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Team Members

Prinicipal Investigator

  • Charles W. Ohse Professor of Orthopaedics & Rehabilitation; Vice Chair of Research, Orthopaedics & Rehabilitation; Professor, Graduate School of Arts and Sciences

    Research Interests
    • Arthritis, Rheumatoid
    • Autoimmune Diseases
    • Bone Regeneration
    • Cartilage
    • Inflammation
    • Musculoskeletal Diseases
    • Osteoarthritis
    • Sodium Channels
    • Lysosomal Storage Diseases
    • Chondrocytes
    • Tissue Engineering
    • Musculoskeletal Development
    • Fractures, Cartilage
    • Musculoskeletal Pain
    Dr. Chuan-Ju Liu holds the position of Charles W. Ohse Professor of Orthopaedics, with tenure in the Traditional Track, and serves as the Vice Chair of Research for the Department of Orthopaedics & Rehabilitation at Yale University School of Medicine. Additionally, he is a Professor in the Graduate School of Arts and Sciences at Yale University. Before joining Yale, he served on the faculty at the New York University Grossman School of Medicine from 2002 to 2023, where he advanced through the academic ranks from Assistant Professor to tenured Associate Professor and Full Professor in Orthopaedic Surgery and Cell Biology. Dr. Liu leads a highly interdisciplinary research program focused on fundamental and translational questions in musculoskeletal biology and disease. His laboratory investigates how inflammation, aging, and cellular stress pathways drive joint and bone degeneration, with the goal of identifying mechanism-based therapeutic strategies. Major areas of emphasis include osteoarthritis, rheumatoid arthritis, fracture healing, and rare genetic disorders such as Gaucher disease, spanning musculoskeletal, autoimmune, and lysosomal storage diseases. His lab is particularly known for uncovering disease-driving mechanisms in joint tissues and translating these discoveries into innovative therapeutic approaches. Dr. Liu has authored more than 200 peer-reviewed publications in leading journals, including Nature and Science. His contributions have been widely recognized, with honors such as the Kappa Delta Award (Orthopaedic Research Society and American Academy of Orthopaedic Surgeons), the Ethelmae Haldan Award for Innovative Science in Osteoarthritis Research (Arthritis National Research Foundation), and the Innovative Research Award from the American College of Rheumatology.

Team Members

  • Clinical Fellow

    I completed my BS in Biological Sciences at the University of Arkansas BS followed by MD and PhD in Interdisciplinary Biological Sciences at the University of Arkansas for Medical Sciences. My specialty interest is in endocrinology with a research interest in Bone and Skeletal biology. My hobbies include cooking, soccer, playing with our 3 dogs.Yale is such an amazing place to work. From your co-residents to fellows to attendings and leadership, everyone has been so genuinely nice and helpful. You never feel alone, and everyone wants you to succeed. When you put that kind of environment together with the great minds and resources that Yale offers, there is so much opportunity for you to become a successful Physician Scientist. Selected articles:MacLeod RS, Cawley KM, Gubrij I, Nookaew I, Onal M, O’Brien CA. Effective CRISPR interference of an endogenous gene via a single transgene in mice. Scientific Reports. 9, 17312 (2019). https://doi.org/10.1038/s41598-019-53611-6 MacLeod RS, Meyer MB, Xiong J, Cawley KM, Liu Y, Onal M, Benkusky NA, Thostenson JD, Pike JW, O’Brien CA. Deletion of a putative promoter-proximal Tnfsf11 regulatory region in mice does not alter bone mass or Tnfsf11 expression in vivo. PLOS ONE. 16(5): e0250974 (2021). https://doi.org/10.1371/journal.pone.0250974