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  1. Fu W, Vasylyev D, Bi Y, Zhang M, Sun G, Khleborodova A, Huang G, Zhao L, Zhou R, Li Y, Liu S, Cai X, He W, Cui M, Zhao X, Hettinghouse A, Good J, Kim E, Strauss E, Leucht P, Schwarzkopf R, Guo EX, Samuels J, Hu W, Attur M, Waxman SG, Liu CJ. Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis. Nature. 2024 Jan 3. doi: 10.1038/s41586-023-06888-7. Epub ahead of print. PMID: 38172636.
  2. Zhao X, Lin Y, Liou B, Fu W, Jian J, Fannie V, Zhang W, Setchell KDR, Grabowski GA, Sun Y, Liu CJ. PGRN deficiency exacerbates, whereas a brain penetrant PGRN derivative protects, GBA1 mutation-associated pathologies and diseases. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2210442120. doi: 10.1073/pnas.2210442120. Epub 2022 Dec 27. PMID: 36574647; PMCID: PMC9910439.
  3. Wang KD, Ding X, Jiang N, Zeng C, Wu J, Cai XY, Hettinghouse A, Khleborodova A, Lei ZN, Chen ZS, Lei GH, Liu CJ. Digoxin targets low density lipoprotein receptor-related protein 4 and protects against osteoarthritis. Ann Rheum Dis. 2022 Apr;81(4):544-555. doi: 10.1136/annrheumdis-2021-221380. Epub 2021 Dec 1. PMID: 34853001; PMCID: PMC9082564.
  4. Fu W, Hettinghouse A, Chen Y, Hu W, Ding X, Chen M, Ding Y, Mundra J, Song W, Liu R, Yi YS, Attur M, Samuels J, Strauss E, Leucht P, Schwarzkopf R, Liu CJ. 14-3-3 epsilon is an intracellular component of TNFR2 receptor complex and its activation protects against osteoarthritis. Ann Rheum Dis. 2021 Dec;80(12):1615-1627. doi: 10.1136/annrheumdis-2021-220000. Epub 2021 Jul 5. PMID: 34226187; PMCID: PMC8595573.
  5. Fu W, Hu W, Yi YS, Hettinghouse A, Sun G, Bi Y, He W, Zhang L, Gao G, Liu J, Toyo-Oka K, Xiao G, Solit DB, Loke P, Liu CJ. TNFR2/14-3-3e signaling complex instructs macrophage plasticity in inflammation and autoimmunity. J Clin Invest. 2021 Aug 16;131(16):e144016. doi: 10.1172/JCI144016. PMID: 34185706; PMCID: PMC8363273.
  6. Liu R, Chen Y, Fu W, Wang S, Cui Y, Zhao X, Lei ZN, Hettinghouse A, Liu J, Wang C, Zhang C, Bi Y, Xiao G, Chen ZS, Liu CJ. Fexofenadine inhibits TNF signaling through targeting to cytosolic phospholipase A2 and is therapeutic against inflammatory arthritis. Ann Rheum Dis. 2019 Nov;78(11):1524-1535. doi: 10.1136/annrheumdis-2019-215543. Epub 2019 Jul 13. PMID: 31302596; PMCID: PMC8157820.
  7. Jian J, Zhao S, Tian QY, Liu H, Zhao Y, Chen WC, Grunig G, Torres PA, Wang BC, Zeng B, Pastores G, Tang W, Sun Y, Grabowski GA, Kong MX, Wang G, Chen Y, Liang F, Overkleeft HS, Saunders-Pullman R, Chan GL, Liu CJ. Association Between Progranulin and Gaucher Disease. EBioMedicine. 2016 Sep;11:127-137. doi: 10.1016/j.ebiom.2016.08.004. Epub 2016 Aug 4. PMID: 27515686; PMCID: PMC5049935.
  8. Zhao YP, Liu B, Tian QY, Wei JL, Richbourgh B, Liu CJ. Progranulin protects against osteoarthritis through interacting with TNF-a and ß-Catenin signalling. Ann Rheum Dis. 2015 Dec;74(12):2244-2253. doi: 10.1136/annrheumdis-2014-205779. Epub 2014 Aug 28. PMID: 25169730; PMCID: PMC4408266.
  9. Lai Y, Bai X, Zhao Y, Tian Q, Liu B, Lin EA, Chen Y, Lee B, Appleton CT, Beier F, Yu XP, Liu CJ. ADAMTS-7 forms a positive feedback loop with TNF-a in the pathogenesis of osteoarthritis. Ann Rheum Dis. 2014 Aug;73(8):1575-84. doi: 10.1136/annrheumdis-2013-203561. Epub 2013 Aug 8. PMID: 23928557; PMCID: PMC4418017.
  10. Tang W, Lu Y, Tian QY, Zhang Y, Guo FJ, Liu GY, Syed NM, Lai Y, Lin EA, Kong L, Su J, Yin F, Ding AH, Zanin-Zhorov A, Dustin ML, Tao J, Craft J, Yin Z, Feng JQ, Abramson SB, Yu XP, Liu CJ. The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science. 2011 Apr 22;332(6028):478-84. doi: 10.1126/science.1199214. Epub 2011 Mar 10. PMID: 21393509; PMCID: PMC3104397.