Alaa Alashi, MD, MHS
Clinical FellowAbout
Research
Publications
2026
Simulated evaluation of large language model stepwise diagnostic reasoning with real-world chest pain encounters and Bayesian networks
Safranek C, Socrates V, Wright D, Huang T, Alashi A, McCann K, Taylor R, Chartash D. Simulated evaluation of large language model stepwise diagnostic reasoning with real-world chest pain encounters and Bayesian networks. BMC Medical Informatics And Decision Making 2026, 26: 97. PMID: 41735989, DOI: 10.1186/s12911-026-03381-9.Peer-Reviewed Original ResearchConceptsBayesian networkRank biased overlapCategory constraintsIterative natureInformation-seeking behaviorInformation-seeking strategiesLanguage modelRobust simulation environmentClinical decision-support toolsSimulation evaluationSimulation environmentProbabilistic frameworkFalse alarmsProbabilistic modelEmergency departmentImage dataResource utilizationDiagnostic reasoningOptimal policyDecision-support toolNetworkDiagnostic decisionsQuery pathwayPhysician practice patternsChest pain
2025
Predicting 30-day and 1-year mortality in heart failure with preserved ejection fraction (HFpEF)
Shin I, Bhatt N, Alashi A, Kandala K, Murugiah K. Predicting 30-day and 1-year mortality in heart failure with preserved ejection fraction (HFpEF). PLOS ONE 2025, 20: e0336809. PMID: 41237168, PMCID: PMC12617840, DOI: 10.1371/journal.pone.0336809.Peer-Reviewed Original ResearchConceptsElectronic health recordsSHapley Additive exPlanationsMachine learningElectronic health record dataIndividual feature importanceOversampling techniquePrediction modelEHR dataPreserved Ejection FractionFeature importanceTest setRandom forestHealth recordsSHapley Additive exPlanations analysisEjection fractionCross-validationModel classPrimary diagnosisHeart failureModel performanceDiagnosis of HFpEFMIMIC-IVHeart failure patientsICD-9Logistic regressionA generalizable diffusion framework for 3D low-dose and few-view cardiac SPECT imaging
Xie H, Gan W, Ji W, Chen X, Alashi A, Thorn S, Zhou B, Liu Q, Xia M, Guo X, Liu Y, An H, Kamilov U, Wang G, Sinusas A, Liu C. A generalizable diffusion framework for 3D low-dose and few-view cardiac SPECT imaging. Medical Image Analysis 2025, 106: 103729. PMID: 40752375, PMCID: PMC12360895, DOI: 10.1016/j.media.2025.103729.Peer-Reviewed Original ResearchConceptsImage qualityNetwork re-trainingDeep learning methodsCardiac SPECT imagingLow-doseSPECT imagesContextual informationDiffusion frameworkLearning methodsConsistency strategyRe-trainingAcquisition settingsLow count levelsFine-tuningSpatial informationVariation constraintCardiac catheterization resultsImage dataMyocardial perfusion imagingCoronary artery diseaseProjection dataCatheterization resultsImage volumesScanner geometryProjective measurementsIncreasing angular sampling for dedicated cardiac single photon emission computed tomography scanner: Implementation with deep learning and validation with human data
Xie H, Alashi A, Thorn S, Chen X, Zhou B, Sinusas A, Liu C. Increasing angular sampling for dedicated cardiac single photon emission computed tomography scanner: Implementation with deep learning and validation with human data. Journal Of Nuclear Cardiology 2025, 49: 102168. PMID: 39986346, PMCID: PMC12227299, DOI: 10.1016/j.nuclcard.2025.102168.Peer-Reviewed Original Research
2024
Association of Histologic Findings With Long-Term Outcomes in Symptomatic Obstructive Hypertrophic Cardiomyopathy Patients Undergoing Surgical Myectomy
Jadam S, Gaballa A, Alashi A, Xu B, Thamilarasan M, Rodriguez E, Tan C, Ospina S, Smedira N, Popovic Z, Desai M. Association of Histologic Findings With Long-Term Outcomes in Symptomatic Obstructive Hypertrophic Cardiomyopathy Patients Undergoing Surgical Myectomy. JACC Heart Failure 2024, 13: 631-640. PMID: 39545888, DOI: 10.1016/j.jchf.2024.10.006.Peer-Reviewed Original ResearchObstructive hypertrophic cardiomyopathySurgical myectomyLong-term outcomesMyocyte hypertrophyInterstitial fibrosisHistological findingsHypertrophic cardiomyopathyObstructive hypertrophic cardiomyopathy patientsHistological scoresAssociated with long-term outcomesSevere histological findingsHypertrophic cardiomyopathy patientsKaplan-Meier analysisMultivariate Cox analysisLeft ventricular hypertrophyComposite of deathPrimary eventDiastolic dysfunctionCardiac transplantationPrimary endpointTertiary centerCardiomyopathy patientsMicrovascular ischemiaVentricular hypertrophyCox analysisMitral Stenosis and Pulmonary Pressure: Rewriting the Classics or Stuck in the Past?
Alashi A, Desai M. Mitral Stenosis and Pulmonary Pressure: Rewriting the Classics or Stuck in the Past? Circulation Cardiovascular Imaging 2024, 17: e017514. PMID: 39714121, DOI: 10.1161/circimaging.124.017514.Peer-Reviewed Original ResearchDiastolic Stress Echocardiography in Patients With Hypertrophy Cardiomyopathy: Association With Exercise Capacity
Fava A, Popovic Z, Alashi A, Thamilarasan M, Xu B, Desai M. Diastolic Stress Echocardiography in Patients With Hypertrophy Cardiomyopathy: Association With Exercise Capacity. The American Journal Of Cardiology 2024, 232: 34-40. PMID: 39307332, DOI: 10.1016/j.amjcard.2024.09.017.Peer-Reviewed Original ResearchTreadmill exercise echocardiographyHypertrophic cardiomyopathyCongestive heart failureDiastolic parametersExercise capacityStress echocardiographyAssociated with reduced exercise capacityPrecipitate congestive heart failureLeft ventricular (LVAsymptomatic/minimally symptomatic patientsDiastolic stress echocardiographyMultivariate logistic regression analysisSymptomatic HCM patientsEtiology of dyspneaHigher Body Mass IndexBody mass indexReduced exercise capacityExercise functional capacityLogistic regression analysisAssociated with <Incremental diagnostic utilityHigher LAViLVOT gradientE/e' ratioDiastolic dysfunctionDevelopment Of Ct Quantitative Tools To Assess Collateral Formation In Rabbit Model Of Hind Limb Ischemia: Implications For Evaluation Of Vascular Reserve.
Vermillion B, Jang S, Alashi A, Burns R, Guerrera N, Depino A, Martins S, Papademetris X, Zeiss C, Guo L, Liu C, Thorn S, Sinusas A. Development Of Ct Quantitative Tools To Assess Collateral Formation In Rabbit Model Of Hind Limb Ischemia: Implications For Evaluation Of Vascular Reserve. Journal Of Cardiovascular Computed Tomography 2024, 18: s50-s51. DOI: 10.1016/j.jcct.2024.05.117.Peer-Reviewed Original ResearchNon-invasive Estimation Of Right Ventricle-Pulmonary Artery Coupling Using Multiphase Cardiac Computed Tomography Angiography In Pig Model Of Acute Respiratory Distress Syndrome
Jang S, Thorn S, Vermillion B, Alashi A, Zohora F, Lee S, Ahn S, Burns R, Dela Cruz C, Zeiss C, Spinale F, Heerdt P, Sinusas A. Non-invasive Estimation Of Right Ventricle-Pulmonary Artery Coupling Using Multiphase Cardiac Computed Tomography Angiography In Pig Model Of Acute Respiratory Distress Syndrome. Journal Of Cardiovascular Computed Tomography 2024, 18: s46. DOI: 10.1016/j.jcct.2024.05.106.Peer-Reviewed Original ResearchComparative study of functional and structural muscle changes in peripheral artery disease: rubidium-82 positron emission tomography and histological correlation
Alashi A, Vermillion B, Callegari S, Burns R, Guo L, Moulton E, Guerrera N, Depino A, Papademetris X, Zeiss C, Thorn S, Liu C, Sinusas A. Comparative study of functional and structural muscle changes in peripheral artery disease: rubidium-82 positron emission tomography and histological correlation. European Heart Journal - Cardiovascular Imaging 2024, 25: jeae142.087. DOI: 10.1093/ehjci/jeae142.087.Peer-Reviewed Original ResearchPeripheral arterial diseaseStandardized uptake valueHindlimb ischemia modelReactive hyperemiaSkeletal muscle perfusionPerfusion reserveCapillary densityPET imagingArtery diseaseNon-ischemicRubidium-82 positron emission tomographyType 2 muscle fibersRelevant pre-clinical modelIndicative of fibrosisManagement of peripheral arterial diseaseCapillary to muscle fiber ratioClinically relevant pre-clinical modelPre-clinical modelsMuscle perfusionFast myosinWeeks post-ligationRb-82 uptakeEvaluate treatment strategiesRabbit hindlimb ischemia modelPositron emission tomography
Academic Achievements & Community Involvement
News
News
- November 12, 2025
Inaugural Cardiovascular Medicine Translational Research Award Announces First Recipients
- April 01, 2024
Yale Faculty Present Groundbreaking Clinical Research at the 2024 American College of Cardiology Scientific Sessions
- February 01, 2023
2023 American College of Cardiology late-breaking clinical trials and abstracts from Yale
- August 12, 2022
Career Development Pathways for Early-Stage Investigators