2022
Mitochondrial dysfunction caused by targeted deletion of Mfn1 does not result in telomere shortening in oocytes.
Cozzolino M, Seli E. Mitochondrial dysfunction caused by targeted deletion of Mfn1 does not result in telomere shortening in oocytes. Zygote 2022, 30: 735-737. PMID: 35730364, DOI: 10.1017/s0967199422000089.Peer-Reviewed Original ResearchConceptsMitochondrial dysfunctionMaintenance of telomeresTargeted deletionEnd-protection functionTTAGGG repeatsMitochondrial fusionTelomeric repeatsSomatic cellsMitofusin 1Reactive oxygen speciesEnzyme complexWild-type miceOocyte growthDNA damageMouse oocytesTelomerase activityOocyte maturationDeletionFollicular depletionOxygen speciesTelomere lengthTelomeresFollicular developmentOocytesRepeats
2020
Mitochondrial Stress Response Gene Clpp Is Not Required for Granulosa Cell Function
Esencan E, Cozzolino M, Imamoglu G, Seli E. Mitochondrial Stress Response Gene Clpp Is Not Required for Granulosa Cell Function. Antioxidants 2020, 10: 1. PMID: 33374937, PMCID: PMC7821922, DOI: 10.3390/antiox10010001.Peer-Reviewed Original ResearchMitochondrial unfolded protein responseUnfolded mitochondrial proteinsLoss of ClpPGerminal vesicleUnfolded protein responseCell functionCumulus cell functionGranulosa/cumulus cellsMitochondrial proteinsClpP deletionClpPProtein responseGermline deletionMetabolic stressGranulosa cell functionDeletionUPRCumulus cellsMice resultsSimilar numberMII oocytesFemale miceWild-type miceEarly antralCells