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Cross-SCOR Collaborations

In collaboration with the MUSC and Minnesota SCORs we conducted the first systematic review and meta-analysis examining the impact of menstrual cycle and ovarian hormones on tonic craving, cue-induced craving, ad-lib smoking, withdrawal, abstinence and relapse.

Weinberger AH, Smith PH, Allen SS, Cosgrove KP, Saladin ME, Gray KM, Mazure CM, Wetherington CL, McKee SA. Systematic and meta-analytic review of research examining the impact of menstrual cycle phase and ovarian hormones on smoking and cessation. Nicotine Tob Res. 2015 Apr;17(4):407-21. doi: 10.1093/ntr/ntu249. Review. PubMed PMID: 25762750; PubMed Central PMCID: PMC4429881.

In collaboration with the MUSC-SCOR and Roswell Park, the Yale-SCOR led an effort to examine data from the International Tobacco Control Policy Evaluation project. We examined smoking cessation medication utilization and efficacy by gender in a large international longitudinal sample of smokers.

Smith PH, Kasza KA, Hyland A, Fong GT, Borland R, Brady K, Carpenter MJ, Hartwell K, Cummings KM, McKee SA. Gender differences in medication use and cigarette smoking cessation: results from the International Tobacco Control Four Country Survey. Nicotine Tob Res. 2015 Apr;17(4):463-72. doi: 10.1093/ntr/ntu212. PubMed PMID: 25762757; PubMed Central PMCID: PMC4402353.

In collaboration with the Minnesota (lead) and MUSC SCORS, we published a methods paper detailing state of the art methods for assessing menstrual cycle phase and hormone levels for clinical research.

Allen AM, McRae-Clark AL, Carlson S, Saladin ME, Gray KM, Wetherington CL, McKee SA, Allen SS. Determining menstrual phase in human biobehavioral research: A review with recommendations. Exp Clin Psychopharmacol. 2016 Feb;24(1):1-11. PubMed PMID: 26570992; PubMed Central PMCID:PMC4821777.

Yale-SCORE led an effort to harmonize a core-baseline battery across the 11 funded SCOREs to facilitate additional cross-SCORE collaborations and capitalize on synergies. We determined that there were several variables which overlapped across SCOREs, including socio-demographics, DSM-IV disorders, tobacco use, menstrual cycle and ovarian hormones, weight/hip/waist ratio, sleep, depression, anxiety, current stress, childhood maltreatment, life event stress, coping, and quality of life.

Based on this overlap, we harmonized measures for these variables, primarily using PRISM assessments and the PhenX toolkit, resulting in a CROSS-SCORE Assessment Battery that takes 20 minutes to administer and provides a tool to allow for cross-study comparisons and collaborations based on combined data.

This assessment battery allowed us to merge data with MUSC-SCORE on resting state fMRI and smoking behavior, as we had similar baseline measures.

Moran-Santa Maria MM, Vanderweyen D, Camp C, Zhu X, McKee SA, Cosgrove KP, Hartwell KJ, Brady KT, Joseph JE. Network analysis of intrinsic functional brain connectivity in male and female adult smokers: A Preliminary Study. Nicotine Tob Res. 2017 Sep 9. Pub Med PMID: 29059410; PubMed Central PMCID: PMC in progress