Molly McAdow
Research & Publications
Biography
News
Extensive Research Description
My primary research focus is mechanisms of endothelial dysfunction in preeclampsia. In particular, I am interested in the role of Plasminogen activator inhibitor (PAI)-1 and -2 in modulating endothelial cell biology and endothelial nitric oxide synthase activity in maternal vasculature and in the placenta. While alterations in circulating PAI-1 and PAI-2 in preeclampsia have been well recognized, a mechanistic role for these changes in preeclampsia has never been identified. These represent a potential novel target for therapeutic intervention in preeclampsia. To pursue this research focus, I have sought mentorship outside my primary department in order to learn new skill sets and understanding that I can bring back to my Department. I have received career development awards for this project from the Yale Center for Clinical Investigation/Yale Physician Scientist Development Program and the Society for Maternal Fetal Medicine/American Association for Obstetricians and Gynecologists Foundation. I also received an award from the Doris Duke Fund to Retain Clinical Scientsits-COVID19 to support this research. I have also received support through the McKern award in the Department of Obstetrics, Gynecology, & Reproductive Sciences. In addition to my own work in preeclampsia, I am collaborating with another physician-scientist investigator at Yale School of Medicine to explore the use of placental-derived exosomes in the diagnosis and pathophysiology of preeclampsia. I am the content expert as a Maternal Fetal Medicine provider and preeclampsia researcher; I have contributed to study design and plans for future work.
A secondary research interest is in the biology of parturition, particularly labor induction. Oxytocin is the most commonly used medication in pregnancy, but there are significant limitations to our understanding of oxytocin biology and which patients will respond to it. After prolonged exposure to oxytocin, myometrial cells lose their sensitivity to it. I am studying the process of the resensitization and the differences in pathway activation between patients who receive exogenous IV oxytocin for induction of labor versus those who use nipple stimulation, to activate their own endogenous pathways. This work has been supported by a research grant from the Perinatal Research Consortium.
The postpartum time is a sensitive window in the life of the mother and newborn, but there are critical disparities in outcomes for non-Hispanic black mothers and their infants. In particular, postpartum preeclampsia is a poorly understood disease and has worse outcomes for Black women. I am conducting work on the use of maternal-infant dyadic care models to reduce healthcare disparities. This work is conducted with colleagues from pediatrics and epidemiologists from the School of Public Health through our mutual support from the Yale Center for Clinical Investigation.
Coauthors
Selected Publications
- Dyadic care to improve postnatal outcomes of birthing people and their infants: A scoping review protocolChoy C, McAdow M, Rosenberg J, Grimshaw A, Martinez-Brockman J. Dyadic care to improve postnatal outcomes of birthing people and their infants: A scoping review protocol. PLOS ONE 2024, 19: e0298927. PMID: 38625992, PMCID: PMC11020692, DOI: 10.1371/journal.pone.0298927.
- Nipple stimulation therapy promotes uterine contractions at lower plasma oxytocin concentration than intravenous oxytocin during labor inductionMcAdow M, Tortal D, Shabanova V, Son M. Nipple stimulation therapy promotes uterine contractions at lower plasma oxytocin concentration than intravenous oxytocin during labor induction. American Journal Of Obstetrics & Gynecology MFM 2024, 6: 101307. PMID: 38331190, DOI: 10.1016/j.ajogmf.2024.101307.
- 1026 Plasminogen Activator Inhibitor 1 promotes endothelial cell inflammatory responseHauschel R, Boutagy N, Sessa W, McAdow M. 1026 Plasminogen Activator Inhibitor 1 promotes endothelial cell inflammatory response. American Journal Of Obstetrics And Gynecology 2024, 230: s540-s541. DOI: 10.1016/j.ajog.2023.11.1053.
- Nipple stimulation results in adequate contractions at lower plasma oxytocin concentration compared with IV oxytocinMcAdow M, Cassello N, Tortal D, Son M. Nipple stimulation results in adequate contractions at lower plasma oxytocin concentration compared with IV oxytocin. American Journal Of Obstetrics And Gynecology 2023, 228: s199-s200. DOI: 10.1016/j.ajog.2022.11.372.
- Salivary oxytocin concentration correlates with plasma oxytocin concentration in patients undergoing induction of laborMcAdow M, Stark E, Cassello N, Son M. Salivary oxytocin concentration correlates with plasma oxytocin concentration in patients undergoing induction of labor. American Journal Of Obstetrics And Gynecology 2023, 228: s547-s548. DOI: 10.1016/j.ajog.2022.11.932.
- Normal Laboratory Values in PregnancyLockwood, Charles J., et al. Creasy & Resnik’s Maternal-fetal Medicine: Principles and Practice. 9th edition. Amsterdam: Elsevier.
- Myometrial‐derived CXCL12 promotes lipopolysaccharide induced preterm labour by regulating macrophage migration, polarization and function in miceZhang L, Mamillapalli R, Habata S, McAdow M, Taylor HS. Myometrial‐derived CXCL12 promotes lipopolysaccharide induced preterm labour by regulating macrophage migration, polarization and function in mice. Journal Of Cellular And Molecular Medicine 2022, 26: 2566-2578. PMID: 35318804, PMCID: PMC9077289, DOI: 10.1111/jcmm.17252.
- 907 2D Sonographic estimation of placental weight at 20 weeks correlates with delivery placental weightMcAdow M, Silasi M, Perley L, Lundsberg L, Gravino C, Stelzl P. 907 2D Sonographic estimation of placental weight at 20 weeks correlates with delivery placental weight. American Journal Of Obstetrics And Gynecology 2021, 224: s563-s564. DOI: 10.1016/j.ajog.2020.12.932.
- Association of Oxytocin Rest During Labor Induction of Nulliparous Women With Mode of Delivery.McAdow M, Xu X, Lipkind H, Reddy UM, Illuzzi JL. Association of Oxytocin Rest During Labor Induction of Nulliparous Women With Mode of Delivery. Obstetrics And Gynecology 2020, 135: 569-575. PMID: 32028487, DOI: 10.1097/aog.0000000000003709.
- Isolated port site recurrence of node-negative clinical stage IB1 cervical adenocarcinomaDeshmukh U, McAdow M, Black J, Hui P, Azodi M. Isolated port site recurrence of node-negative clinical stage IB1 cervical adenocarcinoma. Gynecologic Oncology Reports 2017, 20: 54-57. PMID: 28331901, PMCID: PMC5348602, DOI: 10.1016/j.gore.2017.03.001.
- Connect the Dots—September 2016Saunders KT, Washington KL, McAdow M, Chescheir NC. Connect the Dots—September 2016. Obstetrics And Gynecology 2016, 128: 653-654. PMID: 27500325, DOI: 10.1097/aog.0000000000001602.
- Antibodies against a secreted product of Staphylococcus aureus trigger phagocytic killingThomer L, Emolo C, Thammavongsa V, Kim H, McAdow M, Yu W, Kieffer M, Schneewind O, Missiakas D. Antibodies against a secreted product of Staphylococcus aureus trigger phagocytic killing. Journal Of Experimental Medicine 2016, 213: 293-301. PMID: 26880578, PMCID: PMC4813671, DOI: 10.1084/jem.20150074.
- Coagulases as Determinants of Protective Immune Responses against Staphylococcus aureusMcAdow M, DeDent AC, Emolo C, Cheng AG, Kreiswirth BN, Missiakas DM, Schneewind O. Coagulases as Determinants of Protective Immune Responses against Staphylococcus aureus. Infection And Immunity 2012, 80: 3389-3398. PMID: 22825443, PMCID: PMC3457572, DOI: 10.1128/iai.00562-12.
- Staphylococcus aureus Secretes Coagulase and von Willebrand Factor Binding Protein to Modify the Coagulation Cascade and Establish Host InfectionsMcAdow M, Missiakas DM, Schneewind O. Staphylococcus aureus Secretes Coagulase and von Willebrand Factor Binding Protein to Modify the Coagulation Cascade and Establish Host Infections. Journal Of Innate Immunity 2012, 4: 141-148. PMID: 22222316, PMCID: PMC3388267, DOI: 10.1159/000333447.
- Preventing Staphylococcus aureus Sepsis through the Inhibition of Its Agglutination in BloodMcAdow M, Kim HK, DeDent AC, Hendrickx AP, Schneewind O, Missiakas DM. Preventing Staphylococcus aureus Sepsis through the Inhibition of Its Agglutination in Blood. PLOS Pathogens 2011, 7: e1002307. PMID: 22028651, PMCID: PMC3197598, DOI: 10.1371/journal.ppat.1002307.
- Contribution of Coagulases towards Staphylococcus aureus Disease and Protective ImmunityCheng AG, McAdow M, Kim HK, Bae T, Missiakas DM, Schneewind O. Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity. PLOS Pathogens 2010, 6: e1001036. PMID: 20700445, PMCID: PMC2916881, DOI: 10.1371/journal.ppat.1001036.
- IsdA and IsdB antibodies protect mice against Staphylococcus aureus abscess formation and lethal challengeKim HK, DeDent A, Cheng AG, McAdow M, Bagnoli F, Missiakas DM, Schneewind O. IsdA and IsdB antibodies protect mice against Staphylococcus aureus abscess formation and lethal challenge. Vaccine 2010, 28: 6382-6392. PMID: 20226248, PMCID: PMC3095377, DOI: 10.1016/j.vaccine.2010.02.097.
- Distribution of Protein A on the Surface of Staphylococcus aureus▿DeDent AC, McAdow M, Schneewind O. Distribution of Protein A on the Surface of Staphylococcus aureus▿. Journal Of Bacteriology 2007, 189: 4473-4484. PMID: 17416657, PMCID: PMC1913371, DOI: 10.1128/jb.00227-07.
Clinical Trials
Conditions | Study Title |
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Pregnancy, Childbirth and the Puerperium | The Stimulation To Induce Mothers Study (STIM) |