John H. Krystal MD

Robert L. McNeil, Jr. Professor of Psychiatry and Professor of Neurobiology; Chair, Department of Psychiatry; Chief of Psychiatry, Yale-New Haven Hospital; Director: NIAAA Center for the Translational Neuroscience of Alcoholism; Director, Clinical Neuroscience Division, VA National Center for PTSD; Director, VA Alcohol Research Center; Medical Director, Schizophrenia Biological Research Center, DVA

Research Interests

Neurobiology; Pharmacotherapy; Genetics; Neuroimaging; Schizophrenia; Alcoholism; PTSD


Research Summary

Neurobiology; pharmacotherapy; genetics; neuroimaging; schizophrenia; alcoholism; PTSD


Selected Publications

  • Krystal JH, Sanacora G, Duman RS. Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond. Biol Psychiatry. 2013 Jun 15;73(12):1133-41. doi: 10.1016/j.biopsych.2013.03.026. Review. PubMed PMID: 23726151; PubMed Central PMCID: PMC3671489.
  • Cosgrove KP, McKay R, Esterlis I, Kloczynski T, Perkins E, Bois F, Pittman B, Lancaster J, Glahn DC, O'Malley S, Carson RE, Krystal JH. Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal. Proc Natl Acad Sci U S A. 2014 Dec 1. pii: 201413947. [Epub ahead of print] PubMed PMID: 25453062.
  • Wang XJ, Krystal JH. Computational Psychiatry. Neuron. 2014 Nov 5;84(3):638-654. doi: 10.1016/j.neuron.2014.10.018. Epub 2014 Nov 5. Review. PubMed PMID: 25442941; PubMed Central PMCID: PMC4255477.
  • Krystal JH, State MW. Psychiatric Disorders: Diagnosis to Therapy. Cell. 2014 Mar 27;157(1):201-214. doi: 10.1016/j.cell.2014.02.042. Review. PubMed PMID: 24679536.
  • Jiang L, Gulanski BI, De Feyter HM, Weinzimer SA, Pittman B, Guidone E, Koretski J, Harman S, Petrakis IL, Krystal JH, Mason GF. Increased brain uptake and oxidation of acetate in heavy drinkers. J Clin Invest. 2013 Mar 8. doi:pii: 65153. 10.1172/JCI65153. [Epub ahead of print] PubMed PMID: 23478412.
  • Anticevic A, Gancsos M, Murray JD, Repovs G, Driesen NR, Ennis DJ, Niciu MJ,Morgan PT, Surti TS, Bloch MH, Ramani R, Smith MA, Wang XJ, Krystal JH*, Corlett PR*. NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16720-5. doi: 10.1073/pnas.1208494109. PubMed PMID:23012427; PubMed Central PMCID: PMC3478611.
  • Moghaddam B, Krystal JH. Capturing the angel in "angel dust": twenty years of translational neuroscience studies of NMDA receptor antagonists in animals and humans. Schizophr Bull. 2012 Sep;38(5):942-9. doi: 10.1093/schbul/sbs075. PubMed PMID: 22899397; PubMed Central PMCID: PMC3446228.
  • Krystal JH, Rosenheck RA, Cramer JA, Vessicchio JC, Jones KM, Vertrees JE, Horney RA, Huang GD, Stock C; Veterans Affairs Cooperative Study No. 504 Group. Adjunctive risperidone treatment for antidepressant-resistant symptoms of chronic military service-related PTSD: a randomized trial. JAMA. 2011;306(5):493-502.

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