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INFORMATION FOR

    Ala F Nassar, PhD

    Senior Research Scientist
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    Contact Info

    Yale School of Medicine

    600 west campus drive

    West Haven, CT 06516

    United States

    About

    Titles

    Senior Research Scientist

    Biography

    Ala F. Nassar, PhD, is a faculty member at Yale University. He has over 25 years of experience in Drug Metabolism and Preclinical Drug Development with leadership roles in both big pharma, smaller biotech firms and academics (UCONN, Brandeis and Yale). He has published more than 100 articles and chapters and holds patents in the fields of drug metabolism and bioanalytical chemistry. He leads and executes ADME-Tox experiments supporting grant projects. He was the head of the drug metabolism and bioanalytical department at Vion Pharmaceuticals, where his studies of the ADME-Tox properties of Laromustine led to a fuller, more accurate and detailed understanding of the human toxicities of the drug. He was an Ass. Professor of chemistry department and the director of Mass Spectrometry Facility at Brandeis University in Waltham, MA before coming to Yale. He has served on numerous editorial boards and is the editor of the previous edition of Drug Metabolism Handbook: Concepts and Applications and Biotransformation and Metabolite Elucidation of Xenobiotics: Characterization and Identification. Co-editor of Pharmaceutical Sciences Encyclopedia: Drug Discovery, Development & Manufacturing, 2010. He was honored as a guest editor of the special issue of Metabolites entitled "MS-Based Drug Metabolism in Cancer Research. 2021"

    Courses Taught and Coordinated

    General chemistry 161 and 162, Central Connecticut State University, Spring 2017

    Advanced Mass Spectrometry course at Brandeis University, Fall 2011

    Coordinated and taught graduate-level course on drug metabolism and bioanalytical chemistry at University of Connecticut, 2003, 2005, 2007 and 2011

    Liquid Chromatography-Mass Spectrometry at Cambridge Healthtech Institute’s World Pharmaceutical Congress Annual Meeting, Philadelphia, PA 2005 and 2007

    Drug Metabolism at Cambridge Healthtech Institute’s World Pharmaceutical Congress Annual Meeting, Philadelphia, PA 2007 and 2008

    Capillary Electrophoresis-Mass Spectrometry, at Battelle Memorial Institute, Columbus, OH 1998

    Departments & Organizations

    Education & Training

    Post Doc
    UCONN/Chemistry/Pharmacology
    PhD
    UCONN, Bioanalytical/Drug Metabolism
    Visiting Scientist
    Kyushu and Nagasaki Universities

    Research

    Overview

    Our research focuses on understanding how structure modification can improve the ADME-Tox profile for new chemical entities as they advance toward clinical candidacy. Our recent efforts use Mass Cytometry & MALDI-IHC as novel tools for Cancer Research. With their capacity for tremendous detail, these techniques produce enhanced investigative power for analyses involving simultaneous cellular profiling of multiple cell populations. Our latest endeavors are focused on an advance in single cell analysis using a hybrid mass spectrometry-flow cytometry instrument to identify and characterize rare cell types in clinical samples. Another emphasis is the development of mass spectrometric and proteomic methods for application in biological and clinical contexts to identify and quantify proteins with greater depth and coverage in a single cell.

    Medical Research Interests

    Mass Spectrometry; Metabolism; Metabolomics; Pharmacology; Proteomics; Single-Cell Analysis

    Public Health Interests

    Cancer

    Research at a Glance

    Yale Co-Authors

    Frequent collaborators of Ala F Nassar's published research.

    Publications

    2024

    2022

    2021

    Academic Achievements & Community Involvement

    • activity

      Metabolites

    • activity

      Journal of Drug Metabolism Letters

    • activity

      The American Society for Mass Spectrometry

    • activity

      CT Science Fair

    • activity

      Metabolites

    Get In Touch

    Contacts

    Mailing Address

    Yale School of Medicine

    600 west campus drive

    West Haven, CT 06516

    United States

    Supported Faculty