Voluntary Faculty
Voluntary faculty are typically clinicians or others who are employed outside of the School but make significant contributions to department programs at the medical center or at affiliate institutions.
Voluntary rank detailsBarbara Gulanski, MD, MPH
Associate Clinical ProfessorAbout
Research
Publications
2026
Reversible alterations of brain acetate metabolism associated with alcohol consumption
Kumaragamage C, Jiang L, Angarita G, de Graaf R, Guidone E, Coppoli A, Behar K, Gulanski B, Pittman B, Weinzimer S, Rothman D, Krystal J, Mason G. Reversible alterations of brain acetate metabolism associated with alcohol consumption. Neuropsychopharmacology 2026, 1-9. PMID: 42218273, DOI: 10.1038/s41386-026-02455-6.Peer-Reviewed Original ResearchAlcohol use disorderAlcohol use disorder patientsGlutamate-glutamine neurotransmitter cyclingMedically supervised detoxificationsHeavy drinkersAlcohol consumptionWithin-subject comparisonsLD participantsWeeks abstinenceBrain glucose uptakeUse disorderTreatment-seekingLight drinkersGlutamate-glutamineMagnetic resonance spectroscopyMonths to levelsGlutamate-glutamine cycleNeurotransmitter cyclingGroup effectCerebral metabolic rateDrinkersAbstinenceLong-term recoveryBrainParticipantsTiming of Denosumab Therapy in Relation to Parathyroidectomy in the Setting of Primary Hyperparathyroidism: Case Report
MacLeod R, Ramirez A, Gulanski B, Majumdar S. Timing of Denosumab Therapy in Relation to Parathyroidectomy in the Setting of Primary Hyperparathyroidism: Case Report. Case Reports In Endocrinology 2026, 2026: 8562872. PMID: 42256324, PMCID: PMC13239141, DOI: 10.1155/crie/8562872.Peer-Reviewed Original ResearchDual-energy X-ray absorptiometryBone mineral densityDenosumab therapyPrimary hyperparathyroidismBone densityYears of denosumab therapyReduction of bone mineral densityConsistent with primary hyperparathyroidismRisk of vertebral fracturesMid-normal rangeSteroid-induced osteoporosisTime of parathyroidectomyCalcium/vitamin D supplementationHistory of lupusTreated with alendronateX-ray absorptiometryVitamin D levelsLiberation of calciumOptimal timingPostsurgical hypocalcemiaDenosumab injectionDaily prednisoneDenosumab dosesAntiresorptive therapyParathyroid surgery
2024
Association of Race and Ethnicity with Prescriptions for Continuous Glucose Monitoring Systems Among a National Sample of Veterans with Diabetes on Insulin Therapy
Lipska K, Oladele C, Zawack K, Gulanski B, Mutalik P, Reaven P, Lynch J, Lee K, Shih M, Lee J, Aslan M. Association of Race and Ethnicity with Prescriptions for Continuous Glucose Monitoring Systems Among a National Sample of Veterans with Diabetes on Insulin Therapy. Diabetes Technology & Therapeutics 2024, 26: 908-917. PMID: 39177775, DOI: 10.1089/dia.2024.0152.Peer-Reviewed Original ResearchVeterans with diabetesAssociation of raceCross-sectional analysis of dataU.S. Veterans Health AdministrationNational sample of veteransNational sampleInsulin therapyVeterans Health AdministrationSystem-level factorsSample of veteransNon-Hispanic patientsSelf-reported raceContinuous glucose monitoringCross-sectional analysisContinuous glucose monitoring useRate of prescriptionMultivariate mixed-effects modelAfrican American patientsLatino patientsHealth AdministrationAlaska NativesType 2 diabetesPercentage of patientsSignificant disparitiesMixed-effects models
2023
Metformin prescription for U.S. veterans with prediabetes, 2010–2019
Gulanski B, Goulet J, Radhakrishnan K, Ko J, Li Y, Rajeevan N, Lee K, Heberer K, Lynch J, Streja E, Mutalik P, Cheung K, Concato J, Shih M, Lee J, Aslan M. Metformin prescription for U.S. veterans with prediabetes, 2010–2019. Journal Of Investigative Medicine 2023, 72: 139-150. PMID: 37668313, DOI: 10.1177/10815589231201141.Peer-Reviewed Original ResearchConceptsBody mass indexVeterans Health AdministrationIncident prediabetesHigh riskHealth AdministrationRetrospective observational cohort studyType 2 diabetes mellitusUse of metforminObservational cohort studyProportion of veteransMetformin prescribingGestational diabetesCohort studyMetformin prescriptionDiabetes mellitusDiabetes preventionMass indexCardiovascular diseaseMultivariable modelPrediabetesSubset of individualsMetforminU.S. veteransHealthcare systemVeteransHigher burden of cardiometabolic and socioeconomic risk factors in women with type 2 diabetes: an analysis of the Glycemic Reduction Approaches in Diabetes (GRADE) baseline cohort
Gulanski B, Butera N, Krause-Steinrauf H, Lichtman J, Harindhanavudhi T, Green J, Suratt C, AbouAssi H, Desouza C, Ahmann A, Wexler D, Aroda V, Crandall J, McKee, Behringer-Massera S, Brown-Friday J, Xhori E, Ballentine-Cargill K, Duran S, Estrella H, de la torre S, Lukin J, Phillips L, Burgess E, Olson D, Rhee M, Wilson P, Raines T, Boers J, Costello J, Maher-Albertelli M, Mungara R, Savoye L, White C, Gullett C, Holloway L, Morehead F, Person S, Sibymon M, Tanukonda S, Adams C, Ross A, Balasubramanyam A, Gaba R, Hattery E, Ideozu A, Jimenez J, Montes G, Wright C, Hollander P, Roe E, Jackson A, Smiley A, Burt P, Estrada L, Chionh K, Ismail-Beigi F, Falck-Ytter C, Kassem L, Sood A, Tiktin M, Kulow T, Newman C, Stancil K, Cramer B, Iacoboni J, Kononets M, Sanders C, Tucker L, Werner A, Maxwell A, McPhee G, Patel C, Colosimo L, Krol A, Goland R, Pring J, Alfano L, Kringas P, Hausheer C, Tejada J, Gumpel K, Kirpitch A, Schneier H, Green J, AbouAssi H, Chatterjee R, Feinglos M, Jones J, Khan J, Zimmer R, Furst M, Satterwhite B, Thacker C, Kreider K, Mariash C, Mather K, Ismail H, Lteif A, Mullen M, Hamilton T, Patel N, Riera G, Jackson M, Pirics V, Aguillar D, Howard D, Hurt S, Bergenstal R, Carlson A, Martens T, Johnson M, Hill R, Hyatt J, Jensen C, Madden M, Martin D, Willis H, Konerza W, Yang S, Kleeberger K, Passi R, Fortmann S, Herson M, Mularski K, Glauber H, Prihoda J, Ash B, Carlson C, Ramey P, Schield E, Torgrimson-Ojerio B, Arnold K, Kauffman B, Panos E, Sahnow S, Bays K, Berame K, Cook J, Ghioni D, Gluth J, Schell K, Criscola J, Friason C, Jones S, Nazarov S, Barzilay J, Rassouli N, Puttnam R, Ojoawo B, Nelson R, Curtis M, Hollis B, Sanders-Jones C, Stokes K, El-Haqq Z, Kolli A, Tran T, Wexler D, Larkin M, Meigs J, Chambers B, Dushkin A, Rocchio G, Yepes M, Steiner B, Dulin H, Cayford M, Chu K, DeManbey A, Hillard M, Martin K, Thangthaeng N, Gurry L, Kochis R, Raymond E, Ripley V, Stevens C, Park J, Aroda V, Ghazi A, Magee M, Ressing A, Loveland A, Hamm M, Hurtado M, Kuhn A, Leger J, Manandhar L, Mwicigi F, Sanchez O, Young T, Garg R, Lagari-Libhaber V, Florez H, Valencia, Marks J, Casula S, Oropesa-Gonzalez L, Hue L, Cuadot A, Nieto-Martinez R, Veliz A, Gutt M, Kendal Y, Veciana B, Ahmann A, Aby-Daniel D, Joarder F, Morimoto V, Sprague C, Yamashita D, Cady N, Rivera-Eschright N, Kirchhoff P, Gomez B, Adducci J, Goncharova A, Hox S, Petrovitch H, Matwichyna M, Jenkins V, Broadwater L, Ishii R, Bermudez N, Hsia D, Cefalu W, Greenway F, Waguespack C, King E, Fry G, Dragg A, Gildersleeve B, Arceneaux J, Haynes N, Thomassie A, Pavlionis M, Bourgeois B, Hazlett C, Mudaliar S, Henry R, Boeder S, Pettus J, Diaz E, Garcia-Acosta D, Maggs S, DeLue C, Stallings A, Castro E, Hernandez S, Krakoff J, Curtis J, Killean T, Khalid M, Joshevama E, Diaz E, Martin D, Tsingine K, Karshner T, Albu J, Pi-Sunyer F, Frances S, Maggio C, Ellis E, Bastawrose J, Gong X, Banerji M, August P, Lee M, Lorber D, Brown N, Josephson D, Thomas L, Tsovian M, Cherian A, Jacobson M, Mishko M, Kirkman, Buse J, Dostou J, Machineni S, Young L, Bergamo K, Goley A, Kerr J, Largay J, Guarda S, Cuffee J, Culmer D, Fraser R, Almeida H, Coffer S, Debnam E, Kiker L, Morton S, Josey K, Fuller G, Garvey W, Cherrington A, Dyer D, Lawson M, Griffith O, Agne A, McCullars S, Cohen R, Craig J, Rogge M, Burton K, Kersey K, Wilson C, Lipp S, Meulen M, Adkins C, Onadeko T, Rasouli N, Baker C, Schroeder E, Razzaghi M, Lyon C, Penaloza R, Underkofler C, Lorch R, Douglass S, Steiner S, Sivitz W, Cline E, Knosp L, McConnell J, Lowe T, Herman W, Pop-Busui R, Tan M, Martin C, Waltje A, Katona A, Goodhall L, Eggleston R, Kuo S, Bojescu S, Bule S, Kessler N, LaSalle E, Whitley K, Seaquist E, Bantle A, Harindhanavudhi T, Kumar A, Redmon B, Bantle J, Coe M, Mech M, Taddese A, Lesne L, Smith S, Desouza C, Kuechenmeister L, Shivaswamy V, Burbach S, Rodriguez, Seipel K, Alfred A, Morales A, Eggert J, Lord G, Taylor W, Tillson R, Schade D, Adolphe A, Burge M, Duran-Valdez E, Martinez J, Bancroft A, Kunkel S, Ahmad F, McGinnis D, Pucchetti B, Scripsick E, Zamorano A, DeFronzo R, Cersosimo E, Abdul-Ghani M, Triplitt C, Juarez D, Garza R, Verastiqui H, Wright K, Puckett C, Raskin P, Rhee C, Abraham S, Jordan L, Sao S, Morton L, Smith O, Walker L, Schnurr-Breen L, Ayala R, Kreymer R, Sturgess D, Utzschneider K, Kahn, Wright L, Boyko E, Tsai E, Trence D, Trikudanathan S, Fattaleh B, Montgomery B, Atkinson K, Kozedub A, Concepcion T, Moak C, Prikhodko N, Rhothisen S, Elasy T, Martin S, Shackelford L, Goidel R, Hinkle N, Lovell C, Myers J, Hogan J, McGill J, Salam M, Schweiger T, Kissel S, Recklein C, Clifton M, Tamborlane W, Camp A, Gulanski B, Inzucchi, Pham K, Alguard M, Gatcomb P, Lessard K, Perez M, Iannone L, Montosa A, Magenheimer E, Cefalu W, Fradkin J, Burch H, Bremer A, Nathan D, Lachin J, Krause-Steinrauf H, Younes N, Bebu I, Butera N, Buys C, Fagan A, Gao Y, Ghosh A, Gramzinski, Hall S, Kazemi E, Legowski E, Liu H, Suratt C, Tripputi M, Arey A, Backman M, Bethepu J, Lund C, Dhaliwal P, McGee P, Mesimer E, Ngo L, Steffes M, Seegmiller J, Saenger A, Arends V, Gabrielson D, Conner T, Warren S, Day J, Huminik J, Scrymgeour A, Soliman E, Pokharel Y, Zhang Z, Campbell C, Hu J, Keasler L, Hensley S, Li Y, Mihalcea R, Min D, Perez-Rosas V, Prosser L, Resnicow K, Ye W, Shao H, Zhang P, Luchsinger J, Sanchez D, Assuras S, Groessl E, Sakha F, Chong H, Hillery N, Everett B, Abdouch I, Bahtiyar G, Brantley P, Broyles F, Canaris G, Copeland P, Craine J, Fein W, Gliwa A, Hope L, Lee, Meiners R, Meiners V, O’Neal H, Park J, Sacerdote A, Sledge E, Soni L, Steppel-Reznik J, Turchin A, Brooks-Worrell B, Hampe C, Palmer J, Shojaie A, Higgins J, Fischer L, Golden S, Gonzalez J, Naik A, Walker E, Lotenberg L, Gallivan J, Lim J, Tuncer D. Higher burden of cardiometabolic and socioeconomic risk factors in women with type 2 diabetes: an analysis of the Glycemic Reduction Approaches in Diabetes (GRADE) baseline cohort. BMJ Open Diabetes Research & Care 2023, 11: e003159. PMID: 37094945, PMCID: PMC10151943, DOI: 10.1136/bmjdrc-2022-003159.Peer-Reviewed Original ResearchConceptsBody mass indexRisk factorsSocioeconomic risk factorsCardiovascular diseaseGreater prevalenceContemporary cohortHigher mean body mass indexMean body mass indexType 2 diabetes mellitusBurden of CVDYoung womenBlood pressure targetsGlycemia Reduction ApproachesAngiotensin receptor blockersCardiometabolic risk factorsLow HDL cholesterolPowerful risk factorComparative effectiveness studiesGreater relative riskCross-sectional analysisMetformin monotherapyTarget LDLReceptor blockersPressure targetsSevere obesityPerformance of a modified fracture risk assessment tool for fragility fracture prediction among older veterans living with HIV
Womack J, Murphy T, Leo-Summers L, Kidwai-Khan F, Skanderson M, Gill T, Gulanski B, Rodriguez-Barradas M, Tien P, Yin M, Hsieh E. Performance of a modified fracture risk assessment tool for fragility fracture prediction among older veterans living with HIV. AIDS 2023, 37: 1399-1407. PMID: 37070536, PMCID: PMC10329997, DOI: 10.1097/qad.0000000000003566.Peer-Reviewed Original ResearchConceptsFracture Risk Assessment ToolMajor osteoporotic fractureRisk assessment toolCohort studyHip fractureOsteoporotic fracturesVeterans Aging Cohort StudyAging Cohort StudyMultivariable logistic regressionType of fractureRace/ethnicityAssessment toolGlucocorticoid useHIV cohortFragility fracturesPrevious fractureRheumatoid arthritisSmoking statusFracture riskModest discriminationOlder veteransLogistic regressionOccurrence of fracturesHIVAlcohol usePersonalized Digital Health Information to Substantiate Human-Delivered Exercise Support for Adults With Type 1 Diabetes
Ash G, Nally L, Stults-Kolehmainen M, De Los Santos M, Jeon S, Brandt C, Gulanski B, Spanakis E, Baker J, Weinzimer S, Fucito L. Personalized Digital Health Information to Substantiate Human-Delivered Exercise Support for Adults With Type 1 Diabetes. Clinical Journal Of Sport Medicine 2023, 33: 512-520. PMID: 36715983, PMCID: PMC10898917, DOI: 10.1097/jsm.0000000000001078.Peer-Reviewed Original ResearchConceptsContinuous glucose monitoringExercise supportHealth informationDigital health informationBody mass indexType 1 diabetesCommunity-based sampleSevere hypoglycemiaMass indexPsychosocial assessmentCGM useHigh satisfaction ratingsPhysician oversightType 1Future interventionsGlucose monitoringMedical readinessMolecular biomarkersBaseline observationsInterventionSatisfaction ratingsAdultsExerciseBehavioral skillsSingle group
2022
Glycemia Reduction in Type 2 Diabetes - Glycemic Outcomes.
GRADE Study Research Group, Nathan DM, Lachin JM, Balasubramanyam A, Burch HB, Buse JB, Butera NM, Cohen RM, Crandall JP, Kahn SE, Krause-Steinrauf H, Larkin ME, Rasouli N, Tiktin M, Wexler DJ, Younes N. Glycemia Reduction in Type 2 Diabetes - Glycemic Outcomes. N Engl J Med 2022, 387: 1063-1074. PMID: 36129996, DOI: 10.1056/NEJMoa2200433.Peer-Reviewed Original ResearchGlycemia Reduction in Type 2 Diabetes - Microvascular and Cardiovascular Outcomes.
GRADE Study Research Group, Nathan DM, Lachin JM, Bebu I, Burch HB, Buse JB, Cherrington AL, Fortmann SP, Green JB, Kahn SE, Kirkman MS, Krause-Steinrauf H, Larkin ME, Phillips LS, Pop-Busui R, Steffes M, Tiktin M, Tripputi M, Wexler DJ, Younes N. Glycemia Reduction in Type 2 Diabetes - Microvascular and Cardiovascular Outcomes. N Engl J Med 2022, 387: 1075-1088. PMID: 36129997, DOI: 10.1056/NEJMoa2200436.Peer-Reviewed Original ResearchClinical and Metabolic Characterization of Adults With Type 2 Diabetes by Age in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) Cohort.
Aroda V, Krause-Steinrauf H, Kazemi E, Buse J, Gulanski B, Florez H, Ahmann A, Loveland A, Kuhn A, Lonier J, Wexler D, Crandall J, McKee M, Behringer-Massera S, Brown-Friday J, Xhori E, Ballentine-Cargill K, Duran S, Estrella H, Gonzalez de la torre S, Lukin J, Phillips L, Burgess E, Olson D, Rhee M, Wilson P, Raines T, Boers J, Costello J, Maher-Albertelli M, Mungara R, Savoye L, White C, Gullett C, Holloway L, Morehead F, Person S, Sibymon M, Tanukonda S, Adams C, Ross A, Balasubramanyam A, Gaba R, Gonzalez Hattery E, Ideozu A, Jimenez J, Montes G, Wright C, Hollander P, Roe E, Jackson A, Smiley A, Burt P, Estrada L, Chionh K, Ismail-Beigi F, Falck-Ytter C, Sayyed Kassem L, Sood A, Tiktin M, Kulow T, Newman C, Stancil K, Cramer B, Iacoboni J, Kononets M, Sanders C, Tucker L, Werner A, Maxwell A, McPhee G, Patel C, Colosimo L, Krol A, Goland R, Pring J, Alfano L, Kringas P, Hausheer C, Tejada J, Gumpel K, Kirpitch A, Schneier H, Green J, AbouAssi H, Chatterjee R, Feinglos M, English Jones J, Khan S, Kimpel J, Zimmer R, Furst M, Satterwhite B, Thacker C, Evans Kreider K, Mariash C, Mather K, Ismail H, Lteif A, Mullen M, Hamilton T, Patel N, Riera G, Jackson M, Pirics V, Aguillar D, Howard D, Hurt S, Bergenstal R, Carlson A, Martens T, Johnson M, Hill R, Hyatt J, Jensen C, Madden M, Martin D, Willis H, Konerza W, Yang S, Kleeberger K, Passi R, Fortmann S, Herson M, Mularski K, Glauber H, Prihoda J, Ash B, Carlson C, Ramey P, Schield E, Torgrimson-Ojerio B, Arnold K, Kauffman B, Panos E, Sahnow S, Bays K, Berame K, Cook J, Ghioni D, Gluth J, Schell K, Criscola J, Friason C, Jones S, Nazarov S, Barzilay J, Rassouli N, Puttnam R, Ojoawo B, Nelson R, Curtis M, Hollis B, Sanders-Jones C, Stokes K, El-Haqq Z, Kolli A, Tran T, Wexler D, Larkin M, Meigs J, Chambers B, Dushkin A, Rocchio G, Yepes M, Steiner B, Dulin H, Cayford M, Chu K, DeManbey A, Hillard M, Martin K, Thangthaeng N, Gurry L, Kochis R, Raymond E, Ripley V, Stevens C, Park J, Aroda V, Ghazi A, Magee M, Ressing A, Loveland A, Hamm M, Hurtado M, Kuhn A, Leger J, Manandhar L, Sanchez O, Young T, Mofor F, Garg R, Lagari-Libhaber V, Florez H, Valencia W, Marks J, Casula S, Oropesa-Gonzalez L, Hue L, Cuadot A, Nieto-Martinez R, Riccio Veliz A, Gutt M, Kendal Y, Veciana B, Ahmann A, Aby-Daniel D, Joarder F, Morimoto V, Sprague C, Yamashita D, Cady N, Rivera-Eschright N, Kirchhoff P, Morales Gomez B, Adducci J, Goncharova A, Hox S, Petrovitch H, Matwichyna M, Jenkins V, Broadwater L, Ishii R, Bermudez N, Hsia D, Cefalu W, Greenway F, Waguespack C, King E, Fry G, Dragg A, Gildersleeve B, Arceneaux J, Haynes N, Thomassie A, Pavlionis M, Bourgeois B, Hazlett C, Mudaliar S, Henry R, Boeder S, Pettus J, Diaz E, Garcia-Acosta D, Maggs S, DeLue C, Stallings A, Castro E, Hernandez S, Krakoff J, Curtis J, Killean T, Khalid M, Joshevama E, Diaz E, Martin D, Tsingine K, Karshner T, Albu J, Pi-Sunyer F, Frances S, Maggio C, Ellis E, Bastawrose J, Gong X, Banerji M, August P, Lee M, Lorber D, Brown N, Josephson D, Thomas L, Tsovian M, Cherian A, Jacobson M, Mishko M, Kirkman M, Buse J, Dostou J, Machineni S, Young L, Bergamo K, Goley A, Kerr J, Largay J, Guarda S, Cuffee J, Culmer D, Fraser R, Almeida H, Coffer S, Debnam E, Kiker L, Morton S, Josey K, Fuller G, Garvey W, Cherrington A, Dyer D, Lawson M, Griffith O, Agne A, McCullars S, Cohen R, Craig J, Rogge M, Burton K, Kersey K, Wilson C, Lipp S, Vonder Meulen M, Adkins C, Onadeko T, Rasouli N, Baker C, Schroeder E, Razzaghi M, Lyon C, Penaloza R, Underkofler C, Lorch R, Douglass S, Steiner S, Sivitz W, Cline E, Knosp L, McConnell J, Lowe T, Herman W, Pop-Busui R, Tan M, Martin C, Waltje A, Katona A, Goodhall L, Eggleston R, Kuo S, Bojescu S, Bule S, Kessler N, LaSalle E, Whitley K, Seaquist E, Bantle A, Harindhanavudhi T, Kumar A, Redmon B, Bantle J, Coe M, Mech M, Taddese A, Lesne L, Smith S, Desouza C, Kuechenmeister L, Shivaswamy V, Burbach S, Rodriguez M, Seipel K, Alfred A, Morales A, Eggert J, Lord G, Taylor W, Tillson R, Schade D, Adolphe A, Burge M, Duran-Valdez E, Martinez J, Bancroft A, Kunkel S, Ali Jamaleddin Ahmad F, Hernandez McGinnis D, Pucchetti B, Scripsick E, Zamorano A, DeFronzo R, Cersosimo E, Abdul-Ghani M, Triplitt C, Juarez D, Mullen M, Garza R, Verastiqui H, Wright K, Puckett C, Raskin P, Rhee C, Abraham S, Jordan L, Sao S, Morton L, Smith O, Osornio Walker L, Schnurr-Breen L, Ayala R, Kreymer R, Sturgess D, Utzschneider K, Kahn S, Alarcon-Casas L, Wright L, Boyko E, Tsai E, Trence D, Trikudanathan S, Fattaleh B, Montgomery B, Atkinson K, Kozedub A, Concepcion T, Moak C, Prikhodko N, Rhothisen S, Elasy T, Martin S, Shackelford L, Goidel R, Hinkle N, Lovell C, Myers J, Lipps Hogan J, McGill J, Salam M, Schweiger T, Kissel S, Recklein C, Clifton M, Tamborlane W, Camp A, Gulanski B, Inzucchi S, Pham K, Alguard M, Gatcomb P, Lessard K, Perez M, Iannone L, Magenheimer E, Montosa A, Burch H, Bremer A, Fradkin J, Nathan D, Lachin J, Krause-Steinrauf H, Younes N, Backman M, Bebu I, Butera N, Buys C, Fagan Murphy A, Gao Y, Ghosh A, Gramzinski M, Kazemi E, Hall S, Legowski E, Suratt C, Tripputi M, Arey A, Bethepu J, Lund C, Mangat Dhaliwal P, McGee P, Mesimer E, Ngo L, Steffes M, Seegmiller J, Saenger A, Arends V, Gabrielson D, Conner T, Warren S, Day J, Huminik J, Scrymgeour A, Soliman E, Pokharel Y, Zhang Z, Campbell C, Hu J, Keasler L, Hensley S, Li Y, Herman W, Kuo S, Martin C, Waltje A, Mihalcea R, Min D, Perez-Rosas V, Prosser L, Resnicow K, Ye W, Shao H, Zhang P, Luchsinger J, Sanchez D, Assuras S, Groessl E, Sakha F, Chong H, Hillery N, Everett B, Abdouch I, Bahtiyar G, Brantley P, Broyles F, Canaris G, Copeland P, Craine J, Fein W, Gliwa A, Hope L, Lee M, Meiners R, Meiners V, O’Neal H, Park J, Sacerdote A, Sledge E, Soni L, Steppel-Reznik J, Turchin A, Brooks-Worrell B, Hampe C, Newgard C, Palmer J, Shojaie A, Higgins J, Fischer L, Golden S, Gonzalez J, Naik A, Walker E, Doner Lotenberg L, Gallivan J, Lim J, Tuncer D, Behringer-Massera S. Clinical and Metabolic Characterization of Adults With Type 2 Diabetes by Age in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) Cohort. Diabetes Care 2022, 45: 1512-1521. PMID: 40315175, PMCID: PMC9375440, DOI: 10.2337/dc21-2659.Peer-Reviewed Original ResearchType 2 diabetesGlycemia Reduction ApproachesLower insulin sensitivityMetformin monotherapyInsulin sensitivityType 2 diabetes durationMetabolic characteristicsYoung adultsObesity-related characteristicsGlucose-lowering medicationsType 2 diabetes phenotypeΒ-cell compensationΒ-cell responseComparative effectiveness studiesHigher obesity levelsPearson χ2 testDiabetes durationDiabetic dyslipidemiaTreatment intensificationCommon comorbiditiesPronounced hyperglycemiaStudy cohortAge-related distinctionsLow prevalenceObesity levels