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Candie Paulsen, PhD

Business Title Assistant Professor of Molecular Biophysics & Biochemistry

Appointments

Biography

I love exploring the unknown and the thrill and sense of accomplishment that comes with making the unknown familiar. This passion has inspired me to make significant transitions, both conceptually and with methodology, at every stage of my career. I purposefully choose research projects that serve to improve human health as well as stand to make fundamental discoveries of basic biology and physiology. Moreover, I thoroughly enjoy teaching, mentoring, and helping young scientists find the joy in science. As a graduate student with Kate Carroll at the University of Michigan and The Scripps Research Institute in Jupiter, FL, I studied redox regulation of signal transduction cascades important to cancer. As a postdoctoral fellow with David Julius at the University of California, San Francisco, I determined the first structures of an important pain receptor, TRPA1 by cryo-EM. In the Paulsen Lab, we combine my diverse trainings to take a multidisciplinary approach to understand how TRPA1 is regulated and dysregulated by novel natural variants and through protein-protein interactions. This work is carried out with an eye towards discovering what a pain receptor "sees" in a cellular context, how those molecules can modulate its activity basally, and how those interactions may be modified to contribute to the development of chronic pain/inflammation.

Education & Training

  • Staff Scientist
    Yale University (2017)
  • Staff Scientist
    University of California, San Francisco (2017)
  • Postdoctoral Fellow
    University of California, San Francisco (2017)
  • Postdoctoral Fellow
    The Scripps Research Institute (2012)
  • PhD
    University of Michigan, Chemical Biology (2011)
  • BS
    Purdue University, Genetic Biology (2006)

Activities

  • Structure of the human TRPA1 ion channel suggests regulatory mechanisms
    South Hadley, MA, United States 2016
    Ion Channels Gordon Research Conference
  • Structure of the human TRPA1 ion channel suggests regulatory mechanisms
    Los Angeles, CA, United States 2016
    Biophysical Society Annual Meeting
  • Structure of the human TRPA1 ion channel suggests regulatory mechanisms
    Dedham, MA, United States 2015
    Helen Hay Whitney Fellowship Retreat
  • Activation and Regulatory Mechanisms: Insights From Structures of TRPV1 and TRPA1
    Leuven, Flanders, Belgium 2015
    TRP Channel Symposium
  • Sulfenylation Goes Global: Probing Intracellular Targets of Hydrogen Peroxide Produced for Growth Factor Signaling
    Jupiter, FL, United States 2011
    Chemistry Department Seminar
  • “Identification of the Protein Targets of Hydrogen Peroxide Produced for EGF Signaling
    Saint Petersburg, FL, United States 2011
    Enzyme Mechanisms Conference
  • “Identification of the Protein Targets of Hydrogen Peroxide Produced for EGF Signaling
    Saint Petersburg, FL, United States 2011
    Enzyme Mechanism Conference
  • Painting the Cysteine Chapel: New Tools to Probe Oxidation Biology
    Anaheim, CA, United States 2010
    ASBMB Annual Meeting
  • Chemical Dissection of an Essential Redox Switch in Yeast and Identification of the Protein Targets of Hydrogen Peroxide Produced for EGF Signaling
    Lucca, Tuscany, Italy 2010
    Thiol-Based Redox Regulation and Signaling Gordon Conference
  • Chemical Dissection of an Essential Redox Switch in Yeast and Identification of the Protein Targets of Hydrogen Peroxide Produced for EGF Signaling
    Ann Arbor, MI, United States 2010
    Chemical-Biology Interface Symposium
  • Chemical Dissection of an Essential Redox Switch in Yeast
    Washington, DC, United States 2009
    American Chemical Society National Meeting
  • Chemical Dissection of an Essential Redox Switch in Yeast
    Ann Arbor, MI, United States 2009
    VAUGHN Symposium
  • A Chemical Biology Approach to Probing the Yap1-Gpx3 Redox Relay System in Yeast
    Ann Arbor, MI, United States 2008
    PECRUM Symposium
  • A Chemical Biology Approach to Probing the Yap1-Gpx3 Redox Relay System in Yeast
    Ann Arbor, MI, United States 2008
    Life Sciences Institute Symposium

Honors & Recognition

AwardAwarding OrganizationDate
Award in Pain ScholarRita Allen Foundation and the American Pain Society2018
Early Career Research GrantInternational Association for the Study of Pain2018
Howard Hughes Medical Institute Postdoctoral Fellow of the Helen Hay Whitney FoundationHelen Hay Whitney2014
Cardiovascular Research Institute T-32 Postdoctoral FellowshipNational Institutes of Helath2012
Chemistry-Biology Interface NIH T-32 Training GrantNational Institutes of Health2009

Professional Service

OrganizationRoleDate
Frontiers in Pain ResearchGuest Editor2021 - Present
Communications BiologyReviewer2021 - Present
Exploratorium After Dark EventExpert lecturer on the science of peppers and mint (July 2015) and hot sauces (July 2017)2015 - 2017
CellCo-Ad hoc reviewer2014 - 2017
NatureCo-Ad Hoc Reviewer2014 - 2017
Biophysical SocietyMember2014 - Present
American Heart AssociationMember2012 - 2013
American Chemical SocietyMember2006 - 2007
Alpha Chi SigmaProfessional chemistry fraternity member2003 - Present

Departments & Organizations