Chiang-Shan Ray Li, MD, PhD
Professor of Psychiatry and of NeuroscienceCards
Appointments
Contact Info
Psychiatry
CMHC S112, 34 Park Street
New Haven, CT 06519
United States
About
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Titles
Professor of Psychiatry and of Neuroscience
Biography
I am a Professor of Psychiatry and of Neuroscience at Yale University School of Medicine. I graduated from National Taiwan University College of Medicine and California Institute of Technology and has been a faculty member at Yale since 2003. My earlier work employed non-human primate models to understand the neural bases of cognition. Current research in my laboratory continues to focus on systems neuroscience. By combining psychophysics, computational modeling and brain imaging we explore the circuit mechanisms of a multitude of cognitive constructs, including self control, affect regulation, and reward-related processes. The primary goals are to understand systems neural bases of these cognitive processes and how these neural processes contribute to the etiology of psychiatric and neurological illnesses, with a specific emphasis on addiction.
Appointments
Psychiatry
ProfessorPrimaryNeuroscience
ProfessorSecondary
Other Departments & Organizations
Education & Training
- Resident
- Chang Gung Memorial Hospital (2001)
- Postdoctoral Associate
- Massachusetts Institute of Technology (1998)
- PhD
- California Institute of Technology, Computation and Neural Systems (1996)
- MD
- National Taiwan University, Medicine (1989)
Research
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Overview
Medical Research Interests
ORCID
0000-0002-9393-1212
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Xingguang Luo, MD
Shefali Chaudhary
Jaime Ide, PhD
Sheng Zhang, PhD
Thang Le, PhD
Herta Chao, MD, PhD
Mental Disorders
Central Nervous System
Drug Users
Nervous System Diseases
Publications
2026
Seeking stimulation: Memory and arousal in high vs. low sensation seekers
Li L, Wang P, Wei P, Guo X, Tang X, Li C, Hu K, Li Q, Guo C. Seeking stimulation: Memory and arousal in high vs. low sensation seekers. Personality And Individual Differences 2026, 259: 113859. DOI: 10.1016/j.paid.2026.113859.Peer-Reviewed Original ResearchRegional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder
Cardoso Saraiva L, Sato J, Sebenius I, Dzinalija N, del Río-Torné C, Godinho F, Lopes A, Fernandez T, Lima M, Ramos V, Iglesio R, Abe Y, Alonso P, Ameis S, Anticevic A, Araújo A, Arnold P, Balachander S, Banaj N, Batistuzzo M, Benedetti F, Bollettini I, Bravi B, Brennan B, Buitelaar J, Castelo-Branco M, Choi S, Costa A, Dallaspezia S, Denys D, Duarte I, Echevarria M, Eng G, Fernandes A, Feusner J, Figee M, Fitzsimmons S, Fontenelle L, Grazioplene R, Ha M, Hinojosa A, Hoexter M, Huijser C, Hu H, James A, Kim M, Kwon J, Lazaro L, Lochner C, Machado-Sousa M, van Marle H, Martínez-Zalacaín I, Mataix-Cols D, Menchón J, Minuzzi L, Morgado P, Muñoz-Moreno E, Nakao T, Narayanaswamy J, Nurmi E, O’Neill J, Park I, Phillips M, Piacentini J, Picó-Pérez M, Piras F, Piras F, Postma T, Li C, Reddy J, van Rooij D, Sakai Y, de Salles Andrade J, Scheffler F, Shivakumar V, Soreni N, Stern E, van der Straten A, Thomopoulos S, Tomiyama H, Tovar-Moll F, Vecchio D, Veltman D, Venkatasubramanian G, Vriend C, Wang Z, van der Werf Y, van Wingen G, Zhao Q, Charney A, Cho Y, Shavitt R, Pushkarskaya H, Soriano-Mas C, Romero-Garcia R, Thompson P, Stein D, van den Heuvel O, Winkler A, Miguel Filho E, Pittenger C, Cappi C. Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder. Nature Communications 2026 PMID: 42343090, DOI: 10.1038/s41467-026-74153-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricSex differences in resting-state hypothalamic connectivity and its relationship with negative emotion and behavior measures in young adults
Li G, Shao Y, Yang L, Su Y, Wang M, Zhang Z, Sun X, Li B, Wang X, Chen Y, Bin G, Li C. Sex differences in resting-state hypothalamic connectivity and its relationship with negative emotion and behavior measures in young adults. Brain Structure And Function 2026, 231: 79. PMID: 42223498, DOI: 10.1007/s00429-026-03131-7.Peer-Reviewed Original ResearchGABAergic bases of connectivity alterations in the ventral tegmental area of young drinkers: An analysis using the combined technologies of JuSpace toolbox and resting-state functional magnetic resonance imaging
Wang S, Hao D, Su Y, Wang X, Yan Y, Chen Y, Li G, Li C. GABAergic bases of connectivity alterations in the ventral tegmental area of young drinkers: An analysis using the combined technologies of JuSpace toolbox and resting-state functional magnetic resonance imaging. Advanced Technology in Neuroscience 2026, 3: 49-56. DOI: 10.4103/atn.atn-d-25-00031.Peer-Reviewed Original ResearchEarly Clinical Symptom Patterns Predict the Subsequent Treatment Response of Patients with Acute Schizophrenia
Liu Z, Chen W, Wang X, Huang J, Gou M, Han H, Wang J, Wang D, Chen S, Xie T, Tian L, Luo X, Li C, Li Y, Tan Y. Early Clinical Symptom Patterns Predict the Subsequent Treatment Response of Patients with Acute Schizophrenia. Schizophrenia Bulletin 2026, 52: sbag009. PMID: 41863369, PMCID: PMC13005118, DOI: 10.1093/schbul/sbag009.Peer-Reviewed Original ResearchCitationsHappy and threatening faces differentially influence facilitation and interference over time
Hu K, Hu Y, Liu F, Fan Q, Xu H, Li Q, He S, Li C. Happy and threatening faces differentially influence facilitation and interference over time. Psychological Research 2026, 90: 36. PMID: 41697379, DOI: 10.1007/s00426-026-02237-1.Peer-Reviewed Original ResearchAlcohol misuse and negative emotion processing in neurotypical drinkers: Sex differences in behavioral and neural markers
Chaudhary S, Chen Y, Wong H, Chao H, Li C. Alcohol misuse and negative emotion processing in neurotypical drinkers: Sex differences in behavioral and neural markers. Psychiatry Research Neuroimaging 2026, 358: 112174. PMID: 41691915, PMCID: PMC12990894, DOI: 10.1016/j.pscychresns.2026.112174.Peer-Reviewed Original ResearchModifications on histone tails in psychiatric disorders.
Mao Q, Luo Z, Yu Z, Chen B, Wang K, Cao Y, Ji J, Wang F, Zuo L, Li C, Wang X, Zhang Y, Luo X. Modifications on histone tails in psychiatric disorders. EC Psychology And Psychiatry 2026, 15 PMID: 42079388, PMCID: PMC13134692.Peer-Reviewed Original ResearchFunctional inputs to the subgenual cingulate cortex differentiate levels of depressive symptom severity in neurotypical young adults: granger causality and clustering analyses
Li H, Chen Y, Chaudhary S, Ide J, Li C. Functional inputs to the subgenual cingulate cortex differentiate levels of depressive symptom severity in neurotypical young adults: granger causality and clustering analyses. The International Journal Of Neuropsychopharmacology 2026, 29: pyag005. PMID: 41665262, PMCID: PMC12962302, DOI: 10.1093/ijnp/pyag005.Peer-Reviewed Original ResearchCitationsHippocampal subfield differences in people with and without recreational ketamine use: Insights from multi‐modal neuroimaging
Liu Y, Hung C, Potenza M, Chou K, Lee P, Huang C, Li C, Lee T, Lin C. Hippocampal subfield differences in people with and without recreational ketamine use: Insights from multi‐modal neuroimaging. Addiction 2026, 121: 1541-1556. PMID: 41612591, PMCID: PMC13155325, DOI: 10.1111/add.70331.Peer-Reviewed Original ResearchCitationsAltmetric
Clinical Trials
Current Trials
Biomarkers of Clinical Subtype and Treatment Response in Obsessive-Compulsive Disorder
IRB ID0803003626RoleSub InvestigatorPrimary Completion Date04/19/2025Recruiting ParticipantsGenderBothAge18 years - 70 years
Academic Achievements & Community Involvement
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Activities
activity NIH
07/01/2017 - PresentPeer Review Groups and Grant Study SectionsMember
Honors
honor Fellow, International College of Neuropsychopharmacology
07/01/2019International AwardDetailsUnited Stateshonor Member, American College of Neuropsychopharmacology
12/01/2016International AwardDetailsUnited Stateshonor Fellow, Association of Psychological Science
11/01/2016International AwardDetailsUnited States
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Psychiatry
CMHC S112, 34 Park Street
New Haven, CT 06519
United States