Voluntary Faculty
Voluntary faculty are typically clinicians or others who are employed outside of the School but make significant contributions to department programs at the medical center or at affiliate institutions.
Voluntary rank detailsAnderson M. Winkler, MD, DPhil
Assistant Clinical ProfessorAbout
Research
Publications
2026
Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder
Cardoso Saraiva L, Sato J, Sebenius I, Dzinalija N, del Río-Torné C, Godinho F, Lopes A, Fernandez T, Lima M, Ramos V, Iglesio R, Abe Y, Alonso P, Ameis S, Anticevic A, Araújo A, Arnold P, Balachander S, Banaj N, Batistuzzo M, Benedetti F, Bollettini I, Bravi B, Brennan B, Buitelaar J, Castelo-Branco M, Choi S, Costa A, Dallaspezia S, Denys D, Duarte I, Echevarria M, Eng G, Fernandes A, Feusner J, Figee M, Fitzsimmons S, Fontenelle L, Grazioplene R, Ha M, Hinojosa A, Hoexter M, Huijser C, Hu H, James A, Kim M, Kwon J, Lazaro L, Lochner C, Machado-Sousa M, van Marle H, Martínez-Zalacaín I, Mataix-Cols D, Menchón J, Minuzzi L, Morgado P, Muñoz-Moreno E, Nakao T, Narayanaswamy J, Nurmi E, O’Neill J, Park I, Phillips M, Piacentini J, Picó-Pérez M, Piras F, Piras F, Postma T, Li C, Reddy J, van Rooij D, Sakai Y, de Salles Andrade J, Scheffler F, Shivakumar V, Soreni N, Stern E, van der Straten A, Thomopoulos S, Tomiyama H, Tovar-Moll F, Vecchio D, Veltman D, Venkatasubramanian G, Vriend C, Wang Z, van der Werf Y, van Wingen G, Zhao Q, Charney A, Cho Y, Shavitt R, Pushkarskaya H, Soriano-Mas C, Romero-Garcia R, Thompson P, Stein D, van den Heuvel O, Winkler A, Miguel Filho E, Pittenger C, Cappi C. Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder. Nature Communications 2026 PMID: 42343090, DOI: 10.1038/s41467-026-74153-2.Peer-Reviewed Original ResearchObsessive-compulsive disorderPostmortem brain studiesBrain morphologyStudies of obsessive-compulsive disorderCortical alterationsStudies of brain morphologyDorsolateral prefrontal cortexBrain structural alterationsSubcortical shape alterationsTranscriptomic decodingPrefrontal cortexFrontoparietal networkDefault modeNeuroimaging phenotypesSensorimotor regionsMental illnessNetwork phenotypesRegional alterationsCortical curvatureExcitatory neuronsDisordersStructural phenotypesMedication useGene expression patternsSimilar alterationsBrain age prediction in generalized anxiety disorder using a convolutional neural network
Richier C, Zugman A, Harrewijn A, Cardinale E, Khosravi P, Aghajani M, Bruin W, Hilbert K, Cardoner N, Porta-Casteràs D, Cano M, Gosnell S, Salas R, Jackowski A, Pan P, Salum G, Blair K, Blair J, Milad M, Burkhouse K, Phan K, Schroeder H, Strawn J, Beesdo-Baum K, Jahanshad N, Thomopoulos S, Nielsen J, Smoller J, Soares J, Mwangi B, Wu M, Zunta-Soares G, Assaf M, Diefenbach G, Brambilla P, Maggioni E, Hofmann D, Straube T, Andreescu C, Price R, Manfro G, Agosta F, Canu E, Cividini C, Filippi M, Kostić M, Munjiza Jovanovic A, Benson B, Freitag G, Leibenluft E, Ringlein G, Werwath K, Zwiebel H, Grabe H, Van der Auwera S, Wittfeld K, Völzke H, Bülow R, Balderston N, Ernst M, Mujica-Parodi L, van Nieuwenhuizen H, Critchley H, Makovac E, Mancini M, Meeten F, Ottaviani C, Fonzo G, Paulus M, Stein M, Gur R, Gur R, Kaczkurkin A, Larsen B, Satterthwaite T, Harper J, Perino M, Sylvester C, Yu Q, McClure P, Pereira F, Lueken U, Veltman D, Thompson P, Groenewold N, Bas-Hoogendam J, Stein D, Van der Wee N, Winkler A, Pine D, Sawyers C. Brain age prediction in generalized anxiety disorder using a convolutional neural network. Translational Psychiatry 2026 PMID: 42177199, DOI: 10.1038/s41398-026-04078-3.Peer-Reviewed Original ResearchGeneralized anxiety disorderPredicting age differencesBrain agingAnxiety disordersAge differencesAssociated with several psychiatric disordersHealthy controlsBrain-predicted age differenceBrain age differenceBrain age prediction modelSevere psychiatric disordersBrain aging researchBrain age predictionComorbid diagnosesPsychiatric disordersGroup differencesStructural MRIExploratory analysisAge prediction modelBrainDisordersChronological ageInput modalitiesAging ResearchIndividuals418. Decoding Generalized Anxiety Disorder From Structural Magnetic Resonance Imaging: A Machine Learning ENIGMA-Anxiety Study
Porta-Casteràs D, Bas-Hoogendam J, Groenewold N, Members E, Harrewijn A, Winkler A, Zugman A, Radua J, Thompson P, van der Wee N, Stein D, Pine D, Cardoner N, Cano M. 418. Decoding Generalized Anxiety Disorder From Structural Magnetic Resonance Imaging: A Machine Learning ENIGMA-Anxiety Study. Biological Psychiatry 2026, 99: s278-s279. DOI: 10.1016/j.biopsych.2026.03.652.Peer-Reviewed Original ResearchBrain Age Prediction in Generalized Anxiety Disorder Using Functional Neuroimaging and Graph Convolutional Neural Networks
Richier C, Zugman A, Group E, Winkler A, Pine D, Sawyers C. Brain Age Prediction in Generalized Anxiety Disorder Using Functional Neuroimaging and Graph Convolutional Neural Networks. Biological Psychiatry 2026, 99: s69. DOI: 10.1016/j.biopsych.2026.03.170.Peer-Reviewed Original ResearchBrain Age Examination in Youth Anxiety Disorders: A Mega-Analysis of 4,312 Individuals From 92 Global Sites by the Enigma-Anxiety Working Group
Aghajani M, Bruin W, Ernsting J, Blake K, Bas-Hoogendam J, Groenewold N, Zugman A, Sawyers C, Winkler A, Hilbert K, Lueken U, Thompson P, Pine D, Stein D, van der Wee N, Hahn T. Brain Age Examination in Youth Anxiety Disorders: A Mega-Analysis of 4,312 Individuals From 92 Global Sites by the Enigma-Anxiety Working Group. Biological Psychiatry 2026, 99: s70. DOI: 10.1016/j.biopsych.2026.03.171.Peer-Reviewed Original ResearchBrain Age Prediction in Generalized Anxiety Disorder: Findings From the ENIGMA-Anxiety Working Group
Richier C, Zugman A, members E, Thompson P, van der Wee N, Stein D, Bas-Hoogendam J, Groenewold N, Winkler A, Pine D, Sawyers C. Brain Age Prediction in Generalized Anxiety Disorder: Findings From the ENIGMA-Anxiety Working Group. Biological Psychiatry 2026, 99: s69. DOI: 10.1016/j.biopsych.2026.03.169.Peer-Reviewed Original ResearchStructural brain analysis in focal upper limb dystonia
de Faria D, Paulo A, de Paiva J, Winkler A, Borges V, Silva S, Ferraz H, de Carvalho Aguiar P. Structural brain analysis in focal upper limb dystonia. Scientific Reports 2026, 16: 9112. PMID: 41691019, PMCID: PMC12996275, DOI: 10.1038/s41598-026-39542-z.Peer-Reviewed Original ResearchConceptsDiffusion tensor imagingWhole-brain vertex-wise analysesStructural magnetic resonance imagingWhite matter microstructural integrityVertex-wise analysisTract-based spatial statisticsRight-handed individualsMagnetic resonance imagingDiffusion tensor imaging dataStructural brain analysisROI-based analysisDiffusion tensor imaging metricsPermutation-based statisticsBrain analysisBetween-group differencesWhole-brainWhite matter changesProbabilistic tractographyBasal gangliaMicrostructural integrityCortical morphologyCortical thicknessMulti-modal studyInconsistent findingsLimb dystoniaA comprehensive framework for statistical testing of brain dynamics
Larsen N, Paulsen L, Ahrends C, Winkler A, Vidaurre D. A comprehensive framework for statistical testing of brain dynamics. Nature Protocols 2026, 1-32. PMID: 41555071, DOI: 10.1038/s41596-025-01300-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsHidden Markov ModelNeural activity dataStep-by-step tutorialsPython libraryGraphical interfaceOpen-source Python packageNeural dataTemporal domainPython packageMarkov modelProgramming experienceNon-imaging variablesAnalysis of brain dynamicsBrain dynamicsMonte Carlo resamplingHierarchical relationshipsMultiple testing correctionTask-basedComprehensive frameworkProtocolActivity dataPermutation-based methodsFrameworkStatistical testsComprehensive documentationStructural brain differences associated with panic disorder: an ENIGMA-Anxiety Working Group mega-analysis of 4924 individuals worldwide
Han L, Bruin W, Bas-Hoogendam J, Groenewold N, Hilbert K, Winkler A, Zugman A, Asami T, Barber J, Benedetti F, Blair R, Böhnlein J, Brambilla P, Breuer F, Buckner R, Bülow R, Calkins M, Chechko N, Dannlowski U, Dohm K, Domschke K, Dresler T, Erhardt-Lehmann A, Fonzo G, Forstner A, Grabe H, Grotegerd D, Gur R, Gur R, Harmer C, Hofmann D, van den Heuvel O, Jahanshad N, Kircher T, Koch K, Laansma M, Langhammer T, Lee S, Leehr E, Maggioni E, Marino C, Meinert S, Meinert H, Milrod B, Mwangi B, Nielsen J, Ohrmann P, Pantazatos S, Paulus M, Penninx B, Poletti S, Reinecke A, Ridderbusch I, Rjabtsenkov P, Sämann P, Satterthwaite T, Schmaal L, Schrammen E, Soares J, Solomonov N, Stein M, Straube B, Straube T, Suarez-Jimenez B, Smoller J, Talati A, Thomopoulos S, Vazquez C, Völzke H, Wittfeld K, Wu M, Yang Y, Zunta Soares G, Lueken U, Thompson P, Pine D, Stein D, van der Wee N, Veltman D, Aghajani M. Structural brain differences associated with panic disorder: an ENIGMA-Anxiety Working Group mega-analysis of 4924 individuals worldwide. Molecular Psychiatry 2026, 31: 2402-2417. PMID: 41530384, PMCID: PMC13099435, DOI: 10.1038/s41380-025-03376-4.Peer-Reviewed Original ResearchPanic disorderNeurocircuitry modelsAssociated with panic disorderStructural brain correlatesFronto-temporo-parietal regionsStructural brain differencesTemporo-parietal regionsLarger lateral ventriclesCortical surface areaBrain correlatesBrain differencesCaudate volumeNeuroanatomical findingsModel of PDSubcortical differencesMega-AnalysisNeuroimaging databaseLate adulthoodHealthy controlsInconsistent effectsLateral ventricleDisordersAdulthoodIndividualsNeurocircuitry
2025
Striatal compartment and white matter alterations in focal dystonia Subtypes: An MRI study
Marques Paulo A, Waugh J, Winkler A, Queiroz de Paiva J, de Faria D, Borges V, Silva S, de Ferraz H, Aguiar P. Striatal compartment and white matter alterations in focal dystonia Subtypes: An MRI study. Parkinsonism & Related Disorders 2025, 141: 108096. PMID: 41172714, DOI: 10.1016/j.parkreldis.2025.108096.Peer-Reviewed Original ResearchConceptsWhite matter alterationsHealthy controlsCervical dystoniaStriatal compartmentsUpper limb dystoniaCD patientsDystonia patientsStructural brain differencesDystonia subtypesAssociated with sensorimotorRight corona radiataT1-weighted imagesFocal dystonia patientsLeft caudateBrain differencesLimbic functionsLimb dystoniaSymptom severityLeft striatumNeuroanatomical patternsRight thalamusPutaminal volumeGlobus pallidusStriatumPathophysiological mechanisms