Research

The Section of Pediatric Infectious Diseases at Yale has established a tradition of integrating fundamental scientific research with clinical care. At present, faculty within the section are actively addressing basic laboratory and clinical questions on a variety of topics. The goal of these studies is to enhance our understanding of the epidemiology and pathogenesis of viral, bacterial, and parasitic infections in children, ultimately leading to better strategies for prevention and treatment.

Specific areas of research (and corresponding faculty) include:

• Molecular epidemiology of viral respiratory infections, including Respiratory Syncytial Virus (RSV), Human Metapneumovirus (HMPV), and human Coronaviruses, post-licensure studies of vaccine effectiveness, epidemiology and outcomes of Lyme Disease, epidemiology of diseases caused by human Herpesviruses, including infectious mononucleosis and Varicella Zoster Virus (VZV) infection
  Marietta Vazquez
• Factors controlling expression and immunogenicity of the Nucleocapsid (N) proteins of SARS CoV2 and endemic coronaviruses, molecular pathogenesis of human cancer viruses, including Epstein-Barr virus (EBV) and Kaposi's Sarcoma-Associated Herpes virus (KSHV)
  George Miller
• Molecular pathogenesis and immunoepidemiology of human helminth infections
  Michael Cappello
• Post-licensure studies of vaccine effectiveness, epidemiology of diseases caused by human Herpesviruses, including infectious mononucleosis and Varicella Zoster Virus (VZV) infection, Epidemiology and outcomes of Lyme Disease
  Eugene Shapiro
• Pulmonary infection in cystic fibrosis (CF), disinfection and infection prevention in the CF home and community
  Thomas Murray
• Clinical epidemiology of emerging infectious diseases, medical informatics, mathematical and statistical modeling of vaccine-preventable diseases, vaccine epidemiology
  Carlos Oliveira
• Transplant infectious diseases, immunophenotyping vaccine response in pediatric and adult immunocompromised populations, immunophenotyping and vaccine induced protection in sickle cell disease, epidemiology of streptococcus pneumoniae infections and pneumococcal vaccine effectiveness, immunoepidemiology of vaccine preventable diseases in low and middle income settings, Phase 2 – Phase 4 vaccine clinical trials, safety, immunogenicity, and efficacy of SARS-CoV-2 vaccines
  Inci Yildirim