchange factor TrioRegulation of cytoskeletal dynamicsRho family guanosine triphosphatasesInvasive cell spreadTranscriptional coactivator YAPActivation of Rac1Inhibition of RhoAHyperactivation of YAPHuman breast epithelial cellsIncreased cell migrationBreast epithelial cellsGTPase switchAssociated with cancer metastasisMovement of cellsCytoskeletal dynamicsGuanosine triphosphataseSignaling networksInvasion in vitroIntronic enhancerTranscription factorsCell spreadingRac1Invasive behaviorPathological contextsSpecification of human brain regions with orthogonal gradients of WNT and SHH in organoids reveals patterning variations across cell lines
Scuderi S, Kang T, Jourdon A, Nelson A, Yang L, Wu F, Anderson G, Mariani J, Tomasini L, Sarangi V, Abyzov A, Levchenko A, Vaccarino F. Specification of human brain regions with orthogonal gradients of WNT and SHH in organoids reveals patterning variations across cell lines. Cell Stem Cell 2025, 32: 970-989.e11. PMID: 40315847, PMCID: PMC12145255, DOI: 10.1016/j.stem.2025.04.006.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGradient of WntGene expression programsSingle-cell transcriptomicsBrain lineagesMorphogen gradientsEpigenetic variationDorso-ventral axisShh signalingExpression programsMorphogenFetal human brainHuman iPSC linesPluripotent stem cellsCell linesNeuronal lineageNeural tubeShhWntLineagesLine-to-line variationEarly patterningPattern systemPattern variationHuman brain regionsIPSC linesCas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering
Tang K, Zhou L, Tian X, Fang S, Vandenbulcke E, Du A, Shen J, Cao H, Zhou J, Chen K, Kim H, Luo Z, Xin S, Lin S, Park D, Yang L, Zhang Y, Suzuki K, Majety M, Ling X, Lam S, Chow R, Ren P, Tao B, Li K, Codina A, Dai X, Shang X, Bai S, Nottoli T, Levchenko A, Booth C, Liu C, Fan R, Dong M, Zhou X, Chen S. Cas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering. Nature Biomedical Engineering 2025, 9: 1290-1308. PMID: 40114032, PMCID: PMC12360953, DOI: 10.1038/s41551-025-01371-2.Peer-Reviewed Original ResearchCitationsAltmetricConceptsKnock-In MiceBone marrow-derived dendritic cellsCD8+ T cellsNon-viral delivery vehiclesAdeno-associated virusDisease modelsCD4+Dendritic cellsC57BL/6 backgroundT cellsConstitutive expressionB cellsLipid nanoparticlesEx vivoGenome editingMiceMultiplex genome engineeringROSA26 locusGene interaction networksMultiplex genome editingLiver tissueTargeted genome editingDiseaseDelivery vehiclesCRISPR RNA
2024
TGF-β1 Drives Integrin-Dependent Pericyte Migration and Microvascular Destabilization in Fibrotic Disease
Pellowe A, Wu M, Kang T, Chung T, Ledesma-Mendoza A, Herzog E, Levchenko A, Odell I, Varga J, Gonzalez A. TGF-β1 Drives Integrin-Dependent Pericyte Migration and Microvascular Destabilization in Fibrotic Disease. American Journal Of Pathology 2024, 194: 1171-1184. PMID: 38548268, PMCID: PMC11220919, DOI: 10.1016/j.ajpath.2024.02.021.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSpatial–temporal order–disorder transition in angiogenic NOTCH signaling controls cell fate specification
Kang T, Bocci F, Nie Q, Onuchic J, Levchenko A. Spatial–temporal order–disorder transition in angiogenic NOTCH signaling controls cell fate specification. ELife 2024, 12: rp89262. PMID: 38376371, PMCID: PMC10942579, DOI: 10.7554/elife.89262.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCell fate specificationFate specificationNotch signalingMorphogenic processesCell-cell communicationComplex morphogenic processesCell fateDynamics of spatial patternsDepletion of fibronectinTip cellsSprout extensionAngiogenic morphogenesisHypoxic micro-environmentCell plasticityCellsComputational analysisPre-existing onesCell patternMicro-environmentSpatial patternsLocal enrichmentMorphogenesisEndothelial cellsAngiogenesis modelFibronectinSpatial–temporal order–disorder transition in angiogenic NOTCH signaling controls cell fate specification
Kang T, Bocci F, Nie Q, Onuchic J, Levchenko A. Spatial–temporal order–disorder transition in angiogenic NOTCH signaling controls cell fate specification. ELife 2024, 12 DOI: 10.7554/elife.89262.3.Peer-Reviewed Original ResearchCitationsConceptsCell fate specificationStalk cellsCell type-specificTip cellsNotch signalingFate specificationStalk cell differentiationMorphogenic processesDensity of fibronectinType-specificCell typesCell-cell communicationComplex morphogenic processesResponse to elevated levelsCell fateCell identityDynamics of spatial patternsDepletion of fibronectinEnvironmental cuesSignaling moleculesBlood vessel sproutingSprout extensionAngiogenic morphogenesisSignaling pathwayHypoxic micro-environment
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News
- May 01, 2025Source: Yale News
How Molecular Traffic Cops Guide Development of the Human Brain
- July 27, 2023
Yale Scientists Develop a New Approach to Strengthen CAR-T Cell Therapy for Cancer Treatment
- April 04, 2023Source: Yale Daily News
Researchers explore the role of cellular plasticity in cancer
- February 23, 2023Source: Big Think
Cancer evolution is mathematical
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