Evrim Unsal
Associate Research Scientist
Research & Publications
Biography
Locations
Research Summary
During my career, I focused on rare diseases and reproductive genetics. I am conducting research and clinical studies on genetic applications from screening to diagnosis. I am especially working on consanguinity and pre-conception large carriage panels. I am also continuing my work on Pre-Implantation Genetic Testing and the translation of conventional methods to new technologies based on NGS.
Extensive Research Description
- End-to-end Solution to Inherited Disease Screening from Wet-Lab to Bioinformatics / EUROKA-European Union / No : 2022- 17433 CarrierCheck / 01.11.2022-01.11.2024
- Raising Awareness on the State of the Art Reproductive Technologies for Rare Diseases: From Screening to Diagnosis/ European Joint Program on Rare Diseases (EJP RD) under the “Networking Support Scheme 2022”/ NSSS Application/ No: 40-46300-98-1088: / 2022-2023
- Development of an Effective Diagnostic Method Based on DNA-Seq and RNA-Seq Data for Rare Genetic Diseases / TÜBİTAK TEYDEB-1501 / No: 3210640/ 01.07.2021-30.06.2023
- Ankara Development Agencies Medical devices financing support program for 2021/ Development of Consanguineous Marriages and Premarital Sequencing Based Rare Disease Screening Kit / 2022-2024
- MicroRNA-based biomarkers using minimally invasive methods use in the estimation of the endometrial implantation window/ TÜBİTAK TEYDEB-1501 / No: 5180087 / 01.11.2019-31.10.2021
- Immunohistochemical determination of nitric oxide in human testicular tissue and evaluation of its effect on spermatogenesis./ Istanbul Bilim University, Faculty of Medicine/ BAPKO Project/ 2012-2013
Coauthors
Public Health Interests
Genetics, Genomics, Epigenetics; Reproduction
Selected Publications
- An Incidental Detection of a Cryptic Complex Chromosome Rearrangement Found During NGS Based PGT-SR: A Case ReportÖzer L, Aktuna S, Unsal E, Baltaci A, Baltaci V. An Incidental Detection of a Cryptic Complex Chromosome Rearrangement Found During NGS Based PGT-SR: A Case Report. Journal Of Reproduction & Infertility 2022, 23: 303-309. PMID: 36452189, PMCID: PMC9674458, DOI: 10.18502/jri.v23i4.10817.
- A novel SLC35D1 variant causing milder phenotype of Schneckenbecken dysplasia in a large pedigreeÖzer L, Aktuna S, Unsal E, Ünal M, Sahin G, Baltaci V. A novel SLC35D1 variant causing milder phenotype of Schneckenbecken dysplasia in a large pedigree. American Journal Of Medical Genetics Part A 2022, 188: 3078-3083. PMID: 35934917, DOI: 10.1002/ajmg.a.62939.
- HOW EFFECTIVE IS UNIVERSAL CARRIER SCREENING TO ENCOMPASS TURKISH POPULATION MUTATION PROFILE?Aktuna S, Baltaci V, Unsal E, Ozer L, Polat M. HOW EFFECTIVE IS UNIVERSAL CARRIER SCREENING TO ENCOMPASS TURKISH POPULATION MUTATION PROFILE? Fertility And Sterility 2020, 114: e360-e361. DOI: 10.1016/j.fertnstert.2020.08.1073.
- HOW EFFECTIVE IS TARGET SEQUENCE ENRICHMENT DURING WHOLE GENOME AMPLIFICATION ON THE IMPROVEMENT OF PGT-M RESULTS?Unsal E, Ozer L, Polat M, Aktuna S, Baltaci V. HOW EFFECTIVE IS TARGET SEQUENCE ENRICHMENT DURING WHOLE GENOME AMPLIFICATION ON THE IMPROVEMENT OF PGT-M RESULTS? Fertility And Sterility 2020, 114: e434. DOI: 10.1016/j.fertnstert.2020.08.1259.
- IS IT POSSIBLE TO DETECT ALL SEGMENTAL CHROMOSOMAL IMBALANCES WITH NGS USING CUSTOM ANALYSIS ALGORITHMS?Polat M, Baltaci V, Ozer L, Unsal E, Aktuna S. IS IT POSSIBLE TO DETECT ALL SEGMENTAL CHROMOSOMAL IMBALANCES WITH NGS USING CUSTOM ANALYSIS ALGORITHMS? Fertility And Sterility 2020, 114: e437. DOI: 10.1016/j.fertnstert.2020.08.1268.
- 57. ADDITIONAL DATA FOR CONTROVERSIAL INTER-CHROMOSOMAL EFFECT SUSCEPTIBILITY IN PGT-SR PATIENTSOzer L, Aydin M, Unsal E, Aktuna S, Baltaci V. 57. ADDITIONAL DATA FOR CONTROVERSIAL INTER-CHROMOSOMAL EFFECT SUSCEPTIBILITY IN PGT-SR PATIENTS. Reproductive BioMedicine Online 2019, 39: e61-e62. DOI: 10.1016/j.rbmo.2019.04.110.
- 43. NGS BASED PGT-A / PGT-SR: DATA FROM >7000 EMBRYOSAydin M, Aktuna S, Unsal E, Ozer L, Baltaci V. 43. NGS BASED PGT-A / PGT-SR: DATA FROM >7000 EMBRYOS. Reproductive BioMedicine Online 2019, 39: e53. DOI: 10.1016/j.rbmo.2019.04.096.
- 73. SIMULTANEOUS PGT-M APPLICATIONS FOR MULTIPLE GENETIC CONDITIONSAktuna S, Unsal E, Ozer L, Aydin M, Baltaci V. 73. SIMULTANEOUS PGT-M APPLICATIONS FOR MULTIPLE GENETIC CONDITIONS. Reproductive BioMedicine Online 2019, 39: e72. DOI: 10.1016/j.rbmo.2019.04.126.
- 69. IMPROVED IVF SUCCESS OF COMBINED PGT-M AND PGT-A APPLICATIONSUnsal E, Aktuna S, Aydin M, Ozer L, Baltacı V. 69. IMPROVED IVF SUCCESS OF COMBINED PGT-M AND PGT-A APPLICATIONS. Reproductive BioMedicine Online 2019, 39: e69-e70. DOI: 10.1016/j.rbmo.2019.04.122.
- P-38 Are metabolic disorder carries subject to poor ovarian response in PGD cycles?Baltaci V, Unsal E, Ozer L, Aktuna S, Atik A, Baltaci A. P-38 Are metabolic disorder carries subject to poor ovarian response in PGD cycles? Reproductive BioMedicine Online 2018, 36: e32. DOI: 10.1016/j.rbmo.2017.10.077.
- P-18 What next generation sequencing brings to preimplantation genetic testingUnsal E, Aktuna S, Ozer L, Aydin M, Duman T, Pelin C, Baltaci A, Baltaci V. P-18 What next generation sequencing brings to preimplantation genetic testing. Reproductive BioMedicine Online 2018, 36: e24. DOI: 10.1016/j.rbmo.2017.10.057.
- P-54 Aneuploidy rates of next-generation sequencing in preimplantation genetic diagnosis for balanced translocation carriersOzer L, Aktuna S, Unsal E, Celikkol P, Aydin M, Duman T, Baltaci A, Baltaci V. P-54 Aneuploidy rates of next-generation sequencing in preimplantation genetic diagnosis for balanced translocation carriers. Reproductive BioMedicine Online 2018, 36: e39. DOI: 10.1016/j.rbmo.2017.10.093.
- WGA and NGS read length significantly impact mitochondrial characterisationWarren K, Unsal E, Aktuna S, Aydin M, Baltaci V, Jasper M. WGA and NGS read length significantly impact mitochondrial characterisation. Fertility And Sterility 2017, 108: e289. DOI: 10.1016/j.fertnstert.2017.07.855.
- Mandibuloacral dysplasia and LMNA A529V mutation in Turkish patients with severe skeletal changes and absent breast developmentOzer L, Unsal E, Aktuna S, Baltaci V, Celikkol P, Akyigit F, Sen A, Ayvaz O, Balci S. Mandibuloacral dysplasia and LMNA A529V mutation in Turkish patients with severe skeletal changes and absent breast development. Clinical Dysmorphology 2016, 25: 91-97. PMID: 27100822, DOI: 10.1097/mcd.0000000000000132.
- Oogonial Precursor Cell-Derived Autologous Mitochondria Injection to Improve Outcomes in Women With Multiple IVF Failures Due to Low Oocyte QualityOktay K, Baltaci V, Sonmezer M, Turan V, Unsal E, Baltaci A, Aktuna S, Moy F. Oogonial Precursor Cell-Derived Autologous Mitochondria Injection to Improve Outcomes in Women With Multiple IVF Failures Due to Low Oocyte Quality. Reproductive Sciences 2015, 22: 1612-1617. PMID: 26567266, DOI: 10.1177/1933719115612137.
- Effects of pentoxifylline and platelet activating factor on sperm DNA damageUnsal E, Turan V, Aktuna S, Hurdag C, Bereketoglu G, Canillioglu Y, Baltacı A, Ozcan S, Karayalcin R, Batırbaygil H, Baltacı V. Effects of pentoxifylline and platelet activating factor on sperm DNA damage. European Journal Of Obstetrics & Gynecology And Reproductive Biology 2015, 197: 125-129. PMID: 26748389, DOI: 10.1016/j.ejogrb.2015.12.016.
- Recombinant chromosome with partial 14 q trisomy due to maternal pericentric inversionKurtulgan H, Özer L, Yıldırım M, Ünsal E, Aktuna S, Baltacı V, Akkuş N, Sezgin İ. Recombinant chromosome with partial 14 q trisomy due to maternal pericentric inversion. Molecular Cytogenetics 2015, 8: 92. PMID: 26594242, PMCID: PMC4654821, DOI: 10.1186/s13039-015-0195-7.
- Pentoksifilin ve platelet aktive edici faktör sonrası spermatozoada meydana gelen ultrastrüktürel değişikliklerin kıyaslanmasıÖzdemir Y, Ünsal E, Hürdağ C. Pentoksifilin ve platelet aktive edici faktör sonrası spermatozoada meydana gelen ultrastrüktürel değişikliklerin kıyaslanması. Istanbul Bilim University Florence Nightingale Journal Of Medicine 2015, 1: 11-17. DOI: 10.5606/fng.btd.2015.003.
- Poor ovarian response in women undergoing in vitro fertilization is associated with altered microRNA expression in cumulus cellsKarakaya C, Guzeloglu-Kayisli O, Uyar A, Kallen AN, Babayev E, Bozkurt N, Unsal E, Karabacak O, Seli E. Poor ovarian response in women undergoing in vitro fertilization is associated with altered microRNA expression in cumulus cells. Fertility And Sterility 2015, 103: 1469-1476.e3. PMID: 25910568, PMCID: PMC5648585, DOI: 10.1016/j.fertnstert.2015.02.035.
- Case report: birth of healthy baby after preimplantation genetic diagnosis of junctional epidermolysis bullosaDemirel C, Baltaci V, Baltaci A, Duman T, Ünsal E, Ayvaz Ö. Case report: birth of healthy baby after preimplantation genetic diagnosis of junctional epidermolysis bullosa. Fertility And Sterility 2013, 100: s206-s207. DOI: 10.1016/j.fertnstert.2013.07.1378.
- Preimplantation genetic diagnosis for mucopolysaccharidose type I: analysis of a novel indel mutationBaltaci V, Demirel C, Baltaci A, Ayvaz Ö, Ünsal E, Duman T. Preimplantation genetic diagnosis for mucopolysaccharidose type I: analysis of a novel indel mutation. Fertility And Sterility 2013, 100: s206. DOI: 10.1016/j.fertnstert.2013.07.1377.
- Outcome of preimplantation genetic diagnosis (PGD) for single gene disorders with HLA typingBaltaci A, Baltaci V, Demirel C, Ünsal E, Ayvaz Ö, Duman T. Outcome of preimplantation genetic diagnosis (PGD) for single gene disorders with HLA typing. Fertility And Sterility 2013, 100: s204. DOI: 10.1016/j.fertnstert.2013.07.1368.
- P-33 Case report: Birth of healthy baby after preimplantation genetic diagnosis of junctional epidermolysis bullosaDuman T, Unsal E, Ayvaz O, Demirel C, Ozer L, Baltaci A, Akyigit F, Baltaci V. P-33 Case report: Birth of healthy baby after preimplantation genetic diagnosis of junctional epidermolysis bullosa. Reproductive BioMedicine Online 2013, 26: s40. DOI: 10.1016/s1472-6483(13)60096-6.
- P-49 Preimplantation genetic diagnosis (PGD) for single gene disorders with HLA typing: A brief reportUnsal E, Ayvaz O, Duman T, Ozer L, Akyigit F, Baltaci A, Baltaci V. P-49 Preimplantation genetic diagnosis (PGD) for single gene disorders with HLA typing: A brief report. Reproductive BioMedicine Online 2013, 26: s45. DOI: 10.1016/s1472-6483(13)60112-1.
- P-36 Preimplantation genetic diagnosis for mucopolysaccharidose type I: Analysis of a novel indel mutationAyvaz O, Unsal E, Baltaci A, Duman T, Ozer L, Akyigit F, Baltaci V. P-36 Preimplantation genetic diagnosis for mucopolysaccharidose type I: Analysis of a novel indel mutation. Reproductive BioMedicine Online 2013, 26: s41. DOI: 10.1016/s1472-6483(13)60099-1.
- Impairment of BRCA1-Related DNA Double-Strand Break Repair Leads to Ovarian Aging in Mice and HumansTitus S, Li F, Stobezki R, Akula K, Unsal E, Jeong K, Dickler M, Robson M, Moy F, Goswami S, Oktay K. Impairment of BRCA1-Related DNA Double-Strand Break Repair Leads to Ovarian Aging in Mice and Humans. Science Translational Medicine 2013, 5: 172ra21. PMID: 23408054, PMCID: PMC5130338, DOI: 10.1126/scitranslmed.3004925.
- The efficacy of melatonin administration on oocyte qualityBatıoğlu A, Şahin U, Gürlek B, Öztürk N, Ünsal E. The efficacy of melatonin administration on oocyte quality. Gynecological Endocrinology 2011, 28: 91-93. PMID: 21770829, DOI: 10.3109/09513590.2011.589925.
- Evaluation of in vitro fertilization parameters and estrogen receptor alpha gene polymorphisms for women with unexplained infertilityAyvaz Ö, Ekmekçi A, Baltacı V, Önen H, Ünsal E. Evaluation of in vitro fertilization parameters and estrogen receptor alpha gene polymorphisms for women with unexplained infertility. Journal Of Assisted Reproduction And Genetics 2009, 26: 503-510. PMID: 19866355, PMCID: PMC2788690, DOI: 10.1007/s10815-009-9354-2.
- The effectiveness of intracytoplasmic sperm injection combined with piezoelectric stimulation in infertile couples with total fertilization failureBaltaci V, Ayvaz Ö, Ünsal E, Aktaş Y, Baltacı A, Turhan F, Özcan S, Sönmezer M. The effectiveness of intracytoplasmic sperm injection combined with piezoelectric stimulation in infertile couples with total fertilization failure. Fertility And Sterility 2009, 94: 900-904. PMID: 19464000, DOI: 10.1016/j.fertnstert.2009.03.107.
- Successful application of preimplantation genetic diagnosis for Leigh syndromeÜnsal E, Aktaş Y, Üner Ö, Baltacı A, Özcan S, Turhan F, Baltaci V. Successful application of preimplantation genetic diagnosis for Leigh syndrome. Fertility And Sterility 2008, 90: 2017.e11-2017.e13. PMID: 18778816, DOI: 10.1016/j.fertnstert.2008.07.023.
- Differentiation of Human Embryonic Stem Cells on Periodontal Ligament Fibroblasts In VitroInanç B, Elçin A, Ünsal E, Balos K, Parlar A, Elçin Y. Differentiation of Human Embryonic Stem Cells on Periodontal Ligament Fibroblasts In Vitro. Artificial Organs 2007, 32: 100-109. PMID: 18005274, DOI: 10.1111/j.1525-1594.2007.00499.x.
- Oocyte karyotyping by comparative genomic hybrydization provides a highly reliable method for selecting “competent” embryos, markedly improving in vitro fertilization outcome: a multiphase studySher G, Keskintepe L, Keskintepe M, Ginsburg M, Maassarani G, Yakut T, Baltaci V, Kotze D, Unsal E. Oocyte karyotyping by comparative genomic hybrydization provides a highly reliable method for selecting “competent” embryos, markedly improving in vitro fertilization outcome: a multiphase study. Fertility And Sterility 2007, 87: 1033-1040. PMID: 17258713, DOI: 10.1016/j.fertnstert.2006.08.108.
- Preimplantation genetic diagnosis in two couples with balanced reciprocal translocationsBaltacı V, Şatıroğlu H, Ünsal E, Üner Ö, Ergün M, Batıoğlu S, Sönmezer M, Kabukçu C, Aydınuraz B, Aktaş Y. Preimplantation genetic diagnosis in two couples with balanced reciprocal translocations. European Journal Of Obstetrics & Gynecology And Reproductive Biology 2006, 134: 126-127. PMID: 16876931, DOI: 10.1016/j.ejogrb.2006.06.014.
- Relationship between embryo quality and aneuploidiesBaltaci V, Satiroglu H, Kabukçu C, Ünsal E, Aydinuraz B, Üner Ö, Aktas Y, Çetinkaya E, Turhan F, Aktan A. Relationship between embryo quality and aneuploidies. Reproductive BioMedicine Online 2006, 12: 77-82. PMID: 16454940, DOI: 10.1016/s1472-6483(10)60984-4.
- Peritonsillar Abscess: A Comparison of Outpatient IM Clindamycin and Inpatient IV Ampicillin/Sulbactam following Needle AspirationOzbek C, Aygenc E, Unsal E, Ozdem C. Peritonsillar Abscess: A Comparison of Outpatient IM Clindamycin and Inpatient IV Ampicillin/Sulbactam following Needle Aspiration. Ear, Nose & Throat Journal 2005, 84: 366-368. PMID: 16075861, DOI: 10.1177/014556130508400617.
- P▪47 Relationship between embryo quality and aneuploidiesSatiroglu H, Baltaci V, Kabukçu C, Ünsal E, Aydinuraz B, Üner Ö, Aktas Y, Çetinkaya E, Turhan F. P▪47 Relationship between embryo quality and aneuploidies. Reproductive BioMedicine Online 2005, 10: 45-46. DOI: 10.1016/s1472-6483(11)60369-6.
- P▪50 A simplified blastomere fixation techniqueBaltaci V, Satiroglu H, Aydinuraz B, Unsal E, Uner O, Cetinkaya E, Kabukcu C, Aktas Y, Turhan F. P▪50 A simplified blastomere fixation technique. Reproductive BioMedicine Online 2005, 10: 46. DOI: 10.1016/s1472-6483(11)60372-6.
- A rare and serious complication of chronic otitis media: lateral sinus thrombosisÜnsal E, Ensari S, Koç C. A rare and serious complication of chronic otitis media: lateral sinus thrombosis. Auris Nasus Larynx 2003, 30: 279-282. PMID: 12927292, DOI: 10.1016/s0385-8146(03)00044-0.