Binyam Mogessie, PhD
Assistant Professor of Molecular, Cellular, and Developmental Biology and of Obstetrics, Gynecology, and Reproductive SciencesCards
Appointments
Honors
- 6 International Awards
- 2 National Awards
About
Copy Link
Titles
Assistant Professor of Molecular, Cellular, and Developmental Biology and of Obstetrics, Gynecology, and Reproductive Sciences
Biography
Binyam Mogessie is an Assistant Professor in the Departments of Molecular, Cellular and Developmental Biology and Obstetrics, Gynecology, and Reproductive Sciences at Yale University. His research focuses on the cytoskeletal and chromosomal mechanisms that ensure accurate chromosome segregation during oocyte meiosis and early embryogenesis, and their links to reproductive aging.
Originally from Ethiopia, he earned his undergraduate degree in Biochemistry and Cell Biology from Jacobs University Bremen in Germany. He completed his PhD in Cell Biology from the University of London, conducting research at the Marie Curie Research Institute in Surrey and the Centre for Mechanochemical Cell Biology in Warwick. His doctoral work examined how the microtubule cytoskeleton is organized during skeletal muscle differentiation and cell division.
As a postdoctoral researcher at the MRC Laboratory of Molecular Biology in Cambridge and later at the Max Planck Institute in Göttingen, he discovered a novel role for the actin cytoskeleton in promoting accurate chromosome segregation during female meiosis.
In 2019, Dr. Mogessie established his independent laboratory at the University of Bristol as a Wellcome Trust and Royal Society Sir Henry Dale Fellow and HFSP Young Investigator. He joined Yale University in 2022, where his lab continues to study the molecular mechanisms of female meiosis, early embryogenesis, and reproductive longevity.
Appointments
Molecular, Cellular, and Developmental Biology
Assistant ProfessorPrimary
Other Departments & Organizations
- Biochemistry, Quantitative Biology, Biophysics and Structural Biology (BQBS)
- Genomics, Genetics, and Epigenetics
- Molecular Cell Biology, Genetics and Development
- Molecular, Cellular, and Developmental Biology
- Plant Molecular Biology
- Yale Cancer Center
- Yale Center for Research on Aging (Y-Age)
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Stem Cell Center
- Yale WRHR Advisory Committee
Education & Training
- Postdoctoral Fellow
- MRC Laboratory of Molecular Biology (2015)
- PhD
- University of London, Institute of Cancer Research, Cell Biology (2011)
- BSc
- Jacobs University Bremen, Biochemistry and Cell Biology (2007)
Research
Copy Link
Overview
Medical Research Interests
ORCID
0000-0002-0702-6356- View Lab Website
Mogessie Lab
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Timothy Nottoli, PhD
Xiaojun Xing
Oocytes
Meiosis
Microtubules
Chromosome Segregation
Cytoskeleton
Microtubule-Associated Proteins
Publications
2025
A versatile cohesion manipulation system probes female reproductive age-related egg aneuploidy
Leem J, Lemonnier T, Khutsaidze A, Tian L, Xing X, Bai S, Nottoli T, Mogessie B. A versatile cohesion manipulation system probes female reproductive age-related egg aneuploidy. Nature Aging 2025, 5: 2215-2227. PMID: 41184483, PMCID: PMC12618256, DOI: 10.1038/s43587-025-00997-w.Peer-Reviewed Original ResearchCitationsAltmetricCytoskeletal Organization and Dynamics in Female Meiosis and Early Embryogenesis
Rix A, Giannini F, van Eck H, Mogessie B. Cytoskeletal Organization and Dynamics in Female Meiosis and Early Embryogenesis. 2025, 1-15. DOI: 10.1007/978-3-031-97173-0_1.ChaptersIn preprints: rethinking the foundations of the ovarian reserve.
Rix A, Mogessie B. In preprints: rethinking the foundations of the ovarian reserve. Development 2025, 152 PMID: 40518981, PMCID: PMC12422402, DOI: 10.1242/dev.204939.Peer-Reviewed Original ResearchAltmetricThe retrotransposon-derived capsid genes PNMA1 and PNMA4 maintain reproductive capacity
Wood T, Henriques W, Cullen H, Romero M, Blengini C, Sarathy S, Sorkin J, Bekele H, Jin C, Kim S, Wang X, Laureau R, Chemiakine A, Khondker R, Isola J, Stout M, Gennarino V, Mogessie B, Jain D, Schindler K, Suh Y, Wiedenheft B, Berchowitz L. The retrotransposon-derived capsid genes PNMA1 and PNMA4 maintain reproductive capacity. Nature Aging 2025, 5: 765-779. PMID: 40263616, PMCID: PMC12180178, DOI: 10.1038/s43587-025-00852-y.Commentaries, Editorials and LettersCitationsAltmetric
2024
On the origin of mitosis-derived human embryo aneuploidy
Leem J, Gowett M, Bolarinwa S, Mogessie B. On the origin of mitosis-derived human embryo aneuploidy. Nature Communications 2024, 15: 10391. PMID: 39613785, PMCID: PMC11607320, DOI: 10.1038/s41467-024-54953-0.Peer-Reviewed Original ResearchCitationsAltmetric
2023
Actin limits egg aneuploidies associated with female reproductive aging
Dunkley S, Mogessie B. Actin limits egg aneuploidies associated with female reproductive aging. Science Advances 2023, 9: eadc9161. PMID: 36662854, PMCID: PMC9858517, DOI: 10.1126/sciadv.adc9161.Peer-Reviewed Original ResearchCitationsAltmetric
2022
Cytoskeletal form and function in mammalian oocytes and zygotes
Dunkley S, Scheffler K, Mogessie B. Cytoskeletal form and function in mammalian oocytes and zygotes. Current Opinion In Cell Biology 2022, 75: 102073. PMID: 35364486, DOI: 10.1016/j.ceb.2022.02.007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricThe prophase oocyte nucleus is a homeostatic G-actin buffer
Scheffler K, Giannini F, Lemonnier T, Mogessie B. The prophase oocyte nucleus is a homeostatic G-actin buffer. Journal Of Cell Science 2022, 135: jcs259807. PMID: 35112707, PMCID: PMC8977058, DOI: 10.1242/jcs.259807.Peer-Reviewed Original ResearchCitationsAltmetric
2021
Seeing is believing: Representation as a powerful tool in the fight against racism in science
Mogessie B. Seeing is believing: Representation as a powerful tool in the fight against racism in science. Cell Stem Cell 2021, 28: 793-795. PMID: 33961761, PMCID: PMC9760974, DOI: 10.1016/j.stem.2021.04.017.Peer-Reviewed Original ResearchCitationsAltmetricTwo mechanisms drive pronuclear migration in mouse zygotes
Scheffler K, Uraji J, Jentoft I, Cavazza T, Mönnich E, Mogessie B, Schuh M. Two mechanisms drive pronuclear migration in mouse zygotes. Nature Communications 2021, 12: 841. PMID: 33547291, PMCID: PMC7864974, DOI: 10.1038/s41467-021-21020-x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsActinsAnimalsCell NucleusFemaleFertilizationForminsGene Expression Regulation, DevelopmentalGenes, ReporterGreen Fluorescent ProteinsLuminescent ProteinsMaleMiceMice, Inbred C57BLMice, Inbred CBAMicrofilament ProteinsMicrotubulesMovementNerve Tissue ProteinsOocytesrab GTP-Binding ProteinsRed Fluorescent ProteinSpermatozoaZygote
Academic Achievements & Community Involvement
Copy Link
Activities
activity eLife
11/01/2020 - PresentJournal ServiceAssociate EditorDetailsReviewing Editoractivity Molecular Human Reproduction
08/01/2019 - PresentJournal ServiceAssociate EditorDetailsAssociate Editoractivity Trends in Cell Biology
2024 - PresentJournal ServiceEditorial Board Memberactivity Current Opinion in Cell Biology
2024 - PresentJournal ServiceEditorial Board Memberactivity American Society for Cell Biology
2025 - PresentProfessional OrganizationsCouncil Member
Honors
honor National Edward A. Bouchet Graduate Honor Society
04/11/2026National AwardYale UniversityDetailsUnited Stateshonor SSR Rising Star 2025
04/16/2025International AwardSociety for the Study of Reproductionhonor Pew Scholar
09/01/2024National AwardThe Pew Charitable Trustshonor Vallee Scholar
09/01/2024International AwardThe Vallee Foundationhonor Emerging Investigator Award
09/26/2023International AwardSociety for Reproduction and Fertility (SRF)DetailsUnited Kingdom
News & Links
Copy Link
Media
A high-resolution confocal microscopy image showing discovery of nuclear actin filaments in mammalian oocytes
News
Related Links
Get In Touch
Copy Link
Contacts
Yale University
Department of Molecular, Cellular and Developmental Biology, 266 Whitney Avenue
New Haven, CT 06511
United States