Skip to Main Content


Clinical Virology

Photo by Robert A. Lisak
A medical technologist is preparing patients’ samples for testing. Most virology tests use molecular or immunologic methods and results are available within one to 48 hours

The Clinical Virology Laboratory at Yale New Haven Hospital performs molecular methods, antigen testing for rotavirus, HBV and C. difficile, C. difficile cytotoxin neutralization culture, and viral and syphilis serology.

Virology is a rapidly changing field and the laboratory is continually modifying its test menu and test algorithms in order to keep abreast of current developments and provide the best services to our patients.

COVID-19 real-time PCR testing was offered for patient care on March 13, 2020.

The Clinical Virology Laboratory was the first non-reference laboratory in the U.S. to receive Emergency Use Authorization from the FDA for for a High Complexity Molecular Based SARS CoV-2 Laboratory Developed Test.

Subsequently, multiple commercial SARS CoV-2 RNA amplification tests have been added to our test menu.

SARS CoV-2 antibody testing is currently offered in the Clinical Chemistry Laboratory.

The Virology Laboratory Director and Laboratory Manager are available by phone or email for consultations and questions.

Clinical Virology Teaching Rounds with a focus on laboratory diagnosis are one Tuesday a month. In addition, Clinical Virology Newsletters;are available on line.

A table of seasonal virus activity is updated weekly

Clinical Virology Services

Tests Performed

Download full listing of all Virology Tests Performed:

Virology Tests Performed


Real-time PCR for virus detection and quantification (30 assays)

Viral Antigen

ELISA for Rotavirus antigen


Viral and syphilis antibody tests by ELISA, CIA, latex agglutination, immunochromatography and immunoblot (31 assays)

Clostridium difficile

Rapid bacterial antigen and toxin immunoassay and cytotoxin neutralization