Brianna R. Fram, MD
Cards
About
Research
Publications
2025
Examining our lens: how bias heightens disparities in trauma research
Timmer-Murillo S, Stadeli K, Higgins J, Strong B, Rakhit S, Fram B, Hall G, Robles A, Soltani T, Callcut R, Ho V, Villarreal C, Price M, Cronn S, Betzold R, Bixby P, Buehner M, Callcut R, Castañón L, Cronn S, de Moya M, Duchesne J, Fakhry S, Fram B, Hall G, Higgins J, Ho V, Jain A, Levi B, Moreno A, Pierrie S, Price M, Rakhit S, Robles A, Sims C, Soltani T, Stadeli K, Strong B, Swain S, Timmer-Murillo S, Tseng E, Villarreal C, West M, Zakrison T. Examining our lens: how bias heightens disparities in trauma research. Trauma Surgery & Acute Care Open 2025, 10: e001452. PMID: 40584750, PMCID: PMC12198817, DOI: 10.1136/tsaco-2024-001452.Peer-Reviewed Original ResearchTrauma researchImplicit biasReduce implicit biasInjury preventionSuboptimal careSocioeconomic statusInjury researchPrevention strategiesApplication of findingsEquity researchDisparitiesCareTraumatic injuryAbility statusGroup of peopleMultiple disciplinesTraumaStatusStereotypical beliefsBiasInjuryPracticeDevelopment of researchInterventionEthnicityAccess, delivery and outcomes: the summit on the advancement of Focused Equity Research in Trauma (SAFER-Trauma)
Villarreal C, Price M, Moreno A, Bixby P, Tseng E, Fram B, Strong B, Callcut R, West M, Ho V. Access, delivery and outcomes: the summit on the advancement of Focused Equity Research in Trauma (SAFER-Trauma). Trauma Surgery & Acute Care Open 2025, 10: e001430. PMID: 40589977, PMCID: PMC12207175, DOI: 10.1136/tsaco-2024-001430.Peer-Reviewed Original ResearchAgency for Healthcare Research and QualityHealthcare Research and QualityTrauma researchEquity researchTrauma program managersInjury careIn-personAmerican CollegeResearch equityTrauma surgeonsVirtual attendeesDisparitiesProgram managersThought leadersTopic areasConference websiteEquitySeries of articlesUnified responseConference proceedingsTraumaInnovative solutionsNursesVideo recordingsCareRisk of Distal Femur Fracture in Antegrade Intramedullary Nail Fixation of Proximal Femur Fractures: A Finite Element Study
Roytman G, Lahik S, Tommasini S, Wiznia D, Fram B. Risk of Distal Femur Fracture in Antegrade Intramedullary Nail Fixation of Proximal Femur Fractures: A Finite Element Study. Journal Of Orthopaedic Research® 2025 PMID: 40443200, DOI: 10.1002/jor.26113.Peer-Reviewed Original ResearchSingle-leg stanceAntegrade intramedullary nailingTip terminationMaximum stressFinite element modelFinite element studyFemur fracturesDistal femur fracturesExtent of failureElement modelLoading scenariosBody weight loadElement studyIntramedullary nail fixationProximal femur fracturesOsteoporotic femursRisk of peri-implant fractureNail fixationWeight loadingIntramedullary nailingLoadPeri-implant fracturesGeriatric patientsInterprosthetic Femur Fractures: A Multi-Center Retrospective Study.
Landoch S, Foster J, Cannada L, Obremskey W, Will R, Fram B, Mears S, Stambough J, Stronach B, Brown H, Halvorson J, Andring N, Marenghi N, Dehghan N, Huynh T, Ryan S, Guenthner G, Shiinoki A, Fischman J, Rodriguez E, Moreno-Diaz A, Mika A, Chowdry F, Chen A, Zaidi Z, Miller A, Gutbrod J, Hofer E, Quatman C, Dumpe J, Denisiuk M, Sutherland M, Israel H, Matuszewski P, Aneja A. Interprosthetic Femur Fractures: A Multi-Center Retrospective Study. Journal Of Orthopaedic Trauma 2025 PMID: 40333724, DOI: 10.1097/bot.0000000000003003.Peer-Reviewed Original ResearchInterprosthetic femur fracturesFull weight bearingAmbulation statusAssociated with higher risk of mortalityMortality ratePost-operative complicationsPost-operative outcomesAssociated with higher riskTreated with dual platingHigher risk of mortalityReturn to baseline functionFisher's exact testImpact patient outcomesTherapeutic Level IIIRisk of mortalityDual fixationChi-square testSurgical characteristicsMedian ageOperative fixationMedian timeUnivariate analysisExact testPrimary outcomeLevel IIICD177, MYBL2, and RRM2 Are Potential Biomarkers for Musculoskeletal Infections
Agidigbi T, Fram B, Molloy I, Riedel M, Wiznia D, Oh I. CD177, MYBL2, and RRM2 Are Potential Biomarkers for Musculoskeletal Infections. Clinical Orthopaedics And Related Research® 2025, 483: 1062-1071. PMID: 39915095, PMCID: PMC12106227, DOI: 10.1097/corr.0000000000003402.Peer-Reviewed Original ResearchPeripheral blood mononuclear cellsFracture-related infectionRibonucleotide reductase regulatory subunit M2Peripheral blood mononuclear cell levelsPeripheral blood mononuclear cell concentrationsPeriprosthetic joint infectionMusculoskeletal infectionsMonitoring treatment responseDiabetic foot infectionsTreatment responseReceiver operating characteristicPurulent drainageControl groupSerum levelsSinus tractInflammatory markersBlood samplesFoot infectionsInfection groupDiagnostic accuracyTranscriptomic analysis of peripheral blood mononuclear cellsDiagnosis of musculoskeletal infectionsNormalization of inflammatory markersPeripheral blood mononuclear cells of patientsInflammatory conditionsPredictors of Venous Thromboembolism Following Geriatric Distal Femur Fracture Fixation: Are These Patients at Higher Risk Compared With Hip Fracture Patients?
Seddio A, Vasudevan R, Gouzoulis M, Jabbouri S, Grauer J, Fram B. Predictors of Venous Thromboembolism Following Geriatric Distal Femur Fracture Fixation: Are These Patients at Higher Risk Compared With Hip Fracture Patients? JAAOS Global Research And Reviews 2025, 9: e24.00246. PMID: 39823200, PMCID: PMC11745856, DOI: 10.5435/jaaosglobal-d-24-00246.Peer-Reviewed Original ResearchConceptsOdds of venous thromboembolismDirect oral anticoagulantsVenous thromboembolismHeightened oddsHFx patientsIncreased odds of VTEPredictors of venous thromboembolismRisk factors of venous thromboembolismIncidence of venous thromboembolismRate of venous thromboembolismAssociated with considerable morbidityAssociated with reduced oddsFactors of venous thromboembolismEffective therapeutic optionIndependent risk factorClinical risk factorsHip fracture patientsRetrospective cohort studyFemur fracture fixationCoagulopathy disordersOral anticoagulantsElixhauser Comorbidity IndexSurgical managementActive cancerDistal femur fracture fixation
2024
Complications after low-velocity ballistic femur fractures: a series of 104 patients at a level 1 trauma center
Fram B, Chintalapudi N, Davis J, Yu Z, Seymour R, Karunakar M, Collective E, Hsu J, Kempton L, Phelps K, Sims S, Medda S, Odum S, Wally M, Sweeney J, Hickson K, Young C, Kamath P. Complications after low-velocity ballistic femur fractures: a series of 104 patients at a level 1 trauma center. OTA International The Open Access Journal Of Orthopaedic Trauma 2024, 8: e353. PMID: 39703728, PMCID: PMC11654790, DOI: 10.1097/oi9.0000000000000353.Peer-Reviewed Original ResearchRisk of complicationsComplication rateFemur fracturesProphylactic antibioticsDuration of prophylactic antibioticsAssociated with increased risk of complicationsRisk factors of complicationsDeep surgical site infectionAssociated with increased complicationsIncreased risk of complicationsPatients aged 18+ yearsCase of compartment syndromeAcademic level I trauma centerAll-cause complicationsAssociated with increased riskFactors of complicationsHospital length of staySurgical site infectionRate of complicationsLevel I trauma centerLevel 1 trauma centerRate of vascular complicationsStandard of careAged 18+ yearsLength of stayDeep infections after low-velocity ballistic tibia fractures are frequently polymicrobial and recalcitrant
Chintalapudi N, Fram B, Odum S, Seymour R, Karunakar M, , Hsu J, Kempton L, Phelps K, Sims S, Medda S, Sweeney J, Hickson K, Young C, Kamath P. Deep infections after low-velocity ballistic tibia fractures are frequently polymicrobial and recalcitrant. OTA International The Open Access Journal Of Orthopaedic Trauma 2024, 7: e345. PMID: 39363953, PMCID: PMC11449420, DOI: 10.1097/oi9.0000000000000345.Peer-Reviewed Original ResearchBody mass indexDeep infection rateTibia fracturesDeep infectionCephalosporin prophylaxisMass indexMedian body mass indexIsolated organismsFracture-related infectionAssociated with deep infectionLocal antibiotic treatmentSigns of infectionInfection rateAntibiotic prophylaxisSurgical characteristicsIntraoperative culturesPerioperative prophylaxisPolymicrobial infectionsNo significant differenceProphylactic cefazolinAntibiotic treatmentRecalcitrant infectionsTreatment optionsProphylaxisRisk factorsNeurologic Complications Following Peripheral Nerve Block in Foot and Ankle Surgery
Balboni J, Gianakos A, Fram B, Kregling C, Kermanshahi N, Webber K. Neurologic Complications Following Peripheral Nerve Block in Foot and Ankle Surgery. Foot & Ankle Orthopaedics 2024, 9: 2473011424s00378. PMCID: PMC11686789, DOI: 10.1177/2473011424s00378.Peer-Reviewed Original ResearchPeripheral nerve blocksComplex regional pain syndromeComplication rateNeurological complicationsNerve blockAnkle surgeryNerve injuryBlock administrationIncidence of postoperative neurological complicationsEvaluated risk of biasNeurological complication rateRegional pain syndromeSecondary outcome measuresPostoperative neurological complicationsMotor nerve dysfunctionRisk of biasInvestigate possible risk factorsReflex sympathetic dystrophyGuillain-Barre syndromeAt-risk patientsPrevalence of comorbid mood disordersNon-randomized studiesFoot dropLevel of conscious sedationLong-lasting symptomsNeurologic Complications Following Peripheral Nerve Block in Foot and Ankle Surgery
Balboni J, Kermanshahi N, Kregling C, Webber K, Tung W, Fram B, Gianakos A. Neurologic Complications Following Peripheral Nerve Block in Foot and Ankle Surgery. JBJS Reviews 2024, 12: e24.00081. DOI: 10.2106/jbjs.rvw.24.00081.Peer-Reviewed Original ResearchPeripheral nerve blocksAnkle surgeryNeurological complicationsComplication rateNerve blockNerve injuryDescription of levels of evidenceMotor nerve dysfunctionIncidence of postoperative neurological complicationsLevel of evidenceRisk of nerve injuryLong-lasting symptomsPostoperative neurological complicationsPatient-specific factorsMotor compromiseAnkleChronic painPrimary outcomePregnant populationScreening protocolLevel of sedationTransient paresthesiaNerve deficitsNerve dysfunctionBlock administration
Academic Achievements & Community Involvement
Clinical Care
Overview
Brianna R. Fram, MD, is an orthopaedic trauma surgeon who says she enjoys the variety of her work and making an immediate difference in patients’ lives.
“I am usually seeing people after an acute injury, whether from a car or motorcycle crash, a sports accident, or a simple trip or fall,” Dr. Fram says. Recognizing that coming to the hospital with an injury is understandably stressful for patients, Dr. Fram says she makes sure to walk them through the steps. “Recovering from an injury is a process. The first part of that is a conversation to decide on the right treatment for that specific patient,” she says.
Dr. Fram knows providing patients with information in advance can make it easier to deal with the “life” issues, like time off of work, that often accompany an injury. “I counsel people on what the surgery will entail, expected restrictions while they recover, how we will control their pain,” she says. “I like for them to know what to expect when they wake up. They will follow up with me in the office afterward. We will monitor their healing and work on their range of motion, strength, and anything else they need.”
Dr. Fram’s clinical research interests include outcomes following ballistic fractures and optimizing post-operative protocols.
Clinical Specialties
Fact Sheets
Complex Fracture
Learn More on Yale MedicineBroken Ankle (Ankle Fracture)
Learn More on Yale MedicineOutdoor Emergencies and Injuries
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Orthopaedics & Rehabilitation
P.O. Box 208071
New Haven, CT 06520-8071
United States
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Department of Orthopaedics & Rehabilitation
Academic Office
47 College Street
New Haven, CT 06510
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