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INFORMATION FOR

I. George Miller Jr, MD

John F. Enders Professor of Pediatrics (Infectious Disease) and Professor of Epidemiology (Microbial Diseases) and of Molecular Biophysics and Biochemistry
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John F. Enders Professor of Pediatrics (Infectious Disease) and Professor of Epidemiology (Microbial Diseases) and of Molecular Biophysics and Biochemistry

Biography

Dr. Miller’s laboratory studies the mechanisms underlying the switch between latency and lytic replication of two oncogenic herpesviruses, Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus. Current experiments explore how viral and cellular transcription factors that selectively bind to methylated DNA control expression of viral and cellular genes, how cellular gene expression is selectively inhibited while viral gene expression is enhanced, and how viral DNA replication is regulated by cellular proteins. Recent studies focus on a new class of anti-viral agents that inhibit reactivation of Epstein-Barr virus from latency into lytic infection.

Last Updated on February 20, 2024.

Appointments

Other Departments & Organizations

Education & Training

Research Fellow
Children's Hospital, Boston (1969)
Research Fellow
Harvard Medical School (1969)
Fellow
CDC (1966)
Intern & Assistant Resident
University Hospital, Cleveland (1964)
MD
Harvard Medical School (1962)
AB
Harvard College (1958)

Research

Overview

We study two related human tumor viruses: Epstein-Barr virus (EBV), which is associated with lymphomas and carcinomas; and Kaposi’s sarcoma-associated herpesvirus (KSHV), which is associated with Kaposi’s sarcoma and lymphomas that occur in patients with AIDS. Both viruses establish “latent states” in host cells, during which only a limited number of viral genes are expressed. We have discovered multifunctional virally encoded transcription factors and replication proteins, ZEBRA and Rta in EBV and KSHV ORF50, which mediate a switch between latency and the lytic cycle. Our lab studies the control of ZEBRA, Rta and ORF50 expression and their mechanisms of action and interaction. We are interested in the basis of viral specificity of these activators. We also investigate how the immune system detects and regulates the latent and lytic cycle program of EBV in B cells.

Medical Research Interests

Biophysics; Epstein-Barr Virus Infections; Infectious Disease Medicine; Pediatrics; Sarcoma, Kaposi; Virology

Research at a Glance

Yale Co-Authors

Frequent collaborators of I. George Miller's published research.

Publications

2019

2008

2001

2000

1999

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Clinical Care

Overview

I. George Miller, MD, is a pediatric infectious diseases specialist who has a particular interest in the prevention and treatment of viral diseases.

Dr. Miller treats children at Yale New Haven Children’s Hospital and in outpatient clinics and is an active researcher who has studied and published numerous papers on many viruses including poliovirus, measles, vaccinia, herpes simplex, and HIV.

His lab studies two related viruses that can cause cancer in humans: Epstein-Barr, which also causes infectious mononucleosis and is implicated in some autoimmune diseases; and Kaposi’s sarcoma-associated herpes, which is associated with Kaposi’s sarcoma and lymphomas that occur in patients with AIDS.

Dr. Miller is the John F. Enders Professor of Pediatrics (infectious diseases) and professor of epidemiology (microbial diseases) and of molecular biophysics and biochemistry at Yale School of Medicine.

Clinical Specialties

Pediatrics; Pediatric Infectious Diseases; Internal Medicine; Medical Oncology

Board Certifications

  • Internal Medicine

    Certification Organization
    AB of Internal Medicine
    Original Certification Date
    1972

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Locations

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